Journal of drug research in ayurvedic sciences最新文献

{"title":"Millets: Empowering the society with nutrient-rich superfoods to achieve sustainable development goals","authors":"Pradeep B Patil, Giridhar Goudar, Kommunuri Preethi, Jarapala Sreenivasa Rao, Rabinarayan Acharya","doi":"10.4103/jdras.jdras_207_23","DOIUrl":"https://doi.org/10.4103/jdras.jdras_207_23","url":null,"abstract":"Despite remarkable scientific progress in agriculture and medical sciences, the underlying causes of malnutrition and poverty remain stubborn challenges. This could be attributed to our limited comprehension on the intricate interplay of tradition, cultture, and the economy influence various facets of health. In the past, the sustainable practice of cultivating millets through natural and integrated farming, alongside mixed crop agriculture, played a vital role in maintaining a balanced lifestyle. Unfortunately, this valuable tradition has been neglected over time, partly due to various reasons and a lack of awareness. However, this presents an opportune moment to re-evaluate the potential of millets, not only for their health benefits but also for their positive impact on the environment and agricultural resilience. The Government of India (GoI) has taken steps in promoting millets through various programs and initiatives. Additionally, raising awareness through publications and validating traditional practices with scientific methods will not only facilitate research but also strengthen the bond between people, science, and their cultural heritage. Nonetheless, reintroducing millets into the Indian diet faces considerable challenges, primarily due to the pervasive influence of existing advertisements promoting cereal-based products, internal kitchen politics within households, market-driven agricultural practices, and economic factors. Despite these obstacles, the current manuscript aims to provide insights into developing a roadmap that enables the achievement of sustainable development goals through the integration of millets.","PeriodicalId":484123,"journal":{"name":"Journal of drug research in ayurvedic sciences","volume":"25 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From farm to gut: Unraveling the role of millets in promoting metabolic well-being via gut microbiota","authors":"S B Singh, Ajay Kumar Meena, Brijesh Singh Sisodia, Savita Sharma, MM Sharma, Poornima Mansoria","doi":"10.4103/jdras.jdras_192_23","DOIUrl":"https://doi.org/10.4103/jdras.jdras_192_23","url":null,"abstract":"The human gut microbiota plays a pivotal role in influencing various physiological functions and human health. Dysbiosis, the disruption of gut microbial composition, has been associated with the development of chronic diseases. Dietary interventions, including the consumption of millets, have emerged as a promising strategy to modulate gut microbiota and promote metabolic health. Millets, small-seeded grains cultivated for centuries, offer rich nutritional profiles and bioactive compounds. Their gluten-free nature makes them suitable for individuals with gluten sensitivity. The review explores the intricate relationship between millets and gut microbiota, emphasizing the mechanisms through which millets influence gut microbial composition and functionality. Millets' prebiotic properties and fermentation lead to the production of short-chain fatty acids, promoting gut barrier function and reducing inflammation. ad ditionally, millet consumption may impact gut hormones and exhibit antioxidant and anti-inflammatory effects. The impact of millets on metabolic health is evident, with studies demonstrating improved glycemic control and lipid profiles. Understanding these mechanisms provides valuable insights for personalized dietary recommendations, gut microbiota-targeted interventions, and integrating millets into public health initiatives. Promoting millet cultivation aligns with sustainable food systems, making it a holistic approach to combat metabolic disorders and enhance overall human health.","PeriodicalId":484123,"journal":{"name":"Journal of drug research in ayurvedic sciences","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional and common millet-based food recipes of the tribal communities of Arunachal Pradesh","authors":"Yashpal Bhardwaj, Mumtam Taboh, Yugandhar Pulicherla, Srinivasulu Cheemanapalli, Birina Bhuyan, Shiddamallayya Mathapati","doi":"10.4103/jdras.jdras_190_23","DOIUrl":"https://doi.org/10.4103/jdras.jdras_190_23","url":null,"abstract":"Abstract BACKGROUND: Millets have been cultivated in Arunachal Pradesh for generations, vital to the state's food security and dietary practices. Preserving and promoting culinary traditions not only benefits the local communities but also contributes to the global movement towards a more sustainable and diverse food future. The present study aims to document the common millets based food recipes traditionally prepared in Arunachal Pradesh. MATERIALS AND METHODS: The millet-based food recipes were documented from the ethnic tribal people. This study documented different types of millet-based recipes including millet type, ingredients, recipe type, method of preparation, recipe name in the local languages, and nutritional benefits of millet recipes. RESULTS: The study documented 11 types of millet-based food recipes from the ethnic tribes of Arunachal Pradesh, such as Adi , Apatani , Nyishi , Monpa , and Idu Mishmi . Finger millet is predominantly used to prepare food recipes followed by sorghum and kodo millet. Various ingredients, including local vegetables, milk, egg, ghee, coconut, sugar, etc., are used along with millet flour for food preparation. Various types of cooking techniques, such as steaming, frying, and boiling, have been adopted to prepare these dishes. Apong, a type of alcoholic beverage commonly served during tribal festivals in Arunachal Pradesh, is the most common item prepared mostly with rice and finger millet. CONCLUSION: The present study revealed that various millet-based food recipes are used by local tribes of Arunachal Pradesh.","PeriodicalId":484123,"journal":{"name":"Journal of drug research in ayurvedic sciences","volume":"9 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of foxtail millet (Setaria italica (L.) P. Beauvois) in senile bone degenerative diseases: A conceptual review","authors":"V. S. Nithya, T. P. Athul, Meena Deogade, Tanuja Manoj Nesari","doi":"10.4103/jdras.jdras_218_23","DOIUrl":"https://doi.org/10.4103/jdras.jdras_218_23","url":null,"abstract":"Many of the millets and their health benefits are mentioned in Ayurveda Samhitas and Nighantus including Foxtail millet. Foxtail millet has a wide range of nutritional benefits as it is rich in dietary fiber and minerals such as calcium, magnesium, and phosphorus. Owing to its nutritional profile, foxtail millet possesses the potential to positively influence bone health and structural integrity. Further, the Bhagna sandhana (helps in the union of fractured bone) property mentioned in the classical treatises gives additional evidence for its impact on senile degenerative disorder. To explore the potential of of foxtail millet on senile bone degenerative disorders, a review of the literature from science Direct, PubMed, Scopus, Web of Science, Google Scholar, classical Ayurvedic texts, and other published books was undertaken. This review highlights the potential of foxtail millet ( Kangu ) on senile bone degenerative diseases.","PeriodicalId":484123,"journal":{"name":"Journal of drug research in ayurvedic sciences","volume":"7 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Millets: The sustainable ancient superfood for the modern world","authors":"Dixha Chauhan, Lincon Sethi, Monika Tyagi, Sakshi Sharma","doi":"10.4103/jdras.jdras_248_23","DOIUrl":"https://doi.org/10.4103/jdras.jdras_248_23","url":null,"abstract":"Millets are a category of small-seeded, nutrition-rich grains that have been integral to human subsistence for thousands of years, especially in Africa and Asia. The most extensively grown millets worldwide, notably in India, are pearl millet, finger millet, foxtail millet, Indian barnyard millet, kodo millet, little millet, and proso millet. Millets are explicated under Dhanya Varga in Ayurveda and are referred to by the names Trina Dhanya , Kudhanya , and Kshudra Dhanya across various Samhita . Moreover, indigenous people have long used millets for ethnomedical purposes and prevention of hunger. Millets are a highly resilient crop since they are typically grown on degraded and nutrient-deficit soil receiving little rainfall. Millets are a panacea to various health disorders as they are rich in dietary fiber, proteins, vitamins, minerals, antioxidants, phytochemicals, etc. Millets have surfaced as a possible option to solve current difficulties in the field of agriculture, food security, and public health as there has been a decrease in the yield of main staple grains due to changing agro-climatic conditions for which millets have shown great adaptability with excellent nutritional makeup. This research paper provides a concise overview of millets, highlighting their historical significance, folklore use, cultivation practices, health benefits, their potential to contribute to sustainable farming systems, and food security with government and civil society efforts to encourage millet farming in India. Various Ayurveda literatures, journals, published articles, and books were comprehensively reviewed for this research paper.","PeriodicalId":484123,"journal":{"name":"Journal of drug research in ayurvedic sciences","volume":"25 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An incisive review on Buckwheat—A potential underutilized millet","authors":"Sonam Tamchos, Talat Anjum, Sanjay Kumar Singh","doi":"10.4103/jdras.jdras_214_23","DOIUrl":"https://doi.org/10.4103/jdras.jdras_214_23","url":null,"abstract":"Buckwheat is a short-season, multi-nutrient crop commonly known as “ Kuttu ” in India and used to make flour “ Kuttu ka Atta ” and utilized to prepare a variety of dishes. Buckwheat has small, triangular seeds, frequently used as substitutes for cereals like wheat and rice and commonly cultivated at high altitudes, particularly >1000 masl, where other cereal crops are not as readily available. It is relatively easy to grow, adapts well to various soil types, requires little water, and thrives in moderately fertile soil, which makes it an ideal crop for farmers where water sis scarece and soil is not fertile. Buckwheat is a gluten-free grain that contains carbohydrates, phenolics, protein, dietary fiber, omega-3 and omega-6 fatty acids, and vitamins. Furthermore, it is also said to be beneficial in a number of diseases such as Zn, Cu, Fe, P, Mn, and Mg. Buckwheat has also been used to treat a number of diseases like high blood pressure, digestive troubles, skin problems, and so on. Coordinated efforts are required to improve production and encourage consumption of buckwheat.","PeriodicalId":484123,"journal":{"name":"Journal of drug research in ayurvedic sciences","volume":"25 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the common millets of India: A comprehensive review","authors":"Acharya Balkrishna, Rama Shankar, Uday Bhan Prajapati, Rashmi Atul Joshi, Anupam Srivastava, Chetan Awasthi","doi":"10.4103/jdras.jdras_132_23","DOIUrl":"https://doi.org/10.4103/jdras.jdras_132_23","url":null,"abstract":"Millets were a part of human diet as well as fodder in the past and was helpful in prevention of many diseases especially lifestyle diseases. Because of the dependence on wheat and rice as major source of food and the rise in use of junk food, millets were neglected from routine diet. The rise in incidence of non-communicable diseases, across the globe has helped generate an awareness to include nutri-cereals in the daily food to address the contemporary of lifestyle. Information pertaining to millets, especially on Indian millets, has been collected from various resources, books, research papers and e-platforms for the researches on millets. Nine types of millets are widely used across India. Millets have been the cornerstone of Indian cuisine since centuries and there is much scope for its revival in the present era.","PeriodicalId":484123,"journal":{"name":"Journal of drug research in ayurvedic sciences","volume":"24 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational screening of foxtail millet (Setaria italica (L.) P.Beauv.) polyphenols for finding β-secretase (BACE 1) inhibitors that target the amyloidogenic pathway in Alzheimer’s disease","authors":"Srinivasulu Cheemanapalli, Ramanjaneyulu Golla, Jagadeeswar Reddy Koyyagura, Yugandhar Pulicherla, Yashpal Bhardwaj, Birina Bhuyan, Mumtam Taboh, Shiddamallayya Nagayya, Rajeswara Reddy Saddala","doi":"10.4103/jdras.jdras_184_23","DOIUrl":"https://doi.org/10.4103/jdras.jdras_184_23","url":null,"abstract":"Abstract BACKGROUND: Foxtail millet (FM; Setaria italica (L.) P.Beauv.) is known for its antioxidant and neuroprotective action against Alzheimer's disease (AD); hence the present study aims to screen its polyphenols to find less toxic and potentially effective anti-Alzheimer's drugs. MATERIALS AND METHODS: The details about phyto-compounds of FM and the β-secretase enzyme (BACE 1) of AD have been retrieved from the PubChem compound database and protein data bank, respectively. The Patch Dock server was used to carry out docking experiments. Initially, all the FM phytocompounds and reference drug (MK-8931) were subjected to docking, and subsequently, the best-docked complexes were selected based on their binding energy (in kcal/mol). Rule of five and adsorption, distribution, metabolism, excretion, and toxicity (ADMET) of selected compounds were analyzed using various computational tools. The final docking complexes were developed by using PyMOL. RESULTS: The molecular docking results revealed that among the 24 polyphenols studied, two compounds, namely N′-p-coumaroyl-N″-caffeoylspermidine (NPCNCS) and di-P-coumaroylspermidine (DPCS), demonstrated strong binding to the active site of β-secretase. and exhibited higher binding energies of -300.75 kcal/mol and -193.41 kcal/mol, respectively, in comparison to the reference drug MK-8931, with a binding energy of -154.36 kcal/mol. These compounds established hydrogen bond interactions with catalytic dyad (Asp 32 and Asp 228) and other accessory interactions with residues of the “flap” hairpin loop and “10s loop” of the β-secretase active site involved in the stabilization of substrate/inhibitor binding. In a nutshell, the NPCNCS and DPCS have shown more robust binding affinity than MK-8931 and docked well into the interior side of the active site. On the other hand, NPCNCS and DPCS have satisfied the RO5 and ADMET filters. CONCLUSIONS: The in silico analysis of FM polyphenols revealed that the N′-p-coumaroyl-N″-feruloylspermidine and di-P-coumaroylspermidine compounds exhibited non-toxic, permeability to blood-brain barrier and solid binding affinity toward β-secretase enzyme thereby; these millet compounds might be considered as β-secretase inhibitors for treating AD.","PeriodicalId":484123,"journal":{"name":"Journal of drug research in ayurvedic sciences","volume":"24 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135564823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Millets-based indigenous ethnomedicinal and nutritional practices: Need for scientific validation and value addition","authors":"Narayanam Srikanth","doi":"10.4103/jdras.jdras_354_23","DOIUrl":"https://doi.org/10.4103/jdras.jdras_354_23","url":null,"abstract":"Millets have a long-standing history in India, and one can trace their cultivation and consumption to ancient times. During the Neolithic period in India, millets played a significant role in the agricultural practices and diet of the people. Millets have also contributed in the culture and traditions of many communities around the world for thousands of years. Different millets have been introduced in some of the Yajurveda texts, identifying foxtail millet (priyangu), Barnyard millet (aṇu), and black finger millet (shyamaka), indicating that millet agriculture was prevalent around 1200 BCE in India. In some communities, the harvesting and processing of millet is a communal activity that brings people together and strengthens social bonds. To create domestic and global demand and to provide nutritional food to the people, the Government of India proposed to the United Nations to declare 2023 as the International Year of Millets (IYoM-2023). Millet crops' resilience helps them adjust to different kinds of ecological niches. All these have made them quite indispensable to rainfed, tribal, and hill agriculture, where crop substitution is difficult. That is why it is crucial to enhance the production and productivity of these crops to ensure food and nutritional security for people living in harsh and rugged terrains and other areas. The utilization of these crops is mainly as food for human consumption. The millets are traditionally consumed, and almost all produce is utilized at the farm/village level. Despite the promising nutritional value of millets, their use is primarily confined to rural areas, and very few find their way to urban markets.[1] Commercial Production of Millets: Indian and International Scenario Millets have provided nutrition and ecological benefits to communities throughout Indian history. In recent years, there has been a re-emergence of interest in millets due to their nutritional value, climate resilience, and environmental sustainability. India is among the top 5 exporters of millet in the world. Worldwide millet exports increased from $400 million in 2020 to $470 million in 2021 (ITC trade map). India exported millet worth $75.46 million in 2022–2023, against $62.95 million in 2021–2022. Developing countries produce and consume about 97% of millet, especially in Africa and Asia. According to FAOSTAT (2021), the global millet production in 2019–2020 was 84.17 million metric tonnes from 70.75 M ha, of which 20.50% is produced in India. Currently, millets are used in the diets of about 90 million people in Africa and Asia. Africa accounts for more than 55% of global production, followed by Asia, which accounts for almost 40%, while Europe accounts for around 3% of the worldwide Market. In 2021, the top exporters of Millet were Ukraine ($46.3M), India ($29.6M), United States ($26.7M), Russia ($17.8M), and France ($14.1M). In 2021, the top importers of Millet were Indonesia ($33.2M), Germany ($12.7M), Belgium ($10.9M), United ","PeriodicalId":484123,"journal":{"name":"Journal of drug research in ayurvedic sciences","volume":"75 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135514877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based traditional medicine for transforming global health and well-being","authors":"Bhushan Patwardhan, L Susan Wieland, Obijiofor Aginam, Anchalee Chuthaputti, Ricardo Ghelman, Roshanak Ghods, GohCheng Soon, MotlalepulaG Matsabisa, Georg Seifert, Sione Tu’itahi, KimSung Chol, Shyama Kuruvilla, Kathi Kemper, Holger Cramer, HR Nagendra, Anup Thakar, Tanuja Nesari, Sanjeev Sharma, Narayanam Srikanth, Rabinarayan Acharya","doi":"10.4103/jdras.jdras_194_23","DOIUrl":"https://doi.org/10.4103/jdras.jdras_194_23","url":null,"abstract":"","PeriodicalId":484123,"journal":{"name":"Journal of drug research in ayurvedic sciences","volume":"145 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136116945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}