Annals of Occupational and Environmental Medicine最新文献

{"title":"Particulate matter concentration effects on attention to environmental issues: a cross-sectional study among residents in Korea's Pohang Industrial Complex.","authors":"Hye-Seung Ryu,&nbsp;Jea Chul Ha,&nbsp;Insung Chung,&nbsp;Seonhee Yang,&nbsp;Hyunjoo Kim,&nbsp;Sung-Deuk Choi","doi":"10.35371/aoem.2023.35.e31","DOIUrl":"https://doi.org/10.35371/aoem.2023.35.e31","url":null,"abstract":"<p><strong>Background: </strong>With modernization, air pollution has become increasingly serious, and its effects on health have been revealed. As a result, public interest in environmental pollution has become critical for regulating air pollution. In our study, we aim to evaluate the impact of air pollution levels on public attention to environmental issues and examine whether awareness of the residential environment's impact on health acts as a mediator in this relationship.</p><p><strong>Methods: </strong>We conducted an analysis on 400 individuals surveyed in the preliminary feasibility study on adverse health effects in the Pohang Industrial Complex, to examine the relationship between particulate matter 2.5 (PM2.5) and attention to environmental issues. Logistic regression analysis was performed, and mediation analysis was used to determine whether awareness of the residential environment's impact on health mediated the relationship.</p><p><strong>Results: </strong>The logistic regression analysis results showed that PM2.5 levels were associated with attention to environmental issues (adjusted odds ratio [AOR]: 2.1; 95% confidence interval [CI]: 1.3-3.5; <i>p</i> = 0.003) and awareness of health impacts (AOR: 3.4; 95% CI: 1.6-7.1; <i>p</i> = 0.001). The PM2.5 levels showed 9.9% (95% CI: 5.4-14.0) increase in the prevalence of high attention to environmental issues, of which, only 1.0% (95% CI: 0.2-2.3) were mediated by health impact awareness. In the overall analysis, 10% of the total effect of PM2.5 on attention to environmental issues was mediated by health impact awareness.</p><p><strong>Conclusions: </strong>According to this study's results, there was a correlation between air pollution levels and attention to environmental issues. Awareness of the health impacts of air pollution partially mediated the effect of air pollution levels on attention to environmental issues. In future studies, it is recommended to identify other mediators to further understand this structure.</p>","PeriodicalId":46631,"journal":{"name":"Annals of Occupational and Environmental Medicine","volume":"35 ","pages":"e31"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/1e/aoem-35-e31.PMC10493376.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between skeletal muscle mass and the KOSHA cardiovascular risk in obese male workers","authors":"Hyo Won Chong, JunSeok Son, Changho Chae, Changho Jae","doi":"10.35371/aoem.2023.35.e40","DOIUrl":"https://doi.org/10.35371/aoem.2023.35.e40","url":null,"abstract":"Background Efforts for the prevention and management of cardiovascular diseases (CVDs) in workers have been actively pursued. Obesity is one of the important risk factors related to CVDs. Obesity has various metabolic characteristics, and some individuals can be metabolically healthy. Body composition including skeletal muscle mass is known to have protective effect in obesity. The study aims to investigate the association between skeletal muscle mass and Korea Occupational Safety and Health Agency (KOSHA) CVD risk among obese male manufacturing workers in Korea and to identify appropriate indicators of skeletal muscle mass for predicting risk of CVDs. Methods The study was conducted on 2,007 obese male workers at a manufacturing industry aged more than 19 years. Skeletal muscle mass, skeletal muscle index (SMI), skeletal muscle mass percent (SMM%) and skeletal muscle to body fat ratio (MFR) were used to evaluate body composition and these indicators were divided into quartiles. The odds ratios (ORs) and 95% confidence intervals (CIs) for the KOSHA CVD risk groups according to quartiles of skeletal muscle mass indicators were estimated using ordinal logistic regression analysis. Results The OR for the KOSHA CVD risk groups in the highest quartile of SMI was 1.67 (95% CI: 1.42–1.92), while the ORs for the KOSHA CVD risk groups in the highest quartiles of SMM%, SMM/body mass index (BMI), and MFR were 0.47 (95% CI: 0.22–0.72), 0.51 (95% CI: 0.05–0.76), and 0.48 (95% CI: 0.23–0.74), respectively. Conclusions We found that high SMI increase the likelihood of high risk of CVDs, while high SMM%, SMM/BMI, and MFR lower the likelihood of high risk of CVDs. Accurate evaluation of skeletal muscle mass can help assess the cardiovascular risk in obese male workers.","PeriodicalId":46631,"journal":{"name":"Annals of Occupational and Environmental Medicine","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134889433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased breast cancer incidence among nurses in a tertiary university hospital in South Korea","authors":"Juho Choi, Dong-Wook Lee, Baek-Yong Choi, Seung-Woo Ryoo, Taeshik Kim, Yun-Chul Hong","doi":"10.35371/aoem.2023.35.e44","DOIUrl":"https://doi.org/10.35371/aoem.2023.35.e44","url":null,"abstract":"","PeriodicalId":46631,"journal":{"name":"Annals of Occupational and Environmental Medicine","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135506528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined effect of work from home and work during nonwork time on sleep disturbance.","authors":"Jiyoung Lim,&nbsp;Hyundong Lee,&nbsp;Jae Bum Park,&nbsp;Kyung-Jong Lee,&nbsp;Inchul Jeong,&nbsp;Jaehyuk Jung","doi":"10.35371/aoem.2023.35.e28","DOIUrl":"https://doi.org/10.35371/aoem.2023.35.e28","url":null,"abstract":"Background Owing to the coronavirus disease 2019 pandemic, being exposed to work from home and work during nonwork time simultaneously can lead to sleep disturbance; however, their combined effect is unclear. We aimed to investigate the combined effect of work from home and work during nonwork time on sleep disturbance. Methods This study used data from the Sixth Korean Working Condition Survey and included 27,473 paid workers. Logistic regression analysis was conducted to investigate the relationship between work from home, work during nonwork time, and sleep disturbance according to sex. We re-classified participants into 4 groups based on their working from home (No/Yes) and working during nonwork time (No/Yes). The relative excess risk due to interaction was calculated to examine the effect of exposure to both telecommuting and non-regular work hours on sleep disturbance. Results Workers exposed to work from home and work during nonwork time had significantly higher risks of sleep disturbance for all, men, and women workers (OR [95% CI]: 1.71 [1.46–2.02], 1.79 [1.43–2.23], and 1.64 [1.29–2.08] for work from home and 3.04 [2.70–3.42], 3.61 [3.09–4.22], and 2.41 [2.01–2.90] for work during nonwork time, respectively). Compared to those who were not exposed to both factors, when workers had both job factors, the ORs (95% CI) of sleep disturbance for all, men, and women were 3.93 (2.80–5.53), 5.08 (3.21–8.03), and 2.91 (1.74–4.87), respectively. The relative excess risk due to interaction of work from home and work during nonwork time was not significant for sleep disturbance. Conclusions Work from home and work during nonwork time were each associated with sleep disturbance, but the interaction between the two factors on sleep disturbance was not observed in both men and women.","PeriodicalId":46631,"journal":{"name":"Annals of Occupational and Environmental Medicine","volume":"35 ","pages":"e28"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/11/aoem-35-e28.PMC10493373.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10232598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of algorithm for work intensity evaluation using excess overwork index of construction workers with real-time heart rate measurement device.","authors":"Jae-Young Park,&nbsp;Jung Hwan Lee,&nbsp;Mo-Yeol Kang,&nbsp;Tae-Won Jang,&nbsp;Hyoung-Ryoul Kim,&nbsp;Se-Yeong Kim,&nbsp;Jongin Lee","doi":"10.35371/aoem.2023.35.e24","DOIUrl":"https://doi.org/10.35371/aoem.2023.35.e24","url":null,"abstract":"<p><strong>Background: </strong>The construction workers are vulnerable to fatigue due to high physical workload. This study aimed to investigate the relationship between overwork and heart rate in construction workers and propose a scheme to prevent overwork in advance.</p><p><strong>Methods: </strong>We measured the heart rates of construction workers at a construction site of a residential and commercial complex in Seoul from August to October 2021 and develop an index that monitors overwork in real-time. A total of 66 Korean workers participated in the study, wearing real-time heart rate monitoring equipment. The relative heart rate (RHR) was calculated using the minimum and maximum heart rates, and the maximum acceptable working time (MAWT) was estimated using RHR to calculate the workload. The overwork index (OI) was defined as the cumulative workload evaluated with the MAWT. An appropriate scenario line (PSL) was set as an index that can be compared to the OI to evaluate the degree of overwork in real-time. The excess overwork index (EOI) was evaluated in real-time during work performance using the difference between the OI and the PSL. The EOI value was used to perform receiver operating characteristic (ROC) curve analysis to find the optimal cut-off value for classification of overwork state.</p><p><strong>Results: </strong>Of the 60 participants analyzed, 28 (46.7%) were classified as the overwork group based on their RHR. ROC curve analysis showed that the EOI was a good predictor of overwork, with an area under the curve of 0.824. The optimal cut-off values ranged from 21.8% to 24.0% depending on the method used to determine the cut-off point.</p><p><strong>Conclusion: </strong>The EOI showed promising results as a predictive tool to assess overwork in real-time using heart rate monitoring and calculation through MAWT. Further research is needed to assess physical workload accurately and determine cut-off values across industries.</p>","PeriodicalId":46631,"journal":{"name":"Annals of Occupational and Environmental Medicine","volume":"35 ","pages":"e24"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/ce/aoem-35-e24.PMC10493380.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between discrimination in the workplace and insomnia symptoms.","authors":"Suhwan Ju,&nbsp;Seong-Sik Cho,&nbsp;Jung Il Kim,&nbsp;Hoje Ryu,&nbsp;Hyunjun Kim","doi":"10.35371/aoem.2023.35.e25","DOIUrl":"https://doi.org/10.35371/aoem.2023.35.e25","url":null,"abstract":"<p><strong>Background: </strong>In Korea, little research has focused on the relationship between discrimination in the workplace and sleep health. Thus, this study aims to investigate the association between such discriminatory experiences and insomnia, a common sleep disorder, using Korean employees' data.</p><p><strong>Methods: </strong>This study used data from the 6th Korea Working Conditions Survey. Discrimination experiences due to age, ethnic background, nationality, race, sex, religion, disability, sexual orientation, educational level, hometown, and employment status were investigated. The Minimal Insomnia Symptom Scale estimated insomnia symptoms. The association between discrimination experience and insomnia symptoms were analyzed using survey-weighted logistic regression analysis.</p><p><strong>Results: </strong>Based on experiences of discrimination over the past 12 months, insomnia symptoms were associated with discrimination experience due to religion (odds ratio [OR]: 3.70; 95% confidential interval [CI]: 1.58-8.69), sex (OR: 2.51; 95% CI: 1.87-3.37), age (OR: 2.30; 95% CI: 1.88-2.81), hometown (OR: 2.07; 95% CI: 1.44-2.97), employment status (OR: 1.69; 95% CI: 1.37-2.10), and educational level (OR: 1.67; 95% CI: 1.31-2.14). Furthermore, the prevalence of insomnia symptoms increased with the number of discrimination experiences.</p><p><strong>Conclusions: </strong>In this study, discrimination experiences due to religion, sex, age, hometown, employment status, and educational level were significantly associated with insomnia symptoms. Furthermore, as the number of discrimination experiences increased, so did the prevalence of insomnia. Preventing workplace discrimination may improve workers' sleep health.</p>","PeriodicalId":46631,"journal":{"name":"Annals of Occupational and Environmental Medicine","volume":"35 ","pages":"e25"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/74/e6/aoem-35-e25.PMC10442583.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10063105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environment-wide association study of elevated liver enzymes: results from the Korean National Environmental Health Survey 2018-2022.","authors":"Youngchan Chi,&nbsp;Jong-Tae Park,&nbsp;Sewhan Na,&nbsp;Kyeongmin Kwak","doi":"10.35371/aoem.2023.35.e27","DOIUrl":"https://doi.org/10.35371/aoem.2023.35.e27","url":null,"abstract":"<p><strong>Background: </strong>Environmental exposure is characterized by low concentration, chronic, and complex exposure. Traditional epidemiological studies show limitations in reflecting these characteristics since they usually focus on a single or very limited number of exposure factors at a time. In this study, we adopted the methodology of environment-wide association study (EWAS) to figure out the association of human liver function with various environmentally hazardous substances.</p><p><strong>Methods: </strong>We analyzed 2,961 participants from the Korean National Environmental Health Survey Cycle 4 (2018-2020). Using generalized linear model (GLM) analysis, we analyzed the association of 72 variables with 3 liver function indices (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma glutamyl transferase [GGT]). Finally, we visualized our results with Manhattan plot.</p><p><strong>Results: </strong>In GLM analysis, perfluorooctanesulfonate were positively associated with ALT (odds ratio [OR]: 2.2; 95% confidence interval [CI]: 1.39-3.46; <i>p</i> _adjusted = 0.0147) and perfluorodecanoic acid showed positive association with GGT (OR: 2.73; 95% CI: 1.36-5.5; <i>p</i> _adjusted = 0.0256). Plasma mercury showed positive association with GGT (OR: 1.45; 95% CI: 1.14-1.84; <i>p</i> _adjusted = 0.0315). Using a plastic container while keeping food in the refrigerator was associated with elevated GGT compared to using a glass container (OR: 1.51; 95% CI: 1.16-1.95; <i>p</i> _adjusted = 0.0153). 2-ethyl-5-oxohexyl phthalate, showed a negative trend with all 3 indices, with AST (OR: 0.54; 95% CI: 0.39-0.73; <i>p</i> _adjusted = 0.00357), ALT (OR: 0.5; 95% CI: 0.34-0.75; <i>p</i> _adjusted = 0.036), GGT (OR: 0.55; 95% CI: 0.4-0.76; <i>p</i> _adjusted = 0.00697). Bisphenol S and frequent use of sunblock cream showed negative association with ALT (OR: 0.77; 95% CI: 0.66-0.89), and GGT (OR: 0.25; 95% CI: 0.11-0.55), respectively.</p><p><strong>Conclusions: </strong>We conducted an exploratory study on environmental exposure and human liver function. By using EWAS methodology, we identified 7 factors that could have potential association with liver function.</p>","PeriodicalId":46631,"journal":{"name":"Annals of Occupational and Environmental Medicine","volume":"35 ","pages":"e27"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/9f/aoem-35-e27.PMC10493370.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10241095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of night shift work on the reduction of glomerular filtration rate using data from Korea Medical Institute (2016-2020).","authors":"Beom Seok Ko,&nbsp;Sang Yop Shin,&nbsp;Ji Eun Hong,&nbsp;Sungbeom Kim,&nbsp;Jihhyeon Yi,&nbsp;Jeongbae Rhie","doi":"10.35371/aoem.2023.35.e22","DOIUrl":"https://doi.org/10.35371/aoem.2023.35.e22","url":null,"abstract":"<p><strong>Background: </strong>Shift work increases the risk of chronic diseases, including metabolic diseases. However, studies on the relationship between shift work and renal function are limited. The aim of this study was to investigate the association between shift work and a decreased glomerular filtration rate (GFR).</p><p><strong>Methods: </strong>Data were evaluated for 1,324,930 workers who visited the Korean Medical Institute from January 1, 2016 to December 31, 2020 and underwent a health checkup. Daytime workers were randomly extracted at a ratio of 1:4 after matching for age and sex. In total, 18,190 workers aged over 40 years were included in the analyses; these included 3,638 shift workers and 14,552 daytime workers. Participants were categorized into the shift work group when they underwent a specific health checkup for night shift work or indicated that they were shift workers in the questionnaire. The odds ratio was calculated using a conditional logistic regression to investigate the relevance of shift work for changes in GFR.</p><p><strong>Results: </strong>35 workers in the shift group and 54 in the daytime group exhibited an estimated GFR (eGFR) value of < 60 mL/min/1.73m² (<i>p</i> < 0.01). The difference in eGFR values between two checkups differed significantly depending on the type of work (<i>p</i> < 0.01); the difference in the shift work group (-9.64 mL/min/1.73 m²) was larger than that in the daytime work group (-7.45 mL/min/1.73 m²). The odds ratio for eGFR reduction to < 60 mL/min/1.73 m² in the shift group versus the daytime group was 4.07 (95% confidence interval: 2.54-6.52), which was statistically significant.</p><p><strong>Conclusions: </strong>The results of this study suggest that eGFR decreases by a significantly larger value in shift workers than in daytime workers; thus, shift work could be a contributing factor for chronic kidney disease (CKD). Further prospective studies are necessary to validate this finding and identify measures to prevent CKD in shift workers.</p>","PeriodicalId":46631,"journal":{"name":"Annals of Occupational and Environmental Medicine","volume":"35 ","pages":"e22"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6b/5b/aoem-35-e22.PMC10442584.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10063101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational asthma related to indoor air pollution in a worker at an indoor air gun shooting range: a case report.","authors":"Kwang Min Lee,&nbsp;Seungho Lee,&nbsp;Yoon-Ji Kim,&nbsp;Seung-Eun Lee,&nbsp;Youngki Kim,&nbsp;Dongmug Kang,&nbsp;Se-Yeong Kim","doi":"10.35371/aoem.2023.35.e13","DOIUrl":"https://doi.org/10.35371/aoem.2023.35.e13","url":null,"abstract":"<p><strong>Background: </strong>Indoor air pollution can cause and exacerbate asthma. We report a previously undescribed case of occupational asthma related to indoor air pollution in a worker at an indoor air gun shooting range and highlight the potential risk of developing occupational asthma in this environment.</p><p><strong>Case presentation: </strong>A 31-year-old man presented with dyspnea, cough, and sputum and was diagnosed with asthma complicated by pneumonia. Objective evidence of asthma was obtained by performing a methacholine bronchial provocation test. It was suspected that the patient had occupational asthma, which began one month after changing jobs to work within the indoor air gun shooting range. The highest peak expiratory flow (PEF) diurnal variability on working days was 15%, but the highest variation was 24%, with 4 days out of 4 weeks having a variation of over 20% related to workplace exposure. Conversely, the diurnal variability on the rest days was 7%, and no day showed a variation exceeding 20%. The difference in the average PEF between working and rest days was 52 L/min. PEF deterioration during working days and improvement on rest days were noted.</p><p><strong>Conclusions: </strong>The results obtained from the in-depth analysis of the PEF were adequate to diagnose the patient with occupational asthma. Exposure to indoor air pollution and lead and the patient's atopy and allergic rhinitis may have contributed to the development of occupational asthma.</p>","PeriodicalId":46631,"journal":{"name":"Annals of Occupational and Environmental Medicine","volume":"35 ","pages":"e13"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/7e/aoem-35-e13.PMC10442578.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10063104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of heavy metal complex exposure and neurobehavioral function of children.","authors":"Minkeun Kim,&nbsp;Chulyong Park,&nbsp;Joon Sakong,&nbsp;Shinhee Ye,&nbsp;So Young Son,&nbsp;Kiook Baek","doi":"10.35371/aoem.2023.35.e23","DOIUrl":"https://doi.org/10.35371/aoem.2023.35.e23","url":null,"abstract":"<p><strong>Background: </strong>Exposure to heavy metals is a public health concern worldwide. Previous studies on the association between heavy metal exposure and neurobehavioral functions in children have focused on single exposures and clinical manifestations. However, the present study evaluated the effects of heavy metal complex exposure on subclinical neurobehavioral function using a Korean Computerized Neurobehavior Test (KCNT).</p><p><strong>Methods: </strong>Urinary mercury, lead, cadmium analyses as well as symbol digit substitution (SDS) and choice reaction time (CRT) tests of the KCNT were conducted in children aged between 10 and 12 years. Reaction time and urinary heavy metal levels were analyzed using partial correlation, linear regression, Bayesian kernel machine regression (BKMR), the weighted quantile sum (WQS) regression and quantile G-computation analysis.</p><p><strong>Results: </strong>Participants of 203 SDS tests and 198 CRT tests were analyzed, excluding poor cooperation and inappropriate urine sample. Partial correlation analysis revealed no association between neurobehavioral function and exposure to individual heavy metals. The result of multiple linear regression shows significant positive association between urinary lead, mercury, and CRT. BMKR, WQS regression and quantile G-computation analysis showed a statistically significant positive association between complex urinary heavy metal concentrations, especially lead and mercury, and reaction time.</p><p><strong>Conclusions: </strong>Assuming complex exposures, urinary heavy metal concentrations showed a statistically significant positive association with CRT. These results suggest that heavy metal complex exposure during childhood should be evaluated and managed strictly.</p>","PeriodicalId":46631,"journal":{"name":"Annals of Occupational and Environmental Medicine","volume":"35 ","pages":"e23"},"PeriodicalIF":1.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/47/aoem-35-e23.PMC10442582.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10065846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}