Environment-wide association study of elevated liver enzymes: results from the Korean National Environmental Health Survey 2018-2022.

IF 1.2 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annals of Occupational and Environmental Medicine Pub Date : 2023-01-01 DOI:10.35371/aoem.2023.35.e27

Youngchan Chi, Jong-Tae Park, Sewhan Na, Kyeongmin Kwak

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引用次数: 0

Abstract

Background: Environmental exposure is characterized by low concentration, chronic, and complex exposure. Traditional epidemiological studies show limitations in reflecting these characteristics since they usually focus on a single or very limited number of exposure factors at a time. In this study, we adopted the methodology of environment-wide association study (EWAS) to figure out the association of human liver function with various environmentally hazardous substances.

Methods: We analyzed 2,961 participants from the Korean National Environmental Health Survey Cycle 4 (2018-2020). Using generalized linear model (GLM) analysis, we analyzed the association of 72 variables with 3 liver function indices (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma glutamyl transferase [GGT]). Finally, we visualized our results with Manhattan plot.

Results: In GLM analysis, perfluorooctanesulfonate were positively associated with ALT (odds ratio [OR]: 2.2; 95% confidence interval [CI]: 1.39-3.46; p _adjusted = 0.0147) and perfluorodecanoic acid showed positive association with GGT (OR: 2.73; 95% CI: 1.36-5.5; p _adjusted = 0.0256). Plasma mercury showed positive association with GGT (OR: 1.45; 95% CI: 1.14-1.84; p _adjusted = 0.0315). Using a plastic container while keeping food in the refrigerator was associated with elevated GGT compared to using a glass container (OR: 1.51; 95% CI: 1.16-1.95; p _adjusted = 0.0153). 2-ethyl-5-oxohexyl phthalate, showed a negative trend with all 3 indices, with AST (OR: 0.54; 95% CI: 0.39-0.73; p _adjusted = 0.00357), ALT (OR: 0.5; 95% CI: 0.34-0.75; p _adjusted = 0.036), GGT (OR: 0.55; 95% CI: 0.4-0.76; p _adjusted = 0.00697). Bisphenol S and frequent use of sunblock cream showed negative association with ALT (OR: 0.77; 95% CI: 0.66-0.89), and GGT (OR: 0.25; 95% CI: 0.11-0.55), respectively.

Conclusions: We conducted an exploratory study on environmental exposure and human liver function. By using EWAS methodology, we identified 7 factors that could have potential association with liver function.

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肝酶升高的环境关联研究:2018-2022年韩国国家环境健康调查结果

背景:环境暴露具有低浓度、慢性和复杂暴露的特点。传统的流行病学研究在反映这些特征方面显示出局限性，因为它们通常一次只关注单一或非常有限数量的暴露因素。本研究采用全环境关联研究(environmental -wide association study, EWAS)的方法，研究各种环境有害物质对人体肝功能的影响。方法:我们分析了韩国国家环境健康调查周期4(2018-2020)的2961名参与者。采用广义线性模型(GLM)分析，我们分析了72个变量与3个肝功能指标(天冬氨酸转氨酶[AST]、丙氨酸转氨酶[ALT]和γ谷氨酰转移酶[GGT])的相关性。最后，我们用曼哈顿图将结果可视化。结果:在GLM分析中，全氟辛烷磺酸与ALT呈正相关(优势比[OR]: 2.2;95%置信区间[CI]: 1.39-3.46;p校正= 0.0147)，全氟癸酸与GGT呈正相关(OR: 2.73;95% ci: 1.36-5.5;P调整= 0.0256)。血浆汞与GGT呈正相关(OR: 1.45;95% ci: 1.14-1.84;P调整= 0.0315)。与使用玻璃容器相比，在冰箱中保存食物时使用塑料容器与GGT升高有关(OR: 1.51;95% ci: 1.16-1.95;P校正= 0.0153)。邻苯二甲酸2-乙基-5-氧己基，3项指标均呈阴性趋势，AST (OR: 0.54;95% ci: 0.39-0.73;p调整= 0.00357)，ALT (OR: 0.5;95% ci: 0.34-0.75;p调整= 0.036)，GGT (OR: 0.55;95% ci: 0.4-0.76;P校正= 0.00697)。双酚S和频繁使用防晒霜与ALT呈负相关(OR: 0.77;95% CI: 0.66-0.89)和GGT (OR: 0.25;95% CI: 0.11-0.55)。结论:我们开展了一项环境暴露与人体肝功能的探索性研究。通过EWAS方法，我们确定了7个可能与肝功能有潜在关联的因素。

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来源期刊

Annals of Occupational and Environmental Medicine PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

16 weeks

期刊介绍： Annals of Occupational and Environmental Medicine (AOEM) is an open access journal that considers original contributions relevant to occupational and environmental medicine and related fields, in the form of original articles, review articles, short letters and case reports. AOEM is aimed at clinicians and researchers working in the wide-ranging discipline of occupational and environmental medicine. Topic areas focus on, but are not limited to, interactions between work and health, covering occupational and environmental epidemiology, toxicology, hygiene, diagnosis and treatment of diseases, management, organization and policy. As the official journal of the Korean Society of Occupational and Environmental Medicine (KSOEM), members and authors based in the Republic of Korea are entitled to a discounted article-processing charge when they publish in AOEM.