Clinical Medicine & Research最新文献_第5页

Primary Epiploic Appendagitis: A Mimicker of Abdominal Pain. 原发性网膜阑尾炎:腹痛的模拟。

IF 1.4

Clinical Medicine & Research Pub Date : 2023-09-01 DOI: 10.3121/cmr.2023.1837

Matthew Patel, Imran Haider, Andrew Cheung

{"title":"Primary Epiploic Appendagitis: A Mimicker of Abdominal Pain.","authors":"Matthew Patel, Imran Haider, Andrew Cheung","doi":"10.3121/cmr.2023.1837","DOIUrl":"10.3121/cmr.2023.1837","url":null,"abstract":"Epiploic appendagitis is a rare cause of acute lower abdominal pain. Epiploic appendices are fat-filled serosal outpouchings of the cecum and sigmoid colon. Primary epiploic appendagitis (PEA) is characterized by epiploic inflammation caused by torsion of the appendage leading to ischemia or thrombosis of the appendage draining vein. Secondary epiploic appendagitis occurs in association with other inflammatory conditions of the abdomen or pelvis, most commonly diverticulitis. PEA is an important clinical mimicker of more severe causes of acute abdominal pain, such as diverticulitis, appendicitis, or gynaecological causes. The ease of access to computed tomography (CT), the diagnostic test of choice, has resulted in increased recognition of PEA. The classic CT findings of PEA are an ovoid mass measuring between 1.5 and 3.5 cm surrounded by a hyperattenuating/hyperdense ring with a centrally located hyperdense area. It is important to diagnose PEA as it is self-limiting and the correct diagnosis can prevent unnecessary hospital admission, antibiotic use, or even surgical intervention. We present a case of a 65-year-old male with a history of diverticulitis, presenting with left lower quadrant abdominal pain who was diagnosed with PEA based on CT and successfully managed with conservative treatment.","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"21 3","pages":"159-162"},"PeriodicalIF":1.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Localized Renal Cell Carcinoma Across Different Races. 不同种族的局部肾细胞癌的预后。

IF 1.4

Clinical Medicine & Research Pub Date : 2023-09-01 DOI: 10.3121/cmr.2023.1819

Wei Zheng So, Khi Yung Fong, Ziting Wang, Ho Yee Tiong

{"title":"Outcomes of Localized Renal Cell Carcinoma Across Different Races.","authors":"Wei Zheng So, Khi Yung Fong, Ziting Wang, Ho Yee Tiong","doi":"10.3121/cmr.2023.1819","DOIUrl":"10.3121/cmr.2023.1819","url":null,"abstract":"Introduction: Epidemiological outcomes of renal cell carcinoma (RCC) remain sparse. This study aims to compare preoperative characteristics, surgical outcomes, and oncological outcomes of RCC patients at a urology unit in Singapore.Methods: A retrospective cohort analysis of 137 RCC patients in the National University Hospital of Singapore who had undergone partial nephrectomy between 2009 and 2020 was conducted. χ2 tests (Chi-Square Test, Fisher's Exact Test) and one-way analysis of variance (ANOVA) were used for comparing categorical and continuous variables respectively. Kaplan-Meier estimates were used for survival analysis.Results: In total, 137 patients were identified (Chinese [n=82], Malay [n=19], Indian [n=15], Others [n=21]). Indian patients were diagnosed at an earlier age (52.13±10.52 years, P=0.018). A larger percentage of Malay patients (78.9%, P<0.001) were operated on before 2016, prior to the center's adoption of the robotic surgical technique. More Malay and Indian patients underwent laparoscopic surgery (36.8% and 46.7%, P=0.008), experiencing higher rates of intra-operative conversions compared to the Chinese and other ethnicities (5.3% and 13.3% vs. 0%, P=0.011). They also had longer post-operative stays compared to Chinese (7.42±6.46 days; 7.40±7.69 days vs. 4.88±2.87 days, P=0.036). Malays were much less likely to undergo robotic partial nephrectomy compared to Chinese patients (OR=0.295, 95% CI=0.102-0.856) and had the highest rate of metastatic recurrence (10.5%, P=0.023).","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"21 3","pages":"122-128"},"PeriodicalIF":1.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10659133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138177570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Congenital Eyelid Eversion: Management of a Case Using the Conservative Approach at the CADESSO of the University Hospital Center, Donka, Conakry, Guinea 双侧先天性眼睑外翻:在几内亚科纳克里东卡大学医院中心CADESSO采用保守方法治疗一例

IF 1.4

Clinical Medicine & Research Pub Date : 2023-08-31 DOI: 10.11648/j.cmr.20231204.16

Baldé Abdoul Karim, Bah Thierno Madjou, Diop Mamadou Samba, Zoumanigui Christophe, Camara Sidikiba, Kolié Diariou, Ly Mariame, Cissoko Amadou

引用次数: 0

Research Progress of Microglia in the Intervention Effect of Alzheimer's Disease 小胶质细胞干预阿尔茨海默病的研究进展

IF 1.4

Clinical Medicine & Research Pub Date : 2023-08-22 DOI: 10.11648/j.cmr.20231204.15

Tianying Fang, Caiping Han, Qingli Song, Yaning Hao, Wei Yuan, Meng Yu, Lin Zhang

引用次数: 0

Comparison of the Brock Model and LU-RADS in Differentiating Benign and Malignant Subsolid Pulmonary Nodules Brock模型与LU-RADS鉴别肺实质下结节良恶性的比较

IF 1.4

Clinical Medicine & Research Pub Date : 2023-07-26 DOI: 10.11648/j.cmr.20231204.14

Haolei Liu, Weiyun Cao, Haifen Liu, Jun-Yuan Tan, Xiangxia Zeng, Shikui Wu

引用次数: 0

CADASIL Presenting with Parkinsonism, Intracerebral Hemorrhage, and Atypical White Matter Lesions: A Case Report CADASIL表现为帕金森病、脑出血和非典型白质病变1例报告

IF 1.4

Clinical Medicine & Research Pub Date : 2023-07-21 DOI: 10.11648/j.cmr.20231204.13

Fan Xinman, Xu Yezi, Zhu Huili, Guo Li, Deng Zhe, Xu Xiaohong

引用次数: 0

Bone Marrow Mesenchymal Stem Cells Alleviated Bleomycin-Induced Pulmonary Fibrosis in Mice 骨髓间充质干细胞减轻博来霉素诱导的小鼠肺纤维化

IF 1.4

Clinical Medicine & Research Pub Date : 2023-07-11 DOI: 10.11648/j.cmr.20231204.12

Chunmei Zhang, Chenguang Li, Zhongyan Zhao

{"title":"Bone Marrow Mesenchymal Stem Cells Alleviated Bleomycin-Induced Pulmonary Fibrosis in Mice","authors":"Chunmei Zhang, Chenguang Li, Zhongyan Zhao","doi":"10.11648/j.cmr.20231204.12","DOIUrl":"https://doi.org/10.11648/j.cmr.20231204.12","url":null,"abstract":": Objective: The purpose of this study was to investigate the effect of bone marrow mesenchymal stem cells (BMSCs) on bleomycin-induced pulmonary fibrosis in mice. Methods: Pulmonary fibrosis model in mice was established by bleomycin (BLM) induction. This study was divided into 7 groups, bone marrow mesenchymal stem cells (BMSCs) as the treatment measure in 4 groups, the saline and pirfenidone as other 2 groups. The body weight of mice after BLM modeling was measured. The content of hydroxyproline (HYP) and collagen 1 (COL1) in lung tissue were determined by kits. Pathological changes of lung tissue were observed by hematoxylin-eosin (HE) staining. The levels of cytokines in serum and lung tissue of mice were detected by Enzyme-Linked Immunosorbent Assay (ELISA) kits. Immunohistochemistry was used to detect the expression of collagen-1 and α-SMA protein in lung tissue of mice. The levels of TGF-β/smad-3 and NLRP3/NF-κB signal pathway in lung was detected by western blotting. Results: BMSCs significantly decreased the content of HYP and COL1 in lung tissue of mice. BMSCs significantly decreased cytokines in serum and lung tissue. Immunohistochemistry results shown BMSCs significantly decreased the levels of collagen-1 and α-SMA in lung tissue. In addition, BMSCs significantly inhibited TGF-β/smad-3 and NLRP3/NF-κB signal pathway in lung tissue. Conclusions: BMSCs effectively inhibited bleomycin-induced pulmonary fibrosis in mice, and its mechanism may be related to inhibiting the activation of TGF-β/smad-3 and NLRP3/NF-κB signal pathway.","PeriodicalId":47429,"journal":{"name":"Clinical Medicine & Research","volume":"1974 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90541412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Fetus with 17p13.3 Deletion and 15q24.1q26.3 Duplication Derived from a Paternal Balance Translocation t (15; 17) (q24; p13) 来自父系平衡易位的17p13.3缺失和15q24.1q26.3重复胎儿(15)17)(抓起;p13)

IF 1.4

Clinical Medicine & Research Pub Date : 2023-07-06 DOI: 10.11648/j.cmr.20231203.12

Yinghui Dang, Shanning Wan, Yunyun Zheng, Ying Xu, Jia Li, Hong Yang

引用次数: 0

The Use of Esketamine in Clinical Anesthesia Practice 艾氯胺酮在临床麻醉中的应用

IF 1.4

Clinical Medicine & Research Pub Date : 2023-07-06 DOI: 10.11648/j.cmr.20231204.11

Yanqing Song, Rui-Na Zhou

引用次数: 0

DAPK Gene Methylation Application in the Early Diagnosis of Nasopharyngeal Cancer DAPK基因甲基化在鼻咽癌早期诊断中的应用