Pulmonary Medicine最新文献_第10页

Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome 中年阻塞性睡眠呼吸暂停综合征患者胱抑素C水平

IF 4.3

Pulmonary Medicine Pub Date : 2016-10-24 DOI: 10.1155/2016/8081723

K. Archontogeorgis, E. Nena, C. Tsigalou, A. Voulgaris, M. Xanthoudaki, M. Froudarakis, P. Steiropoulos

{"title":"Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome","authors":"K. Archontogeorgis, E. Nena, C. Tsigalou, A. Voulgaris, M. Xanthoudaki, M. Froudarakis, P. Steiropoulos","doi":"10.1155/2016/8081723","DOIUrl":"https://doi.org/10.1155/2016/8081723","url":null,"abstract":"Background. Obstructive sleep apnea syndrome (OSAS) is associated with systemic inflammation and increased risk of cardiovascular and chronic kidney disease. Cystatin C (Cyst C) is a novel biomarker of both latent renal damage and cardiovascular disease. Aim of the study was to measure serum levels of Cyst C, as well as IL-8 and CRP, in otherwise healthy OSAS patients. Methods. 84 individuals examined with polysomnography for OSAS symptoms without known comorbidities were prospectively recruited. Results. According to apnea hypopnea index (AHI) subjects were divided in two groups: OSAS group (AHI > 5/hour, n = 64) and controls (AHI < 5/hour, n = 20), which were age- and BMI-matched. Cyst C levels were higher in OSAS patients versus controls (1176.13 ± 351.33 versus 938.60 ± 245.83 ng/mL, resp.; p = 0.017) while serum IL-8 and CRP levels did not differ significantly. Positive correlation was found between Cyst C levels and respiratory disturbance index (RDI) (r = 0.240, p = 0.039) and percentage of time with oxygen saturation <90% (r = 0.290, p = 0.02) and negative correlation was found between Cyst C levels and average oxygen saturation during sleep (r = −0.291, p = 0.012). After adjustment for age and BMI, RDI was the only independent predictor of Cyst C levels (β = 0.256, p = 0.039). Conclusion. Cyst C serum levels are increased in OSAS patients without comorbidities, suggesting an increased renal and cardiovascular disease risk.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2016-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83360479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity 血清镁和维生素D水平作为哮喘严重程度的指标

IF 4.3

Pulmonary Medicine Pub Date : 2016-10-12 DOI: 10.1155/2016/1643717

Mohammed Nadeem Shaikh, Brahmareddy Malapati, R. Gokani, B. Patel, Mitul Chatriwala

{"title":"Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity","authors":"Mohammed Nadeem Shaikh, Brahmareddy Malapati, R. Gokani, B. Patel, Mitul Chatriwala","doi":"10.1155/2016/1643717","DOIUrl":"https://doi.org/10.1155/2016/1643717","url":null,"abstract":"Background. Serum magnesium levels affect the concentration of circulating vitamin D in blood and subsequently it affects the immunity; thus it plays significant role in the pathogenesis of asthma. Asthma, in adults, is less studied and hypomagnesemia along with vitamin D deficiency and insufficiency is common in asthmatic individuals, which causes frequent asthma attacks, respiratory infections, severe exacerbations, and poor response to bronchodilators. Objective. To detect the magnitude of vitamin D insufficiency and deficiency and serum magnesium levels among asthmatic patients and to correlate them with the severity of asthma. Materials and Methods. This is a cross-sectional case-control study which includes 60 patients of chronic stable asthma and 60 healthy controls. After taking clinical history and systemic examination, pulmonary function test was done. Serum levels of magnesium, 25-hydroxycholecalciferol [25(OH)D], and calcium were measured in all the subjects. Results. Significant correlation was found between vitamin D deficiency, hypomagnesemia, and asthma severity. Serum calcium levels were unaffected by that. Conclusion. Vitamin D and serum magnesium deficiency are highly prevalent in patients with asthma. Increased asthma severity, frequency of attacks, and exacerbation are associated with lower levels of one or both. Serum 25(OH)D and magnesium levels may serve as important markers of asthma severity.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2016-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81365527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Liver Cirrhosis and Diabetes Mellitus Are Risk Factors for Staphylococcus aureus Infection in Patients with Healthcare-Associated or Hospital-Acquired Pneumonia 肝硬化和糖尿病是医疗保健相关或医院获得性肺炎患者金黄色葡萄球菌感染的危险因素

IF 4.3

Pulmonary Medicine Pub Date : 2016-02-22 DOI: 10.1155/2016/4706150

Huang-Pin Wu, C. Chu, Chun-Yao Lin, Chung-Chieh Yu, C. Hua, Teng-Jen Yu, Yu‐Chih Liu

{"title":"Liver Cirrhosis and Diabetes Mellitus Are Risk Factors for Staphylococcus aureus Infection in Patients with Healthcare-Associated or Hospital-Acquired Pneumonia","authors":"Huang-Pin Wu, C. Chu, Chun-Yao Lin, Chung-Chieh Yu, C. Hua, Teng-Jen Yu, Yu‐Chih Liu","doi":"10.1155/2016/4706150","DOIUrl":"https://doi.org/10.1155/2016/4706150","url":null,"abstract":"Background. The risk factors for Staphylococcus aureus (S. aureus) pneumonia are not fully identified. The aim of this work was to find out the clinical characteristics associated with S. aureus infection in patients with healthcare-associated pneumonia (HCAP) and hospital-acquired pneumonia (HAP), which may be applicable for more appropriate selection of empiric antibiotic therapy. Methods. From July 2007 to June 2010, patients who were admitted to the intensive care unit with severe HCAP/HAP and severe sepsis were enrolled in this study. Lower respiratory tract sample was semiquantitatively cultured. Initial broad-spectrum antibiotics were chosen by Taiwan or American guidelines for pneumonia management. Standard bundle therapies were provided to all patients according to the guidelines of the Surviving Sepsis Campaign. Results. The most frequently isolated pathogens were Pseudomonas aeruginosa, S. aureus, Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli. Patients with positive isolation of S. aureus in culture had significantly higher history of liver cirrhosis and diabetes mellitus, with odds ratios of 3.098 and 1.899, respectively. The S. aureus pneumonia was not correlated with history of chronic obstructive pulmonary disease, hypertension, and hemodialysis. Conclusion. Liver cirrhosis and diabetes mellitus may be risk factors for S. aureus infection in patients with severe HCAP or HAP.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2016-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77940672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

The Protective Effect of Naringin against Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats 柚皮苷对博莱霉素致Wistar大鼠肺纤维化的保护作用

IF 4.3

Pulmonary Medicine Pub Date : 2016-02-10 DOI: 10.1155/2016/7601393

N. Turgut, H. Kara, S. Elagoz, K. Deveci, Huseyin Gungor, E. Arslanbaş

{"title":"The Protective Effect of Naringin against Bleomycin-Induced Pulmonary Fibrosis in Wistar Rats","authors":"N. Turgut, H. Kara, S. Elagoz, K. Deveci, Huseyin Gungor, E. Arslanbaş","doi":"10.1155/2016/7601393","DOIUrl":"https://doi.org/10.1155/2016/7601393","url":null,"abstract":"The aim of the current study was to investigate the protective effect of naringin on bleomycin-induced pulmonary fibrosis in rats. Twenty-four Wistar rats randomly divided into four groups (control, bleomycin alone, bleomycin + naringin 40, and bleomycin + naringin 80) were used. Rats were administered a single dose of bleomycin (5 mg/kg; via the tracheal cannula) alone or followed by either naringin 40 mg/kg (orally) or naringin 80 mg/kg (orally) or water (1 mL, orally) for 14 days. Rats and lung tissue were weighed to determine the lung index. TNF-α and IL-1β levels, hydroxyproline content, and malondialdehyde (MDA) levels were assayed. Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined. Tissue sections were stained with hematoxylin-eosin, Masson's trichrome, and 0.1% toluidine blue. TNF-α, IL-1β, and MDA levels and hydroxyproline content significantly increased (p < 0.01) and GPx and SOD activities significantly decreased in bleomycin group (p < 0.01). Naringin at a dose of 80 mg/kg body weight significantly decreased TNF-α and IL-1β activity, hydroxyproline content, and MDA level (p < 0.01) and increased GPx and SOD activities (p < 0.05). Histological evidence supported the results. These results show that naringin has the potential of reducing the toxic effects of bleomycin and may provide supportive therapy for conventional treatment methods for idiopathic pulmonary fibrosis.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2016-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84701972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam 怀疑阻塞性睡眠呼吸暂停的受试者呼出一氧化氮的研究:越南的一项试点研究

IF 4.3

Pulmonary Medicine Pub Date : 2016-01-13 DOI: 10.1155/2016/3050918

S. Duong-Quy, T. Hua-Huy, Huyen-Tran Tran-Mai-Thi, N. Le-Dong, T. Craig, A. Dinh-Xuan

{"title":"Study of Exhaled Nitric Oxide in Subjects with Suspected Obstructive Sleep Apnea: A Pilot Study in Vietnam","authors":"S. Duong-Quy, T. Hua-Huy, Huyen-Tran Tran-Mai-Thi, N. Le-Dong, T. Craig, A. Dinh-Xuan","doi":"10.1155/2016/3050918","DOIUrl":"https://doi.org/10.1155/2016/3050918","url":null,"abstract":"Background and Objective. The concentration of exhaled nitric oxide (eNO), reflecting the activity of inducible NO synthase in airway epithelium, has been found to increase in patients with obstructive sleep apnea (OSA). This study aimed to measure eNO concentration in patients with suspected OSA and to correlate different eNO parameters with clinical and sleep apnea characteristics. Methods. In this cross-sectional study, all patients underwent in-lab overnight polysomnography (PSG) and eNO measurement using a method of multiple flow rates before and after PSG (pre- and post-PSG). Results. According to the result of PSG, 82 persons were divided into two groups: control subjects (n = 30; 54 ± 14 years) and patients with OSA defined as apnea-hypopnea index (AHI) ≥ 5/hour (n = 52; 53 ± 12 years). Body mass index (BMI) and neck and abdomen circumferences of OSA patients were significantly higher than those from control subjects. In OSA group, post-PSG alveolar NO concentration (CANO) (5.3 ± 1.9 ppb) was significantly higher than pre-PSG CANO (4.0 ± 1.7 ppb; P < 0.001). Significant correlations have been found between CANO and AHI (P < 0.001) and between CANO and nadir SpO2 (P < 0.05). The daytime CANO value of more than 4.1 ppb can be used to screen symptomatic subjects for the presence of OSA with a high specificity of 93.3%. Conclusion. Our findings indicate CANO as a surrogate marker for OSA in persons with suggestive symptoms.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2016-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84658512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension? 大鼠长期慢性间歇性低压缺氧导致不对称二甲基精氨酸/一氧化氮通路和ROS活性失衡:高原肺动脉高压的可能协同机制?

IF 4.3

Pulmonary Medicine Pub Date : 2016-01-01 Epub Date: 2016-05-30 DOI: 10.1155/2016/6578578

Nicole Lüneburg, Patricia Siques, Julio Brito, Karem Arriaza, Eduardo Pena, Hans Klose, Fabiola Leon-Velarde, Rainer H Böger

{"title":"Long-Term Chronic Intermittent Hypobaric Hypoxia in Rats Causes an Imbalance in the Asymmetric Dimethylarginine/Nitric Oxide Pathway and ROS Activity: A Possible Synergistic Mechanism for Altitude Pulmonary Hypertension?","authors":"Nicole Lüneburg, Patricia Siques, Julio Brito, Karem Arriaza, Eduardo Pena, Hans Klose, Fabiola Leon-Velarde, Rainer H Böger","doi":"10.1155/2016/6578578","DOIUrl":"https://doi.org/10.1155/2016/6578578","url":null,"abstract":"Chronic intermittent hypoxia (CIH) and chronic hypoxia (CH) are associated with high-altitude pulmonary hypertension (HAPH). Asymmetric dimethylarginine (ADMA), a NO synthase (NOS) inhibitor, may contribute to HAPH. This study assessed changes in the ADMA/NO pathway and the underlying mechanisms in rat lungs following exposure to CIH or CH simulated in a hypobaric chamber at 428 Torr. Twenty-four adult Wistar rats were randomly assigned to three groups: CIH2x2 (2 days of hypoxia/2 days of normoxia), CH, and NX (permanent normoxia), for 30 days. All analyses were performed in whole lung tissue. L-Arginine and ADMA were analyzed using LC-MS/MS. Under both hypoxic conditions right ventricular hypertrophy was observed (p < 0.01) and endothelial NOS mRNA increased (p < 0.001), but the phosphorylated/nonphosphorylated vasodilator-stimulated phosphoprotein (VASP) ratio was unchanged. ADMA increased (p < 0.001), whereas dimethylarginine dimethylaminohydrolase (DDAH) activity decreased only under CH (p < 0.05). Although arginase activity increased (p < 0.001) and L-arginine exhibited no changes, the L-arginine/ADMA ratio decreased significantly (p < 0.001). Moreover, NOX4 expression increased only under CH (p < 0.01), but malondialdehyde (MDA) increased (up to 2-fold) equally in CIH2x2 and CH (p < 0.001). Our results suggest that ADMA and oxidative stress likely reduce NO bioavailability under altitude hypoxia, which implies greater pulmonary vascular reactivity and tone, despite the more subdued effects observed under CIH. ","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6578578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34585624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Tolerability of Nasal Delivery of Humidified and Warmed Air at Different Temperatures: A Randomised Double-Blind Pilot Study. 不同温度下鼻腔输送加湿和加热空气的耐受性:一项随机双盲先导研究。

IF 4.3

Pulmonary Medicine Pub Date : 2016-01-01 Epub Date: 2016-04-03 DOI: 10.1155/2016/7951272

Susan Bibby, Sumeet Reddy, Terrianne Cripps, Steve McKinstry, Mark Weatherall, Richard Beasley, Janine Pilcher

{"title":"Tolerability of Nasal Delivery of Humidified and Warmed Air at Different Temperatures: A Randomised Double-Blind Pilot Study.","authors":"Susan Bibby, Sumeet Reddy, Terrianne Cripps, Steve McKinstry, Mark Weatherall, Richard Beasley, Janine Pilcher","doi":"10.1155/2016/7951272","DOIUrl":"https://doi.org/10.1155/2016/7951272","url":null,"abstract":"Objectives: Delivery of warmed, humidified air via nasal high flow therapy could potentially reduce replication of temperature-sensitive viruses in the upper respiratory tract. This study investigates whether nasal high flow therapy is well tolerated by healthy adults at 37°C and 41°C.Methods: In this randomised, double-blind, controlled crossover pilot trial, nasal high flow therapy was used to deliver humidified air at 35 L/min, at either 37°C or 41°C, for three one-hour sessions of use over one day. The alternative was delivered at least 14 days later. Ten healthy, nonsmoking adults were asked, via questionnaire after each day's use, whether they would use nasal high flow therapy while being unwell with a cold or flu if it was demonstrated to improve symptoms.Results: All participants completed both interventions. Eighty percent responded \"yes\" to future use of nasal high flow therapy, for both 37°C and 41°C. There was no significant change from baseline in saccharin times following either intervention or in the following morning.Conclusions: Delivering humidified air via nasal high flow therapy at both 37°C and 41°C is well tolerated by healthy adults. This supports investigation into the potential use of nasal high flow therapy as treatment in viral upper respiratory tract infections. Trial Registration. This trial is registered with ACTRN12614000183684 (tolerability study of nasal delivery of humidified & warmed air).","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7951272","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34441334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Minimally Invasive Methods for Staging in Lung Cancer: Systematic Review and Meta-Analysis. 肺癌分期的微创方法：系统综述与元分析》。

IF 4.3

Pulmonary Medicine Pub Date : 2016-01-01 Epub Date: 2016-10-13 DOI: 10.1155/2016/1024709

Gonzalo Labarca, Carlos Aravena, Francisco Ortega, Alex Arenas, Adnan Majid, Erik Folch, Hiren J Mehta, Michael A Jantz, Sebastian Fernandez-Bussy

{"title":"Minimally Invasive Methods for Staging in Lung Cancer: Systematic Review and Meta-Analysis.","authors":"Gonzalo Labarca, Carlos Aravena, Francisco Ortega, Alex Arenas, Adnan Majid, Erik Folch, Hiren J Mehta, Michael A Jantz, Sebastian Fernandez-Bussy","doi":"10.1155/2016/1024709","DOIUrl":"10.1155/2016/1024709","url":null,"abstract":"Introduction. Endobronchial ultrasound (EBUS) is a procedure that provides access to the mediastinal staging; however, EBUS cannot be used to stage all of the nodes in the mediastinum. In these cases, endoscopic ultrasound (EUS) is used for complete staging. Objective. To provide a synthesis of the evidence on the diagnostic performance of EBUS + EUS in patients undergoing mediastinal staging. Methods. Systematic review and meta-analysis to evaluate the diagnostic yield of EBUS + EUS compared with surgical staging. Two researchers performed the literature search, quality assessments, data extractions, and analyses. We produced a meta-analysis including sensitivity, specificity, and likelihood ratio analysis. Results. Twelve primary studies (1515 patients) were included; two were randomized controlled trials (RCTs) and ten were prospective trials. The pooled sensitivity for combined EBUS + EUS was 87% (CI 84-89%) and the specificity was 99% (CI 98-100%). For EBUS + EUS performed with a single bronchoscope group, the sensitivity improved to 88% (CI 83.1-91.4%) and specificity improved to 100% (CI 99-100%). Conclusion. EBUS + EUS is a highly accurate and safe procedure. The combined procedure should be considered in selected patients with lymphadenopathy noted at stations that are not traditionally accessible with conventional EBUS.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85102867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Interpretation of Dyspnea in the Patient with Asthma 哮喘患者呼吸困难的解释

IF 4.3

Pulmonary Medicine Pub Date : 2015-12-24 DOI: 10.1155/2015/869673

M. Lavietes

{"title":"The Interpretation of Dyspnea in the Patient with Asthma","authors":"M. Lavietes","doi":"10.1155/2015/869673","DOIUrl":"https://doi.org/10.1155/2015/869673","url":null,"abstract":"Physicians have noted dyspnea in severely ill asthmatic patients to be associated with fright or panic; in more stable patients dyspnea may reflect characteristics including lung function, personality and behavioral traits. This study evaluates the symptom of dyspnea in 32 asthmatic patients twice: first when acutely ill and again after an initial response to therapy. Spirometry was performed, dyspnea quantified (Borg scale), and panic assessed with a specialized measure of acute panic (the acute panic inventory (API)) in the 32 patients before and again after treatment. After treatment, questionnaires to evaluate somatization and panic disorder were also administered. When acutely ill, both the API and all spirometric measures (PEFR; FEV1; IC) correlated with dyspnea. Multiple linear regression showed that measures of the API, the peak expiratory flow rate, and female sex taken together accounted for 41% of dyspnea in acute asthma. After treatment, the API again predicted dyspnea while spirometric data did not. Those subjects who described themselves as having chronic panic disorder reported high grades of dyspnea after treatment also. We conclude that interpretations of the self-report of asthma differ between acutely ill and stable asthmatic patients.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2015-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90338854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Patients with MAC Lung Disease Have a Low Visceral Fat Area and Low Nutrient Intake MAC肺病患者有低内脏脂肪面积和低营养摄入

IF 4.3

Pulmonary Medicine Pub Date : 2015-11-29 DOI: 10.1155/2015/218253

K. Wakamatsu, N. Nagata, Sanae Maki, H. Omori, H. Kumazoe, K. Ueno, Y. Matsunaga, Makiko Hara, K. Takakura, N. Fukumoto, Nobuhisa Ando, M. Morishige, T. Akasaki, Ichiro Inoshima, S. Ise, M. Izumi, Masayuki Kawasaki

{"title":"Patients with MAC Lung Disease Have a Low Visceral Fat Area and Low Nutrient Intake","authors":"K. Wakamatsu, N. Nagata, Sanae Maki, H. Omori, H. Kumazoe, K. Ueno, Y. Matsunaga, Makiko Hara, K. Takakura, N. Fukumoto, Nobuhisa Ando, M. Morishige, T. Akasaki, Ichiro Inoshima, S. Ise, M. Izumi, Masayuki Kawasaki","doi":"10.1155/2015/218253","DOIUrl":"https://doi.org/10.1155/2015/218253","url":null,"abstract":"Objective. This study aimed to examine the nutritional status and nutrient intake of patients with MAC lung disease with a focus on visceral fat area. Patients and Methods. Among 116 patients of our hospital with nontuberculous mycobacteriosis who were registered between May 2010 and August 2011, 103 patients with MAC lung disease were included in this study. In all patients, nutritional status and nutrient intake were prospectively examined. Results. Patients were 23 men and 80 women (mean age, 72.3 ± 10.9 years). BMI (kg/m2) at the time of registration was 20.4 ± 2.7 in men and 19.2 ± 2.9 in women. Visceral fat area (cm2) was significantly lower in women (35.7 ± 26.6) than in men (57.5 ± 47.4) (p = 0.0111). The comparison with general healthy adults according to age revealed a markedly reduced visceral fat area among patients with MAC lung disease. With respect to nutrient intake, energy adequacy (86.1 ± 15.7%), protein adequacy (82.4 ± 18.2%), lipid adequacy (78.1 ± 21.8%), and carbohydrate adequacy (89.6 ± 19.2%) ratios were all low at the time of registration. BMI was significantly correlated with protein adequacy (p = 0.0397) and lipid adequacy (p = 0.0214) ratios, while no association was found between visceral fat area and nutrient intake. Conclusion. Patients with MAC lung disease had a low visceral fat area and low nutrient intake.","PeriodicalId":46434,"journal":{"name":"Pulmonary Medicine","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2015-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86341330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12