Journal of Pregnancy最新文献

{"title":"Exclusive Breastfeeding and Its Determinants in Yaoundé, Cameroon: A Retrospective Survival Analysis.","authors":"Gloria Akah Ndum Okwen,&nbsp;Esron Daniel Karimuribo,&nbsp;Helena Aminiel Ngowi,&nbsp;Edith Nig Fombang","doi":"10.1155/2022/8396586","DOIUrl":"https://doi.org/10.1155/2022/8396586","url":null,"abstract":"<p><p>Exclusive breastfeeding (EBF) of infants for the first six months of life is a global public health goal that is linked to the reduction of morbidity and mortality in infants, especially in low middle-income countries. In low middle-income countries like Cameroon, it is realistic that compliance with EBF can significantly reduce the burden of under five mortality rate. The purpose of this study was to assess adherence and determinants influencing the duration of exclusive breastfeeding in Yaoundé, Cameroon. Data was collected through a mixed method and systematically through a retrospective survival analysis approach where a total number of 503 randomly selected individuals in Yaoundé, Cameroon, participated in the study. Data was collected between November 2019 and May 2020. A Cox proportional hazard modelling and Kaplan-Meier analysis were employed to identify prognostic factors affecting survival time defined as the duration, in months, from birth until the time of stopping EBF. The average time for nursing mothers to practice EBF was 3.61 ± 0.010 months. This study found that more than 90% of mothers were aware of the importance of compliance with EBF but only 38% practiced EBF and 62% of mothers could not adhere to EBF recommendations. Factors that influence compliance with EBF included a mother being married (HR: 0.70; 95% CI = [0.55-0.89], <i>P</i> =0.003) which was a protective factor while mother's tertiary education (HR: 1.43; 95% CI = [1.11-1.84], <i>P</i> =0.005) was a risk factor with non-compliance with EBF when compared to those with basic or no formal education. The Kaplan-Meier curve indicated that as time goes on, babies are less likely to be exclusively breastfed after a specific time period within two and three months. This implies that the chance for a baby to remain exclusively breastfed after five months is 74.3% (0.74). Continuous sensitization and enforcement measures are recommended to promote EBF.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":" ","pages":"8396586"},"PeriodicalIF":3.2,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33460644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated Factors of Male Participation in Antenatal Care in Muaro Jambi District, Indonesia","authors":"Guspianto, I. N. Ibnu, A. Asyary","doi":"10.1155/2022/6842278","DOIUrl":"https://doi.org/10.1155/2022/6842278","url":null,"abstract":"Objective This study aims to evaluate the level of male participation and factors associated with male participation in antenatal care. Methods A cross-sectional study was performed, involving a survey of 381 men, selected through multistage random sampling. The outcome variable male participation in antenatal care was constructed from eight dichotomized indicators, and measurement results were low (scored 1 and 2) and high (scored 3 and 4). Multiple logistic regression analysis was performed using SPSS 24.0 at a significance level of 0.05. Results The percentage of male participation in antenatal care was low (41.2%). Associated factors included age (OR = 1.858, 95%CI = 1.066–3.240), number of children (OR = 2.909, 95%CI = 1.532–5.522), income (OR = 1.715, 95%CI = 1.060–2.775), and knowledge (OR = 3.706, 95%CI = 2.320–5.919). Knowledge was found to be the main factor for male participation in antenatal care in Muaro Jambi Regency. Conclusion Male participation in antenatal care in Muaro Jambi District was low and was influenced by age, number of children, income, and knowledge. Health promotion programs are needed to empower men to participate in antenatal care by providing communication, education, and information.","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2022 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64783925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and Decision-Making for Pregnant Women: Taking or Relinquishing Control in Response to a Pandemic","authors":"E. Kaselitz, Chelsea Finkbeiner, Sarah Javaid, Sarah Barringer, Sarah D. Compton, M. Muzik, C. Moyer","doi":"10.1155/2022/6436200","DOIUrl":"https://doi.org/10.1155/2022/6436200","url":null,"abstract":"COVID-19 has uniquely impacted pregnant women. From the initial unknowns about its virulence during pregnancy, to frequent and rapidly changing hospital guidelines for prenatal care and delivery, pregnant women have felt intense uncertainty and, based on recent research, increased anxiety. This study sought to determine the impact COVID-19 had on women's birth plans. Open-ended qualitative responses from an anonymous, online survey of pregnant women in the United States, conducted on April 3-24, 2020, were analyzed using the Attride-Stirling qualitative framework. A conceptual framework for understanding the impact of COVID-19 on women's birth plans was generated. 2,320 pregnant women (mean age 32.7 years, mean weeks pregnant 24.6 weeks) responded to the open-ended prompts, reflecting the following themes: the impact(s) of COVID-19 on pregnant women (including unanticipated changes and uncertainty), the effect of COVID-19 on decision-making (including emotional reactions and subsequent questioning of the healthcare system), and how both of those things led women to either exercise or relinquish their agency related to their birth plan. These findings indicate that the changes and uncertainty surrounding COVID-19 are causing significant challenges for pregnant women, and absent more clarity and more provider-driven support, women seeking to cope are considering changes to their birth plans. Health systems and providers should heed this warning and work to provide pregnant women and their families with more information, support, and collaborative planning to ensure a positive, healthy birth experience, even during a pandemic.","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45411126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Different Algorithms and Cut-off Value in Preeclampsia First Trimester Screening","authors":"Piotr Tousty, B. Czuba, D. Borowski, Magda Fraszczyk-Tousty, Sylwia Dzidek, E. Kwiatkowska, A. Cymbaluk-Płoska, A. Torbé, S. Kwiatkowski","doi":"10.1155/2022/6414857","DOIUrl":"https://doi.org/10.1155/2022/6414857","url":null,"abstract":"Results For the cut-off point >1 : 150, 86 women at an increased risk of eo-PE using algorithm 1 were identified. Of these 86 patients, 83 (96%) were identified using algorithm 2, 62 (72%) using algorithm 3, and 60 (69%) using algorithm 4. In addition, it was demonstrated that between 21% and 29% of women at a low risk of eo-PE could be given acetylsalicylic acid if a screening test was used that did not account for PlGF. Conclusions In order to provide the highest level of health care to pregnant women, it is extremely important that full screening for eo-PE should be ensured. The cheapest algorithm based only on MAP and UtPI resulted in our patients being unnecessarily exposed to complications.","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2022 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41937656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preeclampsia, Natural History, Genes, and miRNAs Associated with the Syndrome.","authors":"Laura Parada-Niño,&nbsp;Luisa Fernanda Castillo-León,&nbsp;Adrien Morel","doi":"10.1155/2022/3851225","DOIUrl":"https://doi.org/10.1155/2022/3851225","url":null,"abstract":"<p><p>Preeclampsia (PE) is a hypertensive disease that affects pregnant women after 20 weeks of gestation. This disease is associated with an important risk of maternal and fetal mortality. PE is described as a placental pathology because, after delivery, most women recover normal arterial pressure. Poor invasion of the spiral arteries is a phenomenon well described in PE; this leads to a hypoxic uterine bed and imbalance of antiangiogenic and proangiogenic factors in the uteroplacental region, which in turn triggers the disease phenotype. The causes of the pathology are unclear; nevertheless, numerous approaches, including next-generation sequencing, association, and case control and miRNA studies, have shed light on the genetic/molecular basis of PE. These studies help us better understand the disease to advance new treatment strategies.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":" ","pages":"3851225"},"PeriodicalIF":3.2,"publicationDate":"2022-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39823408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Storytelling in Pregnancy and Childbirth: An Integrative Review of the Literature.","authors":"Zahra Mahdavi,&nbsp;Leila Amiri-Farahani,&nbsp;Sally Pezaro","doi":"10.1155/2022/8483777","DOIUrl":"https://doi.org/10.1155/2022/8483777","url":null,"abstract":"<p><strong>Methods: </strong>An integrative review of the literature was conducted, including peer-reviewed articles published between 2001 and 2022. The following databases were used to search for relevant studies: PubMed, CINAHL, PsycINFO, Web of Science, Ovid, Google Scholar, ScienceDirect, Cochrane Library, Magiran, Irandoc, and SID. A process of thematic synthesis was used to make sense of the data extracted.</p><p><strong>Results: </strong>Whilst 21 studies were retrieved, only 12 were relevant and thus met the inclusion criteria set. Two themes were identified from our thematic synthesis: (1) effects of childbirth storytelling on the storyteller and (2) effects of childbirth storytelling on the listener of the story. Subthemes included \"reducing fear of childbirth,\" \"transferring information and raising awareness in line with community culture,\" and \"adjusting expectations.\"</p><p><strong>Conclusion: </strong>The use of storytelling can be used as an effective method in educational interventions during pregnancy and childbirth. Due to limited high-quality intervention studies in this field, future studies could usefully be more robustly designed and incorporate digital storytelling methods to inform future directions.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2022 ","pages":"8483777"},"PeriodicalIF":3.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10800683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red Light Mitigates the Deteriorating Placental Extracellular Matrix in Late Onset of Preeclampsia and Improves the Trophoblast Behavior.","authors":"Jakara Griffin,&nbsp;John G Krolikowski,&nbsp;Kenisha Kounga,&nbsp;Janine Struve,&nbsp;Agnes Keszler,&nbsp;Brian Lindemer,&nbsp;Michelle Bordas,&nbsp;Grant Broeckel,&nbsp;Nicole L Lohr,&nbsp;Dorothee Weihrauch","doi":"10.1155/2022/3922368","DOIUrl":"https://doi.org/10.1155/2022/3922368","url":null,"abstract":"<p><p>Preeclampsia is a serious pregnancy disorder which in extreme cases may lead to maternal and fetal injury or death. Preexisting conditions which increase oxidative stress, e.g., hypertension and diabetes, increase the mother's risk to develop preeclampsia. Previously, we established that when the extracellular matrix is exposed to oxidative stress, trophoblast function is impaired, and this may lead to improper placentation. We investigated how the oxidative ECM present in preeclampsia alters the behavior of first trimester extravillous trophoblasts. We demonstrate elevated levels of advanced glycation end products (AGE) and lipid oxidation end product 4-hydroxynonenal in preeclamptic ECM (28%, and 32% increase vs control, respectively) accompanied with 35% and 82% more 3-chlorotyrosine and 3-nitrotyrosine vs control, respectively. Furthermore, we hypothesized that 670 nm phototherapy, which has antioxidant properties, reverses the observed trophoblast dysfunction as depicted in the improved migration and reduction in apoptosis. Since NO is critical for placentation, we examined eNOS activity in preeclamptic placentas compared to healthy ones and found no differences; however, 670 nm light treatment triggered enhanced NO availability presumably by using alternative NO sources. Light exposure decreased apoptosis and restored trophoblast migration to levels in trophoblasts cultured on preeclamptic ECM. Moreover, 670 nm irradiation restored expression of Transforming Growth Factor (TGF<i>β</i>) and Placental Growth Factor (PLGF) to levels observed in trophoblasts cultured on healthy placental ECM. We conclude the application of 670 nm light can successfully mitigate the damaged placental microenvironment of late onset preeclampsia as depicted by the restored trophoblast behavior.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2022 ","pages":"3922368"},"PeriodicalIF":3.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9365618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Presentation as a Predictor of the Response to Methotrexate Therapy in Patients with Ectopic Pregnancy.","authors":"Sarah Almutairy,&nbsp;Lateefa Othman Aldakhil","doi":"10.1155/2022/5778321","DOIUrl":"https://doi.org/10.1155/2022/5778321","url":null,"abstract":"<p><strong>Purpose: </strong>Ectopic pregnancy can be fatal if not diagnosed and timely treated. There is an increase in ectopic pregnancy rate which attributes in part to fertility medications and procedures and early diagnosis. Methotrexate, a folic acid antagonist, is widely used in the medical treatment of ectopic pregnancy. Many studies examined the safety and success rate of methotrexate looking into factors affecting the success rate, if the patient may present with symptoms such as abdominal pain, and some consider this as impeding rupture and it might affect the success of medical treatment. This study evaluates the success rate of methotrexate treatment outcomes in regard to presentation and looks into other factors that can help choosing a single or multiple dose modality.</p><p><strong>Methods: </strong>This is a retrospective review of 154 cases of ectopic pregnancy treated with methotrexate from January 2011 to December 2020 at King Khalid University Hospital (KKUH). Demographic data, clinical presentation, treatment progress, and outcome and failure rate were collected and analyzed. Student's <i>t</i>-test was used for statistical analysis of associations in SPSS.</p><p><strong>Results: </strong>154 patients were treated with MTX; of those patients, 25 received more than one dose. The difference between the responses to MTX treatment in symptomatic and asymptomatic individuals was not significant (<i>p</i> = 0.267). 131 (85%) had successful treatment. There were no associations between patient BMI, ectopic mass size, or ectopic mass site, the presence or absence of pelvic fluid on ultrasound at diagnosis, and the treatment success rate. There was a significant decline in the treatment success rate with increasing <i>β</i>-hCG levels on the presentation day (<i>p</i> = 0.035) and on day 4 (<i>p</i> value <0.001) of treatment.</p><p><strong>Conclusion: </strong>MTX treatment can be used to manage symptomatic patients with ectopic pregnancy. The success rate in symptomatic patients is not different from that in asymptomatic patients. <i>β</i> - hCG levels > 5000 IU/L. Pretreatment and on day 4 posttreatment is associated with higher failure rate.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2022 ","pages":"5778321"},"PeriodicalIF":3.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9722302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10345061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic Pregnancy in Tigray, Ethiopia: A Cross-Sectional Survey of Prevalence, Management Outcomes, and Associated Factors.","authors":"Elsa Tesfa Berhe,&nbsp;Kalayu Kiros,&nbsp;Merhawit Gebremeskel Hagos,&nbsp;Hailay Abrha Gesesew,&nbsp;Paul R Ward,&nbsp;Teferi Gebru Gebremeskel","doi":"10.1155/2021/4443117","DOIUrl":"https://doi.org/10.1155/2021/4443117","url":null,"abstract":"<p><strong>Background: </strong>Ectopic pregnancy is a neglected and challenging gynecologic problem in developing countries including Ethiopia.</p><p><strong>Objective: </strong>The present study is aimed at assessing the prevalence of ectopic pregnancy, its management outcomes, and factors associated with management outcomes in Tigray, North Ethiopia.</p><p><strong>Methods: </strong>We employed a four-year retrospective cross-sectional study from September 2015 to August 2019. We extracted data about all pregnant mothers who were admitted and managed for EPs in Axum, Tigray. Ectopic pregnancy and its outcomes (favorable and unfavorable) were the dependent variables, and age, residence, ethnicity, religion, parity, history of abortion, history of EP, pelvic infections, history of surgical procedures, and use contraceptives were the independent variables. We employed descriptive statistics and bivariate and multivariate logistic regression analyses using SPSS. Ethical clearance was obtained from Axum University, Tigray, Ethiopia.</p><p><strong>Results: </strong>The overall prevalence of ectopic pregnancy was 0.52% of total deliveries, which equates to 1 : 193 deliveries. Surgery for ectopic pregnancy accounts for 7.6% of all gynecological surgeries. Most participants were in the age group 26-30 years and lived in rural areas. Among the different EP implantation sites, most cases (92.4%) occurred in the fallopian tube, followed by 5.1% in the ovary and 2.5% in abdominal EPs. Surgical management (laparotomy) was undertaken for all the 79 women diagnosed with EPs, including laparotomy (100%), salpingo-oophorectomy (17.7%), salpingectomy (73.9%), oophorectomy (3.4%), cornual resection (2.5%), and removal of concepts tissue 2.5. The record reports that intraoperative procedure was correctly managed for 47 (59.5%) women but the condition of EP procedure was ruptured for about two-thirds (63.3%) of the women. Thirty (38%) patients had developed some complications after surgery including anemia (hemoglobin < 10.5) (<i>n</i> = 12), fever (<i>n</i> = 10), wound infection (<i>n</i> = 2), and pneumonia (<i>n</i> = 2). Women who were from urban (AOR = 11.2, 95% CI: 2.65-47.2) and who had normal hemoglobin at presentation (AOR = 9.94, 95% CI: 2.03-48.7) were associated with favorable maternal outcomes.</p><p><strong>Conclusions: </strong>More than one-third of women with ectopic pregnancies had an unfavorable maternal outcome, which was higher among rural residents and anemic mothers. Women living in rural areas and anemia during pregnancy should seek special attention in the management of EPs. We also recommend improving the data management of hospitals in Ethiopia.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2021 ","pages":"4443117"},"PeriodicalIF":3.2,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8651379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39709820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological Changes Observed in Placentas Exposed to Medication-Assisted Treatment.","authors":"Cara Staszewski,&nbsp;Kimberly M Herrera,&nbsp;Elizabeth Kertowidjojo,&nbsp;Victoria Ly,&nbsp;Nicole Iovino,&nbsp;Diana Garretto,&nbsp;Cynthia Kaplan,&nbsp;Malini D Persad,&nbsp;David J Garry","doi":"10.1155/2021/2175026","DOIUrl":"https://doi.org/10.1155/2021/2175026","url":null,"abstract":"Introduction To compare the effects of medication-assisted treatment on the placenta in pregnant women with opioid use disorder and uncomplicated pregnancies. Methods This is a case-controlled study of pregnant women utilizing medication-assisted treatment, buprenorphine or methadone, which were matched to healthy uncomplicated controls by gestational age. Placental evaluations and neonatal outcomes were evaluated. Data analysis performed standard statistics and relative risk analysis with a p < 0.05 considered significant. Results There were 143 women who met the inclusion criteria: 103 utilizing MAT, 41 buprenorphine and 62 methadone, and 40 uncomplicated matched healthy controls. The incidence of delayed villous maturation was 36% in the medication-assisted group compared with 10% in controls (RR 3.6: 95% CI 1.37-9.43; p < 0.01). The placental weight was greater (541 ± 117 g versus 491 ± 117 g; p = 0.02), and the fetoplacental weight ratio was lower (5.70 ± 1.1 versus 7.13 ± 1.4; p < 0.01) in the medication-exposed pregnancies compared with controls. The mean birth weight of the MAT newborns was significantly lower than that of the healthy controls (3018 ± 536 g versus 3380 ± 492 g; p < 0.01). When evaluating the subgroups of the MAT newborns, the birth weight of the methadone-exposed newborns (2886 ± 514 g) was significantly lower than that of the buprenorphine-exposed newborns (3218 ± 512 g; p < 0.01). Conclusion Medication-exposed pregnancies have a greater incidence of delayed villous maturation, a larger placental size, and a decreased fetoplacental weight ratio compared to the healthy controls. Larger long-term follow-up studies to evaluate outcomes with the presence of delayed villous maturation are needed.","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2021 ","pages":"2175026"},"PeriodicalIF":3.2,"publicationDate":"2021-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8516570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39527860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}