Human Papillomavirus infection in senegalese female sex workers

IF 3.2

Papillomavirus Research Pub Date : 2019-06-01 DOI:10.1016/j.pvr.2019.02.003

Halimatou Diop-Ndiaye , Kaylin Beiter , Tarik Gheit , Aissatou Sow Ndoye , Aboubacry Dramé , Sandrine McKay-Chopin , Massimo Tommasino , Cheikh Saad Bouh Boye , Bakary Sylla , Coumba Touré Kane

{"title":"Human Papillomavirus infection in senegalese female sex workers","authors":"Halimatou Diop-Ndiaye , Kaylin Beiter , Tarik Gheit , Aissatou Sow Ndoye , Aboubacry Dramé , Sandrine McKay-Chopin , Massimo Tommasino , Cheikh Saad Bouh Boye , Bakary Sylla , Coumba Touré Kane","doi":"10.1016/j.pvr.2019.02.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines.</p></div><div><h3>Methods</h3><p>Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG).</p></div><div><h3>Results</h3><p>Among the 436 FSW samples analyzed, the overall HPV prevalence was 79.8% (N = 348), with 70.1% (N = 244) cases presenting as multiple infections. High Risk HPV genotypes affecting at least 10% of FSWs included in order of decreasing frequency: 52, 16, 35, 51, 33, 31, 18, and 45. Sixty-seven (15.4%) FSWs were HIV positive and they were significantly more affected by HPV (94% <em>vs</em> 77%; p < 0.01) than seronegative FSWs as well as infections with multiple genotype.</p></div><div><h3>Conclusion</h3><p>The present study indicates that FSW in Senegal experience a high burden of HPV infection with a high frequency of coinfection with HIV and multiple HPV genotypes. Public health interventions for this key population should include an earlier cervical dysplasia/cancer detection and preventative measures such as vaccination programs that must consider the HPV genotype distribution.</p></div>","PeriodicalId":46835,"journal":{"name":"Papillomavirus Research","volume":"7 ","pages":"Pages 97-101"},"PeriodicalIF":3.2000,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.pvr.2019.02.003","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Papillomavirus Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405852118301216","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 9

Abstract

Objectives

Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines.

Methods

Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG).

Results

Among the 436 FSW samples analyzed, the overall HPV prevalence was 79.8% (N = 348), with 70.1% (N = 244) cases presenting as multiple infections. High Risk HPV genotypes affecting at least 10% of FSWs included in order of decreasing frequency: 52, 16, 35, 51, 33, 31, 18, and 45. Sixty-seven (15.4%) FSWs were HIV positive and they were significantly more affected by HPV (94% vs 77%; p < 0.01) than seronegative FSWs as well as infections with multiple genotype.

Conclusion

The present study indicates that FSW in Senegal experience a high burden of HPV infection with a high frequency of coinfection with HIV and multiple HPV genotypes. Public health interventions for this key population should include an earlier cervical dysplasia/cancer detection and preventative measures such as vaccination programs that must consider the HPV genotype distribution.

Abstract Image

查看原文本刊更多论文

塞内加尔女性性工作者的人乳头瘤病毒感染

目的几项研究记录了塞内加尔普通人群的HPV基因型。目的是探索塞内加尔FSWs的HPV基因型分布，以评估现有疫苗的潜在相关性。方法随机抽取全国14个地区的阴道拭子样本作为国家综合生物学和行为调查的一部分，采用基于头部的多重基因分型(TS-MPG)进行HPV检测。结果在436份FSW样本中，HPV总患病率为79.8% (N = 348)，其中70.1% (N = 244)为多重感染。高危HPV基因型影响至少10%的FSWs，按频率降序依次为:52、16、35、51、33、31、18和45。67例(15.4%)FSWs为HIV阳性，HPV感染明显增加(94% vs 77%;p < 0.01)高于血清阴性FSWs和多基因型感染。结论本研究表明，塞内加尔FSW人群HPV感染负担高，同时感染HIV和多种HPV基因型的频率高。针对这一关键人群的公共卫生干预措施应包括早期宫颈发育不良/癌症检测和预防措施，如必须考虑HPV基因型分布的疫苗接种计划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Papillomavirus Research VIROLOGY-

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： The official Journal of the International Papillomavirus Society Papillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses publishes innovative papers related to all aspects of papillomaviruses and other small DNA tumor viruses. The official journal of the International Papillomavirus Society, PVR is an open access publication that aims to bring together virologists, immunologists, epidemiologists and clinicians working in the booming field of HPV and animal papillomaviruses, polyomaviruses and other small DNA tumor viruses and their associated diseases, in order to foster and facilitate interdisciplinary communication. The journal welcomes original research articles, reviews, short communications, opinion articles and regional update reports on papillomaviruses and other tumor viruses in the following sections: a. Biology of papillomaviruses and related viruses from life cycle to cancer b. Epidemiology etiology and natural history studies c. Natural and induced immunity including vaccine research d. Intervention studies and strategies including i. Clinical studies and trials ii. HPV treatments iii. HPV vaccination programs iv. Diagnostics and screening e. Infection and disease prevention, modeling studies f. Guidelines and public health recommendations g. HPV Studies in special populations Regional and local studies on these viruses.