Türkiye klinikleri tıp bilimleri dergisi最新文献

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Comparison of the 'Patient Management and Outcomes' of the Pediatric Patient Groups Who Had Appendectomy During the COVID-19 Pandemic Period and the Pre-Pandemic Period in Terms of the Efficiency of the Management Plan: Cross-Sectional Research COVID-19大流行期间和大流行前行阑尾切除术的儿科患者组“患者管理和结果”的管理方案效率比较:横断面研究

Türkiye klinikleri tıp bilimleri dergisi Pub Date : 2023-01-01 DOI: 10.5336/medsci.2022-95123

Denizay AVCI, Ülgen ÇELTİK, Mustafa Orkan ERGÜN, Emre DİVARCI, Geylani ÖZOK, Ahmet ÇELİK

{"title":"Comparison of the 'Patient Management and Outcomes' of the Pediatric Patient Groups Who Had Appendectomy During the COVID-19 Pandemic Period and the Pre-Pandemic Period in Terms of the Efficiency of the Management Plan: Cross-Sectional Research","authors":"Denizay AVCI, Ülgen ÇELTİK, Mustafa Orkan ERGÜN, Emre DİVARCI, Geylani ÖZOK, Ahmet ÇELİK","doi":"10.5336/medsci.2022-95123","DOIUrl":"https://doi.org/10.5336/medsci.2022-95123","url":null,"abstract":"Objective: The restrictions in national policies applied in hospital and patient admissions during the coronavirus disease-2019 pandemic have been observed to have caused delays and additional problems in patient management. The aim of this study was to compare the number and rates of negative appendectomy and complicated appendicitis in patients who underwent appendectomy before and during the pandemic in our clinic. Material and Methods: Patients who presented with abdominal pain to our clinic or were consulted between January 2019 and May 2021 were evaluated retrospectively. The cases were categorized into two groups pre-pandemic (1.1.2019-29.2.2020) and pandemic period (11.3.2020-31.5.2021). In both periods, patients underwent laparoscopic appendectomy. In addition, patients were grouped as negative, non-complicated, and complicated according to pathology results. Results: 324 patients were hospitalized during the pre-pandemic period due to ''abdominal pain.'' Exploration was done in 184 (M-F: 59%-41%) patients with suspected appendicitis. On histopathological examination, negative appendectomy was found in 16 (8.7%), noncomplicated in 113 (68.48%), and complicated in 55 (31.52%) of the patients who were operated on. Post-pandemic period, 232 patients were hospitalized due to abdominal pain. Exploration was done in 162 (M-F: 59%-41%) patients. On histopathological examination, negative appendectomy was found in 11 (6.8%), non-complicated in 100 (66.23%), and complicated in 51 (33.7%) of the patients who were operated on. Conclusion: According to the results of the data, no adverse effects were observed on complications or misdiagnosis due to the changing patient management regarding inpatient follow-up and surgical intervention in our clinic during the pandemic period.","PeriodicalId":485899,"journal":{"name":"Türkiye klinikleri tıp bilimleri dergisi","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135052591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Course of Treatment of Chronic Bleeding and Anemia with Systemic Bevacizumab Treatment in Hereditary Hemorrhagic Telangiectasia: A Retrospective Cohort 系统性贝伐单抗治疗遗传性出血性毛细血管扩张的慢性出血和贫血的疗程:回顾性队列

Türkiye klinikleri tıp bilimleri dergisi Pub Date : 2023-01-01 DOI: 10.5336/medsci.2023-96203

Emine DURAK, Mehmet Can UĞUR, Füsun GEDİZ

{"title":"Course of Treatment of Chronic Bleeding and Anemia with Systemic Bevacizumab Treatment in Hereditary Hemorrhagic Telangiectasia: A Retrospective Cohort","authors":"Emine DURAK, Mehmet Can UĞUR, Füsun GEDİZ","doi":"10.5336/medsci.2023-96203","DOIUrl":"https://doi.org/10.5336/medsci.2023-96203","url":null,"abstract":"Objective: Hereditary hemorrhagic telangiectasia (HHT), is an autosomal dominant disorder that causes abnormal angiogenesis. Interest in targeted therapies has been increasing in recent years, especially for the treatment of severe forms of HHT. One of these treatment options is the vascular endothelial growth factor inhibitor bevacizumab. Purpose of this study is to investigate the effect of systemic bevacizumab use on the treatment of chronic bleeding course and anemia in patients diagnosed with HHT. Material and Methods: The treatment response and adverse events of patients with bevacizumab were evaluated retrospectively. Results: The mean age was 51,5. Mean duration of treatment was 15.4 (4-25 months) months. The first 4 doses of 5 mg/kg intravenous bevacizumab were administered at 2-week intervals in all patients. Bevacizumab maintenance continued at a dose of 5 mg/kg in monthly periods. With bevacizumab treatment, an increase in hemoglobin values, a decrease in epistaxis severity score, parenteral iron and erythrocyte transfusion requirement were achieved. Side effects observed were allergic rash in one patient and arthralgia in one patient. None of the patients required discontinuation of treatment due to side effects. Conclusion: Bevacizumab is a promising treatment option in HHT, which can be mortal if not controlled. However, there remains a need for more comprehensive studies in order to achieve a global consensus on treatment protocols and management of adverse events.","PeriodicalId":485899,"journal":{"name":"Türkiye klinikleri tıp bilimleri dergisi","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135058817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of Liver Enzymes to Homeostatic Model Assessment Insulin Resistance in Non-Alcoholic Fatty Liver Disease Patients: A Meta-Analysis and Systematic Review 肝酶与稳态模型评估非酒精性脂肪肝患者胰岛素抵抗的关系:荟萃分析和系统评价

Türkiye klinikleri tıp bilimleri dergisi Pub Date : 2023-01-01 DOI: 10.5336/medsci.2023-97079

Putu Ijiya DANTA AWATARA, Levrita Nindya POETRI, Jonny Karunia FAJAR, Syifa MUSTIKA

{"title":"Relationship of Liver Enzymes to Homeostatic Model Assessment Insulin Resistance in Non-Alcoholic Fatty Liver Disease Patients: A Meta-Analysis and Systematic Review","authors":"Putu Ijiya DANTA AWATARA, Levrita Nindya POETRI, Jonny Karunia FAJAR, Syifa MUSTIKA","doi":"10.5336/medsci.2023-97079","DOIUrl":"https://doi.org/10.5336/medsci.2023-97079","url":null,"abstract":"Studies have assessed that the liver enzymes were proven having the association with insulin resistance (IR) in patients with liver disease; however, there were conflicting findings across the reports. The purpose of this study was to assess the association between liver enzymes and Homeostatic Model Assessment Insulin Resistance (HOMA-IR) in patients with non-alcoholic fatty liver disease (NAFLD). We conducted a meta-analysis between April 2022 and August 2022. Data were obtained from articles in PubMed, ScienceDirect, Cochrane Library, and Taylor & Francis. Using a Z test, the liver enzymes and the HOMA-IR among patients with NALD were compared. We included 683 patients with elevated liver enzymes and 3.579 patients with normal liver enzymes, retrieved from five papers. HOMA-IR score appeared higher in patients with NAFLD with elevated alanine aminotransferase (ALT) than in patients with normal ALT [ALT, mean difference (MD): 1.02; 95% confidence interval (CI): 0.49, 1.54]. Conversely, the aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) had no crucial impact in affectting the HOMA-IR when compared between patients with NAFLD and control [(AST, MD: 0.81; 95% CI: 0.21, 1.40), (GGT, MD: 0.77; 95% CI: 0.20, 1.34), and (ALP, MD: 0.90; 95% CI: 0.22, 1.57)]. IR assessed using HOMAIR has a significant association with abnormal liver enzymes in patients with NAFLD.","PeriodicalId":485899,"journal":{"name":"Türkiye klinikleri tıp bilimleri dergisi","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135052251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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