Ból最新文献

{"title":"Cryoanalgesia as Essential Component of PerioperativeMultimodal Analgesia in Pediatrics – Literature Review","authors":"S. Zacha, Jakub Miegoń, Jowita Biernawska","doi":"10.5604/01.3001.0054.4387","DOIUrl":"https://doi.org/10.5604/01.3001.0054.4387","url":null,"abstract":"The article introduces the application of cryoanalgesia as an innovative method utilizing low temperatures toalleviate pain, particularly in perioperative care for pediatric patients. Emphasis is placed on the necessity of paincontrol in accordance with Enhanced Recovery After Surgery (ERAS) principles. Temporary or permanent nervestructure damage due to cooling attenuate pain conduction, finding application across various medical fields. Inthe context of pediatric chest surgery, cryoanalgesia proves exceptionally effective in managing acute pain andpreventing chronic pain. Research demonstrates shortened hospitalization times, potential opioid dose reduction,and improved mobility rehabilitation. The article describes the first intraoperative application of intercostal nervecryoablation during the Nuss procedure in Polish children, showcasing its efficacy in treating acute pain. Twocryoanalgesia techniques are discussed in the article: intraoperative – intrathoracic during the thoracoscopy andpercutaneous – before the surgical procedure. Studies underscore the crucial role of precise probe placement foroptimal results. In conclusion, cryoanalgesia serves as an effective complement to pain control methods, presentingfavorable outcomes in various medical specialties, especially pediatric surgery. The article underscores the need forfurther research and a multidisciplinary approach to achieve optimal results.","PeriodicalId":472438,"journal":{"name":"Ból","volume":"223 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140233466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REPRINTED WITH PERMISSION OF IASP – PAIN 164 (2023): 1912–1926: Predicting chronic postsurgical pain: current evidence anda novel program to develop predictive biomarker signatures","authors":"K. Sluka, T. D. Wager, S. P. Sutherland, Patricia A. Labosky, Tessa Balach, Emine O. Bayman, Giovanni Berardi, Chad M. Brummett, John Burns, A. Buvanendran, Brian Caffo, VinceD. Calhoun, Daniel Clauw, Andrew Chang, Christopher S. Coffey, D. Dailey, D. Ecklund, Oliver Fiehn, K. Fisch, L. F. Frey Law, Richard E. Harris, Steve Harte, Timothy D. Howard, Joshua Jacobs, Jon M. Jacobs, K. Jepsen, Nicolas Johnston, Carl D. Langefeld, Louise C. Laurent, Rebecca N. Lenzi, Martin A. Lindquist, A. Lokshin, Ari Kahn, Robert J McCarthy, Michael Olivier, Linda L Porter, Wei-Jun Qian, Cheryse A. Sankar, John Satterlee, Adam C. Swensen, C. Vance, Jennifer Waljee, Laura D. Wandner, David A. Williams, Richard L. Wixson, Xiaohong Joe Zhou","doi":"10.5604/01.3001.0054.4396","DOIUrl":"https://doi.org/10.5604/01.3001.0054.4396","url":null,"abstract":"Chronic pain affects more than 50 million Americans. Treatments remain inadequate, in large part, because thepathophysiological mechanisms underlying the development of chronic pain remain poorly understood. Painbiomarkers could potentially identify and measure biological pathways and phenotypical expressions that arealtered by pain, provide insight into biological treatment targets, and help identify at-risk patients who might benefit from early intervention. Biomarkers are used to diagnose, track, and treat other diseases, but no validated clinicalbiomarkers exist yet for chronic pain. To address this problem, the National Institutes of Health Common Fundlaunched the Acute to Chronic Pain Signatures (A2CPS) program to evaluate candidate biomarkers, develop theminto biosignatures, and discover novel biomarkers for chronification of pain after surgery. This article discussescandidate biomarkers identified by A2CPS for evaluation, including genomic, proteomic, metabolomic, lipidomic,neuroimaging, psychophysical, psychological, and behavioral measures. Acute to Chronic Pain Signatures will providethe most comprehensive investigation of biomarkers for the transition to chronic postsurgical pain undertaken todate. Data and analytic resources generated by A2CPS will be shared with the scientific community in hopes thatother investigators will extract valuable insights beyond A2CPS’s initial findings. This article will review the identifiedbiomarkers and rationale for including them, the current state of the science on biomarkers of the transition fromacute to chronic pain, gaps in the literature, and how A2CPS will address these gaps.","PeriodicalId":472438,"journal":{"name":"Ból","volume":"71 S10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140234461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine treatment – updated recommendations 2024 –development of the Expert Group of the Headache Section ofthe Polish Neurological Society and the Polish Society for theStudy of Pain","authors":"Adam Stępień, Wojciech Kozubski, Jacek J. Rożniecki, Izabela Domitrz","doi":"10.5604/01.3001.0054.4389","DOIUrl":"https://doi.org/10.5604/01.3001.0054.4389","url":null,"abstract":"Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients qualityof life. Migraine treatment recommendations are provided based on a review of the literature from randomizedclinical trials and the consensus of a national expert panel. All available medical reference systems were screened for the range of past and present clinical studies on migraine with and without aura and on migraine-like syndromes.The results of these studies were presented in accordance with the recommendations of the Migraine Section ofthe Polish Neurological Society and the Polish Society for the Study of Pain. For the acute treatment of migraineattacks, oral non-steroidal antiinflammatory drug (NSAID), triptans and new class of drugs gepants and ditans arerecommended. The administration should follow the concept of stratified treatment. Before intake of NSAID andtriptans, oral metoclopramide is recommended. In very severe attacks, subcutaneous sumatriptan are drugs of firstchoice. Status migrainosus can be treated by cortoicosteroids, although this is not universally held to be helpful. Forthe prophylaxis of migraine, old and new drugs – betablockers flunarizine, valproic acid, and topiramate as well asmonoclonal anti CGRP antibodies, gepants and botulin toxin are drugs of first choice.","PeriodicalId":472438,"journal":{"name":"Ból","volume":"38 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140234476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Legal aspects of pain management. Selected problems","authors":"Radosław Tymiński","doi":"10.5604/01.3001.0054.2957","DOIUrl":"https://doi.org/10.5604/01.3001.0054.2957","url":null,"abstract":"The article presents considerations on the legal aspects of pain treatment. On the one hand, the patient's right to pain treatment is discussed, and on the other hand, the duties of physicians are referred to. On the latter issue, various regulations that define physicians duties related to pain management are pointed out, including, i.a., a discussion on the regulations on perinatal pain relief and the outpatient necessity of diagnosing and treating chronic pain and clinically significant pain. Particular emphasis is placed on pointing out that regardless of the medical profession or the type of health care services provided by a given entity, it has obligations related to diagnosing, treating and monitoring the effectiveness of pain treatment.","PeriodicalId":472438,"journal":{"name":"Ból","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140499143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REPRINTED WITH PERMISSION OF IASP – PAIN 164 (2023) 2425–2434: Pain in Parkinson disease: mechanistic substrates, mainclassification systems, and how to make sense out of them","authors":"D. Ciampi de Andrade, Veit Mylius, Santiago Perez-Lloret, R. Cury, Kirsty Bannister, X. Moisset, Gabriel Taricani Kubota, N. Finnerup, Didier Bouhassira, K. R. Chaudhuri, Thomas Graven-Nielsen, R. Treede","doi":"10.5604/01.3001.0054.2958","DOIUrl":"https://doi.org/10.5604/01.3001.0054.2958","url":null,"abstract":"Parkinson disease (PD) affects up to 2% of the general population older than 65 years and is a major cause offunctional loss. Chronic pain is a common nonmotor symptom that affects up to 80% of patients with (Pw) PD bothin prodromal phases and during the subsequent stages of the disease, negatively affecting patient’s quality of lifeand function. Pain in PwPD is rather heterogeneous and may occur because of different mechanisms. Targetingmotor symptoms by dopamine replacement or with neuromodulatory approaches may only partially control PD---related pain. Pain in general has been classified in PwPD according to the motor signs, pain dimensions, or painsubtypes. Recently, a new classification framework focusing on chronic pain was introduced to group different typesof PD pains according to mechanistic descriptors: nociceptive, neuropathic, or neither nociceptive nor neuropathic.This is also in line with the International Classification of Disease-11, which acknowledges the possibility of chronicsecondary musculoskeletal or nociceptive pain due to disease of the CNS. In this narrative review and opinionarticle, a group of basic and clinical scientists revise the mechanism of pain in PD and the challenges faced whenclassifying it as a stepping stone to discuss an integrative view of the current classification approaches and howclinical practice can be influenced by them. Knowledge gaps to be tackled by coming classification and therapeuticefforts are presented, as well as a potential framework to address them in a patient oriented manner.","PeriodicalId":472438,"journal":{"name":"Ból","volume":"8 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140498564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical anaesthesia in dentistry – practical considerations","authors":"M. Pasternak, Jarosław Woroń","doi":"10.5604/01.3001.0054.2959","DOIUrl":"https://doi.org/10.5604/01.3001.0054.2959","url":null,"abstract":"Topical anaesthesia is a reversible block of neurotransmission in the free sensory nerve endings of the conjunctiva,the outermost layers of the skin and mucosa. The anaesthetic effect is obtained after direct application of the agentin the form of an ointment, cream, or gel, application of the solution, or spraying on the surface of the anaesthetizedtissue. In dental practice, topical anaesthesia of the oral mucosa is used routinely at the injection site before the localanaesthesia by infiltration or regional block, and in various fields of dentistry it may also be the only way needed toensure painless performance of some interventions. Furthermore, topical agents play an important role in relievingpost-treatment ailments, such as post-extraction pain, and are a valuable aid in the symptomatic treatment of painfullesions. These drugs are also included in mouthwashes used in stomatitis associated with systemic anticancertreatment. In the paper, clinical situations in dentistry, where topical anaesthesia is particularly useful, factorsinfluencing the effectiveness of the method and formulations as well as the drugs (topical analgetics) themselvesused by dentists were elaborated. Also, potential local and general complications associated with the application ofanaesthetic preparations in dentistry have been discussed with their management.","PeriodicalId":472438,"journal":{"name":"Ból","volume":"78 23-24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140499083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REPRINTED WITH PERMISSION OF IASP – PAIN 164 (2023) 3–13: Ambroxol for neuropathic pain: hiding in plain sight?","authors":"Marc A. Russo, Ralf Baron, Anthony H. Dickenson, Kai-Uwe Kern, Danielle M. Santarelli","doi":"10.5604/01.3001.0053.9555","DOIUrl":"https://doi.org/10.5604/01.3001.0053.9555","url":null,"abstract":"Ambroxol is a multifaceted drug with primarily mucoactive and secretolytic actions, along with anti-inflammatory, antioxidant, and local anaesthetic properties. It has a long history of use in the treatment of respiratory tract diseases and has shown to be efficacious in relieving sore throat. In more recent years, ambroxol has gained interest for its potential usefulness in treating neuropathic pain. Research into this area has been slow, despite clear preclinical evidence to support its primary analgesic mechanism of action—blockade of voltage-gated sodium (Nav) channels in sensory neurons. Ambroxol is a commercially available inhibitor of Nav1.8, a crucial player in the pathophysiology of neuropathic pain, and Nav1.7, a particularly exciting target for the treatment of chronic pain. In this review, we discuss the analgesic mechanisms of action of ambroxol, as well as proposed synergistic properties, followed by the preclinical and clinical results of its use in the treatment of persistent pain and neuropathic pain symptoms, including trigeminal neuralgia, fibromyalgia, and complex regional pain syndrome. With its well-established safety profile, extensive preclinical and clinical drug data, and early evidence of clinical effectiveness, ambroxol is an old drug worthy of further investigation for repurposing. As a patent-expired drug, a push is needed to progress the drug to clinical trials for neuropathic pain. We encourage the pharmaceutical industry to look at patented drug formulations and take an active role in bringing an optimized version for neuropathic pain to market.","PeriodicalId":472438,"journal":{"name":"Ból","volume":"30 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135321884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distributed system of nociception as a physiological basis forpain experience in humans","authors":"Wacław M. Adamczyk, Jacek Skalski, Daria Nowak, Marta Jakubińska, Natalia Kruszyna, Aleksandra Budzisz, Tibor M. Szikszay, Jakub Nastaj","doi":"10.5604/01.3001.0053.9493","DOIUrl":"https://doi.org/10.5604/01.3001.0053.9493","url":null,"abstract":"The human nociceptive system is a complex sensory system that encompasses the peripheral, spinal and supraspinalparts of the nervous system. The article presented here focuses on a critique of the serial model, which iscommonly used to discuss the nociceptive system. The serial model proposes a hierarchical structure, where informationis conducted from the nociceptor through the dorsal horns of the spinal cord to the higher areas of the centralnervous system. A disturbance of the system at one of its lower levels should result in disruption of the integrationof nociceptive information by higher neural centers. However, this model seems to obscure the actual principlesby which the nociceptive system processes information (Coghill, 2020) and is only vaguely reflected in the resultsof animal and human studies. The simplification of the nociceptive system – common in polish textbooks – maylead to a limited understanding of the mechanisms of pain sensation and the utilization of ineffective therapeuticinterventions. In this article, the nociceptive system is discussed in terms of recently proposed distributed (parallel)model. The nociceptive system should not be simplified. Its complexity argues for the use of complex and distributedtherapeutic approaches.","PeriodicalId":472438,"journal":{"name":"Ból","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135253050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthralgia as an unwanted effect of ciprofloxacin usedin combination with other drugs – a case report","authors":"Jarosław Woroń","doi":"10.5604/01.3001.0053.9497","DOIUrl":"https://doi.org/10.5604/01.3001.0053.9497","url":null,"abstract":"The study discusses a case of a patient who developed joint pain after ciprofloxacin administration. The patient hada history of polypharmacy – the underlying cause of the described symptoms, which resulted from pharmacokineticinteractions and additive adverse effects.","PeriodicalId":472438,"journal":{"name":"Ból","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135253051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of Pulsed Radiofrequency in the treatment oftrigeminal neuralgia and painful trigeminal neuropathy –two clinical cases","authors":"Anna Przeklasa-Muszyńska, Bartłomiej Pancerz, Magdalena Kocot-Kępska, Jan Dobrogowski","doi":"10.5604/01.3001.0053.9495","DOIUrl":"https://doi.org/10.5604/01.3001.0053.9495","url":null,"abstract":"Trigeminal neuralgia, one of the pain conditions with severe pain, can be effectively treated with pharmacotherapyand invasive methods of pain treatment (at the level of the peripheral nerve, Gasser's ganglion, or nerve root). Painfultrigeminal neuropathy is defined as facial pain in one or more branches of the trigeminal nerve caused by otherconditions or damage to the nerve. This condition can be effectively treated with individual pharmacotherapy andnon-pharmacological methods, and in some cases, invasive methods. In both diseases, many treatment methodscan be proposed, including the minimally invasive procedure of pulsed radiofrequency (PRF). The following studypresents two cases of successful therapy using pulsed radiofrequency of the peripheral branches of the trigeminalnerve in patients with trigeminal neuralgia and painful trigeminal neuropathy. Prior to the procedure, pain relief wasobtained in the painful branches of the trigeminal nerve after a diagnostic block. pulsed radiofrequency is a minimallyinvasive, safe for the patient treatment method.","PeriodicalId":472438,"journal":{"name":"Ból","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135253052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}