Papillomavirus Research最新文献_第7页

Long-term survival and swallowing outcomes in advanced stage oropharyngeal squamous cell carcinomas 晚期口咽鳞状细胞癌的长期生存和吞咽结局

IF 3.2

Papillomavirus Research Pub Date : 2019-06-01 DOI: 10.1016/j.pvr.2018.09.002

Jessica M. Clark , Emma M. Holmes , Daniel A. O’Connell , Jeffrey Harris , Hadi Seikaly , Vincent L. Biron

{"title":"Long-term survival and swallowing outcomes in advanced stage oropharyngeal squamous cell carcinomas","authors":"Jessica M. Clark , Emma M. Holmes , Daniel A. O’Connell , Jeffrey Harris , Hadi Seikaly , Vincent L. Biron","doi":"10.1016/j.pvr.2018.09.002","DOIUrl":"10.1016/j.pvr.2018.09.002","url":null,"abstract":"<div><h3>Background</h3><p>There is a paucity of studies reporting long-term survival outcomes for HPV/p16 positive oropharyngeal squamous cell carcinoma (OPSCC). This study aims to compare long-term outcomes of advanced stage p16 positive and negative OPSCCs, treated by surgical and non-surgical modalities.</p></div><div><h3>Methods</h3><p>OPSCC patients from 1998 to 2012 were identified through a prospectively collected cancer registry. P16 immunohistochemistry was used as a surrogate marker for HPV-OPSCC. Overall survival (OS) and aspiration free survival (AFS) comparisons were made between patients treated with chemoradiation (CRT) versus primary surgery and radiation/chemoradiation (S+RT/CRT) at 5, 10 and 15 years post-treatment.</p></div><div><h3>Results</h3><p>A total of 319 patients were included. P16 positive patients and non-smokers had significantly higher long-term (5, 10 and 15-year) OS. Smokers and p16 negative patients treated with S+RT/CRT had improved long-term OS compared to patients who received CRT. Smokers and p16 negative patients had lower long-term AFS. Multivariate analysis showed improved OS was associated with p16 positivity (HR 0.42, 0.28–0.61) and surgery (HR 0.47, 0.32–0.69), whereas lower OS was associated with ECOG ≥ 2 (HR 2.46, 1.61–3.77), smoking (HR 2.37, 1.41–3.99) and higher stage (HR 1.68, 1.05–2.68).</p></div><div><h3>Conclusions</h3><p>In smokers and p16-negative OPSCC patients, primary surgery may be associated with improved long-term survival and dysphagia-related outcomes.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2018.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36531530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Two-dose recommendation for Human Papillomavirus vaccine can be extended up to 18 years – updated evidence from Indian follow-up cohort study 来自印度随访队列研究的最新证据表明，两剂人乳头瘤病毒疫苗推荐可延长至18年

IF 3.2

Papillomavirus Research Pub Date : 2019-06-01 DOI: 10.1016/j.pvr.2019.01.004

Partha Basu , Richard Muwonge , Neerja Bhatla , Bhagwan M. Nene , Smita Joshi , Pulikottil O. Esmy , Usha Rani Reddy Poli , Geeta Joshi , Yogesh Verma , Eric Zomawia , Surendra S. Shastri , Sharmila Pimple , Devasena Anantharaman , Priya R. Prabhu , Sanjay Hingmire , Catherine Sauvaget , Eric Lucas , Michael Pawlita , Tarik Gheit , Kasturi Jayant , Rengaswamy Sankaranarayanan

{"title":"Two-dose recommendation for Human Papillomavirus vaccine can be extended up to 18 years – updated evidence from Indian follow-up cohort study","authors":"Partha Basu , Richard Muwonge , Neerja Bhatla , Bhagwan M. Nene , Smita Joshi , Pulikottil O. Esmy , Usha Rani Reddy Poli , Geeta Joshi , Yogesh Verma , Eric Zomawia , Surendra S. Shastri , Sharmila Pimple , Devasena Anantharaman , Priya R. Prabhu , Sanjay Hingmire , Catherine Sauvaget , Eric Lucas , Michael Pawlita , Tarik Gheit , Kasturi Jayant , Rengaswamy Sankaranarayanan","doi":"10.1016/j.pvr.2019.01.004","DOIUrl":"10.1016/j.pvr.2019.01.004","url":null,"abstract":"<div><p>Earlier publication from the ongoing multi-centric study of the International Agency for Research on Cancer to evaluate less than three doses of the quadrivalent Human Papillomavirus (HPV) vaccine in India amongst unmarried girls demonstrated non-inferior total antibody titres, neutralizing antibody titres and antibody avidity in 2-dose recipients compared to 3-dose recipients at 15–18 years of age (Bhatla et al., 2018) [7].</p><p>The number of participants recruited at 15–18 years of age was 1515 and 1795 in the 3-dose and the 2-dose groups respectively. At a median follow-up of 7 years, incident HPV 16/18 infections were detected in 1.6% women receiving two doses and 0.8% women receiving three doses at 15–18 years. Frequency of incident infection was 7.0% in the age- and site-matched unvaccinated women (N = 1484). No persistent infection from HPV 16 was observed in the 2- or 3-dose recipients and one (0.2%) persistent HPV 18 infection was documented, each in the 3-dose and 2-dose cohorts. Among the unvaccinated women, the frequency of HPV 16/18 persistent infection was 1.7%.</p><p>The protection offered by two doses of quadrivalent HPV vaccine against incident and persistent infections in recipients at 15–18 years is comparable to that seen in 3-dose recipients at 15–18 years.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2019.01.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36922020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

“We brought our culture here with us”: A qualitative study of perceptions of HPV vaccine and vaccine uptake among East African immigrant mothers "我们把我们的文化带到了这里":关于东非移民母亲对人乳头瘤病毒疫苗和疫苗接种的看法的定性研究

IF 3.2

Papillomavirus Research Pub Date : 2019-06-01 DOI: 10.1016/j.pvr.2018.12.003

Linda K. Ko , Victoria M. Taylor , Farah Bille Mohamed , H. Hoai Do , Fanaye A. Gebeyaw , Anisa Ibrahim , Ahmed A. Ali , Rachel L. Winer

{"title":"“We brought our culture here with us”: A qualitative study of perceptions of HPV vaccine and vaccine uptake among East African immigrant mothers","authors":"Linda K. Ko , Victoria M. Taylor , Farah Bille Mohamed , H. Hoai Do , Fanaye A. Gebeyaw , Anisa Ibrahim , Ahmed A. Ali , Rachel L. Winer","doi":"10.1016/j.pvr.2018.12.003","DOIUrl":"10.1016/j.pvr.2018.12.003","url":null,"abstract":"<div><h3>Background</h3><p>HPV vaccine studies in East African communities are few and focus mainly on Somali women and girls. We examined how HPV vaccine perceptions and uptake are shaped among Somali, Ethiopian, and Eritrean mothers.</p></div><div><h3>Methods</h3><p>We convened three focus groups in Somali, Amharic, and Tigrinya with mothers of 11–17 year old children. The Socio-Context Framework (social, cultural, and religious factors) and Andersen's Behavioral Model (predisposing, enabling, and need for care factors) informed question development.</p></div><div><h3>Results</h3><p>Negative vaccine perceptions, lack of HPV vaccine knowledge, and concerns about side effects emerged as predisposing factors. Having a provider who engages parents on HPV vaccination and takes responsibility for vaccine-related risks emerged as enabling factors. Availability of vaccine information resources (e.g., person-to-person, word of mouth education for parents) were also enabling factors. Need for care factors included having comprehensive vaccine information, strong recommendation from a doctor, and validation from a co-ethnic medical professional. Women exerted strong social influence on vaccine uptake (social), had concerns about pork gelatin in vaccines (religious), and felt discussions about sex with children were culturally unacceptable (cultural).</p></div><div><h3>Conclusion</h3><p>Strategies for vaccine uptake among East African immigrants need to address factors that shape HPV vaccine perceptions for adolescents, caregivers, and providers.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2018.12.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36822156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Pre-vaccination prevalence of anogenital and oral human papillomavirus in young HIV-infected men who have sex with men 在男男性行为的年轻艾滋病毒感染者中，接种疫苗前肛门生殖器和口腔人乳头瘤病毒的流行率

IF 3.2

Papillomavirus Research Pub Date : 2019-06-01 DOI: 10.1016/j.pvr.2019.01.002

Jessica A. Kahn , Marvin Belzer , Xiaofei Chi , Jeannette Lee , Aditya H. Gaur , Kenneth Mayer , Jaime Martinez , Donna C. Futterman , Elizabeth A. Stier , Mary E. Paul , Elizabeth Y. Chiao , Daniel Reirden , Steven E. Goldstone , Ana P. Ortiz Martinez , Edward R. Cachay , Luis F. Barroso , Maria Da Costa , Craig M. Wilson , Joel M. Palefsky , for the AIDS Malignancy Consortium and Adolescent Medicine Trials Network for HIV/AIDS Interventions

{"title":"Pre-vaccination prevalence of anogenital and oral human papillomavirus in young HIV-infected men who have sex with men","authors":"Jessica A. Kahn , Marvin Belzer , Xiaofei Chi , Jeannette Lee , Aditya H. Gaur , Kenneth Mayer , Jaime Martinez , Donna C. Futterman , Elizabeth A. Stier , Mary E. Paul , Elizabeth Y. Chiao , Daniel Reirden , Steven E. Goldstone , Ana P. Ortiz Martinez , Edward R. Cachay , Luis F. Barroso , Maria Da Costa , Craig M. Wilson , Joel M. Palefsky , for the AIDS Malignancy Consortium and Adolescent Medicine Trials Network for HIV/AIDS Interventions","doi":"10.1016/j.pvr.2019.01.002","DOIUrl":"10.1016/j.pvr.2019.01.002","url":null,"abstract":"<div><p>The aims of this study were to: 1) determine prevalence of anogenital and oral HPV, 2) determine concordance between HPV at anal, perianal, scrotal/penile, and oral sites; and 3) describe factors associated with anogenital HPV types targeted by the 9-valent vaccine. Data were collected from 2012 to 2015 among men who have sex with men 18–26 years of age enrolled in a vaccine trial (N = 145). Penile/scrotal, perianal, anal, and oral samples were tested for 61 HPV types. Logistic regression was used to identify factors associated with types in the 9-valent vaccine. Participants’ mean age was 23.0 years, 55.2% were African-American, and 26.2% were Hispanic; 93% had anal, 40% penile, and 6% oral HPV. Among those with anogenital infection, 18% had HPV16. Concordance was low between anogenital and oral sites. Factors independently associated with a 9-valent vaccine-type HPV were: race (African-American vs. White, OR=2.67, 95% CI=1.11–6.42), current smoking (yes vs. no, OR=2.37, 95% CI=1.03–5.48), and number of recent receptive anal sex partners (2+ vs. 0, OR=3.47, 95% CI=1.16–10.4). Most MSM were not infected with HPV16 or HPV18, suggesting that they may still benefit from HPV vaccination, but anogenital HPV was very common, highlighting the importance of vaccinating men before sexual initiation.</p></div><div><h3>Clinical trial number</h3><p>NCT01209325</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2019.01.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36877583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Human Papillomavirus infection in senegalese female sex workers 塞内加尔女性性工作者的人乳头瘤病毒感染

IF 3.2

Papillomavirus Research Pub Date : 2019-06-01 DOI: 10.1016/j.pvr.2019.02.003

Halimatou Diop-Ndiaye , Kaylin Beiter , Tarik Gheit , Aissatou Sow Ndoye , Aboubacry Dramé , Sandrine McKay-Chopin , Massimo Tommasino , Cheikh Saad Bouh Boye , Bakary Sylla , Coumba Touré Kane

{"title":"Human Papillomavirus infection in senegalese female sex workers","authors":"Halimatou Diop-Ndiaye , Kaylin Beiter , Tarik Gheit , Aissatou Sow Ndoye , Aboubacry Dramé , Sandrine McKay-Chopin , Massimo Tommasino , Cheikh Saad Bouh Boye , Bakary Sylla , Coumba Touré Kane","doi":"10.1016/j.pvr.2019.02.003","DOIUrl":"10.1016/j.pvr.2019.02.003","url":null,"abstract":"<div><h3>Objectives</h3><p>Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines.</p></div><div><h3>Methods</h3><p>Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG).</p></div><div><h3>Results</h3><p>Among the 436 FSW samples analyzed, the overall HPV prevalence was 79.8% (N = 348), with 70.1% (N = 244) cases presenting as multiple infections. High Risk HPV genotypes affecting at least 10% of FSWs included in order of decreasing frequency: 52, 16, 35, 51, 33, 31, 18, and 45. Sixty-seven (15.4%) FSWs were HIV positive and they were significantly more affected by HPV (94% <em>vs</em> 77%; p < 0.01) than seronegative FSWs as well as infections with multiple genotype.</p></div><div><h3>Conclusion</h3><p>The present study indicates that FSW in Senegal experience a high burden of HPV infection with a high frequency of coinfection with HIV and multiple HPV genotypes. Public health interventions for this key population should include an earlier cervical dysplasia/cancer detection and preventative measures such as vaccination programs that must consider the HPV genotype distribution.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2019.02.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36961685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Trends in anogenital wart incidence among Tennessee Medicaid enrollees, 2006–2014: The impact of human papillomavirus vaccination 2006-2014年田纳西州医疗补助计划参保者肛门生殖器疣发病率趋势:人乳头瘤病毒疫苗接种的影响

IF 3.2

Papillomavirus Research Pub Date : 2019-06-01 DOI: 10.1016/j.pvr.2019.04.007

Jaimie Z. Shing , Pamela C. Hull , Yuwei Zhu , Julia W. Gargano , Lauri E. Markowitz , Angela A. Cleveland , Manideepthi Pemmaraju , Ina U. Park , Erin Whitney , Edward F. Mitchel , Marie R. Griffin

{"title":"Trends in anogenital wart incidence among Tennessee Medicaid enrollees, 2006–2014: The impact of human papillomavirus vaccination","authors":"Jaimie Z. Shing , Pamela C. Hull , Yuwei Zhu , Julia W. Gargano , Lauri E. Markowitz , Angela A. Cleveland , Manideepthi Pemmaraju , Ina U. Park , Erin Whitney , Edward F. Mitchel , Marie R. Griffin","doi":"10.1016/j.pvr.2019.04.007","DOIUrl":"10.1016/j.pvr.2019.04.007","url":null,"abstract":"<div><h3>Introduction</h3><p>Evidence of human papillomavirus (HPV) vaccine impact on anogenital warts (AGWs) by race or urbanicity in the US is lacking. We evaluated HPV vaccine impact in Tennessee by assessing AGW trends among Tennessee Medicaid (TennCare) enrollees aged 15–39 years from 2006-2014.</p></div><div><h3>Methods</h3><p>Persons with incident AGWs were identified using diagnosis/pharmacy codes from TennCare billing claims. We calculated sex-specific annual AGW incidence by age group, race, and urbanicity; estimated annual percent changes (APCs) using log-linear models; and performed pairwise comparisons by race and urbanicity.</p></div><div><h3>Results</h3><p>AGW incidence decreased among females aged 15–19 (APC = −10.6; P < 0.01) and 20–24 years (APC = −3.9; P = 0.02). Overall trends were similar between Whites and Blacks, and between those living in metropolitan statistical areas (MSAs) and non-MSAs. Rates among males aged 15–19 years began decreasing after 2010. Among enrollees aged 25–39 years, rates increased or were stable.</p></div><div><h3>Conclusions</h3><p>Following introduction of the HPV vaccine in 2006, AGWs decreased among age groups most likely to be vaccinated. The change in trend among young males after 2010 suggests early herd effects. Our findings indicate vaccine effects and support the importance of improving adherence to current vaccination recommendations for preventing AGWs and other HPV-related diseases.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2019.04.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37147756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Refining our understanding of cervical neoplasia and its cellular origins 完善我们对宫颈肿瘤及其细胞起源的认识

IF 3.2

Papillomavirus Research Pub Date : 2019-06-01 DOI: 10.1016/j.pvr.2019.04.005

John Doorbar, Heather Griffin

{"title":"Refining our understanding of cervical neoplasia and its cellular origins","authors":"John Doorbar, Heather Griffin","doi":"10.1016/j.pvr.2019.04.005","DOIUrl":"10.1016/j.pvr.2019.04.005","url":null,"abstract":"<div><p>Human papillomaviruses (HPV) cause cancer at a number of vulnerable epithelial sites, including the cervix, the anus and the oropharynx, with cervical cancer being the most significant in terms of numbers. The cervix has a complex epithelial organisation, and comprises the stratified epithelium of the ectocervix, the columnar epithelium of the endocervix, and the cervical transformation zone (TZ). Most cervical cancers arise at the TZ, which is a site where a stratified squamous epithelium can develop via metaplasia from a simple columnar epithelium. It is thought that this process is mediated by the cervical reserve cell, a specialised type of stem cell that is located at the TZ, which has been proposed as the target cell for HPV infection. Reserve cells may be derived from the basal cells of the ectocervix, or may originate from the cuboidal cells found at the squamo columnar junction. It appears that HPV infection of these diverse cell types, including the columnar cells of the endocervix, facilitates deregulated viral gene expression and the development of neoplasia, with different epithelial sites having different cancer risk. It is envisaged that these concepts may explain the vulnerability of the oropharynx, and other TZ regions where HPV-associated cancers arise.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2019.04.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37306365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 72

High-resolution anoscopy in HIV-infected men: Assessment of the learning curve and factors that improve the performance 艾滋病毒感染者的高分辨率肛门镜检查:学习曲线的评估和提高性能的因素

IF 3.2

Papillomavirus Research Pub Date : 2019-06-01 DOI: 10.1016/j.pvr.2019.01.003

Karin Neukam , Yusnelkis Milanés Guisado , María Fontillón , Laura Merino , César Sotomayor , Nuria Espinosa , Luis F. López-Cortés , Pompeyo Viciana , On behalf of the SeVIHanal Study Group

{"title":"High-resolution anoscopy in HIV-infected men: Assessment of the learning curve and factors that improve the performance","authors":"Karin Neukam , Yusnelkis Milanés Guisado , María Fontillón , Laura Merino , César Sotomayor , Nuria Espinosa , Luis F. López-Cortés , Pompeyo Viciana , On behalf of the SeVIHanal Study Group","doi":"10.1016/j.pvr.2019.01.003","DOIUrl":"10.1016/j.pvr.2019.01.003","url":null,"abstract":"<div><h3>Objective</h3><p>To determine the required learning time for high-resolution anoscopy (HRA)-guided biopsy to detect histological high-risk squamous intraepithelial lesions (hHSIL) and to identify factors that impact on the training process.</p></div><div><h3>Methods</h3><p>All HIV-infected, screening-naïve men-who-have-sex-with-men who underwent HRA conducted by one single observer from 2010 to 2017 in a Spanish HIV-outpatient clinic were analysed.</p></div><div><h3>Results</h3><p>Eighty-five (14.7%) of the 581 patients included presented hHSIL. The factors associated with the capacity to detect hHSIL [adjusted odds ratio (aOR), 95% confidence interval (95%CI)] were the presence of cytological HSIL (3.04, 1.78–5.21; p < 0.001), infection with high-risk human papilloma virus (HR-HPV) (2.89, 1.38–6.05; p = 0.005), the number of biopsies taken/HRA (aOR: 1.28, 1.07–1.52; p = 0.006) and tobacco smoking (1.75; 1.12–2.73; p = 0.014). Two events independently augmented the detection rate of hHSIL: one single experienced pathologist interpreted biopsies after 409 HRA (2.80, 1.74–4.48; p = 0.035) and the anoscopist underwent an additional training after 536 HRA (2.57, 1.07–6.16; p = 0.035). A learning process could be observed throughout the whole study with stable HR-HPV prevalence.</p></div><div><h3>Conclusion</h3><p>The data support the growing evidence that the proposed training volume of 50–200 performances is underestimated. Extensive training of both anoscopist and pathologist is warranted and the development of tools to support the diagnostic performance may be considered.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2019.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36974693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The cervical microbiota in reproductive-age South African women with and without human papillomavirus infection 南非育龄妇女宫颈微生物群，有无人乳头瘤病毒感染

IF 3.2

Papillomavirus Research Pub Date : 2019-06-01 DOI: 10.1016/j.pvr.2019.04.006

Harris Onywera , Anna-Lise Williamson , Zizipho Z.A. Mbulawa , David Coetzee , Tracy L. Meiring

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引用次数: 32

False positive cervical HPV screening test results 宫颈HPV筛检结果假阳性

IF 3.2

Papillomavirus Research Pub Date : 2019-06-01 DOI: 10.1016/j.pvr.2019.04.012

Mark Schiffman, Silvia de Sanjose

引用次数: 33