Case Reports in Dentistry最新文献

{"title":"Floor of the Mouth Hemorrhage Following Dental Implant Placement or Guided Bone Regeneration (GBR) in the Atrophic Interforaminal Mandible.","authors":"Domenico Sfondrini, Stefano Marelli, Rachele Patriarca, Andrea Scribante, Lorenzo Preda, Gabriele Savioli, Giorgio Novelli, Alessandro Bardazzi","doi":"10.1155/crid/8413875","DOIUrl":"10.1155/crid/8413875","url":null,"abstract":"<p><p>The authors present two cases of mouth floor hemorrhage consequences of implant placement within the atrophic anterior mandible. In one patient, the implant placement was associated with the guided bone regeneration (GBR) technique. This serious complication has been widely described in the literature, especially in the anterior mandible area. In cases of bone resorption, the edentulous ridge becomes closer to the artery, and the risk of vessel injury increases. In both patients, the hematoma rapidly spread in the loose tissues of the mouth floor, displacing the tongue posteriorly and cranially, with airway compromise. The patients were hospitalized with nasotracheal intubation to secure the airway. In both patients, the bleeding stopped spontaneously, and after a few days, the oral floor swallowing was reduced, allowing the endotracheal tube to be removed. In about 2 weeks, the hematoma completely resorbed without surgery. According to the literature, the main cause of floor of the mouth hemorrhage is the mandibular lingual cortical plate perforation during bone drilling with subsequent sublingual-submental artery injury. In fact, in the first patient presented, this surgical error was clearly noticeable on the CT scan. Differently, in the second case reported, no radiological signs of inner cortical perforation were observed, and together with a mouth floor hematoma, a blood collection was also evident on the lower lip, suggesting a different cause of bleeding. Most likely during the periosteal release incision, mandatory in GBR technique, the ascending mental artery was injured, and hematoma spread in the mouth floor through the similar incision done on the lingual flap. Firstly, the mouth floor hemorrhage caused by an injury of a vestibular soft tissue artery during GBR surgery was reported. Strategies and recommendations to avoid this life-threatening event are provided, based on the literature review and the authors' experience.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2024 ","pages":"8413875"},"PeriodicalIF":0.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11688131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological Features of Delayed Foreign Body Granuloma With Epithelioid Histiocyte Aggregation and Eosinophilic Reaction due to Hyaluronic Acid Injection.","authors":"Michiko Nishimura, Shinnichi Sakamoto, Miyako Hoshino, Yuji Miyazaki, Junichiro Yamamoto, Hideaki Sakashita, Kaoru Kusama, Kentaro Kikuchi","doi":"10.1155/crid/5565324","DOIUrl":"10.1155/crid/5565324","url":null,"abstract":"<p><p><b>Background:</b> Dermal fillers such as hyaluronic acid (HA) have been widely used in recent years as a less surgically invasive cosmetic treatment. Although delayed foreign body granuloma may occur as a rare adverse reaction after the procedure, detailed histological reports are still limited. When occurring on the buccal mucosa of the oral cavity, the histopathology may resemble some lesions of minor salivary gland origin due to the material properties of HA. Here we report a delayed foreign body granuloma associated with HA showing eosinophilic infiltration of the buccal mucosa, with characteristic histological and immunohistological features. <b>Case Presentation:</b> A 61-year-old woman presented with swelling and a burning sensation in the right buccal mucosa. On initial examination, a 25 × 20-mm mass was palpated on the anterior margin of the right masseter muscle. Examination of a biopsy specimen revealed multiple pseudoduct-like structures containing mucoid substance within the mucosal lamina propria. The mucoid substance was positively stained with Alcian blue (AB) and surrounded by CD68-positive epithelioid cells and multinucleated giant cells. Many histiocytes had infiltrated into the surrounding area, and numerous eosinophilic infiltrates were also evident. After a review of the patient's history, a diagnosis of delayed foreign body granuloma associated with HA injection was made. <b>Conclusion:</b> We have reported a case of delayed foreign body granuloma with eosinophilic and histiocytic infiltration following injection of HA. It was suggested that the marked eosinophilic infiltration around macrophages was due to not only an allergic reaction, but also in part to increased macrophage aggregation.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2024 ","pages":"5565324"},"PeriodicalIF":0.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Fibrolipomas of the Tongue: A Rare Case Report of a Pediatric Patient With Whole Exome Sequencing of the C2CD3 Gene.","authors":"Fouad Alomari, Zahra H Al Zayer, Hanaa Mohammad Alferdous","doi":"10.1155/crid/5923373","DOIUrl":"10.1155/crid/5923373","url":null,"abstract":"<p><p>Multiple fibrolipomas of the tongue are rare benign tumors with a prevalence of 0.2% among both adults and children. Moreover, this lesion affecting an infant has not been reported in the literature. This is the first reported case of multiple fibrolipomas of the tongue in an infant. This case report describes the genetic sequencing and treatment of a 1-year-old child suffering from multiple fibrolipomas. Irregular growths on the anterior and lateral border of the tongue were reported by the mother of the child at the time of birth. The patient was presented to the hospital at the age of 1, and surgical excision of the lesions was performed under general anesthesia. The surgery was uneventful. Genetic sequencing was performed via whole exome sequencing, and two variants of the C2CD3 gene have been identified that may be associated with this condition, although causation has not yet been confirmed. Although this is a rare entity of the oral cavity, there are various differential diagnoses. Therefore, maxillofacial surgeons should perform histological diagnosis to confirm the findings. This is the first study in literature to understand the genetic sequencing of multiple fibrolipomas in an infant. Hence, the finding of this report can be utilized in further studies registering such cases.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2024 ","pages":"5923373"},"PeriodicalIF":0.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Orofacial Infantile Haemangioma: A Case Report.","authors":"Othman Zuhir, Nurhidayah Muhd Noor, Aminah Marsom","doi":"10.1155/crid/4988221","DOIUrl":"10.1155/crid/4988221","url":null,"abstract":"<p><p>Infantile haemangioma (IH) is the most common childhood tumour, often developing in the head and neck region. It may cause disfigurement, functional impairment, or tooth developmental issues when it is present in the oral cavity. We report a case of a 2-month-old boy referred to the paediatric dentistry team with a segmental IH involving the left periorbital, cheek, and hard palate. The patient had a maculopapular rash in the periorbital area, a telangiectatic patch on his left cheek, and papules on the left posterior hard palate. He was comanaged with the paediatric, ophthalmology, dermatology, and cardiology teams. He was treated with oral propranolol, resulting in the lesions reducing in size. Early intervention is crucial to prevent severe complications affecting the patient's appearance, function, speech, feeding, and dentition. Dentists should be familiar with the clinical presentations and preventative measures, as we may encounter such patients with oral cavity involvement.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2024 ","pages":"4988221"},"PeriodicalIF":0.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guided Bone Regeneration in the Posterior Mandible Using a Resorbable Metal Magnesium Membrane and Fixation Screws: A Case Report.","authors":"Thomas Franke, Tadas Korzinskas","doi":"10.1155/crid/2659893","DOIUrl":"10.1155/crid/2659893","url":null,"abstract":"<p><p><b>Background:</b> Due to bone loss, implant placement in the posterior mandible is often impossible without prior augentative procedures. The reconstruction of bone defects with horizontal and vertical components using particulated bone grafts requires the placement of a mechanically stable structure for stabilization of the grafting material. Although titanium-reinforced membranes and titanium meshes have been shown to be effective in this indication, the necessity of their removal, often in a separate surgical procedure, is seen as a disadvantage. Since the introduction of a new resorbable magnesium metal membrane and fixation screw, a mechanically stable and resorbable system might provide an alternative option for guided bone regeneration (GBR) in the posterior mandible. <b>Case Presentation:</b> A 61-year-old patient was presented with large edentulous areas in all posterior regions and requested fixed dentures in Areas 34-36. Tooth 33 was extracted and treated with an immediate implantation of a ceramic implant, whereas Positions 34-36 were treated with a two-stage approach. The site was augmented horizontally, with a slight vertical component using autologous and allogenic bone and a new completely resorbable magnesium metal membrane and fixation screw. During the initial healing period, the patient reported a tingling sensation at the site of the augmentation. This is an observation that is specific to the magnesium products and is potentially caused by the release of hydrogen gas as the metal degrades and is resorbed. Upon re-entry at 3 months, it was clinically observed that there was a very dense and vascularized bone that was sufficient for placing two 5.5 × 10 mm ceramic dental implants. <b>Conclusion:</b> A completely resorbable magnesium membrane and fixation screw were able to support the bony regeneration in a large GBR situation in the posterior mandible. Due to the use of a new material for GBR, different clinical observations were made compared to the standard material choices.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2024 ","pages":"2659893"},"PeriodicalIF":0.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Management of a Fractured Tooth in a Child Using an Aesthetic Pediatric Crown: A Case Report and Review of Literature.","authors":"Stephan Lampl, Deepa Gurunathan, Deepak Mehta, Jogikalmat Krithikadatta, Desigar Moodley","doi":"10.1155/2024/6888443","DOIUrl":"10.1155/2024/6888443","url":null,"abstract":"<p><p><b>Background:</b> Traumatic dental injuries in children present unique challenges, requiring evidence-based and individualized approaches. Accidental falls are a common cause, resulting in a spectrum of clinical presentations. Managing tooth injuries in mixed dentition adds complexity to treatment decisions. <b>Methods:</b> This case report details the conservative management of an 8-year-old with a fractured permanent lateral incisor following a fall. The child's physical status was assessed, ruling out abuse and associated neurological issues. A novel pediatric full crown fabricated from a hybrid glass material was chosen for its minimally invasive preparation and aesthetic properties. <b>Results:</b> Procedural details, including crown sizing, contouring, and bonding, are outlined. One-year follow-up revealed no discoloration, pain, or adverse effects. The hybrid glass material demonstrated longevity in bonding, maintaining both function and esthetics. The discussion encompasses the choice of crown materials and the advantages of hybrid glass material. <b>Conclusion:</b> The case highlights successful conservative restoration in mixed dentition using a pediatric full crown with a hybrid glass material. This approach achieved functional and aesthetic improvements, preserved tooth vitality, and ensured patient satisfaction.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2024 ","pages":"6888443"},"PeriodicalIF":0.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142630387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal Chondrosarcoma of the Mandible, a Big Dilemma: Report of a Rare Case in Mesenchymal Chondrosarcoma of the Mandible-Report of a Case With Discussion of Diagnostic and Therapeutic Dilemmas.","authors":"Abbas Karimi, Samira Derakhshan, Farzaneh Mosavat, Zahra Gholamhoseini, Monir Moradzadeh Khiavi","doi":"10.1155/2024/8884697","DOIUrl":"10.1155/2024/8884697","url":null,"abstract":"<p><p>Chondrosarcomas are a group of malignant neoplasms with cartilaginous matrix production mostly found in flat and peripheral long bones. Mesenchymal chondrosarcoma is one of the most unusual and rare histological variants of chondrosarcoma, with a distinct histopathological appearance and biologically aggressive behavior. The amount of cartilage in mesenchymal chondrosarcoma may be so abundant that it is easily found in random sections or so scarce that numerous sections are required to discover it. In such cases, it is tough to make an accurate diagnosis, which leads to a big dilemma for pathologists and surgeons regarding diagnosis and treatment. Here, we report a mandibular mesenchymal chondrosarcoma in a 38-year-old male with a diagnosis of malignant small round cell tumor in incisional biopsy without any bone or chondroid formation. After ruling out lymphoma, a complete lesion excision was done. Diagnosis of mesenchymal chondrosarcoma was confirmed with small foci of chondroid material and strong positivity of tumoral cells for CD99 and S100. We highlight the fact that incisional biopsy frequently fails to provide sufficient tissue to establish the diagnosis of mesenchymal chondrosarcoma. Adequate tissue with multiple sections, detailed histopathological examination, and adjunctive IHC study are the keys to a definitive diagnosis.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2024 ","pages":"8884697"},"PeriodicalIF":0.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Multiple Myeloma Identified Following the Diagnosis of Amyloidosis of the Tongue.","authors":"Hideka Kanemoto, Kyoichi Obata, Koichi Kadoya, Kisho Ono, Hotaka Kawai, Yuki Kunisada, Mayumi Yao, Soichiro Ibaragi","doi":"10.1155/2024/8836103","DOIUrl":"10.1155/2024/8836103","url":null,"abstract":"<p><p>Amyloidosis is a disease in which amyloid protein is deposited in organs and tissues, resulting in functional impairment. Amyloidosis occurs in 12%-30% of patients with multiple myeloma, but in rare cases, amyloidosis may precede the diagnosis of multiple myeloma. Our patient was a 76-year-old Japanese male on dialysis. Multiple nodules accompanied by ulcers were observed on his tongue. He had no subjective symptoms or clinical findings associated with multiple myeloma. The histopathological findings suggested amyloidosis. We suspected both systemic and localized amyloidosis and performed a comprehensive systemic examination. Since the patient had been on dialysis for only a short period of time (~3 months), dialysis-related amyloidosis was ruled out. After blood and urine tests, a diagnosis of multiple myeloma was made. Chemotherapy treatment was started, but the patient's multiple myeloma could not be suppressed and the tongue amyloidosis worsened, leading to his death 2 years and 2 months after the initial diagnosis.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2024 ","pages":"8836103"},"PeriodicalIF":0.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mandible Reconstruction With Custom-Made Plates in Medication-Related Osteonecrosis of the Jaw-A Case Series.","authors":"Eiji Mitate, Taichi Demura, Youta Yamauchi, Yasuhisa Sawai, Miho Hasumoto, Satoshi Wada, Hiroyuki Nakano, Noboru Demura","doi":"10.1155/2024/9251185","DOIUrl":"10.1155/2024/9251185","url":null,"abstract":"<p><p><b>Background</b>: Restoration of the mandibular region after segmental resection surgery is crucial for masticatory function and facial aesthetics. The precision of three-dimensional printers has advanced in recent years, enabling the development of fully customized reconstruction plates. In recent years, three-dimensional printing technology has been applied in the field of dental and oral surgery. Among these, the selective laser melting method has been developed. This case report was aimed at exploring the utility in restoring mandibular morphology. <b>Cases:</b> Patients diagnosed with medication-related osteonecrosis of the jaw (MRONJ) in Oral and Maxillofacial Surgery at Kanazawa Medical University Hospital who underwent mandibular disarticulation and immediate completely customized reconstruction plate (COSMOFIX) were included. Case 1 involved a female in her 70s with MRONJ on the right side of the mandible. Case 2 involved a female who received bisphosphonates for extensive metastatic breast cancer, resulting in MRONJ affecting the bilateral mandible. Case 3 involved a woman who developed MRONJ on the right side of the mandible during alendronate treatment for osteoporosis. Completely customized reconstruction plates were used for reconstruction after segmental resections. <b>Findings:</b> The three patients adapted to the remaining bone. The reconstructed and preoperative mandibular morphologies were similar. <b>Conclusions</b>: In conclusion, the use of completely customized reconstruction plates obviates the need for bending and other adaptations, reduces surgical time, and improves postoperative aesthetics. Of significance, preparing completely customized reconstruction plate requires about 3 weeks; thus, careful case selection and scheduling are indispensable.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2024 ","pages":"9251185"},"PeriodicalIF":0.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic Ulceration of the Vestibular Mucous Membrane After Insertion of Four Mini-Implants in the Atrophied Mandible: A Case Report.","authors":"Domagoj Kilić, Sanja Peršić-Kiršić, Asja Čelebić","doi":"10.1155/2024/4662194","DOIUrl":"10.1155/2024/4662194","url":null,"abstract":"<p><p>This clinical report describes how a decubital ulcer arose from the direct contact of the vestibular movable mucous membrane against mini-implant balled-type heads after the mini-implant insertion in the edentulous atrophic mandible of a 78-year-old patient who was not wearing a conventional mandibular complete denture for more than 10 years. Due to severe alveolar ridge atrophy, mini-implant insertion (2.0 mm wide) was an option without extensive surgical procedures. The patient signed the informed consent. A few days after the implant insertion, injury, inflammation, and induration of the vestibular movable mucous membrane were observed on the movable vestibular mucosa on the right side, opposing the mini-implants. The cause of inflammation was attributed to increased perioral muscle tonus which pushed the movable mucosa onto the mini-implant heads and caused mechanical trauma. During the period of edentulism, the perioral muscle tonus increased, directing the mucous membrane of the lips and cheeks against residual ridge to enable food comminution. To treat the persistent decubitus, a bulk of dental composite resin was placed around mini-implant heads and light-cured to protect the mucosa from further mechanical trauma, as the patient did not possess an old mandibular denture to cover the mini-implant heads. Vestibuloplastic surgery (disinsertion of movable attachments and deepening of the vestibulum) was also done. After the surgery, a silicone splint, resembling an occlusal rim, was made to protect the mucous membrane, keep medicaments for faster epitalization in place, to decrease perioral muscle tonus before the new dentures' delivery, and to prevent movable tissue relapse. The custom impression, jaw relationship determination, and try-in of the artificial teeth setup were made with sutures still in place. After the denture delivery and implant loading, the patient was instructed to sleep with the dentures to protect the movable mucous membrane. One year later, almost no peri-implant marginal bone loss was observed, attached and peri-implant mucosa were healthy, and the patient was delighted.</p>","PeriodicalId":46841,"journal":{"name":"Case Reports in Dentistry","volume":"2024 ","pages":"4662194"},"PeriodicalIF":0.7,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}