Journal of Pathology and Translational Medicine最新文献_第3页

Histopathological characteristics of Epstein-Barr virus (EBV)-associated encephalitis and colitis in chronic active EBV infection. 慢性活动性EBV感染中eb病毒相关脑炎和结肠炎的组织病理学特征

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2025-05-01 Epub Date: 2025-04-16 DOI: 10.4132/jptm.2025.02.21

Betty A Kasimo, James J Yahaya, Sun Och Yoon, Se Hoon Kim, Minsun Jung

{"title":"Histopathological characteristics of Epstein-Barr virus (EBV)-associated encephalitis and colitis in chronic active EBV infection.","authors":"Betty A Kasimo, James J Yahaya, Sun Och Yoon, Se Hoon Kim, Minsun Jung","doi":"10.4132/jptm.2025.02.21","DOIUrl":"10.4132/jptm.2025.02.21","url":null,"abstract":"Chronic active Epstein-Barr virus (CAEBV) can induce complications in various organs, including the brain and gastrointestinal tract. A 3-year-old boy was referred to the hospital with a history of fever and seizures for 15 days. A diagnosis of encephalitis based on computed tomography (CT) and magnetic resonance imaging findings and clinical correlation was made. Laboratory tests showed positive serology for Epstein-Barr virus (EBV) and negative for Rotavirus antigen and IgG and IgM antibodies for cytomegalovirus, herpes simplex virus, and varicella zoster virus, respectively. Abdominal CT showed diffuse wall thickening with fluid distension of small bowel loops, lower abdomen wall thickening, and a small amount of ascites. The biopsy demonstrated positive Epstein-Barr encoding region in situ hybridization in cells within the crypts and lamina propria. The patient was managed with steroids and hematopoietic stem cell transplantation (HSCT). This case showed histopathological characteristics of concurrent EBV-associated encephalitis and colitis in CAEBV infection. The three-step strategy of immunosuppressive therapy, chemotherapy, and allogeneic HSCT should be always be considered for prevention of disease progression.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"59 3","pages":"188-194"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lessons learned from the first 2 years of experience with thyroid core needle biopsy at an Indonesian national referral hospital. 印度尼西亚一家国家转诊医院头两年甲状腺核心针活检经验的教训。

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2025-05-01 Epub Date: 2025-04-25 DOI: 10.4132/jptm.2025.02.19

Agnes Stephanie Harahap, Maria Francisca Ham, Retno Asti Werdhani, Erwin Danil Julian, Rafi Ilmansyah, Chloe Indira Arfelita Mangunkusumso, Tri Juli Edi Tarigan

{"title":"Lessons learned from the first 2 years of experience with thyroid core needle biopsy at an Indonesian national referral hospital.","authors":"Agnes Stephanie Harahap, Maria Francisca Ham, Retno Asti Werdhani, Erwin Danil Julian, Rafi Ilmansyah, Chloe Indira Arfelita Mangunkusumso, Tri Juli Edi Tarigan","doi":"10.4132/jptm.2025.02.19","DOIUrl":"10.4132/jptm.2025.02.19","url":null,"abstract":"Background: Core needle biopsy (CNB) improves diagnostic accuracy by providing precise tissue sampling for histopathological evaluation, overcoming the limitation of inconclusive fine-needle aspiration results. This study evaluated the diagnostic performance of CNB in assessing thyroid nodules, with additional analysis of the benefits of BRAF V600E and RAS Q61R immunohistochemical (IHC) markers.Methods: This retrospective study enrolled patients with thyroid nodules who underwent CNB at Dr. Cipto Mangunkusumo Hospital, Jakarta, from July 2022 to July 2024. CNB diagnoses were classified using the Korean Thyroid Association Criteria. Diagnostic efficacy was evaluated for neoplastic and malignant lesions, both independently and with BRAF V600E and RAS Q61R IHC. The correlation between nodule size and postoperative diagnosis was also analyzed.Results: A total of 338 thyroid nodule samples was included, and 52.7% were classified as CNB category II. In the 104 samples with postoperative diagnoses, category IV was the most prevalent (39.4%). CNB demonstrated a sensitivity of 74% and a specificity of 100% for neoplastic lesions and 23.8% sensitivity and 100% specificity for malignant lesions. Combining CNB with BRAF V600E and RAS Q1R IHC increased the sensitivity to 77% for neoplastic lesions and 28.8% for malignant lesions. Larger nodules (>3 cm) were significantly associated with neoplastic (p = .005) and malignant lesions (p = .004).Conclusions: CNB performs well in identifying neoplastic lesions, with or without BRAF V600E and RAS Q61R IHC, but its low sensitivity for malignant lesions warrants caution. While CNB categories V-VI indicate malignancy, the possibility of malignancy in categories I-IV should not be overlooked.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"59 3","pages":"149-160"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytological features of atypical adenomatous hyperplasia and adenocarcinoma in situ of the lung: a case report. 肺非典型腺瘤性增生和原位腺癌的细胞学特征：1例报告。

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2025-05-01 Epub Date: 2025-05-09 DOI: 10.4132/jptm.2025.04.09

Misa Takahashi, Seiya Homma, Chisato Setoguchi, Yoko Umezawa, Atsuhiko Sakamoto

引用次数: 0

Primary Merkel cell carcinoma of the salivary gland: a clinicopathologic study of four cases with a review of literature. 原发性唾液腺默克尔细胞癌：四例临床病理研究并文献复习。

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2025-05-01 Epub Date: 2025-04-30 DOI: 10.4132/jptm.2025.03.25

Gyuheon Choi, Joon Seon Song, Hee Jin Lee, Gi Hwan Kim, Young Ho Jung, Yoon Se Lee, Kyung-Ja Cho

{"title":"Primary Merkel cell carcinoma of the salivary gland: a clinicopathologic study of four cases with a review of literature.","authors":"Gyuheon Choi, Joon Seon Song, Hee Jin Lee, Gi Hwan Kim, Young Ho Jung, Yoon Se Lee, Kyung-Ja Cho","doi":"10.4132/jptm.2025.03.25","DOIUrl":"10.4132/jptm.2025.03.25","url":null,"abstract":"Background: Primary Merkel cell carcinoma of the salivary gland is currently not listed in the World Health Organization classification. However, cases of Merkel cell type neuroendocrine carcinomas of the salivary gland with perinuclear cytokeratin 20 positivity have been intermittently reported. We here investigated the clinicopathologic features of additional cases.Methods: Data of four cases of Merkel cell type small cell neuroendocrine carcinoma of the salivary gland were retrieved. To confirm the tumors' primary nature, clinical records and pathologic materials were reviewed. Optimal immunohistochemical staining was performed to support the diagnosis.Results: All tumors were located in the parotid gland. Possibilities of metastasis were excluded in all cases through a meticulous clinicopathological review. Tumor histology was consistent with the diagnosis of small cell neuroendocrine carcinoma. Tumors' immunohistochemical phenotypes were consistent with Merkel cell carcinoma, including Merkel cell polyomavirus large T antigen positivity in two of the four cases.Conclusions: Merkel cell carcinomas can originate in salivary glands and are partly associated with Merkel cell polyomavirus infection as in cutaneous Merkel cell carcinomas.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":" ","pages":"171-179"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study. 勘误：使用核特征和血管及囊膜侵犯评估甲状腺肿瘤的诊断挑战：一项多中心观察者间一致研究。

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.4132/jptm.2024.07.25.r

Agnes Stephanie Harahap, Mutiah Mutmainnah, Maria Francisca Ham, Dina Khoirunnisa, Abdillah Hasbi Assadyk, Husni Cangara, Aswiyanti Asri, Diah Prabawati Retnani, Fairuz Quzwain, Hasrayati Agustina, Hermawan Istiadi, Indri Windarti, Krisna Murti, Muhammad Takbir, Ni Made Mahastuti, Nila Kurniasari, Nungki Anggorowati, Pamela Abineno, Yulita Pundewi Setyorini, Kennichi Kakudo

引用次数: 0

Categorizing high-grade serous ovarian carcinoma into clinically relevant subgroups using deep learning-based histomic clusters. 使用基于深度学习的组织簇将高级别浆液性卵巢癌分类为临床相关亚组。

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-18 DOI: 10.4132/jptm.2024.10.23

Byungsoo Ahn, Eunhyang Park

{"title":"Categorizing high-grade serous ovarian carcinoma into clinically relevant subgroups using deep learning-based histomic clusters.","authors":"Byungsoo Ahn, Eunhyang Park","doi":"10.4132/jptm.2024.10.23","DOIUrl":"10.4132/jptm.2024.10.23","url":null,"abstract":"Background: High-grade serous ovarian carcinoma (HGSC) exhibits significant heterogeneity, posing challenges for effective clinical categorization. Understanding the histomorphological diversity within HGSC could lead to improved prognostic stratification and personalized treatment approaches.Methods: We applied the Histomic Atlases of Variation Of Cancers model to whole slide images from The Cancer Genome Atlas dataset for ovarian cancer. Histologically distinct tumor clones were grouped into common histomic clusters. Principal component analysis and K-means clustering classified HGSC samples into three groups: highly differentiated (HD), intermediately differentiated (ID), and lowly differentiated (LD).Results: HD tumors showed diverse patterns, lower densities, and stronger eosin staining. ID tumors had intermediate densities and balanced staining, while LD tumors were dense, patternless, and strongly hematoxylin-stained. RNA sequencing revealed distinct patterns in mitochondrial oxidative phosphorylation and energy metabolism, with upregulation in the HD, downregulation in the LD, and the ID positioned in between. Survival analysis showed significantly lower overall survival for the LD compared to the HD and ID, underscoring the critical role of mitochondrial dynamics and energy metabolism in HGSC progression.Conclusions: Deep learning-based histologic analysis effectively stratifies HGSC into clinically relevant prognostic groups, highlighting the role of mitochondrial dynamics and energy metabolism in disease progression. This method offers a novel approach to HGSC categorization.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":" ","pages":"91-104"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Breast fine-needle aspiration cytology in the era of core-needle biopsy: what is its role? 勘误：乳腺细针穿刺细胞学在核心针活检时代：它的作用是什么？

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2025-03-01 Epub Date: 2025-03-14 DOI: 10.4132/jptm.2024.11.01.r

Ahrong Kim, Hyun Jung Lee, Jee Yeon Kim

引用次数: 0

Mucocele of the rectal stump: mucinous cystic neoplasm with low-grade dysplasia simulating low-grade appendiceal mucinous neoplasm. 直肠残端黏液囊肿：黏液囊性肿瘤伴低级别发育不良，类似低级别阑尾黏液性肿瘤。

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-26 DOI: 10.4132/jptm.2024.12.27

Hasan Basri Aydin, Maria Faraz, A David Chismark, Haiyan Qiu, Hwajeong Lee

引用次数: 0

Association study of TYMS gene expression with TYMS and ENOSF1 genetic variants in neoadjuvant chemotherapy response of gastric cancer. TYMS基因表达与TYMS和ENOSF1基因变异在胃癌新辅助化疗反应中的相关性研究。

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2025-03-01 Epub Date: 2025-02-25 DOI: 10.4132/jptm.2024.11.05

Khadijeh Arjmandi, Iman Salahshourifar, Shiva Irani, Fereshteh Ameli, Mohsen Esfandbod

{"title":"Association study of TYMS gene expression with TYMS and ENOSF1 genetic variants in neoadjuvant chemotherapy response of gastric cancer.","authors":"Khadijeh Arjmandi, Iman Salahshourifar, Shiva Irani, Fereshteh Ameli, Mohsen Esfandbod","doi":"10.4132/jptm.2024.11.05","DOIUrl":"10.4132/jptm.2024.11.05","url":null,"abstract":"Background: The present research was designed to study the associations between genetic variants of TYMS and ENOSF1 genes with TYMS and ENOSF1 gene expression in neoadjuvant chemotherapy response among patients with gastric cancer.Methods: Formalin-embedded and paraffin-fixed matched tumor and normal gastric cancer tissue samples from patients who received neoadjuvant 5-fluorouracil (5-FU) treatment were obtained. DNA and RNA were extracted for all samples. A 28-bp variable number tandem repeat (VNTR) at the 5' untranslated region of TYMS gene and rs2612091 and rs2741171 variants in the ENOSF1 gene were genotyped for normal tissue samples. The real-time polymerase chain reaction method was used to study the expression of ENOSF1 and TYMS genes in both normal and tumor tissues. Data were analyzed using REST 2000 and SPSS ver. 26.0 software programs.Results: A significant association between TYMS 2R3R VNTR genotypes and 5-FU therapy was found (p = .032). The 3R3R and 2R2R genotypes were significantly associated with increased and decreased survival time, respectively (p = .003). The 3R3R genotype was significantly associated with TYMS overexpression (p < .001). Moreover, a significant association was found between the rs2612091 genotype and treatment outcome (p = .017).Conclusions: This study highlights the impact of TYMS and ENOSF1 genes as predictive indicators for survival and response to 5-FU-based neoadjuvant chemotherapy in gastric cancer patients.","PeriodicalId":46933,"journal":{"name":"Journal of Pathology and Translational Medicine","volume":"59 2","pages":"105-114"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uncommon granulomatous manifestation in Epstein-Barr virus-positive follicular dendritic cell sarcoma: a case report. 爱泼斯坦-巴氏病毒阳性滤泡树突状细胞肉瘤的罕见肉芽肿表现：病例报告。

IF 1.7

Journal of Pathology and Translational Medicine Pub Date : 2025-03-01 Epub Date: 2024-10-31 DOI: 10.4132/jptm.2024.09.27

Henry Goh Di Shen, Yue Zhang, Wei Qiang Leow

引用次数: 0