International Journal of Health Sciences-IJHS最新文献_第7页

Anti-tumor effect of Fasudil, a ROCK inhibitor, on gastric cancer in mice ROCK抑制剂法舒地尔对小鼠胃癌的抗肿瘤作用

International Journal of Health Sciences-IJHS Pub Date : 2023-11-14 DOI: 10.53730/ijhs.v7n3.14624

Chengcheng Yang, Yan Miao, Qiang Yu, Xiangjie Wang

{"title":"Anti-tumor effect of Fasudil, a ROCK inhibitor, on gastric cancer in mice","authors":"Chengcheng Yang, Yan Miao, Qiang Yu, Xiangjie Wang","doi":"10.53730/ijhs.v7n3.14624","DOIUrl":"https://doi.org/10.53730/ijhs.v7n3.14624","url":null,"abstract":"Gastric cancer remains one of the most common malignant tumors and a leading cause of death. However, there are few reports about the anti-tumor effect of Fasudil (Fas) on the stomach. Establishment of nude mice model of gastric cancer to evaluate the anti-tumor effect of Fas. The mice in each group were weighed every week. Serum and tumor tissue cytokines are detected by commercial kits. Serum and tumor tissue superoxide dismutase and malondialdehyde were detected by commercial kits. Histopathological changes of the tumor were detected by HE staining. Expression of ROS/ TXNIP/NLRP3/Caspase-1 pathway in tumor tissues was detected by Western blot. Our results showed that Fas increased and decreased the body weight of tumor mice, increased serum and tumor tissue cytokines contents of tumor mice, increased serum and tumor tissue oxidative stress of tumor mice, and increased Bax, Caspase-3, Caspase-9 protein expression, reduced Bcl-2 protein expression, also regulated ROS/TXNIP/NLRP3/Caspase-1 pathway expression. Our experiments show that Fas has a significant anti-gastric cancer effect, and its mechanism is related to the regulation of oxidative stress, inflammation and apoptosis in vivo.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"50 13","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134991456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosynthesis of silver nanoparticles using aqueous extract of Lepidium meyenii and testing their antimicrobial activity 麦冬草水提物生物合成纳米银及其抑菌活性研究

International Journal of Health Sciences-IJHS Pub Date : 2023-11-10 DOI: 10.53730/ijhs.v7ns1.14626

Mohammed Hayder Hashim, Marwa Hameed Al Khafaji

{"title":"Biosynthesis of silver nanoparticles using aqueous extract of Lepidium meyenii and testing their antimicrobial activity","authors":"Mohammed Hayder Hashim, Marwa Hameed Al Khafaji","doi":"10.53730/ijhs.v7ns1.14626","DOIUrl":"https://doi.org/10.53730/ijhs.v7ns1.14626","url":null,"abstract":"Lepidium meyenii herb (maca) belongs to the cruciferous family that includes broccoli, radish, watercress, cabbage and turnip. It is also available as a dietary supplement in the form of capsules and liquid extracts. Silver nanoparticles were made using the aqueous extract of maca root for the first time locally and worldwide. As a reducing agent, the extract was utilized. Several approaches were used to diagnose silver nanoparticles, including scanning electron microscopy, atomic force microscopy, FT-IR and UV-vis spectrophotometer analyses. The diagnostic results showed the formation of nanoparticles in various shapes, with a diameter ranging from 56.11 nanometers. The optimum conditions for the bio-synthesis of silver nanoparticles were determined. The optimal conditions were pH 7, 37 °C, with a concentration of 1 mmol silver ions. These are the ideal conditions for making silver nanoparticles from L.meyenii. The antibacterial effectiveness of biosynthesized AgNP against Staphylococcus aureus was found to be very significant. This work promotes green synthesis of AgNP for a range of applications that require low toxicity and are ecologically friendly.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"23 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135091402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of combined use of elastography and von Willebrand factor antigen/thrombocyte ratio in prediction of gastroduodenal mucosal portal hypertension related vascular lesions 弹性成像和血管性血友病因子抗原/血小板比值在预测胃十二指肠黏膜门脉高压相关血管病变中的应用

International Journal of Health Sciences-IJHS Pub Date : 2023-11-05 DOI: 10.53730/ijhs.v7ns1.14620

Gamal Ahmed Abdel Khalik Badra, Hanaa Badran, Olfat Mohamed Hendy, Lashin Saad Ali, Mostafa El Helbawy

{"title":"Utility of combined use of elastography and von Willebrand factor antigen/thrombocyte ratio in prediction of gastroduodenal mucosal portal hypertension related vascular lesions","authors":"Gamal Ahmed Abdel Khalik Badra, Hanaa Badran, Olfat Mohamed Hendy, Lashin Saad Ali, Mostafa El Helbawy","doi":"10.53730/ijhs.v7ns1.14620","DOIUrl":"https://doi.org/10.53730/ijhs.v7ns1.14620","url":null,"abstract":"Background: Liver cirrhosis is the most important cause of portal hypertension, esophageal varices (EVs) represent its major complication as they may rupture and bleed with increased mortality rate. vWF-Ag is an established and valuable marker for determining the grade of fibrosis and cirrhosis and for mortality in patients with cirrhosis. Aim of our work is to search for the utility of combined use of elastography and Von Willebrand Factor Antigen/Thrombocyte Ratio in prediction of gastroduodenal portal hypertension related vascular lesions and identify suitable cutoff values for predicting these lesions. Patients and methods: 80 cirrhotic patients, were divided into 2 main groups, Group I included 20 patients with no evidence of portal hypertension related vascular lesions as verified by endoscopic examination (disease control group), group II, included patients with vascular lesions and was divided into 3 subgroups groups, group IIa included 20 patients with esophageal varices or gastro-esophageal varices, group IIb included 20 patients with isolated gastric varices, group IIc included 20 patients with portal hypertension related lesions other than esophageal and gastric varices.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"136 13","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135725047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

relationship between Physical Activity Level (PAL) and Body Mass Index (BMI) among adolescents (Ages 15-18) 15 ~ 18岁青少年身体活动水平与体重指数的关系

International Journal of Health Sciences-IJHS Pub Date : 2023-11-03 DOI: 10.53730/ijhs.v7ns1.14616

Mohammed Nezzar, Ababsa Houssam Eddine

{"title":"relationship between Physical Activity Level (PAL) and Body Mass Index (BMI) among adolescents (Ages 15-18)","authors":"Mohammed Nezzar, Ababsa Houssam Eddine","doi":"10.53730/ijhs.v7ns1.14616","DOIUrl":"https://doi.org/10.53730/ijhs.v7ns1.14616","url":null,"abstract":"The study aims to investigate the relationship between the level of physical activity among adolescents (aged 15-18) and the Body Mass Index (BMI), which is a universally recognized measure for distinguishing between overweight, obesity, and normal weight in individuals. The study was conducted on a sample of 20 students (both males and females) whose ages ranged from 15 to 18. These students were enrolled in the Hafar Al-Sass Mohammed Al-Eid Secondary School in the Wadi El Zenati Province, Guelma. The researcher employed a descriptive methodology for the study, using a questionnaire that addressed the types of physical activities performed by individuals in their daily lives to assess their level of physical activity. The study also relied on the Body Mass Index (BMI) as determined by IOTF standards. The study results indicated a very weak inverse relationship between the level of physical activity and the Body Mass Index for the study sample, with R = -0.14, which was not statistically significant as the Sig value (0.954) was greater than 0.05. The study also found that individuals in the sample with low levels of physical activity represented 75% of the study sample (15 students).","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"51 17","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135819688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

effects of conditioning sports activity on hypertensive patients 调节性运动对高血压患者的影响

International Journal of Health Sciences-IJHS Pub Date : 2023-11-03 DOI: 10.53730/ijhs.v7ns1.14615

Boumedien Hadjadj, Kerroum Bachir

{"title":"effects of conditioning sports activity on hypertensive patients","authors":"Boumedien Hadjadj, Kerroum Bachir","doi":"10.53730/ijhs.v7ns1.14615","DOIUrl":"https://doi.org/10.53730/ijhs.v7ns1.14615","url":null,"abstract":"The study aimed to investigate whether regular physical activity plays a role in the treatment of high blood pressure in Algerian individuals, given that over 90% of hypertension cases do not respond well to pharmaceutical or surgical treatment. Regular physical activity is an accessible and cost-effective way to maintain health, and recent scientific studies have shown its effectiveness in treating various chronic diseases, such as diabetes and respiratory disorders. To address this, the study was divided into three parts: Preliminary Chapter: This section introduces the research problem, hypotheses, objectives, definitions, challenges faced, and previous studies on the subject. Theoretical Background: This part consists of three chapters. The first chapter covers physical activity, including its concept, historical evolution, types, and its various health, psychological, and economic benefits. The second chapter discusses the cardiovascular system's role in maintaining normal blood pressure and the effects of engaging in physical activity on different body systems. It emphasizes physical activity's crucial role in prevention and the treatment of certain diseases. The third chapter addresses high blood pressure, its nature, types, scientific causes, complications, medications, and how to reduce and manage blood pressure while considering potential side effects.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"48 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135820321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Allergic disorders in Saudi Arabia: Challenges and future perspectives. 沙特阿拉伯过敏性疾病的管理：挑战和未来展望。

IF 2

International Journal of Health Sciences-IJHS Pub Date : 2023-11-01

Zafar Rasheed

引用次数: 0

Linking of oxidative stress and mitochondrial DNA damage to the pathophysiology of idiopathic intrauterine growth restriction. 氧化应激和线粒体DNA损伤与特发性宫内生长受限的病理生理学联系。

IF 2

International Journal of Health Sciences-IJHS Pub Date : 2023-11-01

Apurva Singh, Shyam Pyari Jaiswar, Apala Priyadarshini, Sujata Deo

{"title":"Linking of oxidative stress and mitochondrial DNA damage to the pathophysiology of idiopathic intrauterine growth restriction.","authors":"Apurva Singh, Shyam Pyari Jaiswar, Apala Priyadarshini, Sujata Deo","doi":"","DOIUrl":"","url":null,"abstract":"Objective: A common and serious pregnancy issue known as intrauterine growth restriction (IUGR) occurs when the fetus is unable to reach its full growth potential. Mitochondria are crucial to the development of the fetus and the placenta. We aimed to elucidate the role of oxidative stress parameters and markers of DNA damage. The integrity of the mitochondrial DNA (mtDNA) was studied.Materials and methods: Blood samples were collected from 48 females (cases and controls, respectively). Oxidative stress parameters were analyzed. DNA was extracted followed by high-performance liquid chromatography to study 8-OH-dG and mt DNA by real-time polymerase chain reaction. Western blot analysis was performed for nuclear-encoded mitochondrial proteins and DNA damage markers.Results: When pregnant women were compared to non-pregnant women in their first, second, and third trimesters, a highly significant progressive drop in circulating mtDNA was found. In addition, mtDNA was considerably higher in mothers carrying IUGR fetuses than in healthy pregnancies. Sirtuin-3 protein expression was considerably suppressed in the IUGR placenta (P = 0.027), whereas Nrf1 expression was not statistically different from the control group in the IUGR. Increased oxidative stress led to greater DNA damage in IUGR. The highest concentrations of 8-OH-dG were found in IUGR with levels significantly higher than those in the non-pregnant group.Conclusion: Our research sets the path for further investigation into mitochondrial anomalies in IUGR pregnancies and offers evidence for disturbed mitochondrial homeostasis. The mtDNA might offer a fresh perspective on the processes involved in physiological gestation. In addition, the presence of mtDNA may aid in the diagnosis of IUGR during pregnancy.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"17 6","pages":"15-22"},"PeriodicalIF":2.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated benign neutropenia in healthy individuals from Saudi Arabia's central region: A comprehensive study. 沙特阿拉伯中部地区健康个体中孤立的良性中性粒细胞减少症：一项综合研究。

IF 2

International Journal of Health Sciences-IJHS Pub Date : 2023-11-01

Ahmad AlShomar

{"title":"Isolated benign neutropenia in healthy individuals from Saudi Arabia's central region: A comprehensive study.","authors":"Ahmad AlShomar","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: Neutrophils are the most common cell types in circulation and are considered the first line of defense in the immune system against microorganisms. This study was undertaken to investigate the occurrence of isolated benign neutropenia (IBN) among healthy individuals in the central region of Saudi Arabia.Methods: This retrospective study analyzed complete blood count tests as part of routine checkups for chronic health conditions from April to September 2022. The 10,442 participants were randomly selected and their medical records were reviewed for neutropenia and mean absolute neutrophil counts (ANCs) were calculated. Descriptive analysis was employed to assess the prevalence of IBN across various demographic factors, such as age, gender, and nationality.Results: The prevalence of IBN in the central region of Saudi Arabia was found to be 2.82% across the entire cohort of participants. The mean ANC among all participants was 4.55 × 109/L. The prevalence of neutropenia was higher in male participants compared with female. Male neutropenic had a lower mean ANC than female; however, the differences were not statistically different (P > 0.05). The prevalence of neutropenia was lower in Saudi participants compared with non-Saudis. While the mean ANC was lower among Saudis as compared with non-Saudi participants. However, the differences were not statistically different (P > 0.05).Conclusion: This is the first study from the central region of Saudi Arabia that determined the prevalence of chronic benign neutropenia among healthy individuals. The prevalence of IBN was found to be relatively low. Furthermore, neutropenia was more frequent in males than females. Moreover, male neutropenic individuals have a lower ANC.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"17 6","pages":"23-27"},"PeriodicalIF":2.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of diastasis recti abdominis: Clinimetric properties of four measuring instruments. 腹直分离的评估：四种测量仪器的临床特性。

IF 2

International Journal of Health Sciences-IJHS Pub Date : 2023-11-01

Ojukwu Chidiebele Petronilla, Ezeigwe Anne Uruchi, Ezeigwe Chukwudi Francis, Ugwuonye Chioma Linda

{"title":"Assessment of diastasis recti abdominis: Clinimetric properties of four measuring instruments.","authors":"Ojukwu Chidiebele Petronilla, Ezeigwe Anne Uruchi, Ezeigwe Chukwudi Francis, Ugwuonye Chioma Linda","doi":"","DOIUrl":"","url":null,"abstract":"Objective: The aim of the study was to determine the intra- and inter-rater reliability of palpation technique, digital calipers, and diastometer, as well as their concurrent validity against ultrasound imaging.Methods: Ninety consenting parous women (20-45 years), recruited from a postnatal clinic in Enugu, Nigeria, participated in this observational study. Two physiotherapists and a sonographer measured their inter rectus distance at the level of the umbilicus, 4.5 cm above and below it, respectively, using each of the four modalities. The intra-rater measurements were taken at a week's interval. Data were analyzed with descriptive and inferential statistics of intraclass correlation coefficient and paired samples T-test, at an alpha level set at P < 0.05.Results: It showed the palpation technique (r = 0.749-0.967 and 0.658-0.917), digital calipers (r=0.750-0.955 and 0.685-0.904), and diastometer (r=0.762-0.958 and 0.471-0.902) demonstrated good inter- and intra-rater reliability. The concurrent validity of the palpation technique, digital calipers, and diastometer against the USI was poor at all three reference points.Conclusion: Palpation technique, digital calipers, and diastometer are reliable tools but not valid substitutes to ultrasound imaging for the clinical measurement of diastasis rectus abdominis.","PeriodicalId":47093,"journal":{"name":"International Journal of Health Sciences-IJHS","volume":"17 6","pages":"6-14"},"PeriodicalIF":2.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10624799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prebiotic potential of gum Arabic for gut health. 阿拉伯树胶对肠道健康的益生元潜力。

IF 2

International Journal of Health Sciences-IJHS Pub Date : 2023-11-01

Ahmed A M Elnour, Nour Hamid Abdurahman, Khalid Hamid Musa, Zafar Rasheed

引用次数: 0