{"title":"Molecular mechanism and promising treatments of chronic prostatitis/chronic pelvic pain syndrome: An exploratory bibliometric analysis and literature review of preclinical studies","authors":"Yongfeng Lao, Xin Guan, Jian Wang, Yanan Bai, Zewen Li, Zhiping Wang, Zhilong Dong","doi":"10.1002/uro2.34","DOIUrl":"https://doi.org/10.1002/uro2.34","url":null,"abstract":"As one of the most common diseases in urology, a large number of preclinical studies have been accumulated to explore the etiological mechanism and potential intervention of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).In this study, we systematically evaluated the current status of preclinical research on CP/CPPS through bibliometrics analysis using VOSviewer and Citespace. Characteristics of publication such as year, country/region, institution, author, journal, citation, and keywords were analyzed. Based on the bibliometrics analysis results of keywords, we summarized the possible mechanisms and promising treatments for CP/CPPS narratively.According to the results of this study, the most common mechanisms involved in CP/CPPS were as follows: disturbed immune and inflammation mediators, immune cell dysfunction, oxidative stress, dysregulated signaling pathways, apoptosis, gut microbiota, and testosterone metabolism. Chinese Traditional Medicine and extracorporeal shock wave therapy have important potential in the treatment of CP/CPPS.Further translational studies targeting the above mechanisms and validating the objective efficacy of potential treatments indicated by preclinical studies in clinical patients are needed in the future.","PeriodicalId":478044,"journal":{"name":"UroPrecision","volume":"484 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139860282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UroPrecisionPub Date : 2024-02-05DOI: 10.1002/uro2.30
Liyue Mu, Xiang Zhu, Bing Yang, Lin Yang, Xiaofeng Xu, Yongwei Zhao, Dalin He
{"title":"Development of a high‐power blue diode laser for precision vaporization of prostate tissue for the surgical management of benign prostatic hyperplasia","authors":"Liyue Mu, Xiang Zhu, Bing Yang, Lin Yang, Xiaofeng Xu, Yongwei Zhao, Dalin He","doi":"10.1002/uro2.30","DOIUrl":"https://doi.org/10.1002/uro2.30","url":null,"abstract":"This paper explores the advancement and application of high‐power blue diode lasers in treating benign prostatic hyperplasia (BPH). Addressing the challenges posed by existing techniques, the study focuses on optimizing tissue removal methods. Energy platform for BPH should balance a range of factors, such as operative time, patient conditions, urinary functions, complications, durability, accessibility, and cost, all while prioritizing patient care. Blueray Medical's innovation of high‐power blue diode laser systems for BPH surgery is explored, with emphasis on achieving a balance among these considerations. By illustrating the biomedical effects of lasers and their interaction with soft tissues, particularly emphasizing the role of photon absorption by biomolecules and proteins in tissue behavior, this study outlines the advantages of the high‐power blue diode laser system. The initial laboratory experiments and clinical results consistently align with our theoretical predictions, especially in terms of tissue vaporization efficiency, tissue coagulation, and bleeding control. In conclusion, blue diode lasers hold potential to enhance surgical outcomes for BPH. Their unique properties offer benefits like improved tissue removal rate and reduced thermal damages. Integrating blue laser technology into BPH protocols could lead to shorter hospital stays, cost savings, and expanded patient eligibility, although rigorous clinical studies are needed to fully understand their benefits and limitations.","PeriodicalId":478044,"journal":{"name":"UroPrecision","volume":"1 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139863620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UroPrecisionPub Date : 2024-02-05DOI: 10.1002/uro2.30
Liyue Mu, Xiang Zhu, Bing Yang, Lin Yang, Xiaofeng Xu, Yongwei Zhao, Dalin He
{"title":"Development of a high‐power blue diode laser for precision vaporization of prostate tissue for the surgical management of benign prostatic hyperplasia","authors":"Liyue Mu, Xiang Zhu, Bing Yang, Lin Yang, Xiaofeng Xu, Yongwei Zhao, Dalin He","doi":"10.1002/uro2.30","DOIUrl":"https://doi.org/10.1002/uro2.30","url":null,"abstract":"This paper explores the advancement and application of high‐power blue diode lasers in treating benign prostatic hyperplasia (BPH). Addressing the challenges posed by existing techniques, the study focuses on optimizing tissue removal methods. Energy platform for BPH should balance a range of factors, such as operative time, patient conditions, urinary functions, complications, durability, accessibility, and cost, all while prioritizing patient care. Blueray Medical's innovation of high‐power blue diode laser systems for BPH surgery is explored, with emphasis on achieving a balance among these considerations. By illustrating the biomedical effects of lasers and their interaction with soft tissues, particularly emphasizing the role of photon absorption by biomolecules and proteins in tissue behavior, this study outlines the advantages of the high‐power blue diode laser system. The initial laboratory experiments and clinical results consistently align with our theoretical predictions, especially in terms of tissue vaporization efficiency, tissue coagulation, and bleeding control. In conclusion, blue diode lasers hold potential to enhance surgical outcomes for BPH. Their unique properties offer benefits like improved tissue removal rate and reduced thermal damages. Integrating blue laser technology into BPH protocols could lead to shorter hospital stays, cost savings, and expanded patient eligibility, although rigorous clinical studies are needed to fully understand their benefits and limitations.","PeriodicalId":478044,"journal":{"name":"UroPrecision","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139803877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Consensus on safety management of novel hormonal therapy for advanced prostate cancer","authors":"Sujun Han, Shudong Cheng, Degang Ding, Jianming Guo, Zhisong He, Baiye Jin, Zhigang Ji, Tianxin Lin, Yuanjie Niu, Weijun Qin, Benkang Shi, Jinkai Shao, Xi'nan Sheng, Qiang Wei, Xin Wang, Xinghuan Wang, Shujie Xia, Wanhai Xu, Qing Zou, Xiongbing Zu, Renu Eapen, Chi‐Fai Ng, Hirotsugu Uemura, Hiroji Uemura, Cheol Kwak, Jae Young Joung, Marniza Saad, Edmund Chiong, Nianzeng Xing","doi":"10.1002/uro2.22","DOIUrl":"https://doi.org/10.1002/uro2.22","url":null,"abstract":"Prostate cancer (PCa) is one of the most prevalent malignant tumors in men, accompanied by high incidence and mortality rates. Novel hormonal therapy (NHT) has emerged as the primary treatment for advanced PCa, providing noticeable clinical benefits. However, the diverse range of adverse events (AEs) associated with NHT may influence both treatment efficacy and patients' quality of life. In light of the latest international clinical research evidence and recommendations from domestic and foreign guidelines, this consensus aims to provide a comprehensive overview of the common AEs experienced during NHT for advanced PCa patients. Additionally, it seeks to develop a hierarchical approach to more efficiently manage AEs, presenting valuable insights for clinical medication and adverse reaction management.","PeriodicalId":478044,"journal":{"name":"UroPrecision","volume":"51 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138956982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UroPrecisionPub Date : 2023-10-29DOI: 10.1002/uro2.24
Kyle A. Blum, William Jones, Lauren Conroy, Justin Mehr, Travis Green, Run Wang
{"title":"Complex reimplantation of an inflatable penile prosthesis with scar tissue excision and distal corporal defect repair with Tutoplast® pericardium allograft","authors":"Kyle A. Blum, William Jones, Lauren Conroy, Justin Mehr, Travis Green, Run Wang","doi":"10.1002/uro2.24","DOIUrl":"https://doi.org/10.1002/uro2.24","url":null,"abstract":"Abstract Background Patients with inflatable penile prostheses (IPP) may experience erosions after years of use or after indwelling Foley catheter placement. IPP erosions should be managed as an infection with the entire IPP removed. Replacing IPPs in erosion patients can be challenging due to extensive scarring development. Using proper graft materials may be necessary to close and reinforce the corporal defect after difficult corporal dilation or significant scar removal for the long‐term success of IPP reimplantation. Case Presentation Herein we report a patient with a history of IPP placement in 2007 for erectile dysfunction and Peyronie's disease, presenting in 2018 with dysuria and a feeling of IPP displacement following Foley catheter placement for coronary artery bypass graft surgery. The left cylinder of the IPP was observed by physical examination and a defect near the fossa navicularis was discovered during office cystoscopy. A complete explantation of IPP was then performed. Reimplantation of the IPP was performed in 2021 which required excision of corporal scar tissue and repair of a left distal corporal defect using a Tutoplast® pericardium allograft. The procedure was successful with proper IPP position and good function without any penile deformity. Conclusion The use of graft materials in the management of corporeal defects should be considered in the setting of complex IPP revision. The Tutoplast® pericardium allograft reinforcement can provide long‐term durability, flexibility, and a lower risk of infection.","PeriodicalId":478044,"journal":{"name":"UroPrecision","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UroPrecisionPub Date : 2023-10-20DOI: 10.1002/uro2.25
Guiting Lin, Run Wang, Richard Lo, Tom F. Lue
{"title":"History of World Chinese Urological Society (WCUS)","authors":"Guiting Lin, Run Wang, Richard Lo, Tom F. Lue","doi":"10.1002/uro2.25","DOIUrl":"https://doi.org/10.1002/uro2.25","url":null,"abstract":"The World Chinese Urological Society (WCUS) stands as a dynamic and influential force in uniting professionals of Chinese descent from around the globe. Established with the vision of fostering collaboration, innovation, and knowledge exchange, WCUS serves as a beacon of excellence within the urological community. By providing a forum for urologists, andrologists, and urology/andrology scientists, WCUS is a crucible for exchanging cutting-edge research, groundbreaking techniques, and clinical insights. Through its annual meetings and conferences, WCUS nurtures a culture of shared expertise, where luminaries from China (including Taiwan, Hong Kong, and Macao), Singapore, Malaysia, Australia, and beyond, converge to shape the trajectory of urology. These gatherings facilitate the exploration of diverse facets of the field, from andrology to oncology, offering a tapestry of insights that enrich the practice and research of urology. WCUS not only honors past achievements but also champions the future. By spotlighting rising stars, offering mentorship, and recognizing exceptional contributions through awards, the society invests in the next generation of urological leaders. This commitment ensures that the legacy of WCUS continues to illuminate the path forward for urology. The society keeps pace with technological advancements, explores groundbreaking treatments, and engages with interdisciplinary collaborations that push the boundaries of urological understanding. With a forward-looking mindset, WCUS remains a vanguard of progress within the urology landscape. Beyond its academic pursuits, WCUS extends its impact through international partnerships, forging connections that span continents. By fostering relationships with urological associations and experts worldwide, the society contributes to a global network of professionals united by a shared passion for advancing urological knowledge and patient care. Founded by eight urologists on February 22, 1902, the American Urological Association (AUA), has been holding annual meetings at which world-class urologists and uroscientists give state-of-the-art lectures and present new discoveries in plenary sessions, poster sessions, symposiums, and postgraduate courses. There are more than 20 000 urologists of Chinese descent in the world, and many have actively participated in the activities of the AUA. These Chinese urologists had become integral to the AUA's activities, actively contributing to its programs and initiatives. In 2005, Dr. Joseph N. Corriere Jr., the President of the AUA at the time, and Dr. Carl A. Olsson, the Secretary, championed a groundbreaking idea in response to the request of Dr. Tom F. Lue. Recognizing the contributions and potential of Chinese urologists, they authorized establishing a Chinese urology program within the annual AUA meeting. This visionary concept resonated deeply with Chinese urologists globally, igniting a wave of enthusiastic support. Dr. Corriere Jr. then visited ","PeriodicalId":478044,"journal":{"name":"UroPrecision","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135617579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A survey of emergency blunt urethral injury management in China: Reality versus guidelines","authors":"Yubo Gu, Changhao Hou, Jiahao Lin, Wei Yuan, Zeyu Wang, Xianjie Xiu, Qiang Fu, Lujie Song","doi":"10.1002/uro2.23","DOIUrl":"https://doi.org/10.1002/uro2.23","url":null,"abstract":"Abstract Background Although urethral trauma may lead to serious consequences if mismanaged, treatment concepts are inconsistent. We designed a survey to investigate the current diagnosis and management of emergency blunt urethral trauma to aid future dissemination of relevant concepts. Methods A 15‐item anonymous questionnaire was distributed via an online platform. It addressed items such as the cognition of how to diagnose of urethral trauma, optimal emergency management of a urethral trauma patient, and attitude towards early realignment for pelvic fracture urethral injuries. Results Of 538 respondents, 94.2% and 84.9% had received patients with straddle trauma urethral injuries or pelvic fracture urethral injuries, respectively, within the past year. In the emergency room, attempted urethral catheterization was the most selected examination method by respondents for diagnosis of both straddle injury (500/538) and pelvic fracture urethral injury (469/538). For patients with straddle injury, 41.3% of respondents performed endoscopic realignment and 31.6% preferred suprapubic cystostomy. For hemodynamically stable patients with PFUI, 42.2% of respondents preferred suprapubic cystostomy and 34.9% preferred endoscopic realignment. Most respondents felt favorably toward early realignment for pelvic fracture urethral injuries. After realignment, 61.3%, 24.5%, and 13.8% of respondents performed catheterization for 4, 8, and 12 weeks, respectively. Further, 54.6% of respondents believed catheter traction should be applied after realignment. Conclusion Although the number of yearly emergency urethral trauma cases was small, the opinions and practices of most urologists were consistent with guidelines. However, the significance of retrograde urethrography was not fully understood, and some respondents had incorrect views on catheter traction after realignment.","PeriodicalId":478044,"journal":{"name":"UroPrecision","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135729728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UroPrecisionPub Date : 2023-09-20DOI: 10.1002/uro2.21
Kareim Khalafalla, Laila Ammar, Run Wang
{"title":"Precise review of a male's infertility assessment from a men's health specialist prospective","authors":"Kareim Khalafalla, Laila Ammar, Run Wang","doi":"10.1002/uro2.21","DOIUrl":"https://doi.org/10.1002/uro2.21","url":null,"abstract":"Abstract Infertility is a pervasive issue affecting a considerable proportion of couples in their reproductive years, with a projected 10%–15% prevalence. It is characterized by the incapability to achieve conception following a year of consistent, unprotected intercourse, and its far‐reaching consequences can take a profound emotional, psychological, and social toll on couples, inducing feelings of melancholy, exasperation, and anxiety. The appraisal of infertile couples' cases is a multifaceted and daunting process, necessitating a holistic understanding of the intricate underlying factors contributing to their infertility. Consequently, an individualized evaluation should be conducted, considering diverse parameters, such as the couple's medical history, age, infertility duration, and other relevant criteria. This paper will provide an in‐depth overview of the current approaches utilized in the evaluation of men with infertility, including the commonly employed diagnostic tools and procedures. Enhancing our comprehension of infertility assessment and management holds the promise of helping couples achieve their ultimate desire of conceiving and enriching their overall quality of life.","PeriodicalId":478044,"journal":{"name":"UroPrecision","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136374229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
UroPrecisionPub Date : 2023-03-01DOI: 10.1002/uro2.4
{"title":"Information for Authors","authors":"","doi":"10.1002/uro2.4","DOIUrl":"https://doi.org/10.1002/uro2.4","url":null,"abstract":"UroPrecisionVolume 1, Issue 1 p. vii-ix ISSUE INFORMATIONOpen Access Information for Authors First published: 24 July 2023 https://doi.org/10.1002/uro2.4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume1, Issue1March 2023Pages vii-ix RelatedInformation","PeriodicalId":478044,"journal":{"name":"UroPrecision","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135469419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}