Androloji bülteni最新文献

{"title":"BPH Patofizyolojisi","authors":"Ender Cem Bulut, Ali Atan","doi":"10.24898/tandro.2023.91328","DOIUrl":"https://doi.org/10.24898/tandro.2023.91328","url":null,"abstract":"Benign prostatic hyperplasia (BPH) is histological changes in the prostate that result in increased prostate volume and lower urinary tract symptoms. Although there are several reasons for the development of LUTS in BPH, the most important reason is the enlargement of the prostate gland. In addition, it has not been clarified why prostate size differs between individuals and why similar sizes cause different severity of LUTS. The aging of the world population has made BPH one of the most common diseases in men. The increase in the incidence of BPH has increased its socioeconomic cost. However, since its pathophysiology has not been fully elucidated, a new medical treatment alternative has not been established for years. In this review, possible different mechanisms that cause BPH to occur were examined and the literature on these mechanisms was reviewed. Keywords: prostate, hyperplasia, pathophysiology, androgens, inflamation","PeriodicalId":472476,"journal":{"name":"Androloji bülteni","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135799824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alfa blokerlerin ejakülasyon üzerine etkisi: Literatür güncellemesi","authors":"Enis Mert Yorulmaz, Kürşad Dönmez, Osman Köse, Serkan Özcan, Sacit Nuri Görgel, igit Akın","doi":"10.24898/tandro.2023.91489","DOIUrl":"https://doi.org/10.24898/tandro.2023.91489","url":null,"abstract":"Ejaculation disorders are a complex and multifactorial condition that can significantly impact individuals’ quality of life. Alpha blockers, which are used in the treatment of benign prostatic hyperplasia (BPH), are associated with various sexual side effects, including changes in ejaculation. In this review, the physiological mechanisms and clinical outcomes of the effects of alpha blockers on ejaculation, as documented in the literature, are discussed. Keywords: alpha blocker, benign prostatic hyperplasia, ejaculation","PeriodicalId":472476,"journal":{"name":"Androloji bülteni","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135798978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stres üriner inkontinans hastalarında duloksetin tedavisi sonrası cinsel fonksiyon ve koital inkontinans durumu","authors":"Bahadır Ermeç, Mehmet Gökhan Çulha","doi":"10.24898/tandro.2023.87259","DOIUrl":"https://doi.org/10.24898/tandro.2023.87259","url":null,"abstract":"OBJECTIVES: The aim of this study is to evaluate the effect of duloxetine treatment, used in the treatment of Stress Urinary Incontinence (SUI), on female sexual functions and coital incontinence (CI). MATERIAL and METHODS: Patients who applied to the urology outpatient clinic with complaints of SUI between January 2018 and July 2021 and used Duloxetine 2*40 mg (Nexetin, Nobel İlaç, Turkey) for 12 weeks were included in the study. Demographic characteristics of the patients were recorded. Medical and sexual histories of the patients were taken. In order to evaluate the sexual functions of the patients, the Female Sexual Function Index (FSFI) consisting of 19 questions was filled. It was asked whether there was CI or CI during penetration. RESULTS: A total of 64 patients were included in the study. The mean age of the patients was 43.64±11.08(35-58), and the mean BMI was 27.86±6.43(21.55-34.67) kg/m2. A significant improvement was observed in the patients’ total FSFI score, desire, arousal, lubrication and orgasm subscales after treatment (p<0.001 for each). While 49 patients described CI during sexual intercourse before treatment, CI persisted in 26 patients after 12 weeks of treatment. There was a significant improvement in CI rates after treatment (p<0.001). CONCLUSION: Duloxetine, which is used for the treatment of SUI, improves female sexual functions and reduces coital incontinence. Keywords: Stress urinary incontinence, duloxetine, female sexual function, coital incontinence","PeriodicalId":472476,"journal":{"name":"Androloji bülteni","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135799379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peyronie hastalığı: Cerrahi dışı tedavi yaklaşımları","authors":"Arif Kol, Erhan Ateş","doi":"10.24898/tandro.2023.40222","DOIUrl":"https://doi.org/10.24898/tandro.2023.40222","url":null,"abstract":"Peyronie’s disease is a condition characterized by progressive fibrosis in the tunica albuginea, resulting in deformities such as penile shortening and curvature. This situation not only causes sexual problems, but also can cause an increase in sexual performance anxiety, difficulty in relationship and depression. The course of the disease consists of two periods, acute and chronic. In the acute phase and in the stable disease period, while non-surgical treatments are used to relieve symptoms and regress fibrosis, surgical treatments are on the agenda, especially after serious deformities develop. Non-surgical treatment methods are oral treatments, intralesional injection treatments, topical treatments, vacuum and traction devices and shock wave treatments. Intralesional clostridium histolyticum collagenase treatment has been approved by the US-FDA and it’s indicated in patients with noncalcified plaques. For multimodal treatments, there is no clear consensus yet. Keywords: Peyronie’s disease, penil curvature, medical therapy, vacuum device","PeriodicalId":472476,"journal":{"name":"Androloji bülteni","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135799602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Varikosel Patofizyolojisi 2023","authors":"İrem Orhan, İrfan Orhan, Ahmet Karakeçi","doi":"10.24898/tandro.2023.38268","DOIUrl":"https://doi.org/10.24898/tandro.2023.38268","url":null,"abstract":"Varicocele, which is the most frequently treatable pathology of male infertility, is detected in approximately 15 % of the normal population. The fact that it is detected at such high rates in the general population and that only 20% of the men are infertile and the remaining 80% of them are unaffected, has brought up new research issues in the evaluation of the pathophysiological processes between varicocele and infertility.Conventionally, the possible pathophysiological effect of varicocele on male reproductive system is evaluated by five different mechanisms. These mechanisms are reported as hyperthermia, hypoxia, reflux of toxic cyclical metabolites, hypogonadism and cadmium accumulation. Keywords: infertility, recurrent, pathophysiology","PeriodicalId":472476,"journal":{"name":"Androloji bülteni","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135798987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monocyte-to-high-density lipoprotein-cholesterol ratio as a predictor and severity indicator of erectile dysfunction","authors":"İbrahim Üntan, Ahmet Emin Doğan","doi":"10.24898/tandro.2023.64935","DOIUrl":"https://doi.org/10.24898/tandro.2023.64935","url":null,"abstract":"AMAÇ: Artan enflamasyonun endotel disfonksiyonuna neden olması ve monositlerin ve yüksek yoğunluklu lipoprotein kolesterolün enflamasyondaki rolü gösterilmesine rağmen, monosit - yüksek yoğunluklu lipoprotein kolesterol oranı ile erektil disfonksiyon arasındaki ilişkiyi inceleyen şaşırtıcı derecede az sayıda yayın bulunmaktadır. Bu çalışmada hem enflamasyon sürecinin aktörlerini özetledik hem de monosit - yüksek yoğunluklu lipoprotein kolesterol oranı ile erektil disfonksiyon arasındaki ilişkiyi prognostik veya prediktif bir belirteç olup olamayacağı açısından inceledik. GEREÇ ve YÖNTEMLER: Ocak-Eylül 2021 tarihleri arasında üroloji polikliniğine başvuran ve herhangi bir sistemik hastalığı olmayan 143 erektil disfonksiyonlu hasta ve 140 kontrol hastası seçildi. Tüm hastalardan uygun koşullar altında tam kan sayımı, biyokimyasal parametreler ve hormon örnekleri alındı. Erektil disfonksiyon tanısı, Uluslararası Cinsel İşlev Endeksi anketinin beş maddelik versiyonuyla koyuldu. Elde edilen verilerle gruplar arasında istatistiksel karşılaştırmalar yapıldı. BULGULAR: Yaş, boy, beyaz kan hücresi, trombosit, lenfosit, kreatinin, açlık plazma glukozu, trigliserit, folikül uyarıcı hormon, luteinizan hormon ve total testosteron değişkenleri gruplar arasında farksızdı. Vücut kitle endeksi, ağırlık, toplam kolesterol, düşük yoğunluklu lipoprotein kolesterol, nötrofil sayısı, monosit - yüksek yoğunluklu lipoprotein kolesterol oranı ve nötrofil-lenfosit oranı değişkenleri vaka grubunda anlamlı derecede yüksekti. Uluslararası Cinsel İşlev Endeksi - 5 skorları ve düşük yoğunluklu lipoprotein kolesterol değişkenleri vaka grubunda anlamlı derecede yüksekti. Monosit - yüksek yoğunluklu lipoprotein kolesterol oranı ile Uluslararası Cinsel İşlev Endeksi - 5 skoru arasında anlamlı negatif korelasyon gözlendi. SONUÇ: Monosit - yüksek yoğunluklu lipoprotein kolesterol oranı, enflamasyonu ve endotel hasarını temsil eder ve bu bozuklukların neden olduğu erektil disfonksiyonun kolay ve ucuz bir öngörücüsü veya ciddiyet göstergesi olarak kullanılabilir. Anahtar Kelimeler: endotel disfonksiyonu, erektil disfonksiyon, enflamasyon, monosit, yüksek yoğunluklu lipoprotein kolesterol","PeriodicalId":472476,"journal":{"name":"Androloji bülteni","volume":"282 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135799827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESWT’nin erektil disfonksiyon tedavisindeki rolü","authors":"Kasım Emre Ergün, Fuat Kızılay","doi":"10.24898/tandro.2023.77785","DOIUrl":"https://doi.org/10.24898/tandro.2023.77785","url":null,"abstract":"Oral phosphodiesterase 5 (PDE 5) inhibitors, vacuum pumps, intraurethral drugs, intracavernosal injections, and penile prosthesis implantation are currently accepted treatments for erectile dysfunction (ED). In 2010, low-intensity extracorporeal shock wave therapy (Li-ESWT) was introduced by Vardi as a noninvasive method for the treatment of ED. Since the important mechanism of ED is vascular endothelial dysfunction and Li-ESWT can stimulate the expression of angiogenesis-related factors such as vascular endothelial growth factor (VEGF) to support vascular regeneration, the use of Li-ESWT in the treatment of ED is becoming widespread. Currently, there is no standard treatment protocol for Li-ESWT. Li-ESWT appears to have the potential to be an option for the treatment of ED, particularly in patients who respond poorly to oral medications and do not want more invasive procedures. On the other hand, further studies are needed to understand which patients may benefit most from the treatment and which protocol will produce the best results. Keywords: low-intensity extracorporeal shock wave therapy, erectile dysfunction, international index of erectile function-5 score","PeriodicalId":472476,"journal":{"name":"Androloji bülteni","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135798974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primer infertil erkeklerdeki Y-kromozom mikrodelesyon sıklığı","authors":"Özgür Balasar, Savaş Barış","doi":"10.24898/tandro.2023.79058","DOIUrl":"https://doi.org/10.24898/tandro.2023.79058","url":null,"abstract":"OBJECTIVES: There are SRY (sex-determining region Y) region, which plays a role in testicular development, and genes related to spermatogenesis on the Y chromosome. Its long arm contains the azoospermia factor (AZF) region (AZFa, AZFb, and AZFc subregions). Microdeletions in this region are responsible for azoospermia and oligospermia and cause male infertility. The aim of this study was to analyze the incidence of microdeletion in the AZF region of the Y chromosome in male patients with primary infertility with azoospermia and oligospermia. MATERIAL and METHODS: A total of 206 male patients were analyzed between December 2020 and December 2022. The diagnosis of azoospermia and oligospermia was made based on semen analysis. Patients with normal karyotype were included in the study. For the definitive diagnosis of microdeletions in the AZF region, 20 different sequence tagged sites (STS) were used, including the recommendation of the European Academy of Andrology (EAA) and the European Molecular Genetics Quality Network (EMQN). Each region was amplified by polymerase chain reaction (PCR) method and analyzed by fragment method in ABI 3500 DNA Sequence instrument. RESULTS: Microdeletion was detected in the AZF region of the Y chromosome in 17 of 206 patients (8%, 3) with normal karyotype. With the study, we identified the deletions of each subregion of AZF in our population. The presence of microdeletions in the AZFc region was most common. b2/b4 complete AZF/c microdeletions were higher than the g/gr partial AZF/c deletion. CONCLUSION: The study confirmed that the incidence of microdeletion of AZF subregions in primary infertile male patients was 8%,3 and was prognostically significant. The frequency of Y chromosome microdeletion was found to be consistent with the literature. Keywords: AZF region, azoospermia, oligospermia, primary male infertility, Y-chromosome microdeletion","PeriodicalId":472476,"journal":{"name":"Androloji bülteni","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135799586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proton pompa inhibitörü esomeprazolün uzun süre kullanımına bağlı gelişen reversibl azospermi: Bir olgu sunumu","authors":"Ali Nebioğlu, Selahittin Çayan, Murat Bozlu, Erdem Akbay","doi":"10.24898/tandro.2023.09475","DOIUrl":"https://doi.org/10.24898/tandro.2023.09475","url":null,"abstract":"OBJECTIVES: The long-term use of esomeprazole, a commonly prescribed proton pump inhibitor, has been associated with a decrease in sperm count and motility, as well as infertility in recent studies. We aimed to present the case of reversible azoospermia developed due to the use of esomeprazole in this study. CASE REPORT: In our study, we examined a 25-year-old unmarried male patient with a desire for children who had been using esomeprazole (40 mg/day) for approximately two years due to gastroesophageal reflux disease. The patient presented to our clinic intermittently with a dull scrotal pain, which was present in both testicles and resolved spontaneously after a short period. The physical examination of the patient revealed no pathological findings, and the testicular volumes and serum hormone parameters were within the normal reference values. The result of scrotal color doppler ultrasound performed on the patient in an external center was reported as scrotal color doppler ultrasound examination within normal limits. Upon the initial presentation of the patient, the semen analysis reported azoospermic pellet positivity. Subsequently, a repeat semen analysis was requested from the patient at a 4-week interval, and the result was once again reported as azoospermic pellet positive. As a result, we discontinued the use of esomeprazole for the patient, and during the first and fourth-month follow-ups, there was a gradual improvement in sperm parameters. The semen analysis parameters evaluated in the fourth month were observed within the normal reference values. CONCLUSIONS: We aimed to emphasize the necessity of considering the use of esomeprazole, which is frequently preferred for gastrointestinal system disorders in our country, as a potential etiology of azoospermia, in a young patient who had been using it for a long time and experienced improvement after discontinuation of the medication. Keywords: azoospermia, esomeprazole, infertility","PeriodicalId":472476,"journal":{"name":"Androloji bülteni","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135800115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erkek askeri personelin human papilloma virüsü tarama testi ve aşısına ilişkin bilgi düzeyleri","authors":"Fatih Okan, Sümeyye Kavici, Işıl Miray Dincel, Kübra Topcu, Sümeyya Üstün, Merve Akkoç","doi":"10.24898/tandro.2023.18942","DOIUrl":"https://doi.org/10.24898/tandro.2023.18942","url":null,"abstract":"OBJECTIVES: The aim of the study was to determine the level of knowledge of male military personnel about Human Papillomavirus, screening tests, and vaccination. MATERIALS and METHODS: The descriptive cross-sectional study was conducted with 390 male military personnel working in Provincial Gendarmerie Command between December 2022 and January 2023. Data were obtained using the descriptive information form and the human papillomavirus knowledge scale. Mann-Whitney U test and Kruskall-Wallis test were used to evaluate the data. RESULTS: The mean the human papillomavirus knowledge scale total score of the male military personnel included in the study was 4.89±6.43. In the study, it was found that the total score of the human papilloma virus knowledge scale varied significantly according to marital status, educational status, place of residence, presence of reproductive organ cancer in first-degree relatives or themselves, having received previous education about sexually transmitted diseases and having information about human papillomavirus and sexually transmitted diseases. CONCLUSION: It was found that the total score of the human papillomavirus knowledge scale of male military personnel was quite low. Health professionals who play an important role in protecting and promoting health should plan awareness trainings on human papillomavirus infection and vaccine for military personnel who are among the risky groups and lead the establishment of human papillomavirus vaccination programs for the male population. Keywords: knowledge, military personnel, human papillomavirus, vaccine","PeriodicalId":472476,"journal":{"name":"Androloji bülteni","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135798397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}