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Systemic Anti-inflammatory Activity of American Cockroach (Periplaneta americana) Extract: A Molecular Docking Study 美洲大蠊（Periplaneta americana）提取物的全身抗炎活性：分子对接研究

Media Kedokteran Hewan Pub Date : 2024-05-10 DOI: 10.20473/mkh.v35i2.2024.105-112

Erfan Andrianto Aritonang, Gunanti, Rini Madyastuti Purwono, Supriyono

{"title":"Systemic Anti-inflammatory Activity of American Cockroach (Periplaneta americana) Extract: A Molecular Docking Study","authors":"Erfan Andrianto Aritonang, Gunanti, Rini Madyastuti Purwono, Supriyono","doi":"10.20473/mkh.v35i2.2024.105-112","DOIUrl":"https://doi.org/10.20473/mkh.v35i2.2024.105-112","url":null,"abstract":"Surgery can trigger systemic inflammatory response syndrome. This study aims to determine the effectiveness of Periplaneta americana cockroach extract as an oral systemic anti-inflammatory agent using molecular docking. The molecular docking method consisted of five steps. The first step was preparing the TNF-α converting enzyme (TACE) receptor as a native ligand, dexamethasone as a control ligand, and three test ligands of Periplaneta americana cockroach extract. The second step was docking preparation. The third step was analyzing Gibbs free energy (∆G) and root mean square deviation (RMSD). The fourth step was docking the test and control ligands with TACE. The fifth step was analyzing ∆G, inhibition constant (Ki), visualization of two- and three-dimensional interactions, percentage of binding site similarity (%BSS), and the rule of five (Ro5) on test ligands. The ∆G results for the native, control, and test ligands 1, 2, and 3 were -12.8, -7.1, -7.7, -6.9, and -9.0 kcal/mol, respectively. The Ki values for the native, control, and test ligands 1, 2, and 3 were 4.091, 6.205, 2.253, 9.521, and 2.507 µM, respectively. The results of the Ro5 analysis suggested that the three test ligands satisfied Lipinski’s rule of five. This study concluded that Periplaneta americana cockroach extract is an effective oral systemic anti-inflammatory agent.","PeriodicalId":475723,"journal":{"name":"Media Kedokteran Hewan","volume":" 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141128900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SEROPOSITIVE BRUCELLOSIS IN BEEF CATTLE IN THE FIRST SEMESTER AT PANTOLOAN ANIMAL INSTALLATION 在pantoloan动物装置的第一学期肉牛的血清阳性布鲁氏菌病

Media Kedokteran Hewan Pub Date : 2023-09-08 DOI: 10.20473/mkh.v34i3.2023.150-156

Sri Hidayatul Rohmah

{"title":"SEROPOSITIVE BRUCELLOSIS IN BEEF CATTLE IN THE FIRST SEMESTER AT PANTOLOAN ANIMAL INSTALLATION","authors":"Sri Hidayatul Rohmah","doi":"10.20473/mkh.v34i3.2023.150-156","DOIUrl":"https://doi.org/10.20473/mkh.v34i3.2023.150-156","url":null,"abstract":"Brucellosis is an infectious disease caused by bacteria of the genus Brucella and classified as a zoonotic disease. Brucellosis is usually asymptomatic in infected female animals, but it can cause placentitis, which leads to abortion in the fifth to ninth months of pregnancy in pregnant animals. Brucella infection is lifelong in animals, and Brucella bacteria can be found in the blood, urine, milk, and sperm. To prevent the spread of brucellosis in beef cattle that will be trafficked through the Pantoloan animal quarantine installation. From January to June, blood serum of male beef cattle was collected at the Pantoloan Animal Quarantine Installation, Palu Agricultural Quarantine. The Rose Bengal Test method was used on up to 7.046 serum samples. In the first semester of 2018, the positive incidence of blood serum testing for beef cattle using the Rose Bengal Test (RBT) method at ten beef cattle traffic frequencies revealed seropositive brucellosis in 38 out of 7,046 samples tested. Beef cattle were sourced from the Central Sulawesi, Gorontalo, and South Sulawesi provinces. Blood serum samples from Central Sulawesi showed the highest positive incidence. Based on the prevalence of seropositive brucellosis based on RBT in beef cattle transported through the Pantoloan animal quarantine installation, several cattle breeding areas should be monitored during subsequent traffic, and public awareness should be raised to prevent the spread of brucellosis.","PeriodicalId":475723,"journal":{"name":"Media Kedokteran Hewan","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136363656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment Leptospira Infection In Dog At Pet Vet Clinic, Center of Jakarta 雅加达中心宠物兽医诊所治疗犬钩端螺旋体感染

Media Kedokteran Hewan Pub Date : 2023-09-08 DOI: 10.20473/mkh.v34i3.2023.189-197

Dian Anugrah, Andi Magfira Satya Apada, Fedri Rell, Rian Hari Suharto, Muhammad Fadhlullah Mursalim

引用次数: 0

African Swine Fever and Its Socio-Economic Impacts in Indonesia 非洲猪瘟及其对印度尼西亚的社会经济影响

Media Kedokteran Hewan Pub Date : 2023-09-08 DOI: 10.20473/mkh.v34i3.2023.171-182

Lyvia Angeline Ciputra, Andi Simpurusiang Rahman, Besse Nurfadhillah, None Masyita, Wudhia Windy Toliu, Ihram Kautsar Muslimin, Andi Magfira Satya Apada, Fedri Rell

{"title":"African Swine Fever and Its Socio-Economic Impacts in Indonesia","authors":"Lyvia Angeline Ciputra, Andi Simpurusiang Rahman, Besse Nurfadhillah, None Masyita, Wudhia Windy Toliu, Ihram Kautsar Muslimin, Andi Magfira Satya Apada, Fedri Rell","doi":"10.20473/mkh.v34i3.2023.171-182","DOIUrl":"https://doi.org/10.20473/mkh.v34i3.2023.171-182","url":null,"abstract":"African Swine Fever Virus (ASF) is a viral disease in pigs that affects the supply of food of animal origin. ASF is caused by a double-stranded DNA virus of the family Asfarviridae and genus Asfivirus, which can be transmitted and causes various bleeding events in the internal organs and is accompanied by a very high mortality rate. This disease is generally characterized by fever, lack of appetite, and bleeding from the skin, back, and legs. Even though this virus is not zoonotic and cannot be transmitted to humans, it is fatal and causes tremendous economic loss. This disease spread throughout Asia in a relatively short time in 2019, and it has even been reported that this disease has entered Indonesia since the end of 2019. The impact of this infection resulted in socioeconomic changes in both rural and urban communities, which could then affect the country's economy at the macro level. Several countries are needed in their efforts to control ASF, one of which is to increase quarantine, limit the traffic of pigs, and reduce the population of sick pigs exposed to the ASF virus.","PeriodicalId":475723,"journal":{"name":"Media Kedokteran Hewan","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136363520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Patellar Luxation in Dogs in the Philippines 菲律宾犬髌骨脱位的危险因素

Media Kedokteran Hewan Pub Date : 2023-09-08 DOI: 10.20473/mkh.v34i3.2023.135-149

Rey Barcenas Oronan, Camille Sophia Nacion, Matthew Benedict Calibo

{"title":"Risk Factors for Patellar Luxation in Dogs in the Philippines","authors":"Rey Barcenas Oronan, Camille Sophia Nacion, Matthew Benedict Calibo","doi":"10.20473/mkh.v34i3.2023.135-149","DOIUrl":"https://doi.org/10.20473/mkh.v34i3.2023.135-149","url":null,"abstract":"A retrospective case-control study was conducted on dogs with patellar luxation who presented to the Veterinary Teaching Hospital Diliman Station-Companion Animal Clinic between January 1, 2010, and December 31, 2019. There was a total of 73 dogs were diagnosed with patellar luxation. The majority of the dogs presented with limping, and the causes were mostly unknown. Unilateral medial patellar luxation was the most common type (21.92%). The average age of patients with patellar luxation was 3.24 years old. Puppies are 0.03 less likely to be diagnosed with patellar luxation, while juveniles are 3.74 times more likely, and mature adults are 2.19 times more likely to be diagnosed. The affected dogs included intact males (47.95%), neutered males (4.11%), and intact females (47.95%). The average weight of the affected dogs was 8.39 kg and the majority (35.62%) had a body condition score of 5/9. The Pomeranian was the most common breed for patellar luxation, followed by the mixed breed Shih Tzu, Toy Poodle, and Chihuahua. Mixed breeds are 0.39 times less likely, and dogs fed with dry dog food are 0.51 times less likely to develop the condition. Age and breed were also significantly associated with patellar luxation.","PeriodicalId":475723,"journal":{"name":"Media Kedokteran Hewan","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136363517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seroprevalence, Accuracy and Precision Value of Brucellosis Surveillence at The Region Area of Balai Karantina Pertanian Kelas I Balikpapan 巴莱卡兰提纳-波斯卡拉斯-巴利巴潘地区布鲁氏菌病监测的血清流行率、准确度和精密度

Media Kedokteran Hewan Pub Date : 2023-09-08 DOI: 10.20473/mkh.v34i3.2023.157-170

None Faizal Rafiq, Khairil Anwar Notodipuro, Sachnaz Desta Oktarina, Laily Nissa Mualifah, Niken Pandansari, Linda Dwi Hapsari

{"title":"Seroprevalence, Accuracy and Precision Value of Brucellosis Surveillence at The Region Area of Balai Karantina Pertanian Kelas I Balikpapan","authors":"None Faizal Rafiq, Khairil Anwar Notodipuro, Sachnaz Desta Oktarina, Laily Nissa Mualifah, Niken Pandansari, Linda Dwi Hapsari","doi":"10.20473/mkh.v34i3.2023.157-170","DOIUrl":"https://doi.org/10.20473/mkh.v34i3.2023.157-170","url":null,"abstract":"The Technical Implementation Unit alai Karantina Pertanian Kelas I Balikpapan plays a role in efforts to prevent the entry, spread, and release of HPHK. Direct observation was performed by surveying the target brucellosis in the region of Balai Karantina Pertanian Kelas I Balikpapan. This surveillance aimed to determine the seroprevalence of brucellosis and to support the maintenance of brucellosis status in East Kalimantan. Sampling in areas with reported clinical symptoms and brucellosis reactors. The sampling areas were based on the region of Balai Karantina Pertanian Kelas I Balikpapan in Balikpapan City, North Penajam Paser Regency, Paser Regency, and Kutai Kartanegara Regency. The method for calculating the number of samples to detect the disease uses the Rose Bengal Test (RBT) and Complement Fixation Test (CFT). The test results showed a seroprevalence of 0.29%, positive and negative predictive values of 50% and 99,7%, respectively, an accuracy value of 99.11%, and a precision of 50%. The test performance based on the accuracy value was excellent because it had a value of 99.11%, which means that the ability of the CFT to detect all samples tested correctly was 99.11%. The test carried out using the CFT test on this surveillance had a precision or test consistency of 50%, and the sensitivity and specificity were 50% and 99.7%, respectively.","PeriodicalId":475723,"journal":{"name":"Media Kedokteran Hewan","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136363653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report : Management of Closed Pyometra on a 7 Year Old Bitch 病例报告:7岁母犬闭合性子宫积脓的治疗

Media Kedokteran Hewan Pub Date : 2023-09-08 DOI: 10.20473/mkh.v34i3.2023.183-188

None Mey Vanda Pusparina Sajida, None Muhammad Rizqi Fadhli

引用次数: 0