Pulmonary Medicine最新文献_第10页

Electronic Cigarettes for Curbing the Tobacco-Induced Burden of Noncommunicable Diseases: Evidence Revisited with Emphasis on Challenges in Sub-Saharan Africa 电子烟用于遏制烟草引起的非传染性疾病负担:重新审视证据，重点关注撒哈拉以南非洲的挑战

IF 4.3

Pulmonary Medicine Pub Date : 2016-12-25 DOI: 10.1155/2016/4894352

J. R. Nansseu, J. Bigna

{"title":"Electronic Cigarettes for Curbing the Tobacco-Induced Burden of Noncommunicable Diseases: Evidence Revisited with Emphasis on Challenges in Sub-Saharan Africa","authors":"J. R. Nansseu, J. Bigna","doi":"10.1155/2016/4894352","DOIUrl":"https://doi.org/10.1155/2016/4894352","url":null,"abstract":"Introduction. This review examines whether electronic cigarettes (e-cigs) implementation or vulgarization in sub-Saharan Africa (SSA) could be helpful in curtailing the toll of tobacco smoking in the region. Discussion. There are about 1.3 billion smokers worldwide, with nearly 80% of them living in developing countries where the burden of tobacco-related illnesses and deaths is the heaviest. Studies report that e-cigs may facilitate smoking cessation, reduction, or abstinence and may pose only a small fraction of the risks of traditional tobacco cigarettes; e-cigs may also considerably reduce second-hand smoking. Thereby, implementation of e-cig use could help to substantially reduce the burden driven by tobacco smoking in SSA, in a particular context of lack of regulations and control policies towards this threat. However, the evidence is not clear on whether e-cigs are risk-free, especially if used in the long term. Conclusions. On the whole, if e-cigs were to be introduced in SSA, they should be strictly recommended to current and/or ex-smokers as a method to quit smoking or prevent relapse and never-smokers should be strongly encouraged to avoid using these devices. Bans on sales of e-cigs to youngsters should be legislated, e-cig advertisements prohibited, and their usage continuously controlled and monitored.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":"1 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2016-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83055656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation 棘荆芥蛋白酶抑制剂的提取。影响肺部炎症时激肽的释放

IF 4.3

Pulmonary Medicine Pub Date : 2016-12-01 DOI: 10.1155/2016/9425807

Ilana Cruz-Silva, V. A. Nunes, A. J. Gozzo, Priscila Praxedes-Garcia, A. Tanaka, K. Shimamoto, M. Araujo

{"title":"Protease Inhibitors Extracted from Caesalpinia echinata Lam. Affect Kinin Release during Lung Inflammation","authors":"Ilana Cruz-Silva, V. A. Nunes, A. J. Gozzo, Priscila Praxedes-Garcia, A. Tanaka, K. Shimamoto, M. Araujo","doi":"10.1155/2016/9425807","DOIUrl":"https://doi.org/10.1155/2016/9425807","url":null,"abstract":"Inflammation is an essential process in many pulmonary diseases in which kinins are generated by protease action on kininogen, a phenomenon that is blocked by protease inhibitors. We evaluated kinin release in an in vivo lung inflammation model in rats, in the presence or absence of CeKI (C. echinata kallikrein inhibitor), a plasma kallikrein, cathepsin G, and proteinase-3 inhibitor, and rCeEI (recombinant C. echinata elastase inhibitor), which inhibits these proteases and also neutrophil elastase. Wistar rats were intravenously treated with buffer (negative control) or inhibitors and, subsequently, lipopolysaccharide was injected into their lungs. Blood, bronchoalveolar lavage fluid (BALF), and lung tissue were collected. In plasma, kinin release was higher in the LPS-treated animals in comparison to CeKI or rCeEI groups. rCeEI-treated animals presented less kinin than CeKI-treated group. Our data suggest that kinins play a pivotal role in lung inflammation and may be generated by different enzymes; however, neutrophil elastase seems to be the most important in the lung tissue context. These results open perspectives for a better understanding of biological process where neutrophil enzymes participate and indicate these plant inhibitors and their recombinant correlates for therapeutic trials involving pulmonary diseases.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":"42 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89585721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Early-Phase Recovery of Cardiorespiratory Measurements after Maximal Cardiopulmonary Exercise Testing in Patients with Chronic Obstructive Pulmonary Disease 慢性阻塞性肺疾病患者最大心肺运动试验后心肺测量的早期恢复

IF 4.3

Pulmonary Medicine Pub Date : 2016-11-27 DOI: 10.1155/2016/9160781

M. Bellefleur, D. Debeaumont, A. Boutry, Marie Netchitailo, A. Cuvelier, J. Muir, C. Tardif, J. Coquart

{"title":"Early-Phase Recovery of Cardiorespiratory Measurements after Maximal Cardiopulmonary Exercise Testing in Patients with Chronic Obstructive Pulmonary Disease","authors":"M. Bellefleur, D. Debeaumont, A. Boutry, Marie Netchitailo, A. Cuvelier, J. Muir, C. Tardif, J. Coquart","doi":"10.1155/2016/9160781","DOIUrl":"https://doi.org/10.1155/2016/9160781","url":null,"abstract":"Background. This study investigated respiratory gas exchanges and heart rate (HR) kinetics during early-phase recovery after a maximal cardiopulmonary exercise test (CPET) in patients with chronic obstructive pulmonary disease (COPD) grouped according to airflow limitation. Methods. Thirty control individuals (control group: CG) and 81 COPD patients (45 with “mild” or “moderate” airflow limitation, COPDI-II, versus 36 with “severe” or “very severe” COPD, COPDIII-IV) performed a maximal CPET. The first 3 min of recovery kinetics was investigated for oxygen uptake (V˙O2), minute ventilation (V˙E), respiratory equivalence, and HR. The time for V˙O2 to reach 25% (T1/4 V˙O2) of peak value was also determined and compared. Results. The V˙O2, V˙E, and HR recovery kinetics were significantly slower in both COPD groups than CG (p < 0.05). Moreover, COPDIII-IV group had significantly higher V˙O2 and V˙E during recovery than COPDI-II group (p < 0.05). T1/4 V˙O2 significantly differed between groups (p < 0.01; 58 ± 18 s in CG, 79 ± 26 s in COPDI-II group, and 121 ± 34 s in COPDIII-IV) and was significantly correlated with forced expiratory volume in one second in COPD patients (p < 0.001, r = 0.53) and with peak power output (p < 0.001, r = 0.59). Conclusion. The COPD groups showed slower kinetics in the early recovery period than CG, and the kinetics varied with severity of airflow obstruction.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":"32 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2016-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78791784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

When Women with Cystic Fibrosis Become Mothers: Psychosocial Impact and Adjustments 当患有囊性纤维化的妇女成为母亲:心理社会影响和调整

IF 4.3

Pulmonary Medicine Pub Date : 2016-11-23 DOI: 10.1155/2016/9458980

S. Cammidge, A. Duff, G. Latchford, C. Etherington

{"title":"When Women with Cystic Fibrosis Become Mothers: Psychosocial Impact and Adjustments","authors":"S. Cammidge, A. Duff, G. Latchford, C. Etherington","doi":"10.1155/2016/9458980","DOIUrl":"https://doi.org/10.1155/2016/9458980","url":null,"abstract":"Advances in the treatment and life expectancy of cystic fibrosis (CF) patients mean that motherhood is now a realistic option for many women with CF. This qualitative study explored the psychosocial impact and adjustments made when women with CF become mothers. Women with CF (n = 11) were recruited via an online forum and participated in semistructured telephone interviews about their experiences of becoming a mother. Transcriptions were analysed using Grounded Theory. Analysis revealed three core categories: (i) “Living with CF”: how becoming a mother impacted on health and treatment adherence, requiring a change in support from the CF team, (ii) “Becoming a Mother”: balancing issues common to new mothers with their CF, and (iii) “Pooling Personal Resources”: coping strategies in managing the dual demands of child and CF care. Participants experienced a variety of complex psychosocial processes. Most participants acknowledged an initial negative impact on CF care; however over time they reported successful adaptation to managing dual commitments and that adherence and motivation to stay well had improved. This study highlights the need for preconceptual psychosocial counselling and postpartum adjustment to CF care.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":"75 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2016-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86178426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Diagnosis of Peripheral Lung Lesions via Conventional Flexible Bronchoscopy with Multiplanar CT Planning 常规柔性支气管镜多平面CT规划诊断肺周围性病变

IF 4.3

Pulmonary Medicine Pub Date : 2016-11-13 DOI: 10.1155/2016/5048961

Marianne Anastasia De Roza, Kien Hong Quah, Cheong Kiat Julian Tay, W. Toh, Huihua Li, Ganesh Kalyanasundaram, D. Anantham

{"title":"Diagnosis of Peripheral Lung Lesions via Conventional Flexible Bronchoscopy with Multiplanar CT Planning","authors":"Marianne Anastasia De Roza, Kien Hong Quah, Cheong Kiat Julian Tay, W. Toh, Huihua Li, Ganesh Kalyanasundaram, D. Anantham","doi":"10.1155/2016/5048961","DOIUrl":"https://doi.org/10.1155/2016/5048961","url":null,"abstract":"Background. Conventional flexible bronchoscopy has limited sensitivity in the diagnosis of peripheral lung lesions and is dependent on lesion size. However, advancement of CT imaging offers multiplanar reconstruction facilitating enhanced preprocedure planning. This study aims to report efficacy and safety while considering the impact of patient selection and multiplanar CT planning. Method. Prospective case series of patients with peripheral lung lesions suspected of having lung cancer who underwent flexible bronchoscopy (forceps biopsy and lavage). Endobronchial lesions were excluded. Patients with negative results underwent CT-guided transthoracic needle aspiration, surgical biopsy, or clinical-radiological surveillance to establish the final diagnosis. Results. 226 patients were analysed. The diagnostic yield of bronchoscopy was 80.1% (181/226) with a sensitivity of 84.2% and specificity of 100%. In patients with a positive CT-Bronchus sign, the diagnostic yield was 82.4% compared to 72.8% with negative CT-Bronchus sign (p = 0.116). Diagnostic yield was 84.9% in lesions > 20 mm and 63.0% in lesions ≤ 20 mm (p = 0.001). Six (2.7%) patients had transient hypoxia and 2 (0.9%) had pneumothorax. There were no serious adverse events. Conclusion. Flexible bronchoscopy with appropriate patient selection and preprocedure planning is more efficacious in obtaining a diagnosis in peripheral lung lesions compared to historical data. This trial is registered with ClinicalTrials.gov Identifier: NCT01374542.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":"6 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2016-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84775229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome 中年阻塞性睡眠呼吸暂停综合征患者胱抑素C水平

IF 4.3

Pulmonary Medicine Pub Date : 2016-10-24 DOI: 10.1155/2016/8081723

K. Archontogeorgis, E. Nena, C. Tsigalou, A. Voulgaris, M. Xanthoudaki, M. Froudarakis, P. Steiropoulos

{"title":"Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome","authors":"K. Archontogeorgis, E. Nena, C. Tsigalou, A. Voulgaris, M. Xanthoudaki, M. Froudarakis, P. Steiropoulos","doi":"10.1155/2016/8081723","DOIUrl":"https://doi.org/10.1155/2016/8081723","url":null,"abstract":"Background. Obstructive sleep apnea syndrome (OSAS) is associated with systemic inflammation and increased risk of cardiovascular and chronic kidney disease. Cystatin C (Cyst C) is a novel biomarker of both latent renal damage and cardiovascular disease. Aim of the study was to measure serum levels of Cyst C, as well as IL-8 and CRP, in otherwise healthy OSAS patients. Methods. 84 individuals examined with polysomnography for OSAS symptoms without known comorbidities were prospectively recruited. Results. According to apnea hypopnea index (AHI) subjects were divided in two groups: OSAS group (AHI > 5/hour, n = 64) and controls (AHI < 5/hour, n = 20), which were age- and BMI-matched. Cyst C levels were higher in OSAS patients versus controls (1176.13 ± 351.33 versus 938.60 ± 245.83 ng/mL, resp.; p = 0.017) while serum IL-8 and CRP levels did not differ significantly. Positive correlation was found between Cyst C levels and respiratory disturbance index (RDI) (r = 0.240, p = 0.039) and percentage of time with oxygen saturation <90% (r = 0.290, p = 0.02) and negative correlation was found between Cyst C levels and average oxygen saturation during sleep (r = −0.291, p = 0.012). After adjustment for age and BMI, RDI was the only independent predictor of Cyst C levels (β = 0.256, p = 0.039). Conclusion. Cyst C serum levels are increased in OSAS patients without comorbidities, suggesting an increased renal and cardiovascular disease risk.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":"33 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2016-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83360479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity 血清镁和维生素D水平作为哮喘严重程度的指标

IF 4.3

Pulmonary Medicine Pub Date : 2016-10-12 DOI: 10.1155/2016/1643717

Mohammed Nadeem Shaikh, Brahmareddy Malapati, R. Gokani, B. Patel, Mitul Chatriwala

{"title":"Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity","authors":"Mohammed Nadeem Shaikh, Brahmareddy Malapati, R. Gokani, B. Patel, Mitul Chatriwala","doi":"10.1155/2016/1643717","DOIUrl":"https://doi.org/10.1155/2016/1643717","url":null,"abstract":"Background. Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. Asthma, in adults, is less studied and hypomagnesemia along with vitamin D deficiency and insufficiency is common in asthmatic individuals, which causes frequent asthma attacks, respiratory infections, severe exacerbations, and poor response to bronchodilators. Objective. To detect the magnitude of vitamin D insufficiency and deficiency and serum magnesium levels among asthmatic patients and to correlate them with the severity of asthma. Materials and Methods. This is a cross-sectional case-control study which includes 60 patients of chronic stable asthma and 60 healthy controls. After taking clinical history and systemic examination, pulmonary function test was done. Serum levels of magnesium, 25-hydroxycholecalciferol [25(OH)D], and calcium were measured in all the subjects. Results. Significant correlation was found between vitamin D deficiency, hypomagnesemia, and asthma severity. Serum calcium levels were unaffected by that. Conclusion. Vitamin D and serum magnesium deficiency are highly prevalent in patients with asthma. Increased asthma severity, frequency of attacks, and exacerbation are associated with lower levels of one or both. Serum 25(OH)D and magnesium levels may serve as important markers of asthma severity.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":"29 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2016-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81365527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Liver Cirrhosis and Diabetes Mellitus Are Risk Factors for Staphylococcus aureus Infection in Patients with Healthcare-Associated or Hospital-Acquired Pneumonia 肝硬化和糖尿病是医疗保健相关或医院获得性肺炎患者金黄色葡萄球菌感染的危险因素

IF 4.3

Pulmonary Medicine Pub Date : 2016-02-22 DOI: 10.1155/2016/4706150

Huang-Pin Wu, C. Chu, Chun-Yao Lin, Chung-Chieh Yu, C. Hua, Teng-Jen Yu, Yu‐Chih Liu

{"title":"Liver Cirrhosis and Diabetes Mellitus Are Risk Factors for Staphylococcus aureus Infection in Patients with Healthcare-Associated or Hospital-Acquired Pneumonia","authors":"Huang-Pin Wu, C. Chu, Chun-Yao Lin, Chung-Chieh Yu, C. Hua, Teng-Jen Yu, Yu‐Chih Liu","doi":"10.1155/2016/4706150","DOIUrl":"https://doi.org/10.1155/2016/4706150","url":null,"abstract":"Background. The risk factors for Staphylococcus aureus (S. aureus) pneumonia are not fully identified. The aim of this work was to find out the clinical characteristics associated with S. aureus infection in patients with healthcare-associated pneumonia (HCAP) and hospital-acquired pneumonia (HAP), which may be applicable for more appropriate selection of empiric antibiotic therapy. Methods. From July 2007 to June 2010, patients who were admitted to the intensive care unit with severe HCAP/HAP and severe sepsis were enrolled in this study. Lower respiratory tract sample was semiquantitatively cultured. Initial broad-spectrum antibiotics were chosen by Taiwan or American guidelines for pneumonia management. Standard bundle therapies were provided to all patients according to the guidelines of the Surviving Sepsis Campaign. Results. The most frequently isolated pathogens were Pseudomonas aeruginosa, S. aureus, Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli. Patients with positive isolation of S. aureus in culture had significantly higher history of liver cirrhosis and diabetes mellitus, with odds ratios of 3.098 and 1.899, respectively. The S. aureus pneumonia was not correlated with history of chronic obstructive pulmonary disease, hypertension, and hemodialysis. Conclusion. Liver cirrhosis and diabetes mellitus may be risk factors for S. aureus infection in patients with severe HCAP or HAP.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":"68 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2016-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77940672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

The Protective Effect of Naringin against Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats 柚皮苷对博莱霉素致Wistar大鼠肺纤维化的保护作用

IF 4.3

Pulmonary Medicine Pub Date : 2016-02-10 DOI: 10.1155/2016/7601393

N. Turgut, H. Kara, S. Elagoz, K. Deveci, Huseyin Gungor, E. Arslanbaş

{"title":"The Protective Effect of Naringin against Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats","authors":"N. Turgut, H. Kara, S. Elagoz, K. Deveci, Huseyin Gungor, E. Arslanbaş","doi":"10.1155/2016/7601393","DOIUrl":"https://doi.org/10.1155/2016/7601393","url":null,"abstract":"The aim of the current study was to investigate the protective effect of naringin on bleomycin-induced pulmonary fibrosis in rats. Twenty-four Wistar rats randomly divided into four groups (control, bleomycin alone, bleomycin + naringin 40, and bleomycin + naringin 80) were used. Rats were administered a single dose of bleomycin (5 mg/kg; via the tracheal cannula) alone or followed by either naringin 40 mg/kg (orally) or naringin 80 mg/kg (orally) or water (1 mL, orally) for 14 days. Rats and lung tissue were weighed to determine the lung index. TNF-α and IL-1β levels, hydroxyproline content, and malondialdehyde (MDA) levels were assayed. Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined. Tissue sections were stained with hematoxylin-eosin, Masson's trichrome, and 0.1% toluidine blue. TNF-α, IL-1β, and MDA levels and hydroxyproline content significantly increased (p < 0.01) and GPx and SOD activities significantly decreased in bleomycin group (p < 0.01). Naringin at a dose of 80 mg/kg body weight significantly decreased TNF-α and IL-1β activity, hydroxyproline content, and MDA level (p < 0.01) and increased GPx and SOD activities (p < 0.05). Histological evidence supported the results. These results show that naringin has the potential of reducing the toxic effects of bleomycin and may provide supportive therapy for conventional treatment methods for idiopathic pulmonary fibrosis.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":"57 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2016-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84701972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam 怀疑阻塞性睡眠呼吸暂停的受试者呼出一氧化氮的研究:越南的一项试点研究

IF 4.3

Pulmonary Medicine Pub Date : 2016-01-13 DOI: 10.1155/2016/3050918

S. Duong-Quy, T. Hua-Huy, Huyen-Tran Tran-Mai-Thi, N. Le-Dong, T. Craig, A. Dinh-Xuan

{"title":"Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam","authors":"S. Duong-Quy, T. Hua-Huy, Huyen-Tran Tran-Mai-Thi, N. Le-Dong, T. Craig, A. Dinh-Xuan","doi":"10.1155/2016/3050918","DOIUrl":"https://doi.org/10.1155/2016/3050918","url":null,"abstract":"Background and Objective. The concentration of exhaled nitric oxide (eNO), reflecting the activity of inducible NO synthase in airway epithelium, has been found to increase in patients with obstructive sleep apnea (OSA). This study aimed to measure eNO concentration in patients with suspected OSA and to correlate different eNO parameters with clinical and sleep apnea characteristics. Methods. In this cross-sectional study, all patients underwent in-lab overnight polysomnography (PSG) and eNO measurement using a method of multiple flow rates before and after PSG (pre- and post-PSG). Results. According to the result of PSG, 82 persons were divided into two groups: control subjects (n = 30; 54 ± 14 years) and patients with OSA defined as apnea-hypopnea index (AHI) ≥ 5/hour (n = 52; 53 ± 12 years). Body mass index (BMI) and neck and abdomen circumferences of OSA patients were significantly higher than those from control subjects. In OSA group, post-PSG alveolar NO concentration (CANO) (5.3 ± 1.9 ppb) was significantly higher than pre-PSG CANO (4.0 ± 1.7 ppb; P < 0.001). Significant correlations have been found between CANO and AHI (P < 0.001) and between CANO and nadir SpO2 (P < 0.05). The daytime CANO value of more than 4.1 ppb can be used to screen symptomatic subjects for the presence of OSA with a high specificity of 93.3%. Conclusion. Our findings indicate CANO as a surrogate marker for OSA in persons with suggestive symptoms.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":"169 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2016-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84658512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23