Asian Journal of Urology最新文献

{"title":"Analysis of the urethral stricture score and patient-related factors as predictors of outcomes following oral mucosal graft urethroplasty","authors":"","doi":"10.1016/j.ajur.2023.04.002","DOIUrl":"10.1016/j.ajur.2023.04.002","url":null,"abstract":"<div><h3>Objective</h3><p>The complexity of urethral strictures can predict outcomes following urethroplasty. The previously described urethral stricture score (U score) considered only stricture-related factors to grade the complexity of urethral strictures and to predict recurrence post urethroplasty, but not considered patient-related factors for the same. We aimed to study the correlation of both of these factors to the outcomes of oral mucosal graft urethroplasty.</p></div><div><h3>Methods</h3><p>We retrospectively reviewed data of 101 patients who underwent oral mucosal graft urethroplasty in our institute with a minimum follow-up of 6 months. Baseline patient characteristics and stricture-related parameters were noted. The U score was calculated for all patients which consisted of the length, location, number, and etiology of stricture. Univariate and multivariate Cox proportional hazard regression models were used to determine significant risk factors of recurrence.</p></div><div><h3>Results</h3><p>The mean follow-up of patients was 15 months. Recurrence was seen in 28 patients and the mean time for detection of recurrence was 8 months of follow-up. The Charlson Comorbidity Index, history of previous intervention, length of strictures, location of strictures, number of strictures, history of smoking, and etiology were independent predictors of recurrence following urethroplasty. Based on these parameters, we formulated the modified U score (MU score). The scores ranged from 0 to 6 and a score of &gt;2 was found to be predictive of recurrence. On comparing receiver operating characteristic curves for both scores by the DeLong test, the MU score had larger area under the curve than the U score.</p></div><div><h3>Conclusion</h3><p>The MU scoring system is the first of its kind attempt taking into consideration both patient- and stricture-related factors to predict recurrence following oral mucosal graft urethroplasty.</p></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"11 3","pages":"Pages 473-479"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221438822300070X/pdfft?md5=3c5f457790c971ea066da963146ff405&pid=1-s2.0-S221438822300070X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42861035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-assisted uretero-enteric reimplantation for uretero-enteric anastomotic strictures following robot-assisted radical cystectomy: Surgical approach and outcomes over two decades","authors":"","doi":"10.1016/j.ajur.2023.10.002","DOIUrl":"10.1016/j.ajur.2023.10.002","url":null,"abstract":"<div><h3>Objective</h3><p>We described the technique and outcomes of robot-assisted repair of uretero-enteric strictures (UES) following robot-assisted radical cystectomy (RARC) and urinary diversion.</p></div><div><h3>Methods</h3><p>Retrospective review of our RARC database from November 2005 to August 2023 at Roswell Park Comprehensive Cancer center was performed. Patients who developed UES and ultimately underwent robot-assisted uretero-enteric reimplantation (RUER) were identified. Kaplan–Meier method was used to compute the cumulative incidence recurrence rate of UES after RUER. A multivariable regression model was used to identify variables associated with UES recurrence.</p></div><div><h3>Results</h3><p>A total of 123 (15%) out of 808 RARC patients developed UES, of whom 52 underwent reimplantation (45 patients underwent RUER [<em>n</em>=55 cases] and seven patients underwent open uretero-enteric reimplantation). The median time from RARC to UES was 4.4 (interquartile range 3.0–7.0) months, and the median time between UES and RUER was 5.2 (interquartile range 3.2–8.9) months. The 3-year recurrence rate after RUER is about 29%. On multivariable analysis, longer hospital stay (hazard ratio 1.37, 95% confidence interval 1.16–1.61, <em>p</em>&lt;0.01) was associated with recurrent UES after RUER.</p></div><div><h3>Conclusion</h3><p>RUER for UES after RARC is feasible with durable outcomes although a notable subset of patients experienced postoperative complications and UES recurrence.</p></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"11 3","pages":"Pages 384-390"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214388224000122/pdfft?md5=9408a01ff7d6dc4e7d27e967011a8fc1&pid=1-s2.0-S2214388224000122-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139874475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance in the Fundamentals of Laparoscopic Surgery: Does it reflect global rating scales in the Objective Structured Assessment of Technical Skills in porcine laparoscopic surgery?","authors":"Ho Yee Tiong ,&nbsp;Wei Zheng So ,&nbsp;Jeremy Yuen-Chun Teoh ,&nbsp;Shuji Isotani ,&nbsp;Gang Zhu ,&nbsp;Teng Aik Ong ,&nbsp;Eddie Shu-Yin Chan ,&nbsp;Peggy Sau-Kwan Chu ,&nbsp;Kittinut Kijvikai ,&nbsp;Ming Liu ,&nbsp;Bannakji Lojanapiwat ,&nbsp;Michael Wong ,&nbsp;Anthony Chi-Fai Ng","doi":"10.1016/j.ajur.2022.12.002","DOIUrl":"10.1016/j.ajur.2022.12.002","url":null,"abstract":"<div><h3>Objective</h3><p>To correlate the utility of the Fundamentals of Laparoscopic Surgery (FLS) manual skills program with the Objective Structured Assessment of Technical Skills (OSATS) global rating scale in evaluating operative performance.</p></div><div><h3>Methods</h3><p>The Asian Urological Surgery Training and Educational Group (AUSTEG) Laparoscopic Upper Tract Surgery Course implemented and validated the FLS program for its usage in laparoscopic surgical training. Delegates’ basic laparoscopic skills were assessed using three different training models (peg transfer, precision cutting, and intra-corporeal suturing). They also performed live porcine laparoscopic surgery at the same workshop. Live surgery skills were assessed by blinded faculty using the OSATS rating scale.</p></div><div><h3>Results</h3><p>From March 2016 to March 2019, a total of 81 certified urologists participated in the course, with a median of 5 years of post-residency experience. Although differences in task time did not reach statistical significance, those with more surgical experience were visibly faster at completing the peg transfer and intra-corporeal suturing FLS tasks. However, they took longer to complete the precision cutting task than participants with less experience. Overall OSATS scores correlated weakly with all three FLS tasks (peg transfer time: <em>r</em>=−0.331, <em>r</em>²=0.110; precision cutting time: <em>r</em>=−0.240, <em>r</em>²=0.058; suturing with intra-corporeal knot time: <em>r</em>=−0.451, <em>r</em>²=0.203).</p></div><div><h3>Conclusion</h3><p>FLS task parameters did not correlate strongly with OSATS globing rating scale performance. Although FLS task models demonstrated strong validity, it is important to assimilate the inconsistencies when benchmarking technical proficiency against real-life operative competence, as evaluated by FLS and OSATS, respectively.</p></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"11 3","pages":"Pages 443-449"},"PeriodicalIF":2.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214388223000012/pdfft?md5=fd8a819aaa25302d456d1213a7bbe1a9&pid=1-s2.0-S2214388223000012-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141728984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease","authors":"Andrey Morozov ,&nbsp;Leonid Chuvalov ,&nbsp;Mark Taratkin ,&nbsp;Mikhail Enikeev ,&nbsp;Leonid Rapoport ,&nbsp;Nirmish Singla ,&nbsp;Eric Barret ,&nbsp;Elena Poddubskaya ,&nbsp;Maria Borodina ,&nbsp;Georg Salomon ,&nbsp;Juan Gomez Rivas ,&nbsp;Dmitry Enikeev","doi":"10.1016/j.ajur.2022.03.017","DOIUrl":"10.1016/j.ajur.2022.03.017","url":null,"abstract":"<div><h3>Objective</h3><p>To analyze outcomes and complications of cytoreductive prostatectomy (CRP) for oligometastatic prostate cancer (PCa) in order to elucidate its role in this space.</p></div><div><h3>Methods</h3><p>We performed a systematic literature search using three databases (Medline, Scopus, and Web of Science). The primary endpoints were oncologic outcomes. The secondary endpoints were complication rates and functional results.</p></div><div><h3>Results</h3><p>In all studies, overall survival was better or at least comparable variable in the groups with CRP compared to no local treatment. The greatest benefit from CRP in 5-year overall survival in one study was 67.4% for CRP versus 22.5% for no local treatment. Cancer-specific survival (CSS) showed the same trend. Several authors found significant benefits from CSS in the CRP group: from 79% <em>vs</em>. 46% to 100% <em>vs</em>. 61%. CRP was a predictor of better CSS (hazard ratio 0.264, <em>p</em>=0.004). Positive surgical margin rates differed widely from 28.6% to 100.0%. Urinary continence in CRP versus RP for localized PCa was significantly lower (57.4% <em>vs.</em> 90.8%, <em>p</em>&lt;0.0001). Severe incontinence occurred seldom (2.5%–18.6%). Total complication rates after CRP differed widely, from 7.0% to 43.6%. Rates of grades 1 and 2 events prevailed. Patients on ADT alone also showed a considerable number of complications varying from 5.9% to 57.7%.</p></div><div><h3>Conclusion</h3><p>CRP improves medium-term cancer control in patients with oligometastatic PCa. The morbidity and complication rates of this surgery are comparable with other approaches, but postoperative incontinence rate is higher compared with RP for localized disease.</p></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"11 2","pages":"Pages 208-220"},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214388222001436/pdfft?md5=f0bcf020b877be11f59a4c1add1d8f0d&pid=1-s2.0-S2214388222001436-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43162627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of complications in endourological management of stones: What are the basic measures needed before, during, and after interventions?","authors":"Eric Edison ,&nbsp;Giorgio Mazzon ,&nbsp;Vimoshan Arumuham ,&nbsp;Simon Choong","doi":"10.1016/j.ajur.2023.04.003","DOIUrl":"10.1016/j.ajur.2023.04.003","url":null,"abstract":"<div><h3>Objective</h3><p>This narrative review aims to describe measures to minimise the risk of complications during percutaneous nephrolithotomy (PCNL), ureteroscopy, and retrograde intrarenal surgery.</p></div><div><h3>Methods</h3><p>A literature search was conducted from the PubMed/PMC database for papers published within the last 10 years (January 2012 to December 2022). Search terms included “ureteroscopy”, “retrograde intrarenal surgery”, “PCNL”, “percutaneous nephrolithotomy”, “complications”, “sepsis”, “infection”, “bleed”, “haemorrhage”, and “hemorrhage”. Key papers were identified and included meta-analyses, systematic reviews, guidelines, and primary research. The references of these papers were searched to identify any further relevant papers not included above.</p></div><div><h3>Results</h3><p>The evidence is assimilated with the opinions of the authors to provide recommendations. Best practice pathways for patient care in the pre-operative, intra-operative, and post-operative periods are described, including the identification and management of residual stones. Key complications (sepsis and stent issues) that are relevant for any endourological procedure are then be discussed. Operation-specific considerations are then explored. Key measures for PCNL include optimising access to minimise the chance of bleeding or visceral injury. The role of endoscopic combined intrarenal surgery in this regard is discussed. Key measures for ureteroscopy and retrograde intrarenal surgery include planning and technique to minimise the risk of ureteric injury. The role of anaesthetic assessment is discussed. The importance of specific comorbidities on each step of the pathway is highlighted as examples.</p></div><div><h3>Conclusion</h3><p>This review demonstrates that the principles of meticulous planning, interdisciplinary teamworking, and good operative technique can minimise the risk of complications in endourology.</p></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"11 2","pages":"Pages 180-190"},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214388223000723/pdfft?md5=81716d87353f52f4528f1c2636efe962&pid=1-s2.0-S2214388223000723-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45080186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of a non-randomised audit of single pigtail suture stents in urolithiasis management of Asian patients in Singapore","authors":"Ee Jean Lim ,&nbsp;Zhen Wei Choo ,&nbsp;Reshma Mangat ,&nbsp;Pradeep Durai ,&nbsp;Sarvajit Biligere ,&nbsp;Yiquan Tan ,&nbsp;Loh Hin Yeung Marcus ,&nbsp;Nicole Andrea Seet Li Ting ,&nbsp;Chin Tiong Heng ,&nbsp;Stefania Ferreti ,&nbsp;Vineet Gauhar","doi":"10.1016/j.ajur.2022.03.013","DOIUrl":"10.1016/j.ajur.2022.03.013","url":null,"abstract":"<div><h3>Objective</h3><p>Double-J (DJ) ureteric stents are commonly placed perioperatively for semirigid or flexible ureteroscopic renal surgery. It is believed that lesser stent material within the bladder mitigates stent-related symptoms. This study aimed to evaluate the J-Fil ureteral stent, a single pigtail suture stent compared with conventional DJ stent in relation to stent symptoms in an Asian population undergoing ureterorenal intervention.</p></div><div><h3>Methods</h3><p>Based on internal audit committee recommendation approval, the records of 50 patients retrieved, available data of 41 patients who were prospectively enrolled into two groups (Group 1 [J-Fil stent group], <em>n</em>=21 and Group 2 [DJ stent group], <em>n</em>=20) between August 2020 to January 2021, were analysed. Parameters compared were nature of procedure, stone location and size, ease of deployment or removal, and complications. A modified universal stent symptom questionnaire was used to assess morbidity of stent symptoms within 48 h of insertion and at removal.</p></div><div><h3>Results</h3><p>Both groups had similar median age, distribution in male to female ratio, and stone size. The overall median universal stent symptom questionnaire score at insertion was similar for bladder pain, flank or loin pain, and quality of life between Group 1 and 2; however, at removal Group 1 fared significantly better than Group 2, especially for flank or loin pain and pain at voiding. Both groups had similar ease in insertion with no hospital readmissions.</p></div><div><h3>Conclusion</h3><p>Our audit favoured the single pigtail suture stent in Asian ureters in mitigating stent-related issues. It showed a good safety profile with easy deployment and removal. It promises a new standard in stenting.</p></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"11 2","pages":"Pages 324-330"},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214388222001096/pdfft?md5=e052a12dfd164fd558d81eb7a69f7c7c&pid=1-s2.0-S2214388222001096-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45864801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary study on rectal dose reduction associated with hyaluronic acid implantation in brachytherapy for prostate cancer","authors":"Tairo Kashihara ,&nbsp;Yuka Urago ,&nbsp;Hiroyuki Okamoto ,&nbsp;Mihiro Takemori ,&nbsp;Hiroki Nakayama ,&nbsp;Shohei Mikasa ,&nbsp;Tetsu Nakaichi ,&nbsp;Kotaro Iijima ,&nbsp;Takahito Chiba ,&nbsp;Junichi Kuwahara ,&nbsp;Satoshi Nakamura ,&nbsp;Weishan Chang ,&nbsp;Yoshiyuki Matsui ,&nbsp;Hiroshi Igaki","doi":"10.1016/j.ajur.2022.08.006","DOIUrl":"10.1016/j.ajur.2022.08.006","url":null,"abstract":"<div><h3>Objectives</h3><p>Hydrogel spacer (HS) was developed to reduce rectal toxicities caused by radiotherapy, but has been reported to cause major adverse events. Our institute has attempted to introduce a hyaluronic acid (HA) as an alternative spacer. This study aimed to compare rectal doses and geometric distributions between the HS and HA implantation in prostate cancer.</p></div><div><h3>Methods</h3><p>HS and HA were inserted in 20 and 18 patients undergoing high-dose brachytherapy, respectively. The rectum spacer volumes injected were 10 mL and 22 mL, respectively. In the treatment planning system, 13.5 Gy was administered with common catheter positions. The rectal dose indices were assessed between the spacer groups for dosimetry evaluation. Distances between the prostate and rectum and configurations of the spacers were compared.</p></div><div><h3>Results</h3><p>The mean doses irradiated to 0.1 and 2 mL of the rectum were 10.45 Gy and 6.71 Gy for HS, and 6.73 Gy and 4.90 Gy for HA (<em>p</em>&lt;0.001). The mean minimum distances between the prostate and rectum were 1.23 cm and 1.79 cm for HS and HA, respectively (<em>p</em>&lt;0.05). Geometrical configuration comparisons revealed that HA has a higher ability to expand the space than HS.</p></div><div><h3>Conclusion</h3><p>The rectal dose reduction ability of HA is significantly greater than that of HS, suggesting its potential as a new spacer.</p></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"11 2","pages":"Pages 286-293"},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221438822300022X/pdfft?md5=36080534a3ff1f08ba19966820143982&pid=1-s2.0-S221438822300022X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43901281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The optimal stent pusher position to achieve successful ureteral stent insertion under fluoroscopic guidance","authors":"Makoto Taguchi ,&nbsp;Kaneki Yasuda ,&nbsp;Hidefumi Kinoshita","doi":"10.1016/j.ajur.2022.11.006","DOIUrl":"10.1016/j.ajur.2022.11.006","url":null,"abstract":"<div><h3>Objective</h3><p>To examine factors to predict the optimal stent pusher position when inserting ureteral stents under fluoroscopy.</p></div><div><h3>Methods</h3><p>We retrospectively reviewed 327 patients who underwent ureteral stent insertion. We considered the pubic bone as a useful anatomical landmark to insert ureteral stents under fluoroscopic guidance. Thus, we categorized patients into three groups (proximal, middle, and distal groups) according to the position of the radiopaque tip of the push catheter when inserting the ureteral stent. Success was defined as a completely curled ureteral stent tail. We compared stent insertion success rates among the three groups. A multivariate analysis was performed to identify the factors affecting stent insertion success.</p></div><div><h3>Results</h3><p>In men, 36 (63.2%) cases were deemed successful in the proximal group compared with 40 (80.0%) cases in the middle group and 12 (20.7%) cases in the distal group (<em>p</em>&lt;0.001). In women, 26 (45.6%) cases were deemed successful in the proximal group compared with 54 (98.2%) cases in the middle group and 38 (76.0%) cases in the distal group (<em>p</em>&lt;0.001). With the multivariate analysis, the stent pusher position was the most significant factor influencing successful stent insertion (men: odds ratio 6.00, 95% confidence interval 2.66–13.51, <em>p</em>&lt;0.001; women: odds ratio 37.80, 95% confidence interval 4.94–289.22, <em>p</em>&lt;0.001).</p></div><div><h3>Conclusion</h3><p>The position of the stent pusher affects stent insertion success. The middle of the pubic symphysis is the optimal position for the radiopaque tip of the pusher when inserting ureteral stents under fluoroscopic guidance.</p></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"11 2","pages":"Pages 311-315"},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214388223001261/pdfft?md5=4d7bf23150086ac9b4e52826040d0b23&pid=1-s2.0-S2214388223001261-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135763477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding intrarenal backflow: Intrarenal pressure during ureteroscopy and beyond","authors":"Palle J.S. Osther,&nbsp;Susanne S. Osther,&nbsp;Maria P. Hesselholt,&nbsp;Sofia Byllov,&nbsp;Søren K. Lildal,&nbsp;Louise F. Øbro,&nbsp;Helene Jung","doi":"10.1016/j.ajur.2024.01.008","DOIUrl":"10.1016/j.ajur.2024.01.008","url":null,"abstract":"","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"11 2","pages":"Pages 139-142"},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214388224000080/pdfft?md5=d34abf3711e9895e610dc726bfb3d595&pid=1-s2.0-S2214388224000080-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139883865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy","authors":"Ryan A. Dornbier ,&nbsp;Chirag P. Doshi ,&nbsp;Shalin C. Desai ,&nbsp;Petar Bajic ,&nbsp;Michelle Van Kuiken ,&nbsp;Mark Khemmani ,&nbsp;Ahmer V. Farooq ,&nbsp;Larissa Bresler ,&nbsp;Thomas M.T. Turk ,&nbsp;Alan J. Wolfe ,&nbsp;Kristin G. Baldea","doi":"10.1016/j.ajur.2022.08.007","DOIUrl":"10.1016/j.ajur.2022.08.007","url":null,"abstract":"<div><h3>Objective</h3><p>To identify possible stone-promoting microbes, we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome (MetS). The association between MetS and urinary stone disease is well established, but the exact pathophysiologic relationship remains unknown. Recent evidence suggests urinary tract dysbiosis may lead to increased nephrolithiasis risk.</p></div><div><h3>Methods</h3><p>At the time of percutaneous nephrolithotomy, bladder urine and stone fragments were collected from patients with and without MetS. Both sample types were subjected to expanded quantitative urine culture (EQUC) and 16 S ribosomal RNA gene sequencing.</p></div><div><h3>Results</h3><p>Fifty-seven patients included 12 controls (21.1%) and 45 MetS patients (78.9%). Both cohorts were similar with respect to demographics and non-MetS comorbidities. No controls had uric acid stone composition. By EQUC, bacteria were detected more frequently in MetS stones (42.2%) compared to controls (8.3%) (<em>p</em>=0.041). Bacteria also were more abundant in stones of MetS patients compared to controls. To validate our EQUC results, we performed 16 S ribosomal RNA gene sequencing. In 12/16 (75.0%) sequence-positive stones, EQUC reliably isolated at least one species of the sequenced genera. Bacteria were detected in both “infectious” and “non-infectious” stone compositions.</p></div><div><h3>Conclusion</h3><p>Bacteria are more common and more abundant in MetS stones than control stones. Our findings support a role for bacteria in urinary stone disease for patients with MetS regardless of stone composition.</p></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"11 2","pages":"Pages 316-323"},"PeriodicalIF":2.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2214388223000292/pdfft?md5=7ff3f9efd25e80fed3e36afad0333c83&pid=1-s2.0-S2214388223000292-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42343026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}