发布求助
文献互助 智能选刊 最新文献

Journal of Innovations in Medical Research最新文献

筛选
英文 中文
Advancements and Future Directions of Immunotherapy in Cancer Treatment 免疫疗法在癌症治疗中的进展与未来方向
Journal of Innovations in Medical Research Pub Date : 2023-10-01 DOI: 10.56397/jimr/2023.10.08
Wanqing Zhang, Qishan Liu, Tianxiang Zhou
{"title":"Advancements and Future Directions of Immunotherapy in Cancer Treatment","authors":"Wanqing Zhang, Qishan Liu, Tianxiang Zhou","doi":"10.56397/jimr/2023.10.08","DOIUrl":"https://doi.org/10.56397/jimr/2023.10.08","url":null,"abstract":"Immunotherapy has revolutionized cancer treatment by harnessing the power of the immune system to target and eliminate cancer cells. This approach has shown remarkable success in various cancer types, including melanoma, lung cancer, and breast cancer. However, challenges and limitations exist, such as resistance mechanisms and immune-related adverse effects. To overcome these challenges, future directions in immunotherapy focus on combination therapies, targeting novel immune checkpoints, and identifying reliable biomarkers and predictive factors. These advancements aim to improve treatment outcomes and personalize immunotherapy for individual patients. Continued research and clinical trials in these areas will shape the future of immunotherapy and contribute to the fight against cancer.","PeriodicalId":476009,"journal":{"name":"Journal of Innovations in Medical Research","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136153953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperosmolar Hyperglycaemic State: A Life-Threatening Complication of Type 2 Diabetes Patients 高渗性高血糖状态:2型糖尿病患者危及生命的并发症
Journal of Innovations in Medical Research Pub Date : 2023-10-01 DOI: 10.56397/jimr/2023.10.04
Devajit Mohajan, Haradhan Kumar Mohajan
{"title":"Hyperosmolar Hyperglycaemic State: A Life-Threatening Complication of Type 2 Diabetes Patients","authors":"Devajit Mohajan, Haradhan Kumar Mohajan","doi":"10.56397/jimr/2023.10.04","DOIUrl":"https://doi.org/10.56397/jimr/2023.10.04","url":null,"abstract":"Hyperosmolar hyperglycaemic state (HHS) is a life-threatening complication of type 2 diabetes (T2D), but it is preventable. There is no precise definition of HHS. It is characterized by severe hyperglycaemia with blood glucose levels greater than 600 mg/dl (33.3 mmol/l), a marked increase in serum osmolality greater than 320 mOsm/kg, and severe dehydration without significant ketoacidosis (<3 mmol/l). Early clinical diagnosis and prompt treatment, such as insulin therapy, restoration of electrolyte disturbances and management of concurrent illnesses may improve the outcome. Intravenous insulin and fluid replacement with careful monitoring are the main treatment policy of HHS. In this study an attempt has been taken to discuss various effects of HHS with prevention and treatment of this complication of diabetes.","PeriodicalId":476009,"journal":{"name":"Journal of Innovations in Medical Research","volume":"48 8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136093423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Social Media on Body Image Perception and Eating Disorders 社交媒体对身体形象感知和饮食失调的影响
Journal of Innovations in Medical Research Pub Date : 2023-09-01 DOI: 10.56397/jimr/2023.09.06
Jiakun Wang
{"title":"The Impact of Social Media on Body Image Perception and Eating Disorders","authors":"Jiakun Wang","doi":"10.56397/jimr/2023.09.06","DOIUrl":"https://doi.org/10.56397/jimr/2023.09.06","url":null,"abstract":"This essay discusses the negative impact of social media on body image and the promotion of healthier attitudes towards food and body diversity. It explores the sociocultural and psychological factors that contribute to susceptibility to social media influence, such as self-esteem, body image dissatisfaction, the need for social approval, perfectionism, and social comparison orientation. Peer pressure and social comparison are identified as significant influences on social media platforms. Potential solutions and interventions are proposed, including media literacy education, promoting body positivity and diversity, encouraging responsible social media use, developing evidence-based resources, fostering a supportive online community, collaborating with influencers and content creators, and encouraging individuals to seek professional help. By addressing these issues, we can work towards mitigating the negative impact of social media on body image and promoting healthier attitudes towards food and body diversity.","PeriodicalId":476009,"journal":{"name":"Journal of Innovations in Medical Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134961708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypoglycaemia Among Diabetes Patients: A Preventive Approach 糖尿病患者的低血糖:一种预防方法
Journal of Innovations in Medical Research Pub Date : 2023-09-01 DOI: 10.56397/jimr/2023.09.05
Devajit Mohajan, Haradhan Kumar Mohajan
{"title":"Hypoglycaemia Among Diabetes Patients: A Preventive Approach","authors":"Devajit Mohajan, Haradhan Kumar Mohajan","doi":"10.56397/jimr/2023.09.05","DOIUrl":"https://doi.org/10.56397/jimr/2023.09.05","url":null,"abstract":"Hypoglycaemia is a low blood glucose concentration and an indicator of diabetes mellitus, and are associated with physical and psychological morbidity. It is a common, potentially avoidable consequence of diabetes treatment, and a major barrier to better metabolic control in diabetes. It is due to overtreatment of diabetes patients with insulin or sulfonylureas or glinides or also consumption of too little food or unplanned excessive exercise or physical activity. It is the acute complication of diabetes and is associated with considerable morbidity and mortality. It is important of the early recognition, treatment, and prevention of hypoglycaemia. Immediate treatment of severe hypoglycaemia is needed to avoid life threatening complications of the diabetic patients. In this study an attempt has been taken to discuss the aspects of hypoglycaemia of diabetes mellitus patients.","PeriodicalId":476009,"journal":{"name":"Journal of Innovations in Medical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134961632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predicting Autism Spectrum Disorder Using Pluripotent Stem Cell RNA-Seq Data and Machine Learning 使用多能干细胞RNA-Seq数据和机器学习预测自闭症谱系障碍
Journal of Innovations in Medical Research Pub Date : 2023-09-01 DOI: 10.56397/jimr/2023.09.07
Richard Li
{"title":"Predicting Autism Spectrum Disorder Using Pluripotent Stem Cell RNA-Seq Data and Machine Learning","authors":"Richard Li","doi":"10.56397/jimr/2023.09.07","DOIUrl":"https://doi.org/10.56397/jimr/2023.09.07","url":null,"abstract":"In this work, datasets of gene expression in Autism Spectrum Disorder (ASD) were analyzed with the goal of selecting the most attributed genes and performing classification with machine learning algorithms. The publicly published datasets (GSE129806 and GSE214323) from the Gene Expression Omnibus database, which are both RNA-seq gene count data of humans, were downloaded. Then the workflows with differential expression analysis, principal component analysis (PCA), gene set enrichment analysis (GSEA) (Subramanian et al., 2005) and gene expression Meta-Analysis (Toro-Domínguez et al., 2020) were developed. The datasets were following pipelines which used machine learning algorithms to develop prediction models for classification. The results of this exploratory study suggest that the gene expression profiles identified from the pluripotent stem cell samples with ASD can be used to identify a biological signature for ASD with machine learning techniques. And especially, the gene expression Meta-Analysis of multiple datasets and larger numbers of samples could lead to more practical tools, such as Machine Learning models and workflows, to detect ASD at an early age in the general population.","PeriodicalId":476009,"journal":{"name":"Journal of Innovations in Medical Research","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134961621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective Comparison of Postoperative Results in Whitehead’s and Long’s Surgery Whitehead手术与Long手术术后疗效的回顾性比较
Journal of Innovations in Medical Research Pub Date : 2023-09-01 DOI: 10.56397/jimr/2023.09.01
Václav Šplouchal, František Horálek
{"title":"Retrospective Comparison of Postoperative Results in Whitehead’s and Long’s Surgery","authors":"Václav Šplouchal, František Horálek","doi":"10.56397/jimr/2023.09.01","DOIUrl":"https://doi.org/10.56397/jimr/2023.09.01","url":null,"abstract":"Introduction: The aim of the thesis is a retrospective evaluation of the treatment effect in two groups of patients treated with Whitehead and Long procedure in the surgical department of our medical facility. Method: We evaluated a group of patients diagnosed with hemorrhoidal disease who underwent one of the above-mentioned surgical methods in 2017-2019. We focused on recording the age composition, gender, length of hospitalization and length of outpatient check-ups. Results: 80 patients were operated on in the given period. The average age was 54.2 years. The Whitehead’s surgery was performed on 20 patients. Three patients of them were operated on for acute problems. The average length of hospitalization from the day after the surgery was 4.3 days. The time from the end of the check-ups to full recovery was 115.7 days. Long’s surgery was performed on 60 patients. The average length of hospitalization was 2.6 days, the average duration of the examinations was 82.8 days. Conclusion: The Long’s surgery appears to be equivalent in performance to the Whitehead’s surgery, provided an appropriately chosen indication is performed by an experienced and educated surgeon.","PeriodicalId":476009,"journal":{"name":"Journal of Innovations in Medical Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134917362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of Chinese Traditional and Western Medicine Focuses on Doctors and Showes in Patients 中西医结合以医生为中心，以病人为中心
Journal of Innovations in Medical Research Pub Date : 2023-09-01 DOI: 10.56397/jimr/2023.09.04
Guangcai Wei, Mei Wang, Yanmei Yang, Fengjie He
{"title":"Combination of Chinese Traditional and Western Medicine Focuses on Doctors and Showes in Patients","authors":"Guangcai Wei, Mei Wang, Yanmei Yang, Fengjie He","doi":"10.56397/jimr/2023.09.04","DOIUrl":"https://doi.org/10.56397/jimr/2023.09.04","url":null,"abstract":"Traditional Chinese and western medicine are two independent medical systems. Although the theory formation and treatment ideas are completely different, they are all different interpretations based on human movement. Traditional Chinese medicine is a theory formed by summarizing the experience, and western medicine is an interpretation of life activities based on modern technology. The theoretical experience of TCM can provide a direction for the research of western medicine and make up for the deficiency of the inexperience of western medicine. The advanced technology of western medicine can make TCM more objective and conducive to the dissemination and communication of TCM. The combination of traditional Chinese and western medicine is conducive to the development of medicine, and exploring the combination of traditional Chinese and western medicine is conducive to the rapid integration of medicine.","PeriodicalId":476009,"journal":{"name":"Journal of Innovations in Medical Research","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134961836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Care Models in Geriatric Nursing: A Comparative Analysis and Recommendations for Optimal Care 老年护理中的长期护理模式:比较分析及最佳护理建议
Journal of Innovations in Medical Research Pub Date : 2023-09-01 DOI: 10.56397/jimr/2023.09.02
Shulin Zhang, Ziyan Yin, Guanqun Zhang
{"title":"Long-Term Care Models in Geriatric Nursing: A Comparative Analysis and Recommendations for Optimal Care","authors":"Shulin Zhang, Ziyan Yin, Guanqun Zhang","doi":"10.56397/jimr/2023.09.02","DOIUrl":"https://doi.org/10.56397/jimr/2023.09.02","url":null,"abstract":"This review examines long-term care models in geriatric nursing and their implications for the aging population. Three primary models — home care, nursing home care, and community care — are compared and evaluated. The importance of a person-centered approach, care coordination, technology integration, and supporting family caregivers is emphasized. The review highlights the significance of geriatric nursing in providing effective and compassionate long-term care for the elderly.","PeriodicalId":476009,"journal":{"name":"Journal of Innovations in Medical Research","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134915183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Exercise in Preventing and Managing Cardiovascular Diseases 运动在预防和管理心血管疾病中的作用
Journal of Innovations in Medical Research Pub Date : 2023-09-01 DOI: 10.56397/jimr/2023.09.03
Anning Zhang
{"title":"The Role of Exercise in Preventing and Managing Cardiovascular Diseases","authors":"Anning Zhang","doi":"10.56397/jimr/2023.09.03","DOIUrl":"https://doi.org/10.56397/jimr/2023.09.03","url":null,"abstract":"Regular exercise has significant benefits for cardiovascular health and helps reduce the risk of developing cardiovascular diseases. It improves myocardial function, enhances endothelial function, reduces systemic inflammation, impacts the autonomic nervous system, and leads to metabolic adaptations. Epidemiological and clinical studies consistently show an association between exercise and reduced cardiovascular risk, including lower incidence of coronary artery disease, hypertension, stroke, and improved lipid profile. Various organizations provide exercise guidelines, recommending at least 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic exercise per week, along with muscle-strengthening activities. Individualization of exercise programs based on health status and fitness level is important.","PeriodicalId":476009,"journal":{"name":"Journal of Innovations in Medical Research","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134915224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spinal Cord Injury: Pathophysiology, Neural Stem Cell Treatment and Its Combination with Other Strategies 脊髓损伤:病理生理学、神经干细胞治疗及其与其他策略的结合
Journal of Innovations in Medical Research Pub Date : 2023-08-01 DOI: 10.56397/jimr/2023.08.04
Xinyi Chen
{"title":"Spinal Cord Injury: Pathophysiology, Neural Stem Cell Treatment and Its Combination with Other Strategies","authors":"Xinyi Chen","doi":"10.56397/jimr/2023.08.04","DOIUrl":"https://doi.org/10.56397/jimr/2023.08.04","url":null,"abstract":"Spinal cord injury is associated with the damage to neural circuits and disruption of neural pathways, leading to irreversible long-term complications in terms of physical and mental health. Traditional treatments mainly include surgical decompression and pharmacotherapy whereas none of them could attenuate or even alleviate long-term complications following SCI. This is largely due to complicated pathophysiological process in SCI which includes primary injury and secondary injury. Primary injury is defined as direct mechanical damage on the spinal cord in the initial time course of injury. Secondary injury occurs a few hours after primary injury and it could persist for longer time, promoting a catastrophe of degenerative pathophysiological process in spinal cord and related tissues. Although currently there is no effective cure strategies for SCI, some recent studies have shown that stem cell therapy combined with other strategies is able to enhance neurofunctional recovery and neural stem cell line is one of the stem cell lines which show convincing therapeutic effects (Huang, L., Fu, C., Xiong, F., He, C. &amp; Wei, Q., 2021). Biomaterials can work as carriers which help deliver nutrient biomolecules to help NSC survive and differentiate to more functional cells or as scaffolds which provide structural bridges to lesion site for NSC migration and tissue regeneration (Vismara, I., Papa, S., Rossi, F., Forloni, G. &amp; Veglianese, P., 2017). In addition, the basic principles of magnetic stimulation and electric stimulation are similar and they all involve producing electrical current on brain or spinal cord to modulate brain or spinal cord activity. It has been revealed that electric stimulation and repetitive magnetic stimulation is associated with neuroplasticity which may reduce inappropriate lateral sprouting resulting from NSC therapy, making them become potential complementary strategies to NSC therapy as well (Kricheldorff, J. et al., 2022).","PeriodicalId":476009,"journal":{"name":"Journal of Innovations in Medical Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136221705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书