Clinical Medicine & Research最新文献

{"title":"Hyperuricemia and Adverse Outcomes in Patients Hospitalized for COVID-19 Disease.","authors":"Itamar Feldman,&nbsp;Ayman Natsheh,&nbsp;Gabriel S Breuer","doi":"10.3121/cmr.2023.1782","DOIUrl":"https://doi.org/10.3121/cmr.2023.1782","url":null,"abstract":"<p><p><b>Background:</b> Hyperuricemia is associated with several risk factors for mortality and severe coronavirus disease 2019 (COVID-19) manifestations.<b>Objective:</b> The objective of this research was to examine whether hyperuricemia is a risk factor for mortality and other adverse outcomes in patients hospitalized for COVID-19.<b>Design:</b> This is a retrospective review of patients hospitalized for COVID-19 between March 15 and November 30, 2020, with available uric acid (UA) levels.<b>Results:</b> Among 1566 patients who were hospitalized during the study period, 222 patients had an available UA level. The mean age ± standard deviation (SD) was 56.5 ± 19.5 years. The mean ± SD for UA (mg/dL) among the total cohort was 5.65 ± 2.18, and 21.2% of the total study population had hyperuricemia (UA > 7 mg/dL) on admission. The mortality rate was 14.4%, and mortality was associated with higher UA levels on admission (6.9 ± 2.6 mg/dL vs. 5.5 ± 2 mg/dL in patients who survived, <i>P</i> < 0.05). Patients who needed intensive oxygen support (high-flow nasal cannula or mechanical ventilation) and those who required longer-than-average hospitalization (> 7 days) had more hyperuricemia (intensive oxygen support: 30% vs. 18%, <i>P</i> = 0.07; long hospitalization 29% vs. 16.2%, <i>P</i> < 0.05).<b>Conclusion:</b> Our findings show that high UA levels are associated with adverse outcomes in patients hospitalized for COVID-19. We suggest evaluating hyperuricemia as a marker that integrates and reflects both poor prognostic baseline characteristics and acute components such as inflammatory state, hypovolemic state, and renal failure.</p>","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"21 2","pages":"87-94"},"PeriodicalIF":1.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321726/pdf/0210087.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-Sectional Study of the Physical and Mental Well-Being of Long COVID Patients in Aruba.","authors":"Veronika Duwel,&nbsp;Jaclyn M L de Kort,&nbsp;Caroline M Becker,&nbsp;Selène M Kock,&nbsp;Garreth G Tromp,&nbsp;Jamiu O Busari","doi":"10.3121/cmr.2023.1821","DOIUrl":"https://doi.org/10.3121/cmr.2023.1821","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the pattern and prevalence of persistent symptoms of Post-COVID-19 Syndrome (PCS) at 3, 6, 9, and 18 months after discharge. Associated risk factors were further examined to potentially explain the persistence of these symptoms.<b>Design and Setting:</b> A cross-sectional cohort study was conducted at the primary health care facility of Aruba, Dr. Horacio E. Oduber Hospital (HOH).<b>Participants:</b> Inclusion criteria were adults hospitalized at HOH for at least one night between March and July 2021 and laboratory-confirmed COVID-19 diagnosis. Exclusion criteria were deceased before the follow-up, not able to mobilize before or after discharge, living outside of Aruba or in nursing homes, and patients with psychosis, dementia, or hospitalized due to unrelated diseases.<b>Methods:</b> Eligible and willing participants completed a 20-question survey: a self-reported symptoms questionnaire about symptoms during and after COVID-19 infection, level of dyspnea measurement (mMRC-scale), quality of life measurement (EQ-5D-5E with EuroQoL VAS), and mental well-being (WHO-5). Hospitalization related data were gathered via retrospective analysis of patient records. Chi-square test, logistic regression, and ANOVA analyses were conducted; <i>P</i><0.05 was chosen as level of statistical significance for all analyses.<b>Results:</b> In total, 222 (34.5%) patients were eligible, consenting, and completed the survey. Most participants were interviewed a year or more after their initial COVID-19 infection. Fatigue (37.8%), new-onset dyspnea (38.7%), hair loss (20.3%), and muscle pain (18.0%) were the most frequently reported symptoms at any time post COVID-19 infection. Female participants were found more likely to experience fatigue (<i>P</i><0.05, OR 2.135, 95% CI 1.154-3.949) and new-onset dyspnea (<i>P</i><0.05, OR 2.026 95% CI 1.093-3.756) after initial infection. Participants with one or more respiratory comorbidity were more likely to experience new-onset dyspnea (<i>P</i><0.05, OR 2.681, 95% CI 1.223-5.873). None of the predictor variables was associated with cognitive impairment.<b>Conclusion:</b> This study identified female sex and respiratory comorbidity as crucial risk factors for PCS. Females were also found to have significantly lower health scores. Female participants were more likely to experience fatigue and dyspnea after COVID-19 infection.</p>","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"21 2","pages":"69-78"},"PeriodicalIF":1.4,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10321723/pdf/0210069.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elastic Intramedullary Nail Drainage in the Treatment of Long Bone Cyst with Pathological Fracture in Children","authors":"Hua Zheng","doi":"10.11648/j.cmr.20231203.11","DOIUrl":"https://doi.org/10.11648/j.cmr.20231203.11","url":null,"abstract":"","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"21 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87179286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the Abu Dhabi Bone Marrow Transplant Program (AD-BMT^®) Scope with the Collection and Cryopreservation of Cord Blood Stem Cells","authors":"Rene Antonio Rivero-Jimenez, Antonio Alfonso Bencomo-Hernandez, Yandy Marx Castillo-Aleman, Fatema Mohammed Al Kaabi, Y. Ventura-Carmenate","doi":"10.11648/j.cmr.20231202.12","DOIUrl":"https://doi.org/10.11648/j.cmr.20231202.12","url":null,"abstract":"","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"32 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87160910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis on the Abnormal Detection Rate of Blood Tests in 1790 Medical Radiation Workers in Nanjing","authors":"Xinghai Yan, Xiao Shan","doi":"10.11648/j.cmr.20231201.13","DOIUrl":"https://doi.org/10.11648/j.cmr.20231201.13","url":null,"abstract":"","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"24 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87103001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of Standardized Diagnostic System for Brucella Spondylitis in the Elderly and Clinical Application of Precise Treatment Strategy","authors":"Yang Xinming, Zhan Zhe, Yang Chaowei, Zhang Xuyang","doi":"10.11648/j.cmr.20231202.11","DOIUrl":"https://doi.org/10.11648/j.cmr.20231202.11","url":null,"abstract":"","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"45 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77766742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine in Acute Abdominal Pain in Patients with Lead Poisoning","authors":"S. Rahmani, Rana Kolahi Ahari, Hamed Shokoohsaremi, Roohie Farzaneh, Mohammad Davood Sharifi","doi":"10.11648/j.cmr.20231201.12","DOIUrl":"https://doi.org/10.11648/j.cmr.20231201.12","url":null,"abstract":": Introduction: In this study, we investigated the effect of intravenous ketamine administration on acute abdominal pain in lead poisoning patients. Methods: In this cross sectional study, we evaluated 20 patients with opium abuse with acute abdominal pain due to lead poisoning. With cardiac monitoring, 0.25 mg/kg ketamine (maximum dose was considered as 20 milligrams) was administered during 30 to 60 seconds. To control ketamine complications such as psychological irritability 0.03 mg/kg midazolam (2 milligrams was considered as maximum dose) was injected slowly during one or two minutes. Patients were observed in the ED for the next 6 hours. Pain score was assessed with VAS method, serially. Pain was measured before ketamine administration, every one hour for the next two hours and every two hours for four hours. Results: In this study 20 patients were enrolled with mean age of 37.2 ± 4.2 years (range from 30 to 44 yrs.). Repeated measurement test shows significant reduce in pain score after ketamine administration (P=0.001). Five patients report no pain 4 hours after ketamine injection, and 3 of them left the hospital with personal consent before the end of the study. From 17 remaining patients, 13 ones (76.4%) had no pain, and mean VAS score in other 4 patients was less than 2 after4 6 hours. Conclusion: our results show that low dose ketamine administration can reduce abdominal pain related to lead poisoning in opium abusers.","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"187 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73738818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nursing Students’ Knowledge, Attitudes and Death Attitude Regarding Palliative Care: A Descriptive Correlational Study","authors":"Meng-ru Cao, Wen-Xi Li, M. Wan, Lin Yang, Jun Ma","doi":"10.11648/j.cmr.20231201.11","DOIUrl":"https://doi.org/10.11648/j.cmr.20231201.11","url":null,"abstract":"","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"282 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80186681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Manifestation in COVID-19: A Lesson Over 2 Years Into the Pandemic.","authors":"Retno Danarti,&nbsp;Nikko Vanda Limantara,&nbsp;Dionisia Lintang Unggul Rini,&nbsp;Aries Budiarso,&nbsp;Sri Awalia Febriana,&nbsp;Hardyanto Soebono","doi":"10.3121/cmr.2023.1598","DOIUrl":"https://doi.org/10.3121/cmr.2023.1598","url":null,"abstract":"<p><p>Cutaneous manifestations related to Coronavirus Disease-19 (COVID-19) have been reported over 2 years since the pandemic began. This research aimed to review articles published in English that describe cutaneous manifestations related to COVID-19/SARS-CoV-2. A data search for case reports, original studies, and review articles from the onset of the current COVID-19 pandemic to December 31, 2022, was performed using PUBMED, Cochrane Library, ResearchGate, and Google search engines. Keywords were <i>\"coronavirus\", \"novel coronavirus 2019\", \"COVID-19\", \"SARS-CoV-2\"</i>, and <i>\"2019-nCoV\"</i> in combination with <i>\"cutaneous\", \"skin\"</i> and <i>\"dermatology\"</i> The extracted data included authors, region, sex, age, number of participants with skin signs, cutaneous signs, its location, symptoms, extracutaneous/associated symptoms, suspected or confirmed status for COVID-19, timeline, and healing duration. Six authors independently reviewed the abstracts and full-texts to identify publications providing these details concerning cutaneous manifestations related to COVID-19. A total of 139 publications with full text (122 case reports, 10 case series, and 7 review articles) that reported cutaneous manifestations were identified, and reviewed from 5 continents. The most common cutaneous manifestations of COVID-19 were maculopapular, followed by chilblain-like lesion, urticarial, livedoid/necrotic, vesicular, and other/non-descript rashes/skin lesions. After 2 years into the COVID-19 pandemic, we can conclude that there is no pathognomonic cutaneous manifestation of COVID-19, since it can be also found in other viral infections.</p>","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"21 1","pages":"36-45"},"PeriodicalIF":1.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153677/pdf/0210036.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9405370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes Associated With Early vs. Delayed Invasive Strategy in NSTEMI Complicated by High Degree AV Block: A Nationwide Analysis.","authors":"Raj Patel,&nbsp;Harsh P Patel,&nbsp;Utkarsh Kohli","doi":"10.3121/cmr.2022.1753","DOIUrl":"https://doi.org/10.3121/cmr.2022.1753","url":null,"abstract":"<p><p><b>Background:</b> High degree atrioventricular block (HDAVB) is an uncommon complication of non-ST-segment elevation myocardial infarction (NSTEMI) that frequently necessitates pacemaker implantation. This contemporary analysis compares need for pacemaker implantation based on the timing of intervention in acute NSTEMI complicated by HDAVB.<b>Methods:</b> We used 2016-2017 National Inpatient Sample database to identify admissions with NSTEMI and HDAVB. Time to coronary intervention from initial admission was used to segregate the admissions into two groups: early invasive strategy (EIS) (<24 hours) and delayed invasive strategy (DIS) (>24 hours). Multivariable linear and logistic regression analysis was performed to compare in-hospital outcomes among the two groups.<b>Results:</b> Out of 949,984 NSTEMI related admissions, coexistent HDAVB was present in 0.7% (n=6725) patients. Amongst those, 55.61% (n=3740) hospitalizations included invasive intervention (EIS=1320, DIS=2420). Patients treated with EIS were younger (69.95 years vs. 72.38 years, <i>P</i><0.05) and had concomitant cardiogenic shock. Contrarily, prevalence of chronic kidney disease, heart failure, and pulmonary hypertension was higher in DIS group. EIS was associated with lower length of stay and total hospitalization cost. In-hospital mortality and pacemaker implantation rates were not significantly different between patients in the EIS and DIS groups.<b>Conclusion:</b> HDAVB is a rare complication of NSTEMI and often associated with right coronary artery disease. The timing of revascularization does not appear to influence the rate of pacemaker placement in NSTEMI complicated by HDAVB. Further studies are needed to assess if early invasive strategy can benefit all patients with NSTEMI and HDAVB.</p>","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"21 1","pages":"1-5"},"PeriodicalIF":1.4,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153681/pdf/0210001.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9405367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}