Archivio Italiano di Urologia e Andrologia最新文献

{"title":"Editorial Comment on \"<i>Lady Urologist</i> and male patients with prostate cancer\".","authors":"Elisabetta Costantini, Ester Illiano","doi":"10.4081/aiua.2025.13708","DOIUrl":"10.4081/aiua.2025.13708","url":null,"abstract":"<p><p>As a member of the Editorial Board  and a pioneering woman in the world of urology, I would like to make some comments on the letter published in the present issue of Archivio Italiano di Urologia e Andrologia about Suzanne Koven's book published in 2021...</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13708"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urogenital and extra genital mutilation in gender-affirming surgery: are we violating <i>primum non nocere</i>?","authors":"Zeki Bayraktar","doi":"10.4081/aiua.2025.13324","DOIUrl":"10.4081/aiua.2025.13324","url":null,"abstract":"<p><p>In transgender individuals, there is a mismatch between biological sex and gender (sex-gender discordance), and this mismatch is often attempted to be resolved by changing the sex [...].</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13324"},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival and oncological outcomes for young men (≤55 years) undergoing radical prostatectomy for localized prostate cancer.","authors":"Shahryar Zeighami, Ali Ariafar, Alireza Makarem, Faisal Ahmed, Mohammadreza Askarpour","doi":"10.4081/aiua.2025.12658","DOIUrl":"10.4081/aiua.2025.12658","url":null,"abstract":"<p><strong>Objectives: </strong>This research aimed to compare the prostate cancer (PCa) features, survival rate, and functional outcomes after open suprapubic Radical Prostatectomy (RP) between younger men (≤ 55 years) and older men (> 55 years).</p><p><strong>Methods: </strong>In this retrospective cohort study, we studied 134 patients with clinically localized PCa who underwent RP at our centers between 2011 and 2019, with 26 (19.40%) patients aged ≤ 55. Pathological parameters, survival rate (at 5 and 10 years), and functional outcomes such as erectile function and continence rate (at two years from RP) were evaluated retrospectively, and the two groups were compared. The Chi-square test, Kaplan-Meier, and Cox proportional hazards method were used for statistical analysis.</p><p><strong>Results: </strong>Men aged ≤ 55 had greater rates of organ-confined tumors, lower D'Amico risk grouping, and pathologic Gleason grade than their older counterparts (all p<0.05). The median follow-up was 81 months. The overall survival rate at five and ten years in younger men vs older counterparts was 96.15% vs. 93.47% and 92.15% v. 82.13% but was not statistically significant (p=0.1539). Five-year biochemical recurrence-free and metastasis-free survival rates in younger men vs older counterparts were 96.2% vs 81.5% and 75.7% vs 51.5%. Men > 55 years were associated with worse BCR-free and metastasis-free survival in univariate analysis and worsening BCR in multivariate analysis. The continence rate was significantly improved in men aged ≤ 55 years compared to older counterparts (OR: 5.08; 95% CI: 1.61-22.61; p=0.013). However, erectile function was not statistically significant between groups [for moderate ED: (OR:1.08; 95% CI: 0.43-2.79, p=0.865), for severe ED (OR: 1.60; 95% CI: 0.35-11.50, p=0.579=)].</p><p><strong>Conclusions: </strong>Our study showed that survival rates were similar in younger men (≤ 55 years) and their older counterparts. However, older patients who underwent RP had more advanced disease, worse BCR-free survival, and worse continence rate. For localized prostate cancer patients under 55 years of age, radical prostatectomy is an excellent treatment option with excellent long-term survival results. Given the relatively small number of patients younger than 55, a large cohort study with long-term postprocedural follow-up is needed to validate this observation.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"12658"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced patient recovery with early extensive surgical deb-ridement in Fournier's Gangrene: evaluation of perioperative outcomes in a multicentric experience.","authors":"Giovanni Cochetti, Alessio Paladini, Luca Lepri, Andrea Vitale, Raffaele La Mura, Miriam Russo, Paolo Mangione, Matteo Mearini, Andrea Fabiani, Emanuele Iacobone, Lucilla Servi, Ettore Mearini, Michele Del Zingaro","doi":"10.4081/aiua.2025.13207","DOIUrl":"10.4081/aiua.2025.13207","url":null,"abstract":"<p><strong>Objective: </strong>Fournier's gangrene (FG) is a rare, life-threatening necrotizing fasciitis primarily affecting the perineal, genital, and perianal regions. This rapidly progressing bacterial infection predominantly affects middleaged and elderly men. This multicenter study aims to describe the management in a wide cohort of Fournier's gangrene cases that presented to three tertiary centers with early extensive surgical debridement.</p><p><strong>Materials and methods: </strong>We retrospectively collect data from patients with FG who were referred to the Urology Clinic of the Department of Medicine and Surgery (Perugia), the Urological Andrological Surgery and Minimally Invasive Techniques Unit (Terni) of the University of Perugia, and the Urology Unit of the Surgery Department of the Macerata Civic Hospital between January 2019 and March 2024 for onset of classic signs and symptoms of FG. Extensive surgical debridement was immediately performed under general anesthesia to reach normochromic and vascularized tissue in wide and depth extension, assuring vital and healthy margins. For all patients, intravenous daptomycin plus piperacillin/tazobactam were administered.</p><p><strong>Results: </strong>28 male patients with FG underwent early surgical debridement. In two cases, orchidectomy and partial penectomy were required during surgical debridement due to extensive necrosis. Colon diversion and urinary diversion were not necessary for any of the patients. 32.1% complications were recorded according to the Clavien Dindo classification; 6 patients died in the perioperative. Excluding death data, the average duration of antibiotic therapy was 22.0±9.1 days, and the average length of stay was 17.6±11.8 days.</p><p><strong>Conclusions: </strong>Fournier's gangrene has high mortality rates. It requires timely surgical debridement and antibiotic therapy to achieve positive outcomes. This study shows that a primary extensive debridement can help reduce the need for further intervention and shorten the hospital stay.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13207"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urine alkalinization for dissolution of uric acid stones and treatment of other urological diseases with a treatment combining potassium magnesium citrate and theobromine.","authors":"Celia Abad Rodriguez-Hesles, Hassan Alkhatatbeh, María Belén Alonso Bartolomé, Carmen Arai Valladares Ferreiro, Hector Ricardo Ayllón Blanco, Cristina Calzas Montalvo, Daniel Carrasco Gómez, Marta Casadevall Rubau, Elena Maria Casas Martinez, Sara Esturo Sacristan, Miguel Gómez Garberí, Blanca Gómez-Jordana Mañas, Rosa Maria Gras Martinez, Ana Morales Martínez, Pedro Hernandez-Peñalver, Silvia Juste Alvarez, Alberto López Sierra, Rafael Maria Mas Lucas, Isabel Mohedano Sánchez, Isabel Montuenga Fernandez, Baraa Nakdali Kassab, Maria Negueroles-Garcia, Leticia Ruibal Gago, Laura Sánchez, Bernat Isern, Alberto Trinchieri","doi":"10.4081/aiua.2025.13824","DOIUrl":"10.4081/aiua.2025.13824","url":null,"abstract":"<p><strong>Background: </strong>Urine alkalinization can be used for the treatment of some urological diseases.</p><p><strong>Methods: </strong>A series of cases showing the beneficial effects of urine alkalinization with potassium magnesium citrate, theobromine, zinc and vitamin A for the dissolution of uric acid stones and the treatment of other urological pathological conditions is presented.</p><p><strong>Results: </strong>Alkalinization was effective in the dissolution of uric acid renal stones in various clinical conditions. Two cases of bilateral renal stone, four cases of staghorn renal stone, seven patients with unilateral renal stone, and five cases of ureteral stone were described. In this group the age ranged from 46 to 91 years, the M/F ratio was 7/11, the density of the stones ranged between 300 and 528. In most cases the urinary pH ranged from 5 to 5.5. Diabetes was observed in 4 cases, obesity in 4 cases and hyperuricemia in 7. Alkalinizing treatment achieved complete dissolution of the stone in 12 cases and almost complete or partial dissolution in other 6. A combination of potassium magnesium citrate, theobromine, zinc and vitamin A was used in all the cases.  In 4 cases the administration of allopurinol was associated. In one case with obstructive ureteral stones, stone dissolution was obtained with the combined administration of bicarbonate via nephrostomy and intravenous bicarbonate and oral treatment with citrates.  Stone dissolution of uric acid stones has also been described in some specific clinical conditions such as Crohn's disease with ileostomy, outcome of partial nephrectomy, cross-fused renal ectopia. Alkalinization was also used to prevent encrustation of a self-expanding metallic ureteral stent. Alkalinization has also been employed during the period of Mitomycin administration for the treatment of non-muscle infiltrating bladder tumors and for the treatment of overactive bladder.</p><p><strong>Conclusions: </strong>The findings of these case reports demonstrate that urinary alkalinization with frequent monitoring of urinary pH ​can be successfully employed in the non-surgical treatment of uric acid stones of different sizes in various locations.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":"97 1","pages":"13824"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovering a new nutraceutical based on pollen extract and teupolioside: a prospective monocentric study evaluating its role in alleviating lower urinary tract symptoms in benign prostatic hyperplasia patients.","authors":"Mattia Lo Re, Marta Pezzoli, Anna Cadenar, Elettra Fuligni, Leonardo Gajo, Andrea Minervini, Andrea Cocci","doi":"10.4081/aiua.2025.13412","DOIUrl":"10.4081/aiua.2025.13412","url":null,"abstract":"<p><strong>Background: </strong>Benign prostatic hyperplasia (BPH) is a common condition in men over 50, leading to lower urinary tract symptoms (LUTS). A nutraceutical containing pollen extract (Graminex® G96®) and teupolioside has shown potential in alleviating LUTS by targeting inflammation and dihydrotestosterone production. This prospective, monocentric study enrolled 60 patients with mild to moderate LUTS due to BPH.</p><p><strong>Methods: </strong>Participants received one tablet daily for three months. Assessments included the international prostate symptom score (IPSS), quality of life (QoL), uroflowmetry, postvoid residual (PVR), and sexual function (IIEF-5, MSHQ EjD).</p><p><strong>Results: </strong>Fifty-three patients completed the follow-up. Significant improvements were observed in IPSS and QoL (p<0.001), with scores decreasing from 14 (11-16) at baseline to 10 (8-12) at three months and decreasing from 3 (2-3) to 2 (2-2), respectively. Uroflowmetry parameters (Qmax and PVR) improved, increasing from 12 (11-16) ml/s to 15 (11-17) ml/s and decreasing from 50 (30-55) ml to 35 (25-45) ml, respectively, without statistical significance (p>0.05). Sexual function and PSA levels remained stable, with no significant adverse effects reported.</p><p><strong>Conclusions: </strong>The combination of pollen extract and teupolioside effectively alleviates LUTS in BPH patients with a favorable safety profile, particularly in avoiding sexual dysfunction.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":"97 1","pages":"13412"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepancy between male and female perceptions of ejaculation latency and sexual satisfaction: results from an online open survey.","authors":"Andrea Cocci, Marta Pezzoli, Arturo Lo Giudice, Gaia Polloni, Giorgio Ivan Russo, Leonardo Gajo, Daniel Giunti, Michele Di Dio, Borja Garcia Gòmez, Manuel Alonso Isa, Agustin Fraile Poblador, Javier Romero Otero, Andrea Minervini, Mattia Lo Re","doi":"10.4081/aiua.2025.13445","DOIUrl":"10.4081/aiua.2025.13445","url":null,"abstract":"<p><strong>Background: </strong>Premature ejaculation is a sexual dysfunction that can impact both men and women. This study aimed to shed light on this condition within a cohort as extensive as possible.</p><p><strong>Materials and methods: </strong>We conducted an online open survey, distributed via social media, proposing a questionnaire regarding various aspects including the duration of ejaculatory latency, perceptions of premature or delayed ejaculation, as well as lifestyle and psychological aspects of sexuality. The questionnaire comprised 77 questions for male participants and 16 for female participants, with responses structured on a Likert scale ranging from 1 to 5.</p><p><strong>Results: </strong>A total of 1300 men and 1197 women participated in the survey, completing the entire questionnaire.The median age (IQR) of male participants was 27 (23-32) years, while that of female participants was 22 (19-35) years. Men reported a median (IQR) ejaculatory latency time of 17 (8-20) minutes during sexual intercourse, compared to 20 (15-20) minutes reported by women. Only 7.5% (98) of men and 5% (60) of women reported an ejaculatory latency time of less than 3 minutes in their last five sexual encounters (p=0.0001). Twelve percent (160) of men believed they consistently experienced premature ejaculation, whereas only 3% (41) of women reported this sensation (p=0.0001). Regarding satisfaction with ejaculatory latency time, 7% of men (85) expressed dissatisfaction, whereas only 2% of women (28) reported the same (p=0.0001). Conversely, only 12% of men (160) considered themselves completely satisfied, compared to 30% of women (358) (p=0.0001).</p><p><strong>Conclusions: </strong>These analyses highlight a dissonance between male and female perceptions of premature ejaculation, not only in terms of actual intercourse duration but also in terms of psychological perception and sexual well-being. This should suggest a need to increase awareness among the population regarding the contrast between idealized sexual experiences and reality.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":"97 1","pages":"13445"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between seminal α-glycerylphosphorylcholine and semen parameters in infertile patients pre- and post-sub-inguinal micro-varicocelectomy: a prospective study.","authors":"Ahmed Fathy Aboseif, Nashaat Nabil, Sameh Fayek GamalEl Din, Shaimaa Abdelkareem, Aya Ahmed Onsi, Ahmad Zaghloul, Amgad Elseginy","doi":"10.4081/aiua.2025.12832","DOIUrl":"10.4081/aiua.2025.12832","url":null,"abstract":"<p><strong>Background: </strong>Varicocele (Vx) which is the most treatable cause of male infertility, is also associated with low sperm count, decreased sperm motility and increased sperm abnormal morphology. We aimed in the current study to evaluate the correlation between seminal α-Glycerylphosphorylcholine (αGPC) and semen parameters in infertile patients pre- and post- sub-inguinal micro-varicocelectomy.</p><p><strong>Methods: </strong>The current comparative prospective study was carried out on 20 male patients who presented to Kasr Al-Ainy Hospitals from March 2022 to March 2023 as well as 20 healthy controls. The participants were divided into groups as follows: group (1) included fertile normozoospermic men (n = 20) who served as controls. Group (2) included infertile oligoasthenoteratozoospermia (OAT) men with varicocele (n = 20). Patients in group (2) were followed up to 3 months after microsurgical sub-inguinal Varicocelectomy. The examination included an assessment of Vx with scrotal Duplex. Semen analysis was done according to the 5th Edition of WHO manual for semen analysis.</p><p><strong>Results: </strong>The study demonstrates that αGPC level was significantly higher among fertile normozoospermic control group and infertile OAT men post varicocelectomy when compared to infertile OAT men preoperative (p<0.001). Moreover, it demonstrates that on follow up of infertile OAT group 3 months after sub-inguinal micro-varicocelectomy, all semen parameters showed significant improvement compared to the corresponding semen parameters pre-operatively among Vxs grade II and grade III (p<0.001, p<0.001, respectively). A significant positive correlation was found between αGPC level and semen parameters including sperm normal forms, sperm count and sperm motility. Using ROC curve, αGPC protein showed a sensitivity of (100%) and a specificity of (100%) at cut off value (≤ 1.975 pg/ml) in differentiation between infertile OAT patients with Vx and control fertile normozoospermic men (p<0.001).</p><p><strong>Conclusions: </strong>αGPC may play an important role in infertility in men with Vx and correction of Vx improves the seminal αGPC level.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"12832"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Lady urologist</i> and male patients with prostate cancer.","authors":"Rodolfo Montironi, Antonio Lopez-Beltran, Meredith C Wasserman, Alessia Cimadamore, Liang Cheng","doi":"10.4081/aiua.2025.13343","DOIUrl":"10.4081/aiua.2025.13343","url":null,"abstract":"<p><p>To the Editor In 2022, Dr. Suzanne Koven published a book entitled Letter to a Young Female Physician, Notes from a Medical Life. W.W. Norton & Company, Inc, New York. The book starts with a letter written by the author while participating in a 2017 orientation session...</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13343"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with erectile dysfunction in traumatic urethral strictures following epa urethroplasty: a single center experience.","authors":"Paksi Satyagraha, Gede Wirya Diptanala Putra Duarsa, Fauzan Kurniawan Dhani, Adrianus Gupta Wijaya, Besut Daryanto","doi":"10.4081/aiua.2025.13383","DOIUrl":"10.4081/aiua.2025.13383","url":null,"abstract":"<p><strong>Introduction: </strong>Urethral repair with Excision and Primary Anastomosis (EPA) urethroplasty offers excellent outcome in managing traumatic urethral strictures. However, its impact on erectile function (EF) is largely unknown. Study to evaluate EF outcome post-operatively is still limited worldwide. We report factors associated to EF following EPA Urethroplasty performed by single surgeon in tertiary hospital. In this study, we aim to evaluate the risk of erectile dysfunction (ED) following EPA Urethroplasty.</p><p><strong>Materials and methods: </strong>This is a retrospective study on patients with traumatic urethral strictures who underwent EPA Urethroplasty from 2013 to 2023. Variables including age, body mass index, systemic disease, etiology, stricture length, prior procedures and erection hardness score (EHS) score prior and 12 months after surgery were recorded. Pre-Operative ED was determined using Penile Doppler Ultrasound, which was defined as a peak systolic velocity of less than 25 cm/s. Univariate and Multivariate logistic regression analysis were performed using IBM SPSS Statistic.</p><p><strong>Results: </strong>A total of 89 patients were included. Among them, 33 patients (33.7%) suffered from initial ED prior to surgery. Pelvic fracture urethral injury (PFUI) was the predominant etiology (74%); 29% of the patients were active smokers, and 68.5% had prior endoscopic treatment. Among the 48 patients without ED prior to surgery, 7 of them (14.6%) developed ED following surgery in 12 months of follow up. After EPA, there was a reduction of mean EHS score from 2.70 to 2.53 (p=0.176). Multivariate analysis showed that smoking status (p=0.035; OR 4.41), PFUI as the mechanism of injury (p=0.007; OR 2.89), prior urethrotomy (p=0.020; OR 4.69), and prior dilatations (p=0.046; OR 0.18) were related as risk factors of ED following EPA urethroplasty.</p><p><strong>Conclusions: </strong>Risk of ED following EPA is inevitable, although the number is not as high as expected. Smoking, PFUI and prior treatment rather than EPA, emerge as predominant risk factors associated with the development of ED subsequent to surgical repair.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13383"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}