Journal of Medicinal Chemistry最新文献

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IF 6.8 1区 医学
Journal of Medicinal Chemistry Pub Date : 2025-07-24
Zijian Han, Jintian Li, Qingyi Liao, Ruitong Luo, Leyun Wu, Yulong Shi, Liping Zhou, Qian Zhang, Máté Erdélyi, Weiliang Zhu* and Zhijian Xu*, 
{"title":"","authors":"Zijian Han, Jintian Li, Qingyi Liao, Ruitong Luo, Leyun Wu, Yulong Shi, Liping Zhou, Qian Zhang, Máté Erdélyi, Weiliang Zhu* and Zhijian Xu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":6.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c01043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 6.8 1区 医学
Journal of Medicinal Chemistry Pub Date : 2025-07-24
Sarah M. Glass, David Polidori, Kevin J. Coe, Hariharan Venkatesan and Alexander S. Burns*, 
{"title":"","authors":"Sarah M. Glass, David Polidori, Kevin J. Coe, Hariharan Venkatesan and Alexander S. Burns*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":6.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c00437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 6.8 1区 医学
Journal of Medicinal Chemistry Pub Date : 2025-07-24
Tukki Sarkar*, Milan Paul, Arpan Bera, Arif Ali Mandal, Samya Banerjee*, Swati Biswas* and Bathini Nagendra Babu*, 
{"title":"","authors":"Tukki Sarkar*, Milan Paul, Arpan Bera, Arif Ali Mandal, Samya Banerjee*, Swati Biswas* and Bathini Nagendra Babu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":6.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c01372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 6.8 1区 医学
Journal of Medicinal Chemistry Pub Date : 2025-07-24
Xiaoxue Wang, Cheng Wang, Yakun Ma, Yongjun Piao, Yi Shi, Shuang Yang*, Jia Li* and Yan Fan*, 
{"title":"","authors":"Xiaoxue Wang, Cheng Wang, Yakun Ma, Yongjun Piao, Yi Shi, Shuang Yang*, Jia Li* and Yan Fan*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":6.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c00693","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 6.8 1区 医学
Journal of Medicinal Chemistry Pub Date : 2025-07-24
Xiao-Meng Liu, Zhen-Zhen Zhu, Qing-Tian Li, Zhe Li, Rui Rong, Cheng-Zhi Xie, Xin Qiao*, Yu-Kuan Feng* and Jing-Yuan Xu*, 
{"title":"","authors":"Xiao-Meng Liu, Zhen-Zhen Zhu, Qing-Tian Li, Zhe Li, Rui Rong, Cheng-Zhi Xie, Xin Qiao*, Yu-Kuan Feng* and Jing-Yuan Xu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":6.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c01170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 6.8 1区 医学
Journal of Medicinal Chemistry Pub Date : 2025-07-24
Sandra Kozieł*, Daria Wojtala, Agata Barzowska-Gogola, Barbara Pucelik, Ewelina Waglewska, Miłosz Siczek, Maciej Witwicki, Alessandro Niorettini, Agnieszka Kyzioł, Magdalena Malik, Urszula Bazylińska, Ewa Błaszczak and Urszula K. Komarnicka*, 
{"title":"","authors":"Sandra Kozieł*, Daria Wojtala, Agata Barzowska-Gogola, Barbara Pucelik, Ewelina Waglewska, Miłosz Siczek, Maciej Witwicki, Alessandro Niorettini, Agnieszka Kyzioł, Magdalena Malik, Urszula Bazylińska, Ewa Błaszczak and Urszula K. Komarnicka*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":6.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c00486","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 6.8 1区 医学
Journal of Medicinal Chemistry Pub Date : 2025-07-24
Siyuan Wang, Meidi Luo, Qihao Xu, Rongxian Guo, Wenchao Zhang, Bo Li, Han Qin, Leyan Wei, Yifei Cui, Jinyu Sha, Shanshan Shao, Xintian Yu, Linxiang Zhao, Pinghua Sun, Changjun Bai, Jiachen Wen* and Dan Liu*, 
{"title":"","authors":"Siyuan Wang, Meidi Luo, Qihao Xu, Rongxian Guo, Wenchao Zhang, Bo Li, Han Qin, Leyan Wei, Yifei Cui, Jinyu Sha, Shanshan Shao, Xintian Yu, Linxiang Zhao, Pinghua Sun, Changjun Bai, Jiachen Wen* and Dan Liu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":6.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c00278","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 6.8 1区 医学
Journal of Medicinal Chemistry Pub Date : 2025-07-24
Yueqi Wang, Mingxing Hu, Junjie Wu, Lili Pan, Huijun Zhou, Li Li, Weihong Kuang, Yongmei Xie* and Wei Chen*, 
{"title":"","authors":"Yueqi Wang, Mingxing Hu, Junjie Wu, Lili Pan, Huijun Zhou, Li Li, Weihong Kuang, Yongmei Xie* and Wei Chen*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":6.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c00741","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 6.8 1区 医学
Journal of Medicinal Chemistry Pub Date : 2025-07-24
Chao Zhao, Xiaoyan Huang, Zhuoyang Wu, Wanlu Sun, Yi Pan* and Yi Liu*, 
{"title":"","authors":"Chao Zhao, Xiaoyan Huang, Zhuoyang Wu, Wanlu Sun, Yi Pan* and Yi Liu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 14","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":6.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c01339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Untargeted Diversity-Oriented Synthesis for the Discovery of New Antitumor Agents: An Integrated Approach of Inverse Virtual Screening, Bioinformatics, and Omics for Target Deconvolution. 以非靶向多样性为导向的新抗肿瘤药物合成:一种反虚拟筛选、生物信息学和靶向反褶积组学的综合方法。
IF 7.3 1区 医学
Journal of Medicinal Chemistry Pub Date : 2025-07-24 DOI: 10.1021/acs.jmedchem.5c01344
Tania Ciaglia,Valeria Napolitano,Maria Rosaria Miranda,Danila La Gioia,Simona Musella,Aniello Schiano Moriello,Fabrizio Merciai,Veronica Di Sarno,Simona De Vita,Ester Colarusso,Gerardina Smaldone,Francesca Di Matteo,Eduardo Maria Sommella,Poulami Kumar,Marco Allarà,Alessia Ligresti,Isabel M Gomez-Monterrey,Giuseppe Bifulco,Gianluigi Lauro,Pietro Campiglia,Carmine Ostacolo,Vincenzo Vestuto,Alessia Bertamino
{"title":"Untargeted Diversity-Oriented Synthesis for the Discovery of New Antitumor Agents: An Integrated Approach of Inverse Virtual Screening, Bioinformatics, and Omics for Target Deconvolution.","authors":"Tania Ciaglia,Valeria Napolitano,Maria Rosaria Miranda,Danila La Gioia,Simona Musella,Aniello Schiano Moriello,Fabrizio Merciai,Veronica Di Sarno,Simona De Vita,Ester Colarusso,Gerardina Smaldone,Francesca Di Matteo,Eduardo Maria Sommella,Poulami Kumar,Marco Allarà,Alessia Ligresti,Isabel M Gomez-Monterrey,Giuseppe Bifulco,Gianluigi Lauro,Pietro Campiglia,Carmine Ostacolo,Vincenzo Vestuto,Alessia Bertamino","doi":"10.1021/acs.jmedchem.5c01344","DOIUrl":"https://doi.org/10.1021/acs.jmedchem.5c01344","url":null,"abstract":"Molecular diversity is one of the most pursued objectives in drug discovery, and diversity-oriented synthesis (DOS) perfectly responds to the achievement of this goal. In this paper, we describe a DOS approach applied to the antitumor field with the aim of identifying new anticancer structures and their associated targets. To accomplish this ambitious project, after an initial stage of phenotypic evaluation, we set up an integrated platform of inverse virtual screening (IVS), bioinformatics, and omics to predict the biological targets of the most promising compounds 31 and 63. Several proteins emerged from this study, and the most interesting ones were assessed by biophysical and in cellulo experiments, leading to the validation of six targets involved in calcium regulation, endoplasmic reticulum stress, and apoptosis. This work allowed us to identify two hit compounds with an interesting antitumor mechanism, but principally, to validate our platform as a fruitful tool for untargeted DOS campaigns.","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"115 1","pages":""},"PeriodicalIF":7.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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