{"title":"Cancer Development in Atherosclerotic Cardiovascular Disease","authors":"Jessie M. Dalman BA , Kathryn J. Moore PhD","doi":"10.1016/j.jaccao.2025.05.016","DOIUrl":"10.1016/j.jaccao.2025.05.016","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"7 5","pages":"Pages 514-517"},"PeriodicalIF":12.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Peripheral Ischemia Fuels Breast Cancer Via Myeloid-Skewed Hematopoiesis","authors":"Pilar Martín PhD","doi":"10.1016/j.jaccao.2025.07.002","DOIUrl":"10.1016/j.jaccao.2025.07.002","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"7 5","pages":"Pages 578-579"},"PeriodicalIF":12.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144867404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kapka Miteva PhD , Markus S. Anker MD , Henry Fechner DVM , Lorenz Lehmann MD , Sophie Van Linthout PhD
{"title":"Cancer-Related Immune Therapies","authors":"Kapka Miteva PhD , Markus S. Anker MD , Henry Fechner DVM , Lorenz Lehmann MD , Sophie Van Linthout PhD","doi":"10.1016/j.jaccao.2025.06.008","DOIUrl":"10.1016/j.jaccao.2025.06.008","url":null,"abstract":"<div><div>Immune-based therapies—including immune checkpoint inhibitors, bispecific T cell engagers, chimeric antigen receptor T cells, and tumor-infiltrating lymphocytes— not only have transformed cancer treatment, but also have introduced significant cardiovascular complications, posing new challenges for cardio-oncology. Growing recognition of cardiovascular immune-related adverse events has spurred research into the immune–cardiovascular interface, particularly dysregulated signaling, T cell overactivation, and cytokine release. This review synthesizes recent insights into the role of immune checkpoints in cardiovascular disease, the mechanisms of immune checkpoint inhibitor– and T cell–induced cardiotoxicity, and the therapeutic potential of immune checkpoint modulation and chimeric antigen receptor T cell therapy in cardiovascular applications.</div></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"7 5","pages":"Pages 523-537"},"PeriodicalIF":12.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiovascular Risk Assessment in Patients With Kidney Cancer","authors":"Kriti Mittal MD, MS , Jenica N. Upshaw MD, MSc","doi":"10.1016/j.jaccao.2025.07.004","DOIUrl":"10.1016/j.jaccao.2025.07.004","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"7 5","pages":"Pages 641-643"},"PeriodicalIF":12.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bonnie Ky MD, MSCE, FACC (Editor-in-Chief, JACC: CardioOncology)
{"title":"The Growing Intersection Between Cancer and Cardiovascular Disease","authors":"Bonnie Ky MD, MSCE, FACC (Editor-in-Chief, JACC: CardioOncology)","doi":"10.1016/j.jaccao.2025.07.006","DOIUrl":"10.1016/j.jaccao.2025.07.006","url":null,"abstract":"","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"7 5","pages":"Pages 646-647"},"PeriodicalIF":12.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laith Alhuneafat MD , Avirup Guha MD, MPH , Anne Blaes MD, MS , Suma H. Konety MD, MS
{"title":"Cancer and Cardiovascular Disease","authors":"Laith Alhuneafat MD , Avirup Guha MD, MPH , Anne Blaes MD, MS , Suma H. Konety MD, MS","doi":"10.1016/j.jaccao.2025.07.001","DOIUrl":"10.1016/j.jaccao.2025.07.001","url":null,"abstract":"<div><div>Cancer and cardiovascular disease (CVD) remain the leading causes of morbidity and mortality worldwide, with emerging evidence highlighting their complex and bidirectional interplay. Shared risk factors, including aging, systemic inflammation, metabolic dysregulation, and lifestyle behaviors, can contribute to their co-occurrence while underlying biological mechanisms such as oxidative stress, chronic inflammation, and clonal hematopoiesis further reinforce their connection. These mechanisms drive pathophysiological changes contributing to disease progression, increasing susceptibility to both conditions. This review explores the epidemiology, overlapping biological pathways, and risk factors linking cancer and CVD, emphasizing key mechanisms such as epigenetic modifications, immune system dysregulation, and cellular senescence. Future research should aim to identify biomarkers, refine risk models, and develop targeted strategies to mitigate disease burden and improve outcomes.</div></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"7 5","pages":"Pages 453-469"},"PeriodicalIF":12.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yasutomi Higashikuni MD, PhD , Colin Platt PhD , Margaret H. Hastings PhD , William C.W. Chen MD, PhD , Justin R.B. Guerra BS , Takeshi Tokuyama PhD , Fuad Gandhi Torizal DDS, PhD , Wenhao Liu MD , Takumi Obana , Abraham L. Bayer BS , Hannah Whipple BS , Alexandra Kuznetsov BA , Ashish Yeri PhD , Cole Turissini BS , Robert R. Kitchen PhD , Kota Shibayama , Takayoshi Matsumura MD, PhD , Norihiko Takeda MD, PhD , Hideki Uosaki MD, PhD , Aarti H. Asnani MD , Anthony Rosenzweig MD
{"title":"Mitigation of Doxorubicin Cardiotoxicity With Synergistic miRNA Combinations Identified Using Combinatorial Genetics en masse (CombiGEM)","authors":"Yasutomi Higashikuni MD, PhD , Colin Platt PhD , Margaret H. Hastings PhD , William C.W. Chen MD, PhD , Justin R.B. Guerra BS , Takeshi Tokuyama PhD , Fuad Gandhi Torizal DDS, PhD , Wenhao Liu MD , Takumi Obana , Abraham L. Bayer BS , Hannah Whipple BS , Alexandra Kuznetsov BA , Ashish Yeri PhD , Cole Turissini BS , Robert R. Kitchen PhD , Kota Shibayama , Takayoshi Matsumura MD, PhD , Norihiko Takeda MD, PhD , Hideki Uosaki MD, PhD , Aarti H. Asnani MD , Anthony Rosenzweig MD","doi":"10.1016/j.jaccao.2025.03.007","DOIUrl":"10.1016/j.jaccao.2025.03.007","url":null,"abstract":"<div><h3>Background</h3><div>Cardiomyocyte loss occurs in acute and chronic cardiac injury, including cardiotoxicity due to chemotherapeutics like doxorubicin, and contributes to heart failure development. There is a pressing need for cardiac-specific therapeutics that target cardiomyocyte loss, preventing chemotherapy complications without compromising chemotherapeutic efficacy.</div></div><div><h3>Objectives</h3><div>The authors employed massively parallel combinatorial genetic screening to find microRNA (miRNA) combinations that promote cardiomyocyte survival.</div></div><div><h3>Methods</h3><div>CombiGEM (combinatorial genetics en masse) screening in a cardiomyocyte cell line was followed by validation in the original cell type and screening in primary cardiomyocytes. The top combination was tested in mouse and developing zebrafish models of doxorubicin cardiotoxicity. RNA sequencing provided insight into possible mechanisms.</div></div><div><h3>Results</h3><div>Multiple miRNA combinations protected cardiomyocytes from doxorubicin in vitro. The most effective (miR-222+miR-455) appeared to act synergistically, and mitigated doxorubicin cardiotoxicity phenotypes in murine and zebrafish in vivo models. RNA sequencing revealed overlapping and synergistic regulation of relevant genes and biological processes in cardiomyocytes, including mitochondrial homeostasis, oxidative stress, muscle contraction, and others.</div></div><div><h3>Conclusions</h3><div>We identified miR-222 and miR-455 as a combination with potential therapeutic applications for cardioprotection. This study furthers our knowledge of the cardiac effects of miRNAs and their combinations and demonstrates the potential of CombiGEM for cardioprotective combinatorial therapeutic discovery.</div></div>","PeriodicalId":48499,"journal":{"name":"Jacc: Cardiooncology","volume":"7 4","pages":"Pages 396-410"},"PeriodicalIF":12.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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