Malaysian Journal of Medical Sciences最新文献

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Athlete Identity, Resilience, Satisfaction with Life and Well-Being of Para Badminton Players: A Multinational Survey. 残疾人羽毛球运动员的运动员身份、复原力、生活满意度和幸福感:一项跨国调查。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-06-01 Epub Date: 2024-06-27 DOI: 10.21315/mjms2024.31.3.13
Siew Li Goh, Ngan Ling Wong, Poh Li Lau, Garry Kuan, Li Chongwei, Emily Kui Ling Lau
{"title":"Athlete Identity, Resilience, Satisfaction with Life and Well-Being of Para Badminton Players: A Multinational Survey.","authors":"Siew Li Goh, Ngan Ling Wong, Poh Li Lau, Garry Kuan, Li Chongwei, Emily Kui Ling Lau","doi":"10.21315/mjms2024.31.3.13","DOIUrl":"10.21315/mjms2024.31.3.13","url":null,"abstract":"<p><strong>Objective: </strong>To explore regional differences (i.e. Europe, Asia and others) in the well-being of para-athletes and its potential psychosocial determinants, including the Athletic Identity Measure Scale (AIMS), the Brief Resilience Scale (BRS) and the Satisfaction with Life Scale (SWLS).</p><p><strong>Methods: </strong>The study was a cross-sectional survey using data from multinational badminton federations. The study participants were athletes registered in the Para Badminton Classification Master List of the Badminton World Federation (BWF). The main study outcome is the WHO Quality of Life-Disability Questionnaire (WHOQOL-DIS).</p><p><strong>Results: </strong>There were 1,385 (aged 36 years old, IQR 18 years old) registrants on the master list. Respondents totaled 170. Only 137 (65% were males) were included in the analysis after excluding those with missing data (Europe 40%, Asia 30%, others 30%). Following the results of factor analysis, the original Athletic Identity Measure Scale (AIMS) was separated into self-identity (SI) and AIMS-modified. SI, AIMS-modified, the BRS and the Satisfaction with Life Scale (SWLS) were all scored above average. The AIMS-modified scores of Europeans were significantly lower than those of other non-Asians (U = 757.000, <i>P</i> < 0.05). BRS was statistically higher among those with acquired disabilities (median: 3.33) compared to those with congenital disabilities (median: 3.0) (U = 1,717.000, <i>Z</i> = <i>-</i>2.711, <i>P</i> < 0.05) and among Europeans (median: 3.3) compared to Asians (median: 3.0) (U = 704.500, <i>P</i> < 0.05). The regression model explained 32% of the variability in quality of life (QOL) with five significant predictors. The SWLS (<i>β</i> = 0.307, <i>P</i> = 0.01), BRS (<i>β</i> = 0.269, <i>P</i> = 0.01), full-time employment (<i>β</i> = 0.191, <i>P</i> = 0.05) and being female (<i>β</i> = 0.162, <i>P</i> = 0.05) all had a positive effect on QOL, but not the AIMS (<i>-</i>0.228, <i>P</i> = 0.05).</p><p><strong>Conclusion: </strong>The results show that the athletes' resilience, satisfaction with life and identity vary across regions. Furthermore, satisfaction with life, employment and gender were found to be significant predictors of athletes' QOL.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":"31 3","pages":"173-184"},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weight Change and the Risk of Micro and Macro Vascular Complications of Diabetes: A Systematic Review. 体重变化与糖尿病微血管和大血管并发症的风险:系统回顾
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-06-01 Epub Date: 2024-06-27 DOI: 10.21315/mjms2024.31.3.2
Seyyed Kiarash Sadat Rafiei, Fardad Fateh, Mahla Arab, Mohammad Espanlo, Saba Dahaghin, Helia Karami Gilavand, Mehregan Shahrokhi, Mohammad Sadegh Fallahi, Zahra Zardast, Arina Ansari, Seyyed Alireza Seifhashemi, Ali Kheirandish, Gisou Erabi, Fatemeh Ahmadi Hajikolaei, Mahdi Nakhaee, Niloofar Deravi
{"title":"Weight Change and the Risk of Micro and Macro Vascular Complications of Diabetes: A Systematic Review.","authors":"Seyyed Kiarash Sadat Rafiei, Fardad Fateh, Mahla Arab, Mohammad Espanlo, Saba Dahaghin, Helia Karami Gilavand, Mehregan Shahrokhi, Mohammad Sadegh Fallahi, Zahra Zardast, Arina Ansari, Seyyed Alireza Seifhashemi, Ali Kheirandish, Gisou Erabi, Fatemeh Ahmadi Hajikolaei, Mahdi Nakhaee, Niloofar Deravi","doi":"10.21315/mjms2024.31.3.2","DOIUrl":"10.21315/mjms2024.31.3.2","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM) is a metabolic disease that can be a significant cause of cardiovascular disease (CVD), leading to macrovascular and microvascular diseases. Many researchers around the world have investigated the effects of weight change on micro and macro CVD in patients with T2DM. This study aimed to investigate the effect of weight change (weight gain and loss) on microvascular and macrovascular complications in patients with T2DM. We searched PubMed, Scopus and Google Scholar from the database until January 2023. We screened the title, abstract, and full text of articles, and after quality assessment, we extracted data from interrelated ones into this systematic review. Reviewing the results of 11 cohort studies with 219,839 individuals (T2DM patients) showed that weight loss caused an increase in the mortality rate in diabetic patients, while weight gain after diabetes diagnosis increased the risk of CVD, chronic kidney disease (CKD), microvascular disease, stroke and mortality. It should be noted that severe body weight variability increases the mortality rate and the risk of microvascular disease. Unlike other studies, one study showed that more than 5% weight gain positively affected CVD and coronary heart disease in T2DM patients. Generally, weight change in patients with T2DM is an essential sign of cardiovascular complications. According to our findings, the risk of cardiovascular complications in patients with weight loss is seen to be higher than in patients with weight gain. In regular patients with body mass index (BMI), stable weight in a healthy range is reported to decrease the risk of CVD.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":"31 3","pages":"18-31"},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping the Locations of Medical Specialists in the Ministry of Health's Hospitals in Malaysia by Specialty, Subspecialty and Area of Interest. 按专科、亚专科和兴趣领域划分的马来西亚卫生部医院专科医生分布图。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-06-01 Epub Date: 2024-06-27 DOI: 10.21315/mjms2024.31.3.1
Hirman Ismail, Mohamed Hirman Abdullah, Sabrizan Osman, Faarhana Che Arshad, Siti Norsyazwanis Jalaluddin, Nur Fadzilah Osman, Nor Akmal Hakim Kamarulzaman, Badiuzzaman Abd Kadir
{"title":"Mapping the Locations of Medical Specialists in the Ministry of Health's Hospitals in Malaysia by Specialty, Subspecialty and Area of Interest.","authors":"Hirman Ismail, Mohamed Hirman Abdullah, Sabrizan Osman, Faarhana Che Arshad, Siti Norsyazwanis Jalaluddin, Nur Fadzilah Osman, Nor Akmal Hakim Kamarulzaman, Badiuzzaman Abd Kadir","doi":"10.21315/mjms2024.31.3.1","DOIUrl":"10.21315/mjms2024.31.3.1","url":null,"abstract":"<p><p>Mapping the distribution of medical specialists in the Ministry of Health (MOH) Malaysia facilities is expected to be more complex as the demand for specialty and subspecialty services increases in the future. A more robust and definitive gap analysis is needed to facilitate planning and resource allocation. The Medical Development Division developed a master list of framework of specialties, subspecialties and areas of interest, and Specialist Database Module in the Medical Programme Information System (MPIS) as tools to facilitate mapping of services. Relational database of specialists' location, facilities, workload, population profile and other relevant parameters were developed to provide data visualisation in specific dashboard. Needs versus supply ratio is proposed as one of parameters to visualise specialised medical services distribution by geographical localities.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":"31 3","pages":"1-17"},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of Post-Stroke Cognitive Impairment and the Potential Benefits of Stingless Bee Honey Supplementation. 中风后认知功能障碍及补充无刺蜂蜂蜜的潜在益处综述》(A Review of Post-Stroke Cognitive Impairment and the Potential Benefits of Stlessing Bee Honey Supplementation)。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-06-01 Epub Date: 2024-06-27 DOI: 10.21315/mjms2024.31.3.5
Nor Liyana Ja'afar, Muzaimi Mustapha, Mahaneem Mohamed, Sabarisah Hashim
{"title":"A Review of Post-Stroke Cognitive Impairment and the Potential Benefits of Stingless Bee Honey Supplementation.","authors":"Nor Liyana Ja'afar, Muzaimi Mustapha, Mahaneem Mohamed, Sabarisah Hashim","doi":"10.21315/mjms2024.31.3.5","DOIUrl":"10.21315/mjms2024.31.3.5","url":null,"abstract":"<p><p>Post-stroke cognitive impairment (PSCI) is a common decline in cognitive abilities that occurs within 3 months after a stroke. During recovery, stroke survivors often experience varying degrees of cognitive decline, with some patients experiencing permanent cognitive deficits. Thus, it is crucial to prioritise recovery and rehabilitation after a stroke to promote optimal protection of and improvement in cognitive function. Honey derived from stingless bees has been linked to various therapeutic properties, including neuroprotective effects. However, scientific evidence for the mechanisms through which these honey supplements enhance cognitive function remains limited. This narrative review aims to provide an overview of the causes of PSCI, current treatments, the biomarkers influencing cognition in post-stroke patients and the potential of stingless bee honey (SBH) as a neuroprotective agent against the progression of PSCI.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":"31 3","pages":"75-91"},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychological Resilience among Orang Asli Youths in Selangor during COVID-19 and Its Associated Factors. 雪兰莪州原住民青少年在 COVID-19 期间的心理复原力及其相关因素。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-06-01 Epub Date: 2024-06-27 DOI: 10.21315/mjms2024.31.3.16
Nurjuliana Noordin, Nik Nairan Abdullah, Raudah Mohd Yunus
{"title":"Psychological Resilience among Orang Asli Youths in Selangor during COVID-19 and Its Associated Factors.","authors":"Nurjuliana Noordin, Nik Nairan Abdullah, Raudah Mohd Yunus","doi":"10.21315/mjms2024.31.3.16","DOIUrl":"10.21315/mjms2024.31.3.16","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease (COVID-19) has affected everyone and stress-related mental health issues affect young people more than other groups, including marginalised populations. As a result of this pandemic, society is being urged to examine indigenous psychological resilience, especially among Orang Asli (OA) communities in Malaysia. Hence, this study aims to identify factors associated with psychological resilience among OA youths of Kampung Orang Asli (KOA) in Gombak during the COVID-19 pandemic.</p><p><strong>Method: </strong>A cross-sectional study comprising OA communities was conducted between January 2022 and September 2022 in the Gombak District, Selangor. A self-administered online questionnaire using Google Forms and a self-administered printed questionnaire was used to collect data from youths aged 18 years old-24 years old. The Malay version of Conner-Davidson Resilience Scale-25 (CD-RISC-25) was used to assess psychological resilience. Data analysis was performed using SPSS version 28.0, and multiple linear regression analyses were conducted to evaluate the associated factors and their significance level.</p><p><strong>Result: </strong>A total of 158 participants were involved in this study. The mean score for psychological resilience was estimated at 69.28 (SD = 14.52). The social relationships domain recorded the highest mean score for quality of life (71.54, SD = 13.72). Meanwhile, the total mean score for self-esteem fell into the high-level category (35.77, SD = 4.94), and the domain of relationship and family dynamics under family environment scored the highest mean score of 18.83 (SD = 2.89). Psychological resilience was associated with youths of KOA Batu 12 (<i>β</i> = -14.274, <i>P</i> < 0.05), KOA Ulu Batu (<i>β</i> = -17.789, <i>P</i> < 0.05), less than four siblings (<i>β</i> = -6.495, <i>P</i> < 0.05), owner of residential property (<i>β</i> = -7.543, <i>P</i> < 0.05), high self-esteem (<i>β</i> = 0.612, <i>P</i> < 0.05) and good relationship and family dynamic (<i>β</i> = 1.391, <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Developing interventions aimed at psychological resilience determinants may assist OA youths in coping with future threats.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":"31 3","pages":"204-216"},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors Associated with Cutaneous Reactions Following COVID-19 Vaccine Immunisation: A Registry-Based Case-Control Study. 与接种 COVID-19 疫苗后皮肤反应相关的风险因素:基于登记的病例对照研究。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-06-01 Epub Date: 2024-06-27 DOI: 10.21315/mjms2024.31.3.10
Hwei Lin Teh, Thamron Keowmani, Min Moon Tang
{"title":"Risk Factors Associated with Cutaneous Reactions Following COVID-19 Vaccine Immunisation: A Registry-Based Case-Control Study.","authors":"Hwei Lin Teh, Thamron Keowmani, Min Moon Tang","doi":"10.21315/mjms2024.31.3.10","DOIUrl":"10.21315/mjms2024.31.3.10","url":null,"abstract":"<p><strong>Background: </strong>In Malaysia, following extensive COVID-19 vaccination, Hospital Kuala Lumpur reported an increase in cutaneous reactions post-immunisation. To understand this, a case-control study was initiated to identify potential risk factors.</p><p><strong>Methods: </strong>This registry-based, unmatched case-control study encompasses all adverse event following immunisation (AEFI) reports associated with COVID-19 vaccines, received by the Department of Pharmacy at Hospital Kuala Lumpur through the Malaysian Adverse Drug Reactions Advisory Committee (MADRAC) AEFI reporting forms. Twenty-four potential risk factors were evaluated, including demographic information, medical history, food allergies, COVID-19 vaccination history and prior SARS-CoV-2 infection, were evaluated using MADRAC AEFI reporting forms. Odds ratio (OR) with 95% confidence interval (CI) were estimated using univariable and multivariable logistic regression.</p><p><strong>Results: </strong>Cutaneous reactions were more frequent in middle-aged females, especially after the first COVID-19 vaccine dose. These reactions, primarily mild and generalised, included pruritus and urticaria. Notably, 52% were delayed reactions (more than 4 h post-vaccination). Factors associated with increased risk of cutaneous reaction following COVID-19 immunisation included history of seafood and shellfish allergy (adjusted odds ratio [adjOR]: 2.11; 95% CI: 1.12, 3.96; <i>P</i> = 0.020), history of vaccine allergy (adjOR: 4.07; 95% CI: 1.44, 11.54; <i>P</i> = 0.008), past dermatological diseases (adjOR: 5.48; 95% CI: 2.03, 14.78; <i>P</i> = 0.001), and past medication allergy (adjOR: 2.12; 95% CI: 1.36, 3.31; <i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>Self-reported histories of allergies to vaccines, foods or medications were found to increase the likelihood of cutaneous reactions following COVID-19 vaccination. These reactions, which were predominantly mild, did not hinder the administration of the second vaccine dose. The majority of reactions occurred after the first dose, manifesting as generalised pruritus and urticaria. They were effectively managed with oral antihistamines and low-dose corticosteroids, thereby avoiding the need for hospitalisation.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":"31 3","pages":"133-148"},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Affiliate Stigma, Resilience and Quality of Life among Parents of Children with Autism Spectrum Disorder in Two Public Hospitals in Kelantan, Malaysia. 马来西亚吉兰丹州两家公立医院自闭症谱系障碍儿童家长的附属耻辱感、复原力和生活质量。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-06-01 Epub Date: 2024-06-27 DOI: 10.21315/mjms2024.31.3.17
Noor Shuhada Salleh, Li Yoong Tang, Maruzairi Husain, Khatijah Lim Abdullah, Yee Cheng Kueh
{"title":"Affiliate Stigma, Resilience and Quality of Life among Parents of Children with Autism Spectrum Disorder in Two Public Hospitals in Kelantan, Malaysia.","authors":"Noor Shuhada Salleh, Li Yoong Tang, Maruzairi Husain, Khatijah Lim Abdullah, Yee Cheng Kueh","doi":"10.21315/mjms2024.31.3.17","DOIUrl":"10.21315/mjms2024.31.3.17","url":null,"abstract":"<p><strong>Background: </strong>Often, the indirect impact of autism spectrum disorder (ASD) presents the family with significant challenges. One of these challenges is affiliate stigma due to parental affiliation with their child. This study aimed to explore affiliate stigma, resilience and quality of life (QoL) among parents of children with ASD.</p><p><strong>Methods: </strong>Cross-sectional study of 144 parents of children with ASD were recruited from two main tertiary hospitals in Kelantan, Malaysia, a developing country in Southeast Asia. Pearson correlation was used to examine the relationship between parental affiliate stigma, resilience and QoL. Simple and multiple linear regression analyses were used to identify the significant associated factors of affiliate stigma, resilience and QoL.</p><p><strong>Results: </strong>Correlational analyses revealed that perceived affiliate stigma demonstrated an inverse relationship with resilience and QoL. Additionally, resilience had a positive relationship with QoL. Regression analyses revealed that the father's employment status, the mother's level of education, having a disability card, the child's age at ASD diagnosis, comorbidities of the child and ASD severity perceived by parents were associated with parental affiliate stigma, resilience and QoL.</p><p><strong>Conclusion: </strong>Study findings highlight the contribution of socio-demographic characteristics of children with ASD and their families in the determination of affiliate stigma, resilience and QoL.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":"31 3","pages":"217-228"},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of DNA-Based Lateral Flow Assay for Detection of LDLR Gene Mutation for Familial Hypercholesterolemia. 开发基于 DNA 的侧流检测法,用于检测家族性高胆固醇血症的 LDLR 基因突变。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-06-01 Epub Date: 2024-06-27 DOI: 10.21315/mjms2024.31.3.6
Lina Khalida Saidi, Zam Zureena Md Rani, Siti Aishah Sulaiman, Rahman Jamal, Aziah Ismail, Anis Amirah Alim, Sharipah Nadzirah Syed Ahmad Ayob, Chang Fu Dee, Azrul Azlan Hamzah, Nor Azian Abdul Murad
{"title":"Development of DNA-Based Lateral Flow Assay for Detection of LDLR Gene Mutation for Familial Hypercholesterolemia.","authors":"Lina Khalida Saidi, Zam Zureena Md Rani, Siti Aishah Sulaiman, Rahman Jamal, Aziah Ismail, Anis Amirah Alim, Sharipah Nadzirah Syed Ahmad Ayob, Chang Fu Dee, Azrul Azlan Hamzah, Nor Azian Abdul Murad","doi":"10.21315/mjms2024.31.3.6","DOIUrl":"10.21315/mjms2024.31.3.6","url":null,"abstract":"<p><strong>Background: </strong>The techniques for detecting single nucleotide polymorphisms (SNP) require lengthy and complex experimental procedures and expensive instruments that may only be available in some laboratories. Thus, a deoxyribonucleic acid (DNA)-based lateral flow assay (LFA) was developed as a point-of-care test (POCT) diagnostic tool for genotyping. In this study, single nucleotide variation (E101K) in the low-density lipoprotein receptor <i>(LDLR)</i> gene leading to familial hypercholesterolemia (FH) was chosen as a model.</p><p><strong>Methods: </strong>Hypercholesterolemic individuals (<i>n</i> = 103) were selected from the Malaysian Cohort project (UKM Medical Molecular Biology Institute) while the control samples were selected from the Biobank (UKM Medical Molecular Biology Institute). The DNA samples were isolated from whole blood. Polymerase chain reaction (PCR) amplification process was performed using bifunctional labelled primers specifically designed to correspond to the variant that differentiates wild-type and mutant DNA for visual detection on LFA. The variant was confirmed using Sanger sequencing, and the sensitivity and specificity of the LFA detection method were validated using the Agena MassARRAY<sup>®</sup> technique.</p><p><strong>Results: </strong>Out of 103 hypercholesterolemic individuals, 5 individuals (4.8%) tested positive for E101K, <i>LDLR</i> mutation and the rest, including healthy control individuals, tested negative. This result was concordant with Sanger sequencing and Agena MassARRAY<sup>®</sup>. These five individuals could be classified as Definite FH, as the DNA diagnosis was confirmed. The sensitivity and specificity of the variant detection by LFA is 100% compared to results using the genotyping method using Agena MassARRAY<sup>®</sup>.</p><p><strong>Conclusion: </strong>The developed LFA can potentially be used in the POC setting for detecting the E101K variant in the <i>LDLR</i> gene. This LFA can also be used to screen family members with E101K variant in the <i>LDLR</i> gene and is applicable for other SNP's detection.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":"31 3","pages":"92-106"},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First 100 Reported Cases of Supine Percutaneous Nephrolithotomy in Malaysia: An Alternative Effective and Safe Approach to Treat Renal Stones. 马来西亚首100例报告的仰卧位经皮肾镜取石术:治疗肾结石的另一种有效而安全的方法。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-06-01 Epub Date: 2024-06-27 DOI: 10.21315/mjms2024.31.3.9
Han Kun Ng, Chee Hoong Loo, Meng Shi Lim
{"title":"First 100 Reported Cases of Supine Percutaneous Nephrolithotomy in Malaysia: An Alternative Effective and Safe Approach to Treat Renal Stones.","authors":"Han Kun Ng, Chee Hoong Loo, Meng Shi Lim","doi":"10.21315/mjms2024.31.3.9","DOIUrl":"10.21315/mjms2024.31.3.9","url":null,"abstract":"<p><strong>Background: </strong>Supine percutaneous nephrolithotomy (s-PCNL) offers great benefits from urological and anaesthetic points of view. We present the first evaluation of the outcomes of s-PCNL in Malaysia. Our aim was to explore the safety and efficacy of s-PCNL.</p><p><strong>Methods: </strong>Institutional review board approval was obtained from the National Medical Research Register (NMRR ID-21002225-WLP). We retrospectively reviewed 115 patients with renal pelvis stones who underwent single renal access during s-PCNL between November 2020 and May 2023. Patients who underwent simultaneous ipsilateral or contralateral endourological procedures were included. The data were analysed to determine stone-free rates (SFR), major complication rates, blood transfusion rates, operative times and lengths of hospital stay (LOS).</p><p><strong>Results: </strong>The SFR was higher for the single middle calyceal renal access (MCA) group than for the lower calyceal renal access (LCA) or upper calyceal renal access (UCA) groups (OR: 1.76; 95% confidence interval [CI]: 0.63, 4.92). In total, 0, 1 and 2 patients had major complications in the UCA, MCA and LCA groups, respectively (<i>P</i> = 0.453). One of the 115 patients (0.9%) needed blood transfusion. Subgroup analysis revealed mean operative times of 76.3 min and 78.6 min for patients who underwent sole s-PCNL (PCNL-only group) and those who had simultaneous ipsilateral and contralateral endourological procedures (PCNL-plus group), respectively (<i>P</i> = 0.786). The overall mean LOS was 2.9 days.</p><p><strong>Conclusion: </strong>s-PCNL is a safe and effective alternative treatment for renal stones. We would recommend s-PCNL for patients who require an ipsilateral/contralateral endourological procedure (URS/RIRS) because it is time-efficient. All renal accesses are safe. Single MCA is recommended for complete stone clearance.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":"31 3","pages":"125-132"},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial Effects of Various Types of Bee Products in Malaysia: A Systematic Review. 马来西亚各种蜂产品的抗菌效果:系统综述。
IF 1.1
Malaysian Journal of Medical Sciences Pub Date : 2024-06-01 Epub Date: 2024-06-27 DOI: 10.21315/mjms2024.31.3.3
Nur Aliah Mohamad, Alaa' Fahed Al-Emerieen, Ahmad Adebayo Irekeola, Rafidah Hanim Shueb
{"title":"Antibacterial Effects of Various Types of Bee Products in Malaysia: A Systematic Review.","authors":"Nur Aliah Mohamad, Alaa' Fahed Al-Emerieen, Ahmad Adebayo Irekeola, Rafidah Hanim Shueb","doi":"10.21315/mjms2024.31.3.3","DOIUrl":"10.21315/mjms2024.31.3.3","url":null,"abstract":"<p><p>Antibiotics are widely used to treat bacterial infections. The effectiveness of antibiotics is very important, but unfortunately, prolonged exposure leads to the development of antibiotic resistance in some bacteria. Hence, using natural products as antibacterial agents is an attractive alternative, given that they have been used as traditional medicine since the existence of humanity. This study systematically reviewed the antibacterial activity of Malaysian bee products such as honey, propolis and bee bread. Five electronic databases: i) PubMed; ii) ScienceDirect; iii) Scopus; iv) Web of Science Core Collection and v) Google Scholar, were searched for relevant articles. A total of 153 articles were obtained from the initial search. Of these, 32 articles, including 24 on honey, eight on propolis and one on bee bread, were selected based on inclusion and exclusion criteria. Most studies reported that honey, propolis and bee bread demonstrated antibacterial properties against Gram-positive and Gram-negative bacteria.</p>","PeriodicalId":47388,"journal":{"name":"Malaysian Journal of Medical Sciences","volume":"31 3","pages":"32-51"},"PeriodicalIF":1.1,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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