Debasish Biswal, Kunal Gandhi, Anubhav Pandey, Sadia Khan, Sharmila Sengupta
{"title":"Bloodstream infection with <i>Cupriavidus pauculus</i> in a haemodialysis patient: A clinical vignette and literature review.","authors":"Debasish Biswal, Kunal Gandhi, Anubhav Pandey, Sadia Khan, Sharmila Sengupta","doi":"10.1177/14782715251389263","DOIUrl":"10.1177/14782715251389263","url":null,"abstract":"<p><p><i>Cupriavidus pauculus</i> is a rare opportunistic pathogen primarily affecting immunocompromised hosts. We present a case of bloodstream infection caused by <i>C. pauculus</i> in a 52-year-old male with end-stage renal disease on maintenance haemodialysis. This report describes the clinical presentation, microbiological findings and treatment approach, accompanied by a comprehensive literature review and systematic analysis of all reported cases to provide insights into the management of this uncommon pathogen.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"278-282"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145453485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antia Garcia Fernandez, Alice Sinclair, Paul Elkington, Andrew Rosser, Dinny Wallis
{"title":"An unusual case of cutaneous tuberculosis and paradoxical TB in a patient with spondyloarthritis treated with adalimumab.","authors":"Antia Garcia Fernandez, Alice Sinclair, Paul Elkington, Andrew Rosser, Dinny Wallis","doi":"10.1177/14782715251401766","DOIUrl":"10.1177/14782715251401766","url":null,"abstract":"<p><p>Cutaneous tuberculosis (TB) is an uncommon condition, the diagnosis of which can be challenging. Biologic disease-modifying anti-rheumatic drugs (bDMARDs) are associated with a higher risk of opportunistic infections, including TB. We present a case of cutaneous TB in a 56-year-old male with psoriatic arthritis on adalimumab. He developed skin lesions on his thumb and axilla, and <i>Mycobacterium tuberculosis</i> was isolated in cultures sent from a skin biopsy. Four months after commencement of TB treatment, he presented with a new onset of seizures. An MRI head showed two tuberculomas, with no further lesions identified in cross-sectional imaging. A tapering course of steroids was started alongside a 12-month course of anti-TB treatment for post-tuberculous treatment paradoxical reaction. In conclusion, although uncommon, cutaneous TB should be considered in patients on bDMARD treatment with atypical skin lesions.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"299-301"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucy Bagley, Thomas Cowdall, Lucy Searle, Rebecca Burney, Michael Whiteside
{"title":"Pancreatic panniculitis: The presenting feature of a metastatic adenocarcinoma.","authors":"Lucy Bagley, Thomas Cowdall, Lucy Searle, Rebecca Burney, Michael Whiteside","doi":"10.1177/14782715251388291","DOIUrl":"10.1177/14782715251388291","url":null,"abstract":"","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"324-325"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145373150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Registered Reports in medical journals.","authors":"Christopher J Graham, Kelly E Lloyd","doi":"10.1177/14782715251388208","DOIUrl":"10.1177/14782715251388208","url":null,"abstract":"","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"358-359"},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marese Kathleen O'Reilly, Stephanie Logan, Susan Yule, Rodney Mountain, Ewan Eadie, Robert Dawe, Sally Ibbotson
{"title":"Realising realistic medicine by enhancing patient-centred care: The Scottish Photobiology Service's approach to engaging patients with photosensitivity disorders.","authors":"Marese Kathleen O'Reilly, Stephanie Logan, Susan Yule, Rodney Mountain, Ewan Eadie, Robert Dawe, Sally Ibbotson","doi":"10.1177/14782715251351787","DOIUrl":"10.1177/14782715251351787","url":null,"abstract":"<p><p>The Scottish Photobiology Service (SPS), hosted in the Photobiology Unit at Ninewells Hospital, Dundee, celebrated its 50th anniversary in 2023. Dedicated to providing diagnostic and therapeutic services for individuals with cutaneous photosensitivity disorders, the SPS has consistently sought to improve patient care. In 2015, the Chief Medical Officer for Scotland, published a national report entitled 'Realistic Medicine', which challenged medical practitioners to improve patient care through the development of personalised approaches, with patients placed at the centre of their care. In 2019, the SPS initiated a patient engagement programme aimed at better understanding the needs of patients with photosensitivity conditions, underpinning the objectives of the Realistic Medicine concept. This article outlines the development, implementation and outcomes of this initiative, which has become a core function of the service. Through ongoing collaboration with patients and staff, the programme has informed service improvements, addressed key issues such as referral delays, peer support and educational resources, and fostered an inclusive approach to care.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"216-223"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low-risk pulmonary embolism.","authors":"Chris Isles","doi":"10.1177/14782715251357369","DOIUrl":"10.1177/14782715251357369","url":null,"abstract":"","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"240"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tracing medusa's signature: Uncovering tales of prothrombotic state.","authors":"Arul Rajamurugan Ps, Arockiaraj Barnabas, Sabarinath M, Durga Lakshmi J, Ramesh Subramanian","doi":"10.1177/14782715251357370","DOIUrl":"10.1177/14782715251357370","url":null,"abstract":"<p><p>Hypercoagulable states can present with complex vascular manifestations, including rare inferior vena cava (IVC) thrombosis and intracardiac masses, often resulting in delayed diagnosis and adverse outcomes. We describe a 30-year-old female who initially presented with right leg swelling, later developing systemic symptoms such as anaemia and thrombocytopenia. Despite initial management for deep vein thrombosis, progressive clinical deterioration led to further evaluation, revealing hepatic IVC thrombosis with collateral circulation and a mitral valve mass consistent with Libman-Sacks endocarditis. A diagnosis of primary antiphospholipid syndrome was confirmed through serologic testing. She was successfully managed with anticoagulation, antiplatelet therapy and supportive treatment. This case underscores the need for comprehensive evaluation in patients with recurrent thrombotic events, emphasising the importance of early detection and sustained anticoagulation therapy to mitigate the risk of embolic complications and optimise long-term patient outcomes.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"202-204"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simulation demystified and reimagined-using simulation to transform clinical practices.","authors":"Craig Brown, David Savage","doi":"10.1177/14782715251365452","DOIUrl":"10.1177/14782715251365452","url":null,"abstract":"<p><p>Simulation has traditionally been used for paedagogical purposes. More recently, simulation has been advocated for use in transformational ways - leveraging simulation to test and improve clinical systems and service delivery. This article presents a narrative account of transformational simulation in stroke care. We describe three simulation-based initiatives: a review of simulation on door-to-needle times, development of a telethrombolysis protocol and implementation of a thrombectomy pathway. This article demonstrates how simulation can be used to transform healthcare. Our examples have focussed on stroke presentations; however, the 'seven I's model' outlines how simulation can be used to identify, improve and innovate across the care spectrum.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"224-227"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Remarks on delirium assessment, management and barriers to effective care across Scotland.","authors":"Fnu Wajeeha, Sohaib Raza, Zernain Toor","doi":"10.1177/14782715251344462","DOIUrl":"10.1177/14782715251344462","url":null,"abstract":"","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"234-235"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harikrishnan Gangadharan, Sandra Pulickal Babu, Rohit Ram Kumar, Aditya Nair, Manjit Ps, Jacob George
{"title":"Overlap of limited cutaneous systemic sclerosis with ocular myasthenia gravis- report of a case and a brief review of literature.","authors":"Harikrishnan Gangadharan, Sandra Pulickal Babu, Rohit Ram Kumar, Aditya Nair, Manjit Ps, Jacob George","doi":"10.1177/14782715251362060","DOIUrl":"10.1177/14782715251362060","url":null,"abstract":"<p><p>A 39-year-old woman with a 4-year history of limited cutaneous systemic sclerosis (lcSSc) and no prior exposure to D-penicillamine presented with bilateral fluctuating ptosis of 1 week duration. On evaluation, she was found to have elevated acetylcholine receptor antibody levels and a positive neostigmine test confirming the diagnosis of ocular myasthenia gravis (MG). The patient was treated with oral prednisolone and pyridostigmine resulting in significant improvement within 2 weeks. The co-occurrence of systemic sclerosis (SSc) and MG is rare and when such an association is seen, it is usually seen in the background of D-Penicillamine therapy for SSc. The presence of fluctuating ptosis in SSc is a valuable clinical clue to suspect co-existence of neuromuscular junction disorder like MG.</p>","PeriodicalId":46606,"journal":{"name":"Journal of the Royal College of Physicians of Edinburgh","volume":" ","pages":"188-192"},"PeriodicalIF":0.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}