Indian Journal of Critical Care Medicine最新文献

{"title":"Author Response: Continuous Infusion of Linezolid: Explaining the Discrepant Survival Outcomes between Two Studies.","authors":"Ahmed M Albadry","doi":"10.5005/jp-journals-10071-24998","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-24998","url":null,"abstract":"","PeriodicalId":47664,"journal":{"name":"Indian Journal of Critical Care Medicine","volume":"29 7","pages":"623"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmapheresis for Hypertriglyceridemia-induced Acute Pancreatitis: A Systematic Review and Meta-summary of Case Reports.","authors":"Prashant Nasa, Ravi Jain, Omender Singh, Deven Juneja","doi":"10.5005/jp-journals-10071-25010","DOIUrl":"10.5005/jp-journals-10071-25010","url":null,"abstract":"<p><strong>Background and aims: </strong>Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). However, the evidence on the management of hypertriglyceridemia-induced AP is lacking. We undertook a systematic review of all published case reports and series to evaluate the clinical characteristics of hypertriglyceridemia-induced AP patients in whom plasmapheresis was used, and the effect of plasmapheresis on plasma triglycerides levels and procedure-related safety.</p><p><strong>Materials and methods: </strong>A systematic literature search was performed for case reports and series published between January 1, 1975 and April 30, 2023 in PubMed, Science Direct, Embase and Google Scholar databases using keywords \"hypertriglyceridemia\" AND \"pancreatitis\" AND \"plasmapheresis\" OR \"plasma exchange.\" The inclusion criteria were (1) hypertriglyceridemia-induced AP and (2) use of plasmapheresis to manage AP.</p><p><strong>Results: </strong>Seventy-one studies involving 91 unique patients were included in this meta-summary. Nearly three-fourth had severe AP and one-fifth with recurrent pancreatitis. A previous history of hypertriglyceridemia and diabetes was known in 52.7% of the patients, and alcohol abuse in 17.6%. The majority of the patients were young males, with 15 pregnant females. A median of two sessions with a plasma exchange volume of 3 L significantly reduced serum triglycerides in patients with hypertriglyceridemia. Most (96.7%) of the patients recovered with a median hospital and intensive care unit length of stay (LOS) of 11 and 5 days, respectively.</p><p><strong>Conclusion: </strong>Plasmapheresis is an effective therapeutic procedure that can significantly reduce triglycerides levels in hypertriglyceridemia-induced AP. The procedure is reasonably safe, including in patients with severe AP and pregnancy. Future prospective randomized studies are required to evaluate the impact of plasmapheresis on patient-centered outcomes compared with pharmacological management of AP.</p><p><strong>How to cite this article: </strong>Nasa P, Jain R, Singh O, Juneja D. Plasmapheresis for Hypertriglyceridemia-induced Acute Pancreatitis: A Systematic Review and Meta-summary of Case Reports. Indian J Crit Care Med 2025;29(7):604-611.</p>","PeriodicalId":47664,"journal":{"name":"Indian Journal of Critical Care Medicine","volume":"29 7","pages":"604-611"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Response: The Sleep Quality of Intensive Care Unit Patients on Noninvasive Ventilation Depends Not Only on Noninvasive Ventilation- and ICU-related Factors but Also on Numerous Other Factors.","authors":"Aiswarya Kunjappan, Madhura M Reddy","doi":"10.5005/jp-journals-10071-25005","DOIUrl":"https://doi.org/10.5005/jp-journals-10071-25005","url":null,"abstract":"","PeriodicalId":47664,"journal":{"name":"Indian Journal of Critical Care Medicine","volume":"29 7","pages":"631"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of <i>Enterococcal</i> Bacteremia with Potential Therapeutic Options.","authors":"Ekadashi Rajni, Ayushi Jorwal, Kriti Goyal, Vishnu K Garg","doi":"10.5005/jp-journals-10071-25008","DOIUrl":"10.5005/jp-journals-10071-25008","url":null,"abstract":"<p><strong>Background and aims: </strong><i>Enterococci</i>, particularly vancomycin-resistant <i>Enterococci</i> (VRE), pose a significant clinical challenge due to rising pathogenicity and antimicrobial resistance. This study aims to examine the prevalence of <i>Enterococcal</i> bacteremia and their antibiotic susceptibility pattern in a Tertiary Care Hospital in Western India. The study also highlights clinical implications of resistance patterns, emphasizing therapeutic challenges and the need for targeted antimicrobial stewardship to guide effective treatment of <i>Enterococcal</i> infections.</p><p><strong>Patients and methods: </strong>This is a retrospective observational study conducted in a Tertiary Care Teaching University Hospital. All blood cultures received in the laboratory from October 2022 to September 2023 were included in the study. They were processed using the automated BD BACTEC system and species identification and antibiotic susceptibility testing (AST) were performed using the VITEK 2 Compact system, following Clinical and Laboratory Standards Institute (CLSI) guidelines.</p><p><strong>Results: </strong>From 10,449 blood cultures received during the study period, 13.18% showed bacterial growth. Of these, 30.33% were gram-positive, with <i>Enterococcus</i> spp. constituting 30.14%. <i>Enterococcus faecium</i> was most prevalent (85.71%), and VRE prevalence was 8.73%. All VRE isolates were resistant to benzylpenicillin and fluoroquinolones, with 80% additionally resistant to linezolid. VanA phenotype was present in all isolates. A total of 100% susceptibility was observed for daptomycin and tigecycline.</p><p><strong>Conclusion: </strong>Findings of this study underscore the urgent need for stringent infection control measures and prudent antibiotic stewardship to effectively manage and prevent VRE infections.</p><p><strong>How to cite this article: </strong>Rajni E, Jorwal A, Goyal K, Grag VK. An Overview of <i>Enterococcal</i> Bacteremia with Potential Therapeutic Options. Indian J Crit Care Med 2025;29(7):612-614.</p>","PeriodicalId":47664,"journal":{"name":"Indian Journal of Critical Care Medicine","volume":"29 7","pages":"612-614"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Inflammatory Biomarker Subphenotypes on Acute Respiratory Distress Syndrome Prognosis: A Systematic Review and Meta-analysis.","authors":"Saurabh K Das, Nang Sujali Choupoo, Bram Rochwerg, Debarsee Goswami, Sumit Ray, Ajay Gupta, Parveen Kaur","doi":"10.5005/jp-journals-10071-25007","DOIUrl":"10.5005/jp-journals-10071-25007","url":null,"abstract":"<p><strong>Background and aims: </strong>Acute respiratory distress syndrome (ARDS) is a syndrome that incorporates a wide group of patients with sign and symptoms of acute hypoxemic respiratory failure. Various studies describing hypo- and hyperinflammatory subphenotypes among ARDS cohorts have been performed. The objective of this systematic review and meta-analysis was to examine how biomarker-based subphenotypes of ARDS impact mortality.</p><p><strong>Methods: </strong>Medline, Cochrane Library, KoreaMed, LILACS, TRIP Database, and World Health Organization Clinical Trial Registry were searched for studies on subphenotyping of ARDS on the basis of inflammatory biomarkers that reported mortality. Pooled relative risk (RR) of mortality and mean difference (MD) of ventilator-free days (VFDs) were calculated. Grading of recommendations, assessment, development, and evaluations (GRADE) approach for prognostic outcomes was used to assess the certainty of evidence.</p><p><strong>Results: </strong>A total of 12 studies comprising 6,643 patients were included in the review. Pooled analysis demonstrated that hyperinflammatory subphenotype ARDS may be associated with a higher risk of dying as compared with hypoinflammatory subphenotype ARDS (RR 2.50, 95% confidence interval (CI) 1.77-2.86). Hyperinflammatory ARDS may be associated with fewer VFDs compared with hypoinflammatory ARDS (MD: 15.90 days, 95% CI 2.23-29.57 days fewer). These findings, although based on low certainty evidence, were robust to multiple sensitivity analyses.</p><p><strong>Conclusion: </strong>The review demonstrates that hyperinflammatory subphenotype of ARDS may be associated with increased mortality and decreased VFDs. This may help patients and clinicians to know clinical outcome of patient with ARDS.</p><p><strong>How to cite this article: </strong>Das SK, Choupoo NS, Rochwerg B, Goswami D, Ray S, Gupta A, <i>et al</i>. The Impact of Inflammatory Biomarker Subphenotypes on Acute Respiratory Distress Syndrome Prognosis: A Systematic Review and Meta-analysis. Indian J Crit Care Med 2025;29(7):597-603.</p>","PeriodicalId":47664,"journal":{"name":"Indian Journal of Critical Care Medicine","volume":"29 7","pages":"597-603"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter on \"Impact of Noninvasive Ventilation on Quality of Sleep among Patients Admitted to the Critical Care Unit\" - Limitations and Recommendations.","authors":"Swapnil N Deshmukh, Sneha S Deore","doi":"10.5005/jp-journals-10071-25004","DOIUrl":"10.5005/jp-journals-10071-25004","url":null,"abstract":"","PeriodicalId":47664,"journal":{"name":"Indian Journal of Critical Care Medicine","volume":"29 7","pages":"632-633"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining the Evidence on HFNC for Post-traumatic Lung Contusion: A Critical Perspective.","authors":"Swapnil Narayan Deshmukh, Rishi Govind Orakkan, Madhu Sudan Barthwal","doi":"10.5005/jp-journals-10071-24946","DOIUrl":"10.5005/jp-journals-10071-24946","url":null,"abstract":"","PeriodicalId":47664,"journal":{"name":"Indian Journal of Critical Care Medicine","volume":"29 7","pages":"615"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Profile, Intensive Care Needs, and Outcome of Children with Adenoviral Pneumonia: A Retrospective Study from a Tertiary Care Hospital in North India.","authors":"Siva Vyasam, Jyothi Jayaram, Subhabrata Sarkar, Suresh Kumar Angurana, Shubham Raj, Ishani Bora, Karthi Nallasamy, Arun Bansal, Jayashree Muralidharan, Radha K Ratho","doi":"10.5005/jp-journals-10071-24999","DOIUrl":"10.5005/jp-journals-10071-24999","url":null,"abstract":"<p><strong>Background and aims: </strong>Adenoviral pneumonia is a significant cause of morbidity and mortality among children. There is limited data about the clinical profile, intensive care needs, and outcomes of children with adenoviral pneumonia from resource-limited settings.</p><p><strong>Patients and methods: </strong>This retrospective study was conducted in the pediatric emergency room (PER) and pediatric intensive care unit (PICU) of a tertiary care hospital in North India over a period of a period of 2 years (July 2022 to June 2024). The data collection included demographic and clinical features, laboratory investigations, complications, treatment, intensive care needs, and outcomes.</p><p><strong>Results: </strong>Eighty-five children were enrolled, majority were <1 year of age and males (71.7% each). All presented with fever and respiratory symptoms. The common complications were acute respiratory distress syndrome (ARDS) (47%), multiple organ dysfunction syndrome (MODS) (26%), shock (25%), and encephalopathy (25%). PICU admission was needed in 46% of children. The intensive care needs included invasive mechanical ventilation (48%), CPAP (39%), HFNC (9%), vasoactive drugs (25%), IVIG (8%), RRT (6%), and cidofovir (5%). The duration of ER, PICU, and hospital stay was 48 (24-96) hours, 7 (4-14) days, and 9 (5-18) days, respectively. The mortality rate was 22%. On multivariate analysis, the independent predictors of mortality were low admission pH, myocardial dysfunction, acute kidney (AKI), ARDS, shock, encephalopathy, MODS, and healthcare-associated infection (HCAI).</p><p><strong>Conclusion: </strong>Infants constituted the largest group of patients requiring admission for adenoviral infection to pediatric emergency in a tertiary care center. Common complications were ARDS, shock, MODS, and encephalopathy. Nearly half required PICU admission for organ support. The mortality rate was 22%; and low admission pH, myocardial dysfunction, AKI, ARDS, shock, encephalopathy, MODS, and HCAI were independent predictors of mortality.</p><p><strong>How to cite this article: </strong>Vyasam S, Jayaram J, Sarkar S, Angurana SK, Raj S, Bora I, <i>et al</i>. Clinical Profile, Intensive Care Needs, and Outcome of Children with Adenoviral Pneumonia: A Retrospective Study from a Tertiary Care Hospital in North India. Indian J Crit Care Med 2025;29(7):586-591.</p>","PeriodicalId":47664,"journal":{"name":"Indian Journal of Critical Care Medicine","volume":"29 7","pages":"586-591"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining the Acute Respiratory Distress Syndrome - Are You a Splitter or a Lumper? The Choice Matters more than You Think.","authors":"Prashant Nasa, Deven Juneja, Marcus J Schultz","doi":"10.5005/jp-journals-10071-25016","DOIUrl":"10.5005/jp-journals-10071-25016","url":null,"abstract":"","PeriodicalId":47664,"journal":{"name":"Indian Journal of Critical Care Medicine","volume":"29 7","pages":"551-553"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Response: Challenges in Implementing High Protein Nutrition for ICU Patients.","authors":"Vetriselvan Parasuraman, Bikash Ranjan Ray, Puneet Khanna, Rahul K Anand, Rakupathy Shanmugam","doi":"10.5005/jp-journals-10071-25002","DOIUrl":"10.5005/jp-journals-10071-25002","url":null,"abstract":"","PeriodicalId":47664,"journal":{"name":"Indian Journal of Critical Care Medicine","volume":"29 7","pages":"619-620"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}