Geriatric Orthopaedic Surgery & Rehabilitation最新文献

{"title":"Does Fracture Type or Surgical Technique Influence Mortality in Elderly Hip Fracture Patients?","authors":"Fatih Günaydın, Yusuf Bayram, Mahmud Aydın, Ali Çelik","doi":"10.1177/21514593251345390","DOIUrl":"10.1177/21514593251345390","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and compare the 1-year mortality outcomes of elderly patients with hip fractures treated with either hemiarthroplasty (HA) or proximal femoral nailing (PFN), focusing on both intracapsular and extracapsular fractures.</p><p><strong>Methods: </strong>This retrospective cohort study included 210 patients aged 60 years or older who underwent hip fracture surgery between January 2020 and December 2021. Patients were categorized into three groups: Group 1 (PFN for extracapsular fractures), Group 2 (HA for intracapsular fractures), and Group 3 (HA for extracapsular fractures). Demographic variables, surgical details, and 1-year mortality were analyzed.</p><p><strong>Results: </strong>The overall 1-year mortality rate was 37.6%. Mortality was lowest in patients treated with PFN for extracapsular fractures and highest in those treated with HA for extracapsular fractures. Older age and male gender were associated with increased mortality, while female gender had a protective effect.</p><p><strong>Conclusion: </strong>PFN should be considered the preferred surgical approach for elderly patients with extracapsular hip fractures due to its lower mortality and complication rates. HA, while effective for intracapsular fractures, presents higher risks in extracapsular cases. Tailoring surgical strategies to fracture type is essential to optimize patient outcomes.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251345390"},"PeriodicalIF":1.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Factors Contributing to Age-Related Gait Dysfunction in Older Adults.","authors":"Yoshihito Sakai, Tsuyoshi Watanabe, Norimitsu Wakao, Hiroki Matsui, Naoaki Osada, Yui Adachi, Yosuke Takeichi, Akira Katsumi, Ken Watanabe","doi":"10.1177/21514593251340758","DOIUrl":"10.1177/21514593251340758","url":null,"abstract":"<p><strong>Objective: </strong>As walking ability and balance deteriorate with age for bipedal humans, ambulating independently becomes cumbersome without using walking aids. However, age-related risk factors for loss of independent walking ability are not well characterized. We aimed to analyze the clinically relevant factors for ambulatory device aid from the perspectives of nutrition, body composition, and postural abnormalities between independent and assisted walkers based on their ambulatory status.</p><p><strong>Methods: </strong>Among the 3640 patients aged ≥65 years initially enrolled in the study, 1557 patients with a history of fragility fractures were excluded. Patients were categorized into those who could walk independently and those who required assistance. Body composition, including skeletal muscle mass index, whole-spine sagittal alignment, and blood biochemical findings, were compared.</p><p><strong>Results: </strong>Among the 2083 participants, 1323 and 760 were included in the independent and assisted groups, respectively. The logistic regression analysis identified five significant factors (<i>P</i> < 0.01): age, body mass index, red blood cell distribution width, skeletal muscle mass index, and sagittal vertical axis. The receiver operating characteristic analysis determined the threshold for assisted walking to be age 81.0 years, red blood cell distribution width of 14.0%, skeletal muscle mass index of 5.96 kg/m², and a sagittal vertical axis of 54.64 mm with areas under the curve of 0.727, 0.677, 0.645, and 0.708, respectively. Combining these four factors as propensity scores revealed an area under the curve of 0.768.</p><p><strong>Conclusion: </strong>The comparison of independent and assisted walkers among older adults revealed the importance of age, red blood cell distribution width, skeletal muscle mass, and spinal sagittal balance as clinical factors of assisted walkers.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251340758"},"PeriodicalIF":1.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the JRI Cemented Hip Hemiarthroplasty: Mid-Term Results Including Patient-Reported Outcomes.","authors":"Felix Morriss, Joseph M Battle, Jonny Varma, Ahmed M M Shaheen, Steven Barnfield, Jonathan M R French, Michael Kelly","doi":"10.1177/21514593251332462","DOIUrl":"https://doi.org/10.1177/21514593251332462","url":null,"abstract":"<p><strong>Background: </strong>Hemiarthroplasty is the primary treatment for displaced intracapsular hip fractures in frail patients. Implant selection is crucial to reduce reoperations, which carry a high complication risk. This study reports on reoperations, mortality, revisions, and patient-reported outcome measures (PROMs) following the use of the JRI (Joint Replacement Instrumentation Limited) Furlong Cemented Hemiarthroplasty prosthesis.</p><p><strong>Methods: </strong>We undertook a retrospective cohort study at a major trauma centre in the United Kingdom. All intracapsular neck of femur patients aged over 60 who underwent cemented hip hemiarthroplasty with the JRI Furlong femoral stem over a 5 year period from January 2018 to December 2022 were included. The primary outcome measure was reoperation, including closed reduction of dislocation. Secondary outcome measures were dislocation specifically, revision, mortality and PROMs.</p><p><strong>Results: </strong>1183 patients in the study period (793 female, 390 male) with an average age of 84.3 were followed up to 6 years. For a subset of patients, PROMs were recorded at 4 months (n = 237) and 3 years (n = 215). The reoperation rate at 1 year was 1.13% (95% CI 0.64% to 1.99%), increasing to 1.62% (95% CI 0.95% to 2.75%) at 5 years. The 5-year revision rate was 0.68% (95% CI 0.39% to 1.55%); 5-year dislocation rate was 0.87% (95% CI 0.45% to 1.67%). Mean EQ5D utility score was 0.621 at 4 months and 0.603 at 3 years for those alive.</p><p><strong>Conclusions: </strong>Our cohort shows low re-operation, revision and dislocation rates in the mid-term. We describe acceptable PROMS in the context of a frail population.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251332462"},"PeriodicalIF":1.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geriatric Nutritional Risk Index and Prognostic Nutritional Index as Predictors of One-Year Mortality in Older Patients After Hip Fracture Surgery: A Retrospective Cohort Study.","authors":"Wei Wu, Huanyi Zhu, Xiangxu Chen, Yucheng Gao, Chuwei Tian, Chen Rui, Tian Xie, Liu Shi, Yingjuan Li, Yunfeng Rui","doi":"10.1177/21514593251340568","DOIUrl":"https://doi.org/10.1177/21514593251340568","url":null,"abstract":"<p><strong>Background: </strong>Malnutrition is a prevalent issue among older patients with hip fracture and is significantly associated with poor outcomes. The Geriatric Nutritional Risk Index (GNRI) and Prognostic Nutritional Index (PNI) are nutritional screening tools that may assist in predicting outcomes in older patients undergoing hip fracture surgery. This study aimed to evaluate the effects of GNRI and PNI on 1-year mortality after hip fracture surgery in older patients.</p><p><strong>Methods: </strong>This retrospective study included 577 patients aged 60 years and older with hip fractures treated surgically at a single center from January 2018 to December 2021. Nutritional status was evaluated using GNRI and PNI. The primary outcomes were 180-day and 1-year mortality, while secondary outcomes included short-term postoperative complications and length of stay. Univariate and multivariate analyses were performed to identify independent risk factors for 1-year mortality. Subgroup analysis was employed to identify potential population heterogeneity.</p><p><strong>Results: </strong>Patients with low GNRI and low PNI had significantly higher 1-year mortality rates and short-term postoperative complication rates compared to those with higher scores. Low GNRI was an independent risk factor for one-year mortality (95% CI 1.09 - 3.25, <i>P</i> = 0.022). Subgroup analyses revealed significant heterogeneity, with males patients and patients with ASA III-IV showing higher hazard ratios for 1-year mortality associated with low GNRI. Pulmonary infections and older age were also identified as independent risk factors for one-year mortality.</p><p><strong>Conclusion: </strong>This study demonstrated that low GNRI was the risk factor for 1-year mortality after hip fracture surgery in older patients.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251340568"},"PeriodicalIF":1.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality After Iliosacral Screw Fixation for Osteoporotic Pelvic Ring Fractures.","authors":"Alexander Böhringer, Florian Gebhard, Alexander Eickhoff, Raffael Cintean, Tobias Gruber, Konrad Schütze, Carlos Pankratz","doi":"10.1177/21514593251327912","DOIUrl":"https://doi.org/10.1177/21514593251327912","url":null,"abstract":"<p><strong>Background: </strong>Fragility fractures of the posterior pelvic ring are associated with osteoporosis and are becoming more common with demographic change. Known limitations of conservative therapy include a significant loss of autonomy and high mortality. Surgical stabilisation using percutaneous sacroiliac (SI) or trans-iliac trans-sacral (TITS) screws, has been established to increase mobility, but long-term results have not yet been studied.</p><p><strong>Materials and methods: </strong>138 patients with percutaneous SI and TITS screw fixation of the posterior pelvic ring in osteoporotic fragility fractures were followed up for more than a year postoperatively in this retrospective study. Thereby, all patients were operated in the conventional supine position in a hybrid operating room consisting of a fixed, robot-assisted 3D flat-panel detector and a navigation system.</p><p><strong>Results: </strong>34 patients were male and 104 female. The mean age was 77.6 ± 9 years. 26 patients were ASA 1 + 2, 93 patients ASA 3 and 19 patients ASA 4. 80 fractures were classified as FFP 2, 23 FFP 3 and 35 FFP 4. Time to surgery was 127.5 ± 113.2 hours. Hospitalisation lasted an average of 15.7 ± 8.5 days. At the time of discharge, 68.8% of the patients had regained their original mobility, while 31.2% remained limited. The home situation remained unchanged in 73.9% of the patients, worsened in 26.1% and improved in 2.8%. 90.6% of the screw fixations showed no signs of loosening. In 9.4%, loosening could not be ruled out radiologically, but a surgical revision was not necessary. The 1-year mortality rate was 10.1%.</p><p><strong>Conclusion: </strong>Percutaneous navigated screw fixation of the posterior pelvic ring in fragility fractures is a simple, safe, minimally invasive and precise method with good clinical results in terms of rapid recovery with early mobilization of patients to maintain autonomy and reduce mortality. Further clinical studies with controlled cohorts and a large number of patients with long follow-up periods should be carried out to compare the procedure with other methods. In particular, the question of an additional standardized treatment of the anterior pelvic ring in unstable dislocated fragility fractures should be investigated.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251327912"},"PeriodicalIF":1.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete Joint Capsule-Preserving Posterior Approach in Hemiarthroplasty for Femoral Neck Fractures: A Technical Note and Learning Curve Analysis of Trainee Surgeons.","authors":"Takashi Fukushima, Tsuneari Takahashi, Katsushi Takeshita","doi":"10.1177/21514593251338596","DOIUrl":"https://doi.org/10.1177/21514593251338596","url":null,"abstract":"<p><p><b>Introduction:</b> The posterior approach is widely used in hemiarthroplasty for femoral neck fractures. However, it has a high dislocation rate. In hemiarthroplasty, the joint capsule is commonly incised. This study aimed to identify a posterior surgical technique that completely preserves the joint capsule without incision and the use of special devices to remove the head, perform a trial, and place an implant. Further, the learning curves (LCs) of trainee surgeons and the associated complications of the posterior approach were evaluated via a retrospective case series. <b>Materials and Methods:</b> The LCs of trainee surgeons for surgical duration and volume of intraoperative blood loss in 60 cases were examined. The surgical procedures were conducted by three trainee surgeons for femoral neck fractures at a single institution between September 2018 and June 2021. Each surgeon consecutively performed 20 surgical procedures. Each surgeon's cases were divided into four groups, with 15 cases each: 1-5, group A; 6-10, group B; 11-15, group C; and 16-20, group D. Then, these cases were analyzed. Surgery-related complications, such as dislocation, femoral fractures, paralysis, and infection were investigated. <b>Results:</b> The four groups significantly differed in terms of the median operative duration (<i>P</i> = 0.017). In particular, there was a significant difference between groups A and C (<i>P</i> = 0.007) and between groups A and D (<i>P</i> = 0.006). There was an LC for the surgical duration. In 10 cases, the surgical duration was shorter. However, there was no significant difference in the volume of intraoperative blood loss among the four groups. None of the patients presented with dislocation or major complications. <b>Discussion and Conclusions:</b> An LC was observed for the surgical duration in 10 cases among the trainee surgeons. Moreover, the volume of intraoperative blood loss did not significantly increase during the LC period.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251338596"},"PeriodicalIF":1.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle Atrophy Around the Hip Joint in Patients with Femoral Neck Fracture is Associated with Postoperative Walking Ability.","authors":"Hyonmin Choe, Takahiro Yoneda, Masatoshi Oba, Koki Abe, Hiroyuki Ike, Ken Kumagai, Naomi Kobayashi, Yutaka Inaba","doi":"10.1177/21514593251336626","DOIUrl":"https://doi.org/10.1177/21514593251336626","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with femoral neck fractures (FNF) have reduced walking ability owing to muscle weakness. Preoperative muscle volume and quality may have an association with prolonged rehabilitation and can be useful to predict the postoperative walking ability in patients with FNF. This study aimed to compare the muscle volume and computed tomography (CT)-assessed density around the hip joint in patients with FNF with patients having hip osteoarthritis (HOA) and assess the association of these measurement with postoperative walking ability.</p><p><strong>Materials and methods: </strong>This retrospective observational study included 15 patients with FNF and 15 with unilateral HOA who were matched for age, sex, and osteoporosis medication. Muscle volume and CT-assessed density of the gluteus maximus, gluteus medius, gluteus minimus, iliacus, psoas major, rectus femoris, and rectus abdominis on the unaffected side were measured three-dimensionally using 3D Slicer software with preoperative CT data. The associations of muscle measurement with patient background, load to FNF (measured using the finite element method), and pre- or postoperative walking ability were assessed.</p><p><strong>Results: </strong>Muscle volume of gluteus maximus, CT-assessed density of all muscles, and femoral strength were significantly lower in the FNF group than in the OA group (<i>P</i> < .01, <i>P</i> < .01, and <i>P</i> = .04, respectively). Muscle volume showed a moderate-to-strong correlation with body mass index (r = 0.66-0.81) and FNF load (r = 0.51-0.70), and CT-assessed density showed a moderate correlation with serum nutritional markers (r = 0.33-0.60). Postoperative walking ability was significantly correlated with the muscle volumes of iliacus and gluteus maximus (r = 0.40 and 0.49) and CT-assessed density of all muscles (r = 0.47-0.64).</p><p><strong>Conclusion: </strong>Muscle volume and CT-assessed density significantly correlated with femoral bone strength, serum total protein levels, and pre- and postoperative walking ability. These findings suggest that muscle CT analysis around the hip joint may serve as a valuable tool for assessing musculoskeletal status in patients with FNF.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251336626"},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsychosocial Determinants for Total Knee Replacement Decisions Among Older Adults With Chronic Knee Osteoarthritis: A Scoping Review.","authors":"Chia Voon Lim, Deepashini Harithasan, Mohd Azzuan Bin Ahmad, Normala Mesbah, Saravana Kumar, Devinder Kaur Ajit Singh","doi":"10.1177/21514593251335882","DOIUrl":"https://doi.org/10.1177/21514593251335882","url":null,"abstract":"<p><p><b>Background:</b> Total knee replacement (TKR) is a common surgical intervention for older adults with chronic knee osteoarthritis (KOA). Given the prevalence of comorbidities in this population, health priorities may vary, influencing decision-making regarding TKR. Despite the increasing number of TKRs, no scoping review has systematically examined the determinants shaping older adults' decisions using a biopsychosocial (BPS) model. <b>Materials and Methods:</b> Searches were undertaken in commercially produced and grey literature sources. Eligible studies included English-language qualitative and quantitative studies that investigated determinants influencing older adults' decision towards TKR. Two independent reviewers screened the results. The data were then independently extracted, which was then collated and synthesized, using the BPS model. <b>Results:</b> Out of 999 abstracts screened, 23 studies met the inclusion criteria. The included studies took place in Australia, Canada, Germany, Japan, Kuwait, Sweden, Taiwan, Turkey, the United Kingdom and the United States. Ten studies used qualitative study designs while thirteen used varying quantitative study designs. Under BPS model, these determinants were grouped into biological determinants: baseline physical health, disease severity, and pain symptoms; psychological determinants, including coping strategies, feelings of loss, mental stress, depression, and anxiety; and social determinants: support networks, financial resources, health insurance, and access to referral systems and surgery. <b>Conclusion:</b> The decision for TKR in older adults with chronic KOA is shaped by an intricate interplay of biological, psychological, and social factors. The most consistent determinants included the desire for pain relief and the ability to regain physical function. Religion and spirituality significantly influence stress and anxiety in older adults and transportation system also presents significant challenges for TKR surgery. A multifaceted strategy that improves the structures, processes, and outcomes of decision for TKR surgery is required among older adults with chronic KOA. Future research with large, representative samples and a focus on the BPS framework is needed to further explore this complex decision-making process.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251335882"},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the Interplay of Frailty, Age, and Gender in Orthopedic Surgical Outcomes Among the Elderly: Insights From a Prospective Cohort Study.","authors":"Rushama Tandon, Ashutosh Kapoor, Rajan Kumar Singh, Anil Kumar Verma, Nand Kishor Kaushale","doi":"10.1177/21514593251332875","DOIUrl":"https://doi.org/10.1177/21514593251332875","url":null,"abstract":"<p><p><b>Background:</b> With India's aging population on the rise, the prevalence of frailty among elderly patients undergoing major orthopedic surgeries presents a significant challenge for healthcare systems. Frailty, characterized by decreased physiological reserve and increased vulnerability to adverse health outcomes, necessitates a comprehensive approach to preoperative evaluation and care. This study aims to explore the correlation between frailty and socio-demographic variables, particularly age and gender, utilizing the Edmonton Frailty Scale (EFS) to assess frailty among elderly orthopedic surgery patients. <b>Material and Methods:</b> A prospective cohort study was conducted, encompassing 157 patients aged 60 years and above, undergoing major orthopedic procedures between June 2019 and June 2021. The EFS was employed to evaluate frailty, categorizing patients across a spectrum from 'Not Frail' to 'Severe Frail'. Statistical analysis was performed to examine the relationship between frailty levels and socio-demographic variables. <b>Results:</b> The majority of participants were males (59.2%) in the age group of 60-65 years (63.7%). The distribution of frailty revealed 40.1% of patients as not frail, with a substantial proportion displaying varying degrees of frailty. A significant correlation was found between increased frailty severity and advancing age (<i>P</i> < .001), while gender differences in frailty distribution suggested a higher predisposition towards severe frailty among females. <b>Conclusion:</b> The study underscores the high prevalence of frailty among elderly orthopedic patients and its significant association with age and gender. These findings highlight the necessity for frailty-informed preoperative assessments and interventions tailored to the specific needs of elderly patients. Incorporating frailty evaluations into clinical practice can enhance surgical outcomes and improve the quality of care for this vulnerable population.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251332875"},"PeriodicalIF":1.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-Wide Study of the UK Biobank Highlights the Importance of the Homeobox-C Gene Cluster in Hip Fracture Risk.","authors":"Louis John Koizia, Matteo Di Giovannantonio, Ping Zhang, Michael Barry Fertleman, Benjamin Howell Lole Harris","doi":"10.1177/21514593251336568","DOIUrl":"https://doi.org/10.1177/21514593251336568","url":null,"abstract":"<p><strong>Introduction: </strong>Hip fractures are among the most common major orthopaedic injuries globally, with one in three women and one in twelve men projected to sustain a hip fracture in their lifetime. Identifying genetic factors that contribute to hip fracture risk could improve risk stratification and inform prevention strategies. This study aims to identify genetic variants associated with hip fracture susceptibility through a genome-wide association study (GWAS).</p><p><strong>Materials and methods: </strong>A GWAS was undertaken using the UK Biobank to identify risk loci for hip fractures.</p><p><strong>Results: </strong>At the time of analysis, 2165 neck of femur fractures were identified among the 502 507 participants. Thirteen SNPs in five putative haplotypes were identified as significantly associated with hip fracture using the stringent GWAS threshold of 5E-8. Two of these loci appear to affect HOXC8, either by influencing the 3' UTR (rs4142680[T]) or via the miRNA hsa-miR-196a (rs11614913[T]). These two SNPs were also found to be expression quantitative trait loci for homeobox-C cluster genes (HOXC6, HOXC9, and HOXC-AS1).</p><p><strong>Conclusions: </strong>Polymorphisms affecting homeobox-C cluster genes influence hip fracture risk in the general population. Future research should focus on validating these genetic associations and exploring optimal therapeutic interventions that could mitigate fracture risk in subpopulations carrying these polymorphisms.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251336568"},"PeriodicalIF":1.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}