Journal of Pregnancy最新文献

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Determinants of Preeclampsia among Women Attending Delivery Services in Public Hospitals of Central Tigray, Northern Ethiopia: A Case-Control Study. 埃塞俄比亚北部提格雷中部公立医院分娩妇女子痫前期的决定因素:一项病例对照研究
IF 3.2
Journal of Pregnancy Pub Date : 2021-06-01 eCollection Date: 2021-01-01 DOI: 10.1155/2021/4654828
Teklehaimanot Gereziher Haile, Nega Assefa, Tadesse Alemayehu, Teklewoini Mariye, Gebreamlak Gebremedhn Geberemeskel, Degena Bahrey, Guesh Mebrahtom, Biniyam Demisse, Hailemikael Gebrekidan, Tamirat Getachew
{"title":"Determinants of Preeclampsia among Women Attending Delivery Services in Public Hospitals of Central Tigray, Northern Ethiopia: A Case-Control Study.","authors":"Teklehaimanot Gereziher Haile,&nbsp;Nega Assefa,&nbsp;Tadesse Alemayehu,&nbsp;Teklewoini Mariye,&nbsp;Gebreamlak Gebremedhn Geberemeskel,&nbsp;Degena Bahrey,&nbsp;Guesh Mebrahtom,&nbsp;Biniyam Demisse,&nbsp;Hailemikael Gebrekidan,&nbsp;Tamirat Getachew","doi":"10.1155/2021/4654828","DOIUrl":"https://doi.org/10.1155/2021/4654828","url":null,"abstract":"<p><strong>Background: </strong>Preeclampsia occurs in up to 5% of all pregnancies, in 10% of first pregnancies, and 20-25% of women with a history of chronic hypertension.</p><p><strong>Objective: </strong>This study aims to assess the determinants of preeclampsia among women attending delivery services in public hospitals of central Tigray, Ethiopia.</p><p><strong>Methods: </strong>Hospital-based unmatched case-control study design was conducted. Women diagnosed with preeclampsia were cases, and women who had no preeclampsia were controls admitted to the same hospitals. A systematic sampling technique was used to select study participants for both cases and controls. The data were entered in EPI data 3.1 statistical software and, then, exported to SPSS Version 22 for cleaning and analysis.</p><p><strong>Results: </strong>Family history of hypertension (AOR: 2.60; 95% CI: 1.15, 5.92), family history of preeclampsia (AOR: 5.24; 95% CI: 1.85, 14.80), history of diabetes mellitus (AOR: 4.31; 95% CI: 1.66, 11.21), anemia (AOR: 3.23; 95% CI: 1.18, 8.86), history of preeclampsia on prior pregnancy (AOR: 5.55; 95% CI: 1.80, 17.10), primigravida (AOR: 5.41; 95% CI: 2.85, 10.29), drinking alcohol during pregnancy (AOR: 4.06; 95% CI: 2.20, 7.52), and vegetable intake during pregnancy (AOR: 0.39; 95% CI: 0.21, 0.74) were significantly associated with preeclampsia.</p><p><strong>Conclusion: </strong>This study concludes that a family history of hypertension and preeclampsia; a history of diabetes mellitus and anemia; and a history of preeclampsia on prior pregnancy, primigravida, and drinking alcohol were found to be risk factors for preeclampsia. However, vegetable intake was found to be a protective factor for the development of preeclampsia.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2021 ","pages":"4654828"},"PeriodicalIF":3.2,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39023018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Cost-Effectiveness of Contraceptive Use in Indonesia after the Implementation of the National Health Insurance System. 国家健康保险制度实施后印度尼西亚避孕药具使用的成本效益。
IF 3.2
Journal of Pregnancy Pub Date : 2021-05-08 eCollection Date: 2021-01-01 DOI: 10.1155/2021/3453291
Auliya A Suwantika, Neily Zakiyah, Irma M Puspitasari, Rizky Abdulah
{"title":"Cost-Effectiveness of Contraceptive Use in Indonesia after the Implementation of the National Health Insurance System.","authors":"Auliya A Suwantika,&nbsp;Neily Zakiyah,&nbsp;Irma M Puspitasari,&nbsp;Rizky Abdulah","doi":"10.1155/2021/3453291","DOIUrl":"https://doi.org/10.1155/2021/3453291","url":null,"abstract":"<p><p>Since 2014, Indonesia has initiated to implement a national health insurance system, which included both of short- (SARC) and long-acting reversible contraceptive (LARC) into the benefit package. The aim of this study was to analyze the cost-effectiveness of contraceptive use in Indonesia after the implementation of the national health insurance in 2014-2017. A decision tree model was developed to analyze the cost-effectiveness of contraceptive use in Indonesia in 2014-2017 by comparing two strategies of pregnancy prevention: contraceptive and non-contraceptive. For contraceptive strategy, we took into account SARC and LARC. In a comparison with non-contraceptive, we calculated that the incremental cost-effectiveness ratio (ICER) of SARC would be $5.18, $4.80 and $3.76 per pregnancy averted for injection, condom, and pill, respectively. For LARC, we calculated that the ICER would be $1.67 and $0.84 for implant and intrauterine device (IUD), respectively, compared with non-contraceptive. In general, the cost-effectiveness value of LARC ($1.25) was much better than SARC ($4.58). The cost of contraceptive was considered to be the most influential parameter affecting both the ICER of SARC and LARC. In conclusion, the use of LARC in Indonesia was considered to be more cost-effective than SARC since the implementation of national health insurance system. In particular, IUD yielded the greatest cost-effectiveness value, compared with other methods.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2021 ","pages":"3453291"},"PeriodicalIF":3.2,"publicationDate":"2021-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39026948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis. COVID-19对孕妇和产后妇女死亡率的影响:系统回顾和荟萃分析
IF 3.2
Journal of Pregnancy Pub Date : 2021-03-05 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8870129
Leila Karimi, Somayeh Makvandi, Amir Vahedian-Azimi, Thozhukat Sathyapalan, Amirhossein Sahebkar
{"title":"Effect of COVID-19 on Mortality of Pregnant and Postpartum Women: A Systematic Review and Meta-Analysis.","authors":"Leila Karimi, Somayeh Makvandi, Amir Vahedian-Azimi, Thozhukat Sathyapalan, Amirhossein Sahebkar","doi":"10.1155/2021/8870129","DOIUrl":"10.1155/2021/8870129","url":null,"abstract":"<p><strong>Background: </strong>Based on what is known at this time, pregnant women are at an increased risk of severe illness from COVID-19 compared to nonpregnant women. Additionally, pregnant women with COVID-19 might have an increased risk of adverse pregnancy outcomes. To investigate the effects of coronavirus disease 2019 (COVID-19) on mortality of pregnant and postpartum women, we performed a systematic review of available published literature on pregnancies affected by COVID-19.</p><p><strong>Methods: </strong>Web of Science, SCOPUS, and MEDLINE- databases were searched for original studies concerning the effect of COVID-19 on mortality of pregnant and postpartum women published by July 10, 2020. Meta-analyses of proportions were used to combine data and report pooled proportions.</p><p><strong>Results: </strong>117 studies with a total of 11758 pregnant women were included. The age ranged between 15 and 48 years. Most subjects were infected with SARS-CoV-2 in the third trimester. Disease severity was not reported in 1125 subjects. Maternal mortality was 1.3%. In 100% of fatal cases with adequate data, fever alone or with cough was one of the presenting symptoms. Also, dyspnea (58.3%) and myalgia (50%) were the most common symptoms. Sore throat (8.3%) and gastrointestinal symptoms (anorexia, nausea) (8.3%) were rare. The rate of comorbidities was 20% among COVID-19 deaths. The majority of COVID-19-infected women who died had cesarean section (58.3%), 25% had a vaginal delivery, and 16.7% of patients were not full term.</p><p><strong>Conclusion: </strong>COVID-19 infection in pregnant women was associated with higher rates (and pooled proportions) of cesarean section and mortality. Because new data are continuously being generated and published, the findings of this study can be complete and updated with new researches. The results of this study can guide and improve prenatal counseling of COVID-19-infected pregnant women.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2021 ","pages":"8870129"},"PeriodicalIF":3.2,"publicationDate":"2021-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25486897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictors of Preterm Birth among Mothers Who Gave Birth in Silte Zone Public Hospitals, Southern Ethiopia. 埃塞俄比亚南部西尔特区公立医院分娩的母亲早产的预测因素
IF 3.2
Journal of Pregnancy Pub Date : 2021-02-24 eCollection Date: 2021-01-01 DOI: 10.1155/2021/1706713
Jida Ali Hassen, Mengistu Nunemo Handiso, Bitiya Wossen Admassu
{"title":"Predictors of Preterm Birth among Mothers Who Gave Birth in Silte Zone Public Hospitals, Southern Ethiopia.","authors":"Jida Ali Hassen,&nbsp;Mengistu Nunemo Handiso,&nbsp;Bitiya Wossen Admassu","doi":"10.1155/2021/1706713","DOIUrl":"https://doi.org/10.1155/2021/1706713","url":null,"abstract":"<p><strong>Background: </strong>A preterm birth is the leading cause of death in both neonatal and children under five years of age every year throughout the world, particularly in Sub-Saharan Africa. The causes of a preterm birth are complex and multifactorial; many risk factors that contribute it are not fully understood. The aim of this study was to identify predictors of a preterm birth among mothers who gave birth in Silte Zone Public Hospitals, Southern Ethiopia (2019/20).</p><p><strong>Methods and materials: </strong>A hospital-based unmatched case-control study design was carried out from July 15<sup>th</sup> to October 30<sup>th</sup>, 2019, by assigning mothers who gave preterm births as cases and those with term births as controls. A total of 365 respondents (91 cases and 274 controls) were selected by a consecutive simple random sampling until the required sample size was achieved. For each case, three consecutive controls were included. Data were collected using a structured interview questionnaire complement with record reviewing. The data were entered into Epi Info 7 and exported into SPSS 25 for analysis. Descriptive analysis was computed to obtain summary values for cases and controls separately. All candidate variables in bivariate analysis were entered into the multivariable logistic regression model by using the backward likelihood ratio selection methods. Finally, variables with <i>p</i> value ≤ 0.05 were considered as potential determinants of a preterm birth and reported in the form of adjusted odds ratio with 95% confidence interval.</p><p><strong>Results: </strong>Among a total of 365 mothers who gave live birth, 91 (24.9%) were cases compared to 274 (75.1%) which were controls. The final multivariable logistic regression analysis results showed that having history of a previous preterm birth (AOR = 3.51; 95%CI = 1.40 - 8.81), having shorter interpregnancy interval (AOR = 4.46; 95%CI = 1.95 - 10.21), experiencing obstetric complication (AOR = 3.82; 95%CI = 1.62 - 9.00), and having infant born with low birth weight (AOR = 5.58; 95%CI = 2.39 - 13.03) were found to be independent predictors of a preterm birth.</p><p><strong>Conclusions: </strong>According to this finding, mothers having previous history of a preterm birth, experiencing obstetric complication, having shorter interpregnancy interval, and having infant born with low birth weight were reported as the independent predictors of a preterm birth. Improving the quality of antepartum and intrapartum, counseling on birth space, creating awareness on family planning, and early screening of preterm determinants are mandatory.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2021 ","pages":"1706713"},"PeriodicalIF":3.2,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25467090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia. 健康妊娠和子痫前期的母体血清细胞因子浓度。
IF 3.2
Journal of Pregnancy Pub Date : 2021-02-23 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6649608
Toni Spence, Philip J Allsopp, Alison J Yeates, Maria S Mulhern, J J Strain, Emeir M McSorley
{"title":"Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia.","authors":"Toni Spence, Philip J Allsopp, Alison J Yeates, Maria S Mulhern, J J Strain, Emeir M McSorley","doi":"10.1155/2021/6649608","DOIUrl":"10.1155/2021/6649608","url":null,"abstract":"<p><p>The maternal immune response is essential for successful pregnancy, promoting immune tolerance to the fetus while maintaining innate and adaptive immunity. Uncontrolled, increased proinflammatory responses are a contributing factor to the pathogenesis of preeclampsia. The Th1/Th2 cytokine shift theory, characterised by bias production of Th2 anti-inflammatory cytokine midgestation, was frequently used to reflect the maternal immune response in pregnancy. This theory is simplistic as it is based on limited information and does not consider the role of other T cell subsets, Th17 and Tregs. A range of maternal peripheral cytokines have been measured in pregnancy cohorts, albeit the changes in individual cytokine concentrations across gestation is not well summarised. Using available data, this review was aimed at summarising changes in individual maternal serum cytokine concentrations throughout healthy pregnancy and evaluating their association with preeclampsia. We report that TNF-<i>α</i> increases as pregnancy progresses, IL-8 decreases in the second trimester, and IL-4 concentrations remain consistent throughout gestation. Lower second trimester IL-10 concentrations may be an early predictor for developing preeclampsia. Proinflammatory cytokines (TNF-<i>α</i>, IFN-<i>γ</i>, IL-2, IL-8, and IL-6) are significantly elevated in preeclampsia. More research is required to determine the usefulness of using cytokines, particularly IL-10, as early biomarkers of pregnancy health.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2021 ","pages":"6649608"},"PeriodicalIF":3.2,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25453655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antenatal Depression and Associated Factors among Pregnant Women Attending Antenatal Care Service in Kochi Health Center, Jimma Town, Ethiopia. 在埃塞俄比亚吉马镇科奇保健中心接受产前护理服务的孕妇的产前抑郁症及其相关因素。
IF 3.2
Journal of Pregnancy Pub Date : 2021-02-08 eCollection Date: 2021-01-01 DOI: 10.1155/2021/5047432
Yonas Tesfaye, Liyew Agenagnew
{"title":"Antenatal Depression and Associated Factors among Pregnant Women Attending Antenatal Care Service in Kochi Health Center, Jimma Town, Ethiopia.","authors":"Yonas Tesfaye, Liyew Agenagnew","doi":"10.1155/2021/5047432","DOIUrl":"10.1155/2021/5047432","url":null,"abstract":"<p><strong>Background: </strong>Antenatal depression has immense public health importance, as it can adversely affect both the mother and child health. The problem contributes to the disease burden in both developed and developing countries. Despite this, it is less investigated and not getting the necessary attention in the study setting.</p><p><strong>Objective: </strong>The aim of the study was to assess the prevalence of antenatal depression and associated factors among women attending antenatal care (ANC) service in Kochi Health Center, Jimma town, southwest Ethiopia, 2019.</p><p><strong>Method: </strong>Institutional based cross-sectional survey was conducted on 314 pregnant women attending Kochi Health Center from February 15 to April 15, 2019. A systematic random sampling technique was used to include the study participants. Antenatal depression was assessed using the Patient Health Questionnaire (PHQ-9) tool. Data was collected through face-to-face interviews using a pretested and structured questionnaire. Descriptive statistics was done to summarize the dependent and independent variables. Moreover, the chi-square test analysis was done to determine the association between the outcome and explanatory variables.</p><p><strong>Results: </strong>A total of 314 pregnant women participated in the study, making a response rate of 96.7%. The study has revealed a total of 52 (16.6%) of the respondent had antenatal depression. A chi-square test of independence analysis showed a significant association between antenatal depression and marital status, family history of depression, pregnancy planning, history of abortion, social support, and intimate partner violence (<i>P</i> < 0.00001).</p><p><strong>Conclusion: </strong>The study has shown that the prevalence of antenatal depression was high and associated with multiple psychosocial, clinical, and obstetric factors. Therefore, screening pregnant women for depression and the provision of necessary mental health services is recommended to mitigate the adverse health outcome of the problem.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2021 ","pages":"5047432"},"PeriodicalIF":3.2,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25408452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Social Marketing to Reduce Intention of Cesarean Section in Iranian Women. 利用社会营销降低伊朗妇女剖宫产的意愿。
IF 3.2
Journal of Pregnancy Pub Date : 2021-01-27 eCollection Date: 2021-01-01 DOI: 10.1155/2021/3920126
Mostafa Maleki, Ali Mousavizadeh, Saadat Parhizkar, Mohsen Shams
{"title":"Using Social Marketing to Reduce Intention of Cesarean Section in Iranian Women.","authors":"Mostafa Maleki,&nbsp;Ali Mousavizadeh,&nbsp;Saadat Parhizkar,&nbsp;Mohsen Shams","doi":"10.1155/2021/3920126","DOIUrl":"https://doi.org/10.1155/2021/3920126","url":null,"abstract":"<p><strong>Introduction: </strong>In Iran, the rate of cesarean section is three times more than the acceptable rate considered by the World Health Organization. This study aimed at reducing the selection of cesarean section by primigravida through an intervention based on social marketing in Boyer-Ahmad County, Iran, 2015.</p><p><strong>Methods: </strong>In this field trial, 39 of primigravida women were identified and selected as a target group. Formative research (a quantitative survey and a qualitative study) was done to achieve the social marketing mix. The tailored intervention was developed based on the findings of formative research. The intervention was implemented for one month for pregnant women who had cesarean section intention. Their intention for the cesarean section was studied again one month after the implementation of the intervention. The effectiveness of the intervention was evaluated by the proportion test.</p><p><strong>Results: </strong>The average age of the women was 25.82. All of the women 38.5 percent had a diploma degree and lower than and 61.5 percent had a university degree. Before the intervention, 39 women intended to do Cesarean. The intention of 30 pregnant women was changed significantly one month after the intervention.</p><p><strong>Conclusion: </strong>The study showed the effectiveness of an intervention based on consumer-oriented social marketing theory and could be used to reduce Cesarean intention. More studies about related factors of vaginal delivery selection especially from behavioral intention up to behavior are suggested.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2021 ","pages":"3920126"},"PeriodicalIF":3.2,"publicationDate":"2021-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25360326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Matrix Metalloproteinases MMP-2 and MMP-9 Occupy a New Role in Severe Preeclampsia. 基质金属蛋白酶MMP-2和MMP-9在重度子痫前期中的新作用
IF 3.2
Journal of Pregnancy Pub Date : 2020-12-16 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8369645
Elena Timokhina, Alexander Strizhakov, Sapiyat Ibragimova, Evgeny Gitel, Irina Ignatko, Vera Belousova, Nikoleta Zafiridi
{"title":"Matrix Metalloproteinases MMP-2 and MMP-9 Occupy a New Role in Severe Preeclampsia.","authors":"Elena Timokhina,&nbsp;Alexander Strizhakov,&nbsp;Sapiyat Ibragimova,&nbsp;Evgeny Gitel,&nbsp;Irina Ignatko,&nbsp;Vera Belousova,&nbsp;Nikoleta Zafiridi","doi":"10.1155/2020/8369645","DOIUrl":"https://doi.org/10.1155/2020/8369645","url":null,"abstract":"<p><strong>Introduction: </strong>Preeclampsia (PE) is a life-threatening condition for the mother, the fetus, and the newborn. Matrix metalloproteinases (MMP) participate in the two primary stages of PE: remodeling of blood vessels at the stage of placental formation and the development of hypertension due to damage to the basement membrane of blood vessels. The object of the present study was to reveal the role of MMP-2 and MMP-9 in the development of severe preeclampsia.</p><p><strong>Materials and methods: </strong>We conducted a retrospective study that included 92 pregnant women at a gestational age of 26-38 weeks, of which the principal group consisted of 61 patients with severe PE. We divided the principal group into two subgroups: the first subgroup was designated the severe early-onset preeclampsia (EO-PE) group and consisted of 30 pregnant women. The second group was designated the severe late-onset preeclampsia (LO-PE) group, comprising 31 patients. We determined the plasma concentrations of MMPs 2 and 9 in the groups with an ELISA.</p><p><strong>Results: </strong>In the group of PE patients with both EO-PE and LO-PE, the level of MMP-2 was significantly higher compared to the women undergoing normal pregnancy; and we observed no significant differences when we compared the levels of MMP-2 in the subgroups with EO-PE and LO-PE. Analysis of the concentrations of MMP-9 in EO-PE and LO-PE subgroups revealed attenuated levels of MMP-9 in both groups relative to the control group. We also noted a diminished level of MMP-9 in the EO-PE group compared to the LO-PE group.</p><p><strong>Conclusions: </strong>The significantly increased levels of MMP-2 in women-both in the EO-PE and LO severe PE subgroups-explain the participation of this enzyme in endothelial dysfunction in the second stage of severe PE. A diminution in MMP-9 in the EO-PE group confirmed the participation of MMP-9 in the process of spiral artery transformation.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2020 ","pages":"8369645"},"PeriodicalIF":3.2,"publicationDate":"2020-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8369645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38767735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Effect of Implementing a Free Delivery Service Policy on Women's Utilization of Facility-Based Delivery in Central Ethiopia: An Interrupted Time Series Analysis. 实施免费分娩服务政策对埃塞俄比亚中部妇女利用设施分娩的影响:中断时间序列分析。
IF 3.2
Journal of Pregnancy Pub Date : 2020-12-12 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8649598
Ayalneh Demissie, Alemayehu Worku, Yemane Berhane
{"title":"Effect of Implementing a Free Delivery Service Policy on Women's Utilization of Facility-Based Delivery in Central Ethiopia: An Interrupted Time Series Analysis.","authors":"Ayalneh Demissie,&nbsp;Alemayehu Worku,&nbsp;Yemane Berhane","doi":"10.1155/2020/8649598","DOIUrl":"https://doi.org/10.1155/2020/8649598","url":null,"abstract":"<p><strong>Background: </strong>Access to and utilization of facility delivery services is low in Ethiopia. The government of Ethiopia introduced a free delivery service policy in all public health facilities in 2013 to encourage mothers to deliver in health facilities. Examining the effect of this intervention on the utilization of delivery services is very important.</p><p><strong>Objective: </strong>In this study, we assessed the effect of provisions of free maternity care services on facility-based delivery service utilization in central Ethiopia.</p><p><strong>Methods: </strong>Data on 108 time points were collected on facility-based delivery service utilization (72 pre- and 36 postintervention) for a period of nine years from July 2007 to June 2016. Routine monthly data were extracted from the District Health Information System and verified using data from the delivery ward logbooks across the study facilities. An interrupted time-series analysis was conducted to assess the effect of the intervention.</p><p><strong>Results: </strong>The implementation of the free delivery services policy has significantly increased facility deliveries. During the study period, there was a statistically significant increase in the number of facility-based deliveries after the 24<sup>th</sup> and 36<sup>th</sup> months of intervention (<i>p</i> < 0.05). Program effects on the use of public facilities for deliveries were persisted over a longer exposure period.</p><p><strong>Conclusion: </strong>The findings suggested that the provision of free delivery services at public health facilities increased facility delivery use. The improved utilization of facility delivery services was more marked over a longer exposure period. Policy-makers may consider mobilizing the communities aware of the program at its instigation.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2020 ","pages":"8649598"},"PeriodicalIF":3.2,"publicationDate":"2020-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8649598","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38794611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Using the Robson Classification to Explain the Fluctuations in Cesarean Section. 使用罗布森分类法解释剖腹产的波动。
IF 3.2
Journal of Pregnancy Pub Date : 2020-11-12 eCollection Date: 2020-01-01 DOI: 10.1155/2020/2793296
H Cammu, E Martens, G Van Maele
{"title":"Using the Robson Classification to Explain the Fluctuations in Cesarean Section.","authors":"H Cammu, E Martens, G Van Maele","doi":"10.1155/2020/2793296","DOIUrl":"10.1155/2020/2793296","url":null,"abstract":"<p><strong>Purpose: </strong>As the rate of cesarean sections (CS) continues to rise in Flanders (northern part of Belgium), it is important to understand the reasons behind this evolution and to find ways to achieve appropriate CS rates. For this analysis, we categorized CS changes between 1992 and 2016, applying the Robson 10-Group Classification System (TGCS). We also applied the TGCS to analyze the information of the only clinics where between 2008 and 2016, the absolute CS rate had fallen by more than two percent.</p><p><strong>Methods: </strong>This paper is based on a population-based cross-sectional study. Robson's TGCS was used to analyze CS rates for the years 1992, 2000, 2008, and 2016, using the Flemish population-based birth register.</p><p><strong>Results: </strong>Between 1992 and 2016, the overall CS rate increased from 11.8% in 1992 to 20.9% in 2016. The major contributors to that increase were (a) single, cephalic nulliparous women, at term in spontaneous labor (Robson group 1); (b) single, cephalic nulliparous women, at term in induced labor or CS before labor (group 2); and (c) multiparous women with single cephalic at term pregnancy with history of CS (group 5). In the subgroup of the seven clinics where the collective CS rate had decreased from 23.2% in 2008 to 19.3% in 2016, the main contributors to this decrease were Robson groups 1 and 2.</p><p><strong>Conclusions: </strong>The CS increase in Flanders between 1992 and 2016 is mainly the result of the absolute CS increase in the childbirth of nulliparous women with a single cephalic baby at term in spontaneous or induced labor and in women with a single cephalic presentation at term and a previous CS. Further research in these aforementioned groups is needed to identify the real reasons for the CS increase.</p>","PeriodicalId":47062,"journal":{"name":"Journal of Pregnancy","volume":"2020 ","pages":"2793296"},"PeriodicalIF":3.2,"publicationDate":"2020-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38683908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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