Asian Journal of Urology最新文献

{"title":"Combining prostate-specific membrane antigen PET/CT with Memorial Sloan Kettering Cancer Center and Briganti 2012 nomograms enhances lymph node metastasis prediction in prostate cancer patients with a risk above 5%","authors":"Yujie Xie,&nbsp;Ting Yang,&nbsp;Siqi Hu,&nbsp;Zijie Shen,&nbsp;Guangfeng Chen,&nbsp;Yueming Zha,&nbsp;Qiong Zou,&nbsp;Yong Zhang","doi":"10.1016/j.ajur.2025.04.007","DOIUrl":"10.1016/j.ajur.2025.04.007","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate intermediate- to high-risk prostate cancer patients with a predicted lymph node metastasis (LNM) probability over 5%, for whom pelvic lymph node dissection (PLND) is recommended, we assessed the ability of prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) to reduce unnecessary PLND and its effectiveness when integrated with clinical nomograms like the Memorial Sloan Kettering Cancer Center (MSKCC) nomogram and the Briganti 2012 nomogram.</div></div><div><h3>Methods</h3><div>A total of 112 patients were selected. Univariate and multivariate logistic analyses were performed. The receiver operating characteristic curve and decision curve analysis were generated for assessing the incremental value of PET/CT diagnosis of LNM combined with the MSKCC and Briganti 2012 nomograms. The reduction in unnecessary PLND across risk thresholds based on the net benefit was further assessed, to evaluate the impact of adding PSMA PET/CT.</div></div><div><h3>Results</h3><div>Surgical pathology confirmed LNM in 46 (41%) patients. PSMA PET/CT detected all metastases in patients with a 5%–25% LNM probability predicted by the MSKCC nomogram and three of four cases predicted by the Briganti 2012 nomogram in the same range. Multivariate logistic regression identified PSMA PET/CT as a significant predictor of LNM (<em>p</em>&lt;0.001), improving the area under the curve from 0.830 to 0.895 for the MSKCC nomogram (<em>p</em>=0.023) and from 0.808 to 0.889 for the Briganti 2012 nomogram (<em>p</em>=0.009). Decision curve analysis showed that integrating PSMA PET/CT within a 5%–25% risk range reduced unnecessary PLND, with reductions of 10%–26% for the MSKCC nomogram and 7.4%–19% for the Briganti 2012 nomogram, but did not improve predictive efficacy for probabilities above 60%.</div></div><div><h3>Conclusion</h3><div>Integrating PSMA PET/CT with the MSKCC and Briganti 2012 nomograms improves LNM prediction in prostate cancer and significantly reduces unnecessary dissections in patients with a predicted LNM probability between 5% and 25%.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"13 3","pages":"Pages 354-360"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148699380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tips and tricks for reducing radiation exposure during retrograde intrarenal surgery: A literature review by the European Association of Urology Section of Endourology","authors":"Otas Durutovic,&nbsp;Milos Petrovic,&nbsp;Vincent De Coninck,&nbsp;Laurian Dragos,&nbsp;Marcos Cepeda,&nbsp;Guido M. Kamphuis,&nbsp;Panagiotis Kallidonis,&nbsp;Andreas Skolarikos,&nbsp;Amelia Pietropaolo,&nbsp;Bhaskar Somani,&nbsp;Vineet Gauhar,&nbsp;Thomas Tailly","doi":"10.1016/j.ajur.2026.01.003","DOIUrl":"10.1016/j.ajur.2026.01.003","url":null,"abstract":"<div><h3>Objective</h3><div>Fluoroscopy is an important component of retrograde intrarenal surgery (RIRS), as it facilitates safe and accurate access, guidance, and intraoperative navigation. Fluoroscopy during surgery exposes patients and medical personnel to the harmful effects of ionizing radiation. To reduce radiation exposure, multiple strategies have been proposed. The objective of this review is to analyze strategies for minimizing radiation exposure during RIRS and to provide recommendations for their implementation.</div></div><div><h3>Methods</h3><div>A comprehensive literature review was performed by searching the PubMed, Cochrane Library, EMBASE, and Web of Science databases, as well as the <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> registry, for publications on strategies for reducing fluoroscopy use during RIRS, using various combinations of the following Medical Subject Headings: “fluoroscopy”, “radiation safety”, “radiation exposure”, “urology”, “endourology”, “flexible ureterorenoscopy”, “FURS”, “retrograde intrarenal surgery”, “RIRS”.</div></div><div><h3>Results</h3><div>A substantial corpus of evidence, encompassing original articles, clinical trials, and narrative and systematic reviews, was identified. Several preoperative measures, including thorough analysis of available imaging studies and the application of quality checklists to guarantee optimal patient positioning, C-arm settings, and the use of radiation protection equipment, have been associated with a significant reduction in radiation exposure. Intraoperatively, the use of fluoroless or fluoroscopy-free RIRS, along with equipment optimization techniques such as intermittent fluoroscopy, collimation, and last image hold, has been identified as a promising approach for radiation reduction. The implementation of radiation safety and simulation-based training can further decrease radiation exposure.</div></div><div><h3>Conclusion</h3><div>Minimizing radiation exposure during RIRS necessitates a comprehensive strategy that integrates careful preoperative planning, fluoroless or fluoroscopy-free techniques, equipment optimization, and radiation safety training and education. Current evidence suggests that these approaches can be performed safely and effectively in appropriately selected patients. However, further high-quality randomized controlled trials are needed to confirm these findings and guide their broader adoption.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"13 3","pages":"Pages 261-272"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148699353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of suction mini-percutaneous nephrolithotomy using disposable versus reusable sheaths: Real-world observations and inferences from the Suction Technology Utility in Mini-Percutaneous nephrolithotomy Study (STUMPS) registry","authors":"Carlo Giulioni,&nbsp;Vineet Gauhar,&nbsp;Daniele Castellani,&nbsp;Steffi Kar-Kei Yuen,&nbsp;Federico Falsetti,&nbsp;Angelo Cafarelli,&nbsp;Khi Yung Fong,&nbsp;Jaisukh Kalathia,&nbsp;Nariman Gadzhiev,&nbsp;Alexey G. Martov,&nbsp;Vigen Malkhasyan,&nbsp;Abu Baker,&nbsp;Arun Chawla,&nbsp;Abhay Mahajan,&nbsp;Kazumi Taguchi,&nbsp;Lazaros Tzelves,&nbsp;Leonardo Gomes Lopes,&nbsp;Yiloren Tanidir,&nbsp;Mohamed Omar,&nbsp;Mahmoud Laymon,&nbsp;Bhaskar Somani","doi":"10.1016/j.ajur.2025.11.001","DOIUrl":"10.1016/j.ajur.2025.11.001","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the perioperative outcomes of suction mini-percutaneous nephrolithotomy (SM-PCNL) using disposable versus reusable sheaths, based on data from the global Suction Technology Utility in Mini-Percutaneous nephrolithotomy Study (STUMPS) registry.</div></div><div><h3>Methods</h3><div>This prospective, multicenter observational study analyzed adult patients undergoing SM-PCNL using either disposable or reusable suction sheaths (14–22 Fr) between March 2024 and November 2024 across 30 centers in 21 countries. Propensity score matching was employed to balance key variables, including age, sex, Guy's stone score, stone volume, and patient position. Primary outcomes included 30-day stone-free rates, complications, and operative metrics. Multivariable logistic regression was performed to identify predictors of complete (Grade A) stone clearance.</div></div><div><h3>Results</h3><div>Among 1524 patients, 1024 were matched for analysis (512 in each group). Both groups had comparable distributions of 30-day postoperative residual fragment grades (<em>p</em>=0.90), with similar stone-free rates (Grade A clearance: 80% in the reusable group <em>vs.</em> 81% in the disposable group). The disposable group demonstrated a significantly lower 30-day complication rate (9.4% <em>vs.</em> 15%; <em>p</em>=0.01), including fewer renal pelvic injuries and bleeding events. However, operative time was longer in this group (median 50 min <em>vs.</em> 44 min; <em>p</em>=0.02), and the reintervention rate was higher (3.3% <em>vs.</em> 1.0%; <em>p</em>=0.02). Predictors of reduced stone clearance included supine positioning, smaller sheath size, and larger stone volume.</div></div><div><h3>Conclusion</h3><div>Both disposable and reusable sheaths yield comparable stone clearance in SM-PCNL. However, disposable sheaths are associated with fewer complications and may offer practical advantages in settings with limited reprocessing capabilities. Further randomized trials and cost-effectiveness studies are warranted to guide sheath selection in diverse clinical environments.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"13 3","pages":"Pages 313-322"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148699375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative insights into upper tract urothelial carcinoma: Aligning Chinese Urological Association and European Association of Urology guidelines with clinical practice","authors":"Shuxiong Zeng,&nbsp;Wei He,&nbsp;Zhensheng Zhang","doi":"10.1016/j.ajur.2026.06.001","DOIUrl":"10.1016/j.ajur.2026.06.001","url":null,"abstract":"","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"13 3","pages":"Pages 339-342"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148699378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of flexible and navigable suction ureteral access sheath in pediatric ureteroscopy: A systematic review from the European Association of Urology Section of Endourology","authors":"Ali Talyshinskii,&nbsp;Patrick Juliebø-Jones,&nbsp;Vineet Gauhar,&nbsp;Steffi Kar Kei Yuen,&nbsp;Selcuk Güven,&nbsp;Theodoros Tokas,&nbsp;Nariman Gadzhiev,&nbsp;Bhaskar Somani","doi":"10.1016/j.ajur.2025.10.001","DOIUrl":"10.1016/j.ajur.2025.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>The introduction of a flexible and navigable suction ureteral access sheath (FANS-UAS) has further enhanced retrograde intrarenal surgery (RIRS) by improving kidney stone clearance and reducing operative challenges. However, evidence for its use in the pediatric population remains sparse. Thus, this systematic review focuses on the current evidence on the use of a FANS-UAS during RIRS in children with renal stones.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, Cochrane Library, and Google Scholar was conducted in May 2025 following the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines and PROSPERO registration (CRD420251049140). Studies were included if they reported original data on the use of a suction ureteral access sheath (UAS) during RIRS in pediatric patients (&lt;18 years). Data on patient demographics, stone characteristics, surgical outcomes, and complications were extracted and analyzed descriptively.</div></div><div><h3>Results</h3><div>Out of 49 screened studies, three met the inclusion criteria, including 74 pediatric patients. A FANS-UAS was used in all cases, with 97% utilizing 10/12 Fr UAS and 91% employing a 7.5 Fr flexible ureteroscope. The pooled stone-free rate was 99%, with complications limited to minor ureteral injury (4.1%) and Clavien–Dindo Grade I/II events (9.5%). One study showed the superiority of a FANS-UAS over a conventional UAS in operative time and initial stone-free rate. However, the evidence was limited by small sample sizes and heterogeneity.</div></div><div><h3>Conclusion</h3><div>RIRS with a FANS-UAS a is a safe and effective option for managing pediatric urolithiasis, including large and multiple stones. Nevertheless, current evidence is based on a small number of studies with limited generalizability. Further prospective research is needed to validate these findings, to explore the role of suction, and to investigate various UAS and endoscope configurations.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"13 3","pages":"Pages 285-294"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148699351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do failed endoscopic manipulations increase the complexity of ureteral stricture? A multicenter experience","authors":"Qiyu He,&nbsp;Kun Liu,&nbsp;Yu Liu,&nbsp;Lei Xiang,&nbsp;Hong Li,&nbsp;Banghua Liao,&nbsp;Liang Zhou,&nbsp;Kunjie Wang","doi":"10.1016/j.ajur.2025.10.002","DOIUrl":"10.1016/j.ajur.2025.10.002","url":null,"abstract":"<div><h3>Objective</h3><div>Endoscopic management is the preferred initial approach for short ureteral stricture (US), yet the impact of failed attempts on stricture characteristics requiring salvage reconstruction remains unclear. This study aimed to investigate how prior endoscopic interventions influence the complexity of stone-related US.</div></div><div><h3>Methods</h3><div>Between January 2022 and January 2024, patients with stone-related US were included and underwent reconstructive surgery. Stricture length was measured intraoperatively via ureteral catheter or stent. Reconstruction was classified as simple (ureteroureterostomy or pyeloplasty, and reimplantation) or complex (oral mucosa graft onlay, appendiceal flap, Boari flap or psoas hitch, and ileal ureter substitution). Follow-up ranged from 15 months to 39 months, with success defined as resolved obstruction and improved hydronephrosis on imaging, while failure was characterized by persistent obstruction or the need for reintervention. Statistical analyses, including Pearson's correlation and regression models, were used to identify associations and adjust for confounding factors.</div></div><div><h3>Results</h3><div>Among 142 patients with stone-related US, 76% had US in the upper-mid ureter. Prior endoluminal treatments (22%) were linked to longer US (mean: 2.00 cm <em>vs.</em> 1.00 cm, <em>p</em>&lt;0.001) and independently predicted higher complexity. Treated cases frequently required complex reconstructions, such as oral mucosa grafts (48% <em>vs.</em> 15%, <em>p</em>=0.003), while simpler approaches, like ureteroureterostomy, were more common in untreated cases (80% <em>vs.</em> 48%, <em>p</em>=0.005). For distal US, reimplantation was numerically more frequent in the non-endoluminal group than in the endoluminal group (65% <em>vs.</em> 38%, <em>p</em>=0.2), while ileal ureter substitution was more frequent in treated cases (25% <em>vs.</em> 0%, <em>p</em>=0.049). Treated patients also had longer operative time (mean: 216 min <em>vs.</em> 192 min, <em>p</em>=0.048), though success rates remained comparable (86% <em>vs.</em> 88%, <em>p</em>=0.7).</div></div><div><h3>Conclusion</h3><div>Prior endoluminal treatment independently predicted increased ureteral reconstruction complexity, characterized by longer US, more intricate procedures, and extended operative time. However, overall reconstruction success rates remained consistent between groups. These findings highlight the need for careful evaluation of risks and benefits when selecting initial treatment strategies.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"13 3","pages":"Pages 361-370"},"PeriodicalIF":2.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148699381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of prostate-specific membrane antigen–adjusted Prostate Imaging Reporting and Data System: A new approach to enhancing the accuracy of diagnosing treatment-naïve primary prostate cancer","authors":"Xiaoyuan Li ,&nbsp;Jieping Song ,&nbsp;Xiaochen Yao ,&nbsp;Zhenyu Zhao ,&nbsp;Qing Zhang ,&nbsp;Rushuai Li ,&nbsp;Pengjun Zhang ,&nbsp;Wenyu Wu ,&nbsp;Hongwei Sun ,&nbsp;Shuyue Ai ,&nbsp;Fengjiao Yang ,&nbsp;Hongqian Guo ,&nbsp;Kuangyu Shi ,&nbsp;Ali Afshar-Oromieh ,&nbsp;Longjiang Zhang ,&nbsp;Guangming Lu ,&nbsp;Ali Cahid Civelek ,&nbsp;Feng Wang","doi":"10.1016/j.ajur.2025.05.001","DOIUrl":"10.1016/j.ajur.2025.05.001","url":null,"abstract":"<div><h3>Objective</h3><div>The diagnostic efficacy of hybrid positron emission tomography (PET)/MRI in detecting primary prostate cancer (PCa) is limited due to the lack of a quantitative integrated analysis. A new Prostate Imaging Reporting and Data System (PI-RADS) incorporating prostate-specific membrane antigen (PSMA) PET for PET/MRI has been introduced to improve primary detection of PCa.</div></div><div><h3>Methods</h3><div>One hundred and twenty consecutive patients with high clinical suspicion of PCa were enrolled in this prospective study to assess the diagnostic performance of PSMA-adjusted PI-RADS (PAPI-RADS) using ⁶⁸Ga-PSMA-11 PET/MRI. Tumor PSMA uptake was assessed semi-quantitatively using the maximum and peak standardized uptake values. The PAPI-RADS was obtained by combining tumor PSMA uptake with PI-RADS. Patients were divided into two groups: a training group (90 patients) and a validation group (30 patients). The cutoff value of PSMA intensity was determined via receiver operating characteristic analysis. PAPI-RADS was then applied to the validation group. Histopathology was used as the gold standard to verify the diagnostic efficacy.</div></div><div><h3>Results</h3><div>In the training group, PAPI-RADS detected more cases of PCa than PI-RADS. PAPI-RADS had a sensitivity of 99%, specificity of 100%, negative predictive value of 92%, and overall accuracy of 99%. PI-RADS had a sensitivity of 94%, specificity of 75%, negative predictive value of 64%, and overall accuracy of 90%. PAPI-RADS was significantly better than PI-RADS in detecting PCa (<em>χ</em>^<em>2</em>=6.57, <em>p</em>=0.010). The external validation of this study confirmed the diagnostic efficacy of PAPI-RADS in PCa patients.</div></div><div><h3>Conclusion</h3><div>PAPI-RADS is significantly better than PI-RADS in detecting PCa. PAPI-RADS can improve the diagnostic accuracy of PCa detection, especially in patients with a PI-RADS score &lt;3 lesions. PAPI-RADS can improve the accuracy of PCa diagnosis and avoid unnecessary biopsies.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"13 2","pages":"Pages 154-162"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148020900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of renal parenchymal thickness and hydronephrosis: A technetium-99m dimercaptosuccinic acid single-photon emission CT and ultrasonography study","authors":"Maryam Sadeghi ,&nbsp;Neda Pak ,&nbsp;Mostafa Nazari ,&nbsp;Negar Mohammadi Ganjaroudi ,&nbsp;Marzieh Ebrahimi ,&nbsp;Mahboobeh Ahmadi ,&nbsp;Shima Yavari ,&nbsp;Abdol-Mohammad Kajbafzadeh ,&nbsp;Zeinab Paymani","doi":"10.1016/j.ajur.2024.09.008","DOIUrl":"10.1016/j.ajur.2024.09.008","url":null,"abstract":"<div><h3>Objective</h3><div>To explore a functional anteroposterior pelvis diameter (APD) cutoff for diagnosing hydronephrosis (HDN) in the pediatric population, and to evaluate the correlation between structural and functional renal parenchymal thickness (PT) measured by ultrasonography (US) and technetium-99m dimercaptosuccinic acid single-photon emission CT (^99mTc-DMSA SPECT), respectively.</div></div><div><h3>Methods</h3><div>This single-center cohort study enrolled 76 pediatric patients (152 kidney units) referred to the Department of Nuclear Medicine of Children's Medical Center. Structural and functional PT were measured by US and ^99mTc-DMSA SPECT, respectively. The ^99mTc-DMSA SPECT was assessed by a pediatric nuclear medicine specialist blinded to the US findings. The ^99mTc-DMSA SPECT and US were performed on the same day. The correlation between structural and functional PT measurements was evaluated through the Spearman correlation analysis while the functional APD cutoff for HDN diagnosis was established by using the receiver operating characteristic curve.</div></div><div><h3>Results</h3><div>The study demonstrated a poor to moderate relationship between structural and functional PT (Spearman's rho=0.30–0.52, <em>p</em>&lt;0.05). A functional APD cutoff of 14 mm in the ^99mTc-DMSA SPECT was in concordance with the ultrasonographic cutoff of 10 mm for diagnosing HDN.</div></div><div><h3>Conclusion</h3><div>This study can give the experts new insights into using the ^99mTc-DMSA SPECT as an additional modality in measuring the functional renal dimensions, especially PT alongside the US findings.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"13 2","pages":"Pages 234-240"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148020851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific advances in drug development and clinical trials for urothelial carcinoma: Highlights from the 2025 American Society of Clinical Oncology Genitourinary Cancers Symposium","authors":"Ruicheng Wu,&nbsp;Dengxiong Li,&nbsp;Dechao Feng","doi":"10.1016/j.ajur.2025.07.002","DOIUrl":"10.1016/j.ajur.2025.07.002","url":null,"abstract":"","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"13 2","pages":"Pages 246-250"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148020873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between grip strength and kidney stones: A National Health and Nutrition Examination Survey and Mendelian randomization study","authors":"Xiangyu Zhang ,&nbsp;Haiyan Ju ,&nbsp;Guangyuan Zhang ,&nbsp;Bo Xiao","doi":"10.1016/j.ajur.2025.03.013","DOIUrl":"10.1016/j.ajur.2025.03.013","url":null,"abstract":"<div><h3>Objective</h3><div>The formation of kidney stones is influenced by multiple factors, including physical health indicators such as grip strength (GS), which reflects overall muscle health. This study aimed to investigate the relationship between GS and the risk of developing kidney stones.</div></div><div><h3>Methods</h3><div>Data from the National Health and Nutrition Examination Survey between 2011 and 2014 were analyzed. The maximum value of six GS measurements was selected as the definitive value. Relative grip strength (rGS) was calculated to adjust for body size differences. Chi-square tests and <em>t</em>-tests were employed for categorical and continuous variables, respectively. Logistic regression models were used to evaluate the relationships of GS and rGS with the prevalence of kidney stones. Two-sample Mendelian randomization using the inverse-variance weighted method verified the causal association.</div></div><div><h3>Results</h3><div>The study included 9306 participants, with 302 having kidney stones. Participants with kidney stones had lower mean GS (32.0 kg <em>vs.</em> 37.3 kg, <em>p</em>&lt;0.001) and rGS (1.12 <em>vs.</em> 1.34, <em>p</em>&lt;0.001). Logistic regression showed that higher GS and rGS (divided into quartiles Q1–Q4) were associated with a reduced risk of kidney stones (GS: Q4 <em>vs.</em> Q1, odds ratio 0.32, 95% confidence interval 0.20–0.51, <em>p</em>&lt;0.001; rGS: Q4 <em>vs.</em> Q1, odds ratio 0.45, 95% confidence interval 0.28–0.71, <em>p</em>&lt;0.001). Two-sample Mendelian randomization results confirmed a negative association between right-hand GS and the risk of kidney stones.</div></div><div><h3>Conclusion</h3><div>Lower GS is linked to a higher risk of kidney stones, highlighting the importance of muscle health in the prevention of kidney stones.</div></div>","PeriodicalId":46599,"journal":{"name":"Asian Journal of Urology","volume":"13 2","pages":"Pages 177-186"},"PeriodicalIF":2.4,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148020903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}