Neurological Sciences and Neurophysiology最新文献_第10页

Different attitudes in the management of different types of status epilepticus: A survey study among neurologists demonstrating evidence gap 不同类型癫痫持续状态管理的不同态度：一项显示证据差距的神经学家调查研究

IF 0.4 4区医学

Neurological Sciences and Neurophysiology Pub Date : 2021-01-01 DOI: 10.4103/NSN.NSN_70_20

Y. Gomceli, Ebru Altındağ, B. Baykan

{"title":"Different attitudes in the management of different types of status epilepticus: A survey study among neurologists demonstrating evidence gap","authors":"Y. Gomceli, Ebru Altındağ, B. Baykan","doi":"10.4103/NSN.NSN_70_20","DOIUrl":"https://doi.org/10.4103/NSN.NSN_70_20","url":null,"abstract":"Purpose: The aim is to identify current diagnostic and therapeutic approach to different types of status epilepticus (SE) including convulsive SE (CSE), non-CSE (NCSE), and epilepsia partialis continua (EPC) to detect unmet needs and problems encountered during the management of these neurological emergencies in our country, Turkey. Methods: The specifically designed SE survey included 31 questions that were related to the incidence, the distribution of etiological causes, the diagnostic process, and the treatment approaches of the neurologists and individual electroencephalography (EEG) facilities of the institutions. Results: The total number of respondents was 152 with a median years of experience in professional practice of 10.8 years (1–39 years). The great majority of the neurologists preferred diazepam plus phenytoin as the first choice drug in the treatment of CSE. Of the respondents, only 55% accepted the SE as refractory after applying the second drug and they monitored these patients in the intensive care unit (ICU). Most of the participants (67.7%) did not provide any treatment except the standard medical approaches, while only 39 (30.7%) had used immunotherapy in the treatment of super-refractory SE. Forty-seven respondents (37%) indicated that they had difficulty identifying NCSE on EEG. While 37% of the participants treated EPC patients with preserved consciousness in ICU by general anesthesia, only 15% were previously applied immunotherapy. Strikingly, 41% of the participants stated that they did not feel themselves as sufficiently competent in terms of practical and theoretical knowledge about the management of SE. Conclusion: We demonstrated that there are no standardized attitudes for the management of different types of SE among neurologists. It is worth to emphasize that the neurologists did not feel themselves sufficiently competent in terms of practical and theoretical knowledge, especially with regard to the subtypes of SE.","PeriodicalId":48555,"journal":{"name":"Neurological Sciences and Neurophysiology","volume":"38 1","pages":"37 - 44"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44851555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of ozone oxidative preconditioning on subarachnoid hemorrhage via rat cerebral vasospasm model 臭氧氧化预处理对大鼠脑血管痉挛模型蛛网膜下腔出血的影响

IF 0.4 4区医学

Neurological Sciences and Neurophysiology Pub Date : 2021-01-01 DOI: 10.4103/NSN.NSN_74_20

H. Suslu, N. Tatarlı, D. Ceylan, H. Süslü, S. Bozkurt, Timucin Avşar, B. Güçlü

{"title":"The effects of ozone oxidative preconditioning on subarachnoid hemorrhage via rat cerebral vasospasm model","authors":"H. Suslu, N. Tatarlı, D. Ceylan, H. Süslü, S. Bozkurt, Timucin Avşar, B. Güçlü","doi":"10.4103/NSN.NSN_74_20","DOIUrl":"https://doi.org/10.4103/NSN.NSN_74_20","url":null,"abstract":"Objective: Cerebral vasospasm after subarachnoid hemorrhage (SAH) is a major cause of morbidity and mortality. Inflammation is the major molecular mechanism observed in vasospastic SAH. Ozone (O3) has been used as a therapeutic agent in the treatment of various conditions and diseases for years. The aim of this study was to evaluate the anti-inflammatory effect of ozone oxidative preconditioning (OOP) in a rat model of SAH in order to assess the therapeutic potential of O3 in SAH therapy. Materials and Methods: In the presented study, an experimental in vivo SAH rat model that provided constriction of large cerebral arteries was used. The inflammatory response of cerebral vasospasm after SAH and the effects of OOP were evaluated by comparing the mRNA levels of inflammatory molecules (tumor necrosis factor-α, interleukin-1β, and intercellular adhesion molecule-1) in the serum samples of rats. Results: The level of inflammatory molecules increased in vasospasm at 12 h, 24 h, and 48 h in the posttreatment groups. However, intraperitoneal OOP decreased the level of inflammatory molecules dramatically. Conclusions: Our study indicated that O3 treatment has potential in the management of inflammation created in a rat SAH model. These findings may inform further studies investigating possible uses of O3 in the treatment of vasospasm.","PeriodicalId":48555,"journal":{"name":"Neurological Sciences and Neurophysiology","volume":"38 1","pages":"60 - 66"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43620898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of oxidative stress in relapse and remission periods of patients with relapsing-Remitting multiple sclerosis 复发缓解型多发性硬化症患者复发和缓解期氧化应激的研究

IF 0.4 4区医学

Neurological Sciences and Neurophysiology Pub Date : 2021-01-01 DOI: 10.4103/nsn.nsn_142_20

S. Oncel, M. Ozturk, R. Gozubatik-Celik, A. Soysal, S. Baybaş

{"title":"Investigation of oxidative stress in relapse and remission periods of patients with relapsing-Remitting multiple sclerosis","authors":"S. Oncel, M. Ozturk, R. Gozubatik-Celik, A. Soysal, S. Baybaş","doi":"10.4103/nsn.nsn_142_20","DOIUrl":"https://doi.org/10.4103/nsn.nsn_142_20","url":null,"abstract":"Introduction: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The role of oxidative stress has gained importance in the pathogenesis of free radicals in cells such as protein, lipid, and nucleic acids by showing myelin loss and axonal degeneration. In this study, serum total oxidant level total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase (PON) in patients with relapsing-remitting-MS (RRMS) were examined. The hypothesis was that antioxidants might indicate the attack phase or the progression phase. Methods: Twenty-four patients with RRMS known to have undergone new attacks and 24 healthy controls whose demographic data were appropriate were included. PON and TAS/TOS measurements were performed once in the healthy group and twice in the serum samples of patients during relapse and remission periods. The Number Cruncher Statistical System 2007 and Power Analysis and Sample Size 2008 Statistical Software (Utah, USA) program was used for statistical analysis. Results: TAS, TOS, and PON levels were similar in the patient and control groups during the attack. In remission, only a positive, statistically significant relationship between the duration of the disease and TAS measurements was noted (r = 0.435; P = 0.034). No significant relationship was found between sociodemographic characteristics, illness duration, laboratory/imaging findings, and antioxidant parameters in blood. Conclusion: In this study, TOS, TAS, OSI, and PON serum levels had no role in determining attack and remission periods in RRMS. There were only significant differences between disease duration and TAS results during the remission period. Following TAS results may help in monitoring progression in patients with early MS.","PeriodicalId":48555,"journal":{"name":"Neurological Sciences and Neurophysiology","volume":"38 1","pages":"67 - 72"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48905779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reliability and validity of the Turkish version of the morningness – Eveningness questionnaire 土耳其版早-晚性问卷的信度和效度

IF 0.4 4区医学

Neurological Sciences and Neurophysiology Pub Date : 2021-01-01 DOI: 10.4103/NSN.NSN_110_20

Firat Ozdalyan, Ö. Tütüncü, H. Gümüş, O. Açıkgöz

{"title":"Reliability and validity of the Turkish version of the morningness – Eveningness questionnaire","authors":"Firat Ozdalyan, Ö. Tütüncü, H. Gümüş, O. Açıkgöz","doi":"10.4103/NSN.NSN_110_20","DOIUrl":"https://doi.org/10.4103/NSN.NSN_110_20","url":null,"abstract":"Background: People are divided into different chronotypes in relation to their circadian rhythm features. The Morningness–Eveningness Questionnaire (MEQ), developed by Horne and Östberg, was the first and is the most used questionnaire for determining the chronotype of people. The reliability and validity of MEQ were tested in this study due to some deficiencies and inconsistencies in previous reliability and validity studies for the Turkish versions of MEQ and deficiencies regarding the validity and reliability of other versions of MEQ. Subjects and Methods: MEQ was translated into Turkish based on the opinions of five academics who were experts in their respective fields and the suitability and content validity of the questionnaire were ensured. The Turkish MEQ was administered to 419 undergraduate students aged 18–34 years. Robust minimum rank factor analysis (MRFA) was used to reveal the construct validity of the questionnaire. Results: As a result of the analyses, the questionnaire was examined in three factors. None of the items were excluded from the study and all items were collected under three factors. The explained total variance value was 42.7%, and the factors explained 64% of common (shared) variance in MRFA. According to the reliability analysis, Cronbach's alpha value for the MEQ Turkish version was satisfactory for the overall questionnaire (0.765). Conclusions: The MEQ version developed in this study is more valid and reliable compared with other versions. However, these results support that a more detailed instrument for morningness and eveningness can be developed.","PeriodicalId":48555,"journal":{"name":"Neurological Sciences and Neurophysiology","volume":"38 1","pages":"50 - 59"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42325992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Renal involvement in children with tuberous sclerosis 结节性硬化症患儿肾脏受累

IF 0.4 4区医学

Neurological Sciences and Neurophysiology Pub Date : 2021-01-01 DOI: 10.4103/NSN.NSN_35_20

A. Keskinoğlu, H. Tekgül, C. Kabasakal

{"title":"Renal involvement in children with tuberous sclerosis","authors":"A. Keskinoğlu, H. Tekgül, C. Kabasakal","doi":"10.4103/NSN.NSN_35_20","DOIUrl":"https://doi.org/10.4103/NSN.NSN_35_20","url":null,"abstract":"Objectives: Tuberous sclerosis (TS) is a multisystemic disease with a genetic component. The central nervous system is most commonly involved. Renal involvement is also common. In this study, renal involvement was investigated descriptively and analytically in children with TS. Methods: A retrospective cohort study was performed on TS patients followed in a neurology clinic. The result variable is renal involvement. Other demographic, health-related, and family characteristics were examined as independent variables. Other system involvements in children with TS were presented analytically. Descriptive and analytical statistics were performed with SPSS 24.0 software. Results: The total number of children diagnosed with TS was 52. Renal involvement was found in 9 (17.3%) of these children. Frequency of renal involvement was not statistically increased according to independent characteristics which were obtained from patient files (demographic characteristics, presence of neurological problems in the family, weight and height percentiles, and other system involvements in children with TS). Conclusion: In our study, renal involvement was found to be less frequent than the reported in the literature. It may be more relevant to conduct studies with higher number of children with TS for risk assessment of renal involvement.","PeriodicalId":48555,"journal":{"name":"Neurological Sciences and Neurophysiology","volume":"38 1","pages":"33 - 36"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42130236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of melatonin treatment on headache and vasomotor reactivity in patients with chronic tension-type headache 褪黑素治疗对慢性紧张型头痛患者头痛及血管舒缩反应性的影响

IF 0.4 4区医学

Neurological Sciences and Neurophysiology Pub Date : 2021-01-01 DOI: 10.4103/nsn.nsn_7_21

E. Eroğlu, B. Öztürk, A. Özön, G. Koc, Ö. Karadaş

{"title":"The effects of melatonin treatment on headache and vasomotor reactivity in patients with chronic tension-type headache","authors":"E. Eroğlu, B. Öztürk, A. Özön, G. Koc, Ö. Karadaş","doi":"10.4103/nsn.nsn_7_21","DOIUrl":"https://doi.org/10.4103/nsn.nsn_7_21","url":null,"abstract":"Objectives: Chronic tension-type headache (TTH) is a serious disease that disrupts quality of life. In this study, the effect of prophylactic oral melatonin treatment on headache and cerebral vasomotor reactivity (VMR) was investigated in patients diagnosed with chronic TTH per the International Classification of Headache Disorders criteria. Subjects and Methods: Twenty patients with chronic TTH and 20 healthy individuals were included in the study. The patients were administered a melatonin treatment at 3 mg/day for 12 weeks. The number of monthly painful days and pain severity were recorded with the “Visual Analog Scale” before and after the treatment. Cerebral VMR measurements were performed at baseline in the control group and in patients before and after the treatment. Results: The median number of monthly painful days was 20 (15–27) before the treatment and 10 (4–18) after the treatment; the median pain severity score was 70.00 (45–80) before the treatment and 42.50 (15–75) after the treatment. The difference was statistically significant (P = 0.001). No statistically significant difference between the VMR values was observed (P > 0.05). Conclusions: Melatonin treatment was effective in reducing the pain severity and decreasing the number of monthly painful days in patients with chronic TTH but demonstrated no effect on the cerebral VMR.","PeriodicalId":48555,"journal":{"name":"Neurological Sciences and Neurophysiology","volume":"38 1","pages":"28 - 32"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47888979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coexistence of hypokalemic periodic paralysis with central hypersomnolence: An attack of paralysis in polysomnographic recording 低钾性周期性麻痹与中枢性嗜睡共存:多导睡眠图记录的一次麻痹发作

IF 0.4 4区医学

Neurological Sciences and Neurophysiology Pub Date : 2021-01-01 DOI: 10.4103/NSN.NSN_145_20

G. Şenel, D. Karadeniz

引用次数: 0

Pembrolizumab-induced myasthenia gravis in a patient with thymic carcinoma: A case report and review of the literature Pembrolizumab诱发胸腺癌患者重症肌无力1例报告及文献复习

IF 0.4 4区医学

Neurological Sciences and Neurophysiology Pub Date : 2021-01-01 DOI: 10.4103/NSN.NSN_105_20

S. Aykac, Büşra Erkılınç, B. Uludaǧ

{"title":"Pembrolizumab-induced myasthenia gravis in a patient with thymic carcinoma: A case report and review of the literature","authors":"S. Aykac, Büşra Erkılınç, B. Uludaǧ","doi":"10.4103/NSN.NSN_105_20","DOIUrl":"https://doi.org/10.4103/NSN.NSN_105_20","url":null,"abstract":"Pembrolizumab is an immune checkpoint inhibitor. Most cases of myasthenia gravis (MG) reported with the use of immune checkpoint inhibitors have been in melanomas, and small and non-small cell lung carcinoma, but there are no reported cases in thymic epithelial carcinoma. A 57-year-old male with thymic carcinoma presented with symptoms of diplopia, drooping eyelids, and difficulty in talking and swallowing after a second dose of pembrolizumab. Contrast-enhanced brain magnetic resonance imaging, laboratory tests, and electroneuromyography were normal. Single-fiber electromyography showed increased jitter (six muscle fibers were collected, range of jitter 29–140 μs, mean 75 μs; normal <35 μs) in bilateral orbicularis oculi muscles supporting MG. Serum screening showed no any positivity for acetylcholine receptor and muscle-specific tyrosine kinase autoantibodies. The patient died of bulbar dysfunction related to aspiration pneumonia despite receiving intravenous immunoglobulin and methylprednisolone therapy. Physicians should be alert to possible exacerbations of autoimmune diseases and associated risks, especially during treatment with checkpoint inhibitors in thymic malignancy.","PeriodicalId":48555,"journal":{"name":"Neurological Sciences and Neurophysiology","volume":"38 1","pages":"73 - 78"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48890836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sensory brain responses and lateralization in nonpainful tactile stimuli during sleep 睡眠中无痛触觉刺激的感觉脑反应和侧化

IF 0.4 4区医学

Neurological Sciences and Neurophysiology Pub Date : 2021-01-01 DOI: 10.4103/NSN.NSN_102_20

Gonca Inanc, M. Özgören, A. Öniz

{"title":"Sensory brain responses and lateralization in nonpainful tactile stimuli during sleep","authors":"Gonca Inanc, M. Özgören, A. Öniz","doi":"10.4103/NSN.NSN_102_20","DOIUrl":"https://doi.org/10.4103/NSN.NSN_102_20","url":null,"abstract":"Aims and Objectives: The aim of this study was to investigate the difference between sensory brain responses of nonpainful tactile stimuli applied to the fingers of the right-hand dominant individuals between the hemispheres. Materials and Methods: Nineteen healthy volunteers (9 women, mean age ± standard deviation: 23.00 ± 2.24 years) participated in the study. Electroencephalogram (EEG) recordings were taken from 40 channels polysomnography system. A uniform nonpainful stimulus was applied to two fingers (index and middle fingers) of the right and left hand with a pneumatic stimulator unit. Results: Non-rapid eye movement sleep (NREM) whole night sleep-related potentials were evaluated. When the stimulus was applied to the right hand, central and parietal regions of the P50 response component appeared significantly earlier in the left hemisphere. When the left-hand stimulus was applied, the P50 and N100 response components appeared significantly early in central, parietal, and temporal regions in the left hemisphere. Hence, amplitudes of the right-hand response components (P50 and N100) were found to be greater in the central, parietal, and temporal regions in the left hemisphere. When the stimulus is applied to the left hand, the amplitude of the P50 component was greater in the central and temporal regions in the left hemisphere. Conclusion: P50 and N100 are components related to sensory processing. The difference in latency and amplitude observed in these components between hemispheres indicates the presence of lateralization in sensory processing during sleep.","PeriodicalId":48555,"journal":{"name":"Neurological Sciences and Neurophysiology","volume":"38 1","pages":"12 - 19"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47813048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The effect of vision on top.down modulation of hand blink reflex 视觉对眨眼反射上下调节的影响

IF 0.4 4区医学

Neurological Sciences and Neurophysiology Pub Date : 2021-01-01 DOI: 10.4103/NSN.NSN_77_20

F. Çalıkuşu, A. Gündüz, M. Kiziltan

{"title":"The effect of vision on top.down modulation of hand blink reflex","authors":"F. Çalıkuşu, A. Gündüz, M. Kiziltan","doi":"10.4103/NSN.NSN_77_20","DOIUrl":"https://doi.org/10.4103/NSN.NSN_77_20","url":null,"abstract":"Objective: The magnitude of hand blink reflex (HBR) increases when a threatening stimulus is positioned in the peripersonal space (PPS) compared with stimulus in the extrapersonal space (EPS). We hypothesized that the reflex increase in PPS might change depending on whether the stimulus was seen. We aimed to investigate the alterations in HBR response to understand the effects of vision on cortical modulation of HBR. Methods: The HBR was recorded from 11 healthy volunteers while the hand was far away from the face (EPS), close to the face with eyes open (PPS-eyes open), and close to the face with eyes closed (PPS-eyes closed). Changes in the response magnitudes were compared between the three conditions. Results: HBR was obtained in all subjects. As expected, there was an increase in the reflex magnitude in the PPS-eyes open condition relative to EPS. In the PPS-eyes closed condition, the duration and latency were shorter and the area under the curve was significantly smaller compared with the PPS-eyes open condition. Conclusion: The enhancement of HBR in PPS is attributed to tonic top-down modulation. Our study provides evidence for the special sensory modulation of the PPS effect on HBR and may suggest cortical modulation of top-down modulation of brainstem neural circuits.","PeriodicalId":48555,"journal":{"name":"Neurological Sciences and Neurophysiology","volume":"38 1","pages":"6 - 11"},"PeriodicalIF":0.4,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41371261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0