Archivio Italiano di Urologia e Andrologia最新文献

{"title":"Recovery of functional outcomes after robot assisted radical prostatectomy (RaRP): impact of vacuum therapy compared to PDE5 inhibitors alone.","authors":"Pier Paolo Prontera, Francesca Romana Prusciano, Marco Lattarulo, Arman Tsaturyan, Carmine Sciorio, Francesco Saverio Grossi","doi":"10.4081/aiua.2025.13639","DOIUrl":"10.4081/aiua.2025.13639","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the primary efficacy of vacuum therapy combined with phosphodiesterase type 5 inhibitors (PDE5i) vs. PDE5i alone in improving erectile function recovery, assessed via the International Index of Erectile Function (IIEF) questionnaire, after robotic-assisted radical prostatectomy (RARP). A secondary objective was to assess the impact of the combined therapy on continence outcomes, including pad usage and continence scores. The study also explored predictors of rehabilitation success and the potential synergistic effects of the combined approach.</p><p><strong>Materials and methods: </strong>A retrospective analysis of 101 patients who underwent RARP (2021-2023) was conducted. Patients were divided into Group 1 (PDE5i only, n=70) and Group 2 (PDE5i + vacuum therapy, n=31). Vacuum therapy was started within 20 days postoperatively and performed daily under specialist supervision. All data were completely anonymous. Primary outcomes included IIEF-5 scores for erectile function and continence recovery (pad usage, continence scores based on three levels: 0 - complete incontinence, 1 - stress incontinence and 2 - full continence). Predictive factors were analysed using repeated measures ANOVA and multivariate regression.</p><p><strong>Results: </strong>Group 2 showed significantly higher mean IIEF-5 scores at 12 months (10.2 vs. 2.5, p<0.001) and earlier continence recovery, with better scores at 3 and 6 months (p < 0.05). Vacuum therapy and PDE5i accelerate continence recovery during the early postoperative period, with fewer pads required, compared with patients treated with PDE5i alone, at 6 months (1.32 vs. 1.62; p=0.358) and 9 months (0.54 vs. 1.08; p=0.034). Key predictors of recovery included age, BMI, nervesparing status, and preoperative continence levels.</p><p><strong>Conclusions: </strong>This study demonstrates the benefits of combining vacuum therapy with PDE5i for improving erectile function and early continence recovery after RARP, highlighting the importance of early, individualized rehabilitation. Vacuum therapy enhances oxygenation, reduces fibrosis and complements PDE5i effects. Further research is needed to refine predictive factors for success and explore the impact of intraoperative blood loss on erectile recovery, enabling optimized, tailored strategies for post-RARP rehabilitation.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13639"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buccal mucosal graft for onlay ureteroplasty in the management of proximal ureteral stricture. Single centre, prospective trial.","authors":"Ahmed Salah Nasef, Ibrahim Alaa Eldin Tagrida, Mohamed Fawzy Salman, Adel Elatreisy, Sabry Mahmoud Khaled","doi":"10.4081/aiua.2025.13695","DOIUrl":"10.4081/aiua.2025.13695","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the outcomes of oral buccal mucosa graft (BMG) ureteroplasty in managing recurrent long-segment proximal ureteric strictures and recurrent uretero-pelvic junction obstruction (UPJO).</p><p><strong>Methods: </strong>A single-centre prospective study included patients with recurrent long-segment proximal ureteric strictures and recurrent UPJO treated with open onlay BMG ureteroplasty from January 2022 to September 2024. Patient demographics, intraoperative and postoperative characteristics, and the percentage of stricture-free status at the last visit were documented. Complication rates were categorized according to the modified Clavien-Dindo grading system Results: The study included 21 patients, 11 males (52.4%) and 10 females (47.6%), with a mean age ± SD of 45.8 ± 13.7 years. Regarding the stricture etiology, Ten patients (47.6%) had previously undergone complicated endoscopic stone surgeries, seven patients (33.3%) had a history of open surgery for stone disease, while the remaining four (19%) had undergone previously failed pyeloplasty for congenital UPJO. The mean operative time was 145 minutes, the mean stricture length ±SD was 3.94±1.4 cm, and the mean harvested BMG length ±SD was 7.6±1.1 cm. Six patients (28.6%) developed postoperative complications of Clavien II and III grade. The follow-up duration ranged from 9 to 24 months, with a mean duration of 16.3 months. At the last follow-up visit, 18 out of 21 patients (85.7%) were stricture-free.</p><p><strong>Conclusions: </strong>Buccal mucosa graft for onlay ureteroplasty represents an effective surgical intervention for managing recurrent, long-segment proximal ureteric strictures and recurrent cases of ureteropelvic junction obstruction.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13695"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis and adherence to guidelines of mobile health application for bladder cancer, where are we?","authors":"Roberto La Rocca, Ernesto Di Mauro, Alfonso Falcone, Enrico Sicignano, Luigi Cirillo, Pasquale Reccia, Lorenzo Romano, Michelangelo Olivetta, Gennaro Mattiello, Felice Crocetto, Biagio Barone, Luigi De Luca, Ugo Amicuzi, Francesco Mastrangelo, Carmine Turco, Corrado Aniello Franzese, Ferdinando Fusco, Davide Arcaniolo, Vincenzo Maria Altieri, Luigi Napolitano","doi":"10.4081/aiua.2025.13455","DOIUrl":"10.4081/aiua.2025.13455","url":null,"abstract":"<p><strong>Introduction: </strong>Mobile health applications (MHAs) represent a tool to assist patients affected by different disease including bladder cancer (BCa), although the scientific quality and adherence to guidelines are not yet addressed.</p><p><strong>Materials and methods: </strong>On September 2024, we conducted a search in the Apple App Store and Google Play Store. We reviewed all mobile apps from Apple App Store and Google Play Store for BC and evaluated their usage in screening, prevention, management, and adherence to EAU guidelines.</p><p><strong>Results: </strong>In total 10 MHA were reviewed. All MHAs are geared towards the patient and provide information about diagnoses and treatment of BC. The mean score was 3.29 in Engagement, 3.26 in Functionality, 3.06 in Aesthetics, 3.13 in Information, and 3 in Subjective quality respectively. MHAs reported low and medium adherence to EAU guidelines.</p><p><strong>Conclusions: </strong>MHAs provide different services in many medical fields, including BCa. There are several drawbacks regarding scientific validation, content, and quality. Future research is necessary to promote new user designed, and high-quality apps.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13455"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased expression of transglutaminase-2 is associated with invasive disease in bladder cancer.","authors":"Yavuz Karaca, Şükran Kayıpmaz, Dilek Telci, Oktay Akça","doi":"10.4081/aiua.2025.13615","DOIUrl":"10.4081/aiua.2025.13615","url":null,"abstract":"<p><strong>Purpose: </strong>Transglutaminase-2 is associated with tumor invasion, metastasis development, chemoresistance and poor prognosis in various cancer types. In this study, our aim was to show the association between increased transglutaminase-2 expression and the invasive pattern of bladder cancer.</p><p><strong>Materials and methods: </strong>Tumor tissues from eighty-eight patients with bladder cancer (43 muscle-invasive, 45 non-muscle invasive bladder cancer) were immunohistochemically evaluated for TG2 expression.</p><p><strong>Results: </strong>Transglutaminase-2 expression score was higher in muscle- invasive bladder cancer compared to non-muscle invasive bladder cancer tissues (5.37±1.5 vs 0.71±1.4, p<0.001). No statistically significant difference was found in transglutaminase- 2 expression scores between metastatic and non-metastatic disease in MIBC group. Different tumor and lymphnode stages in MIBC were also found to be not correlated with transglutaminase- 2 expression scores.</p><p><strong>Conclusions: </strong>The over-expression of transglutaminase-2 is associated with invasive disease in bladder cancer. According to our results, transglutaminase-2 has the potential to be useful for predicting the invasion in bladder cancer and addressing treatment.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13615"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of large reservoirs in inflatable penile prosthesis surgery.","authors":"Ibrahim Alnadhari, Muammer Alshrani, Osama Abdeljaleel, Omar Ali, Abdulla Al-Ansari, Ahmad Shamsodini","doi":"10.4081/aiua.2025.13480","DOIUrl":"10.4081/aiua.2025.13480","url":null,"abstract":"<p><strong>Introduction: </strong>The use of inflatable penile prostheses (IPP) has become a well-established treatment for erectile dysfunction, offering significant improvements in the quality of life for many patients. The reservoir site and size in IPP surgery are areas of ongoing research and debate. This study aims to evaluate the outcomes associated with the use of large reservoirs in IPP, focusing on both the surgical techniques and postoperative complications.</p><p><strong>Materials and methods: </strong>Our study is a retrospective study of 60 patients who underwent inflatable penile prosthesis (IPP) with large reservoir irrespective of the size of the prosthesis in Al Wakra Hospital from the period of 1st of January 2022 to 30th of August 2024.</p><p><strong>Results: </strong>Successful insertion of the large reservoir was carried out in all patients from the same penoscrotal incision. There was no recorded migration, urethral injury, infection, device failure, pain, erosion or LUTS in our patients. Revision was done in one patient.</p><p><strong>Conclusions: </strong>The use of large-volume reservoirs in inflatable penile prosthesis (IPP) surgery demonstrates a favorable safety profile, with no significant increase in complication rates compared to standard reservoir sizes.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13480"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BRCA mutations and prostate cancer: should urologist improve daily clinical practice?","authors":"Simona Vatrano, Pietro Pepe, Ludovica Pepe, Nuccia Vella, Cristina Alario, Alessia Chiarandà, Chiara Taranto, Renato Scillieri, Cristina Mauceri, Filippo Fraggetta","doi":"10.4081/aiua.2025.13635","DOIUrl":"10.4081/aiua.2025.13635","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate BRCA1-2 (breast cancer) detection in men with high risk PCa, including the oncological consequences for the patient and family members.</p><p><strong>Materials and methods: </strong>From January 2023 to December 2024, 52 men (median age 73 years;) with confirmed PCa diagnosis underwent somatic and germline BRCA1 and BRCA2 assessment; 11/52 (21%) patients documented a family history of cancer. Patients were at different clinical stages: high-grade (71% had a Gleason score ≥ 8), locally advanced (54% of cases) and/or metastatic PCa (46% of cases) at initial diagnosis, hormone-sensitive and/or castration-resistant PCa (38.2% of cases) at clinical progression. Formalin-fixed paraffin-embedded (FFPE) tissues and next generation sequencing (NGS) analyses of BRCA genes were evaluated on 52 samples (prostate biopsies or definitive samples) collected at Gravina Hospital (Caltagirone, Italy) from different Sicilian pathology departments. The therapeutic and clinical impact of genetic testing for BRCA somatic and germline mutations was evaluated for patients and their families.</p><p><strong>Results: </strong>All FFPE cases were successfully genotyped, with a good library and sequencing CQ metrics for all genes of interest; 10/52 (19.2%) patients had somatic or germline BRCA mutations, specifically, 3/52 (5.7%) had somatic and 7/52 (13.5%) had germline mutations. In the seven cases with germline variants, 4/7 (57%) had a family history of PCa or other diseases, while the remaining 3/7 (43%) patients had no hereditary predisposition. All identified genetic variants were related to the BRCA2 gene; after genetic screening of the corresponding relatives, various members of the analysed families carried the mutation identified in the proband, so that cancer prevention and/or active surveillance was possible.</p><p><strong>Conclusions: </strong>NGS analysis for BRCA genetic testing using FFPE tissue in the clinical setting of patients with high-grade and/or metastatic PCa appears to be a valuable tool, not only for therapeutic purposes, but also to identify families with genetic predisposition who may be underdiagnosed according to canonical criteria.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13635"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of laparoscopic sleeve gastrectomy (LSG) on the erectile function of Egyptian obese men.","authors":"Ahmed Lamey, Tamer A Abouelgreed, Osama Abdelmoneim, Mohamed Sherif Ali, Ahmed Elshaboury, Mohamed Rehan, Saed Khater, Osama M Ghoneimy, Maha M Elzamek, Esam A Elnady, Mohamed F Elebiary, Mohamed Hindawy, Ahmed Wahsh, Satyabrata Garanayka, Mohamed Y Elamir","doi":"10.4081/aiua.2025.13912","DOIUrl":"10.4081/aiua.2025.13912","url":null,"abstract":"<p><strong>Objective: </strong>The primary aim of the study is to identify the effect of laparoscopic sleeve gastrectomy on the erectile function of Egyptian obese men via measurement of subjective feelings measured by the International Index of Erectile Function questionnaire (IIEF-5) and objective sex hormone test. The secondary aim of the study is to evaluate weight loss changes and changes in other blood test results.</p><p><strong>Patients and methods: </strong>One hundred Egyptian men with morbid obesity (mean BMI 45.5 kg/m², mean age 37.3 years) who underwent laparoscopic sleeve gastrectomy (LSG), were included retrospectively from the period of January 2022 to January 2024 on this study and 80 completed the 1-year follow-up. All operations were performed by the same surgical team in our hospital. Informed consents were taken from all the patients who were recruited in the study.</p><p><strong>Results: </strong>Significant reductions in comorbidities such as hypertension, diabetes, osteoarthritis, and dyslipidemia were observed after laparoscopic sleeve gastrectomy. Sexual function improved notably in orgasmic function, intercourse satisfaction, and overall satisfaction, along with a significant rise in serum testosterone levels. Patients also experienced substantial decreases in weight, BMI, waist and hip circumference, and improvements in lipid profile, HbA1c, inflammatory markers, and sex hormones. No severe complications or mortality were reported during the study period.</p><p><strong>Conclusions: </strong>A significant enhancement in the erectile function was observed in obese Egyptian men following LGS. This improvement was evidenced both clinically through increased IIEF scores after surgery and biochemically through increased serum testosterone level.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13912"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of forgotten double J stents: insight from a systematic review of case reports.","authors":"Antonius Galih Pranesdha Putra, Yufi Aulia Azmi, Soetojo Wirjopranoto, Nadya Rahmatika, Agustin Junior Nanda De Niro, Alviano Satria Wibawa, Kevin Muliawan Soetanto","doi":"10.4081/aiua.2025.13301","DOIUrl":"10.4081/aiua.2025.13301","url":null,"abstract":"<p><strong>Background: </strong>Double J Stent is one of the procedures frequently performed in the field of urology. Forgotten DJ Stent is a problem that can cause serious complications. This systematic review aims to explore complications and management of patients with forgotten double J stents.</p><p><strong>Methods: </strong>Scientific literature was obtained from PubMed, ScienceDirect, and Google Scholar with a publication year limited to 2013-2023. The search string included 'forgotten DJ stent, case report, complication'. Inclusion criteria were as follows: (1) case report or series, (2) available individual patient data, and (3) English language. Data are presented descriptively.</p><p><strong>Results: </strong>Of the 210 records, 14 articles published were analyzed after the full-text assessment. Forgotten DJ stent sufferers vary from age 7 years to 88 years. Male gender was predominant. The initial symptoms were flank pain and micturition disorders. The complications experienced were encrustation, multiple stones formation, emphysematous pyelonephritis, emphysematous perinephric abscess, fragmentation, and vesical calculus. In management, it was found that procedures were selected according to patient's situation at that time and the condition of the stent. There are case reports that report management that differed from those initially planned. All the patients were alive after treatment.</p><p><strong>Conclusions: </strong>A forgotten DJ stent can have serious consequences. The management approach requires a combination of various endourological procedures. In consideration of potential complications, urologists need to be careful in making decisions about the choice of technique used.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13301"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143068724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New biomarkers for diagnosis of bladder cancer: a bibliometric analysis.","authors":"Roberto Falabella, Valentina De Simone, Felice Crocetto, Francesco Del Giudice, Angelo Porreca, Nazario Foschi, Biagio Barone, Luca Di Gianfrancesco, Valentina Di Pasquale, Vincenzo Francesco Caputo","doi":"10.4081/aiua.2025.13396","DOIUrl":"10.4081/aiua.2025.13396","url":null,"abstract":"<p><strong>Background/objectives: </strong>Bladder cancer is a multifactorial disease, ranking as the 10th most common cancer globally and the fourth most common cancer in men and the ninth in women in the Western world. This bibliometric analysis aims to identify and evaluate scientific literature addressing new biomarkers for bladder cancer diagnosis, as well as to identify the most prolific organizations, authors, journals, countries, and keywords within this research domain.</p><p><strong>Methods: </strong>An electronic search was conducted using Elsevier's Scopus database. From a total of 940 retrieved papers (published between 2019 and 2024), 493 were selected. For data analysis and visualization, the titles of articles, year of publication, countries, authors, journals, articles, and keywords were analyzed using Microsoft Excel, VOSviewer, and Biblioshiny.</p><p><strong>Results: </strong>China published the most papers (200 articles) and received the highest number of citations, followed by the USA. While some countries, such as Egypt and India, published exclusively Single Country Publications (SCPs), others demonstrated a higher level of international collaboration, with at least half of their publications being Multi-Country Publications (MCPs). Countries with higher rates of MCPs were Greece (66.6%), Italy (53.8%), Korea, and France (50%). The journals that produced the most publications and received the highest number of citations were Cancers, International Journal of Molecular Sciences, and Frontiers in Oncology, confirming their role in producing high-impact research.</p><p><strong>Conclusions: </strong>The consistent distribution of publications over the years considered indicates a sustained interest in this field.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13396"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten years' single surgeon experience of excision and primary anastomosis urethroplasty for traumatic urethral stricture: an analysis of risk factors for urethral stricture recurrence.","authors":"Paksi Satyagraha, Edi Wibowo, Besut Daryanto, Gede Wirya Diptanala Putra Duarsa, Adrianus Gupta Wijaya, Fauzan Kurniawan Dhani","doi":"10.4081/aiua.2025.13268","DOIUrl":"10.4081/aiua.2025.13268","url":null,"abstract":"<p><strong>Introduction: </strong>Excision and primary anastomosis (EPA) urethroplasty is the standard treatment for traumatic urethral strictures, but managing them remains challenging for urologists. Identifying factors leading to EPA urethroplasty failure benefits both patients and surgeons. This study aims to analyze risk factors for urethral stricture recurrence after one-year follow-up of EPA urethroplasty.</p><p><strong>Materials and methods: </strong>Data on male patients undergoing EPA urethroplasty at the Urology Department of Saiful Anwar General Hospital from January 2013 until December 2023 were prospectively recorded. Successful urethroplasty, defined as the absence of additional treatment necessity, was assessed until 12 months follow-up. Demographic data, time to surgery, stricture etiology, comorbidities, prior urethral interventions, and operation steps were recorded. Univariate and multivariate Cox regression analyses were performed using IBM SPSS Statistics version 21.</p><p><strong>Result: </strong>Total 95 patients were observed, and 89 patients were included, averaging 41.2 ± 15.59 years old. EPA urethroplasty succeeded in 91% of cases over a median follow-up of 16.3 months. Pelvic fracture urethral injury (PFUI) was the predominant etiology in 74% of cases, with an average stricture length of 25.4 ± 16.3 mm. The average time to surgery was performed on average 6.67 ± 4.07 months after diagnosis. In univariate analysis, body mass index (BMI), time to surgery, and stricture length were associated with urethral stricture recurrence. However, only time to surgery showed a significant association in multivariate analysis.</p><p><strong>Conclusions: </strong>Obesity, the length of the stricture, and delayed surgical intervention are associated with an increased risk of urethral stricture recurrence in patients following EPA. EPA urethroplasty demonstrates a high success rate in managing traumatic urethral strictures.</p>","PeriodicalId":46900,"journal":{"name":"Archivio Italiano di Urologia e Andrologia","volume":" ","pages":"13268"},"PeriodicalIF":1.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}