Journal of Medical Imaging and Radiation Sciences最新文献

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Preparing for happenstance 为突发事件做准备
IF 1.3
Journal of Medical Imaging and Radiation Sciences Pub Date : 2025-06-05 DOI: 10.1016/j.jmir.2025.101990
Jennifer Carey
{"title":"Preparing for happenstance","authors":"Jennifer Carey","doi":"10.1016/j.jmir.2025.101990","DOIUrl":"10.1016/j.jmir.2025.101990","url":null,"abstract":"","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":"56 5","pages":"Article 101990"},"PeriodicalIF":1.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to “Letter to the Editor on: “Radiographers’ knowledge, clinical expertise and application of pain management strategies in the radiology department: Results from a qualitative focus group” 对“致编者信:放射科放射技师的知识、临床专长和疼痛管理策略的应用:定性焦点小组的结果”的回应
IF 1.3
Journal of Medical Imaging and Radiation Sciences Pub Date : 2025-06-02 DOI: 10.1016/j.jmir.2025.101993
Mohmmad Rawashdeh , Mark F. McEntee , Daniah Kashabash , Andrew England
{"title":"Response to “Letter to the Editor on: “Radiographers’ knowledge, clinical expertise and application of pain management strategies in the radiology department: Results from a qualitative focus group”","authors":"Mohmmad Rawashdeh , Mark F. McEntee , Daniah Kashabash , Andrew England","doi":"10.1016/j.jmir.2025.101993","DOIUrl":"10.1016/j.jmir.2025.101993","url":null,"abstract":"","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":"56 5","pages":"Article 101993"},"PeriodicalIF":1.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Footsteps in fresh snow: A narrative of radiation therapy, purpose, and living “determified” 新雪中的脚步:关于放射治疗、目的和“坚定”生活的叙述
IF 1.3
Journal of Medical Imaging and Radiation Sciences Pub Date : 2025-05-23 DOI: 10.1016/j.jmir.2025.101978
Mikki Campbell
{"title":"Footsteps in fresh snow: A narrative of radiation therapy, purpose, and living “determified”","authors":"Mikki Campbell","doi":"10.1016/j.jmir.2025.101978","DOIUrl":"10.1016/j.jmir.2025.101978","url":null,"abstract":"","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":"56 5","pages":"Article 101978"},"PeriodicalIF":1.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect to dose and diagnostic quality of limiting source-to-image distance on anterior-posterior semi-erect adult chest X-rays 限制源像距离对成人前后半直立胸部x线片剂量和诊断质量的影响
IF 1.3
Journal of Medical Imaging and Radiation Sciences Pub Date : 2025-05-17 DOI: 10.1016/j.jmir.2025.101986
A. Fitzgerald , P. Lockwood
{"title":"The effect to dose and diagnostic quality of limiting source-to-image distance on anterior-posterior semi-erect adult chest X-rays","authors":"A. Fitzgerald ,&nbsp;P. Lockwood","doi":"10.1016/j.jmir.2025.101986","DOIUrl":"10.1016/j.jmir.2025.101986","url":null,"abstract":"<div><h3>Introduction</h3><div>Mobile chest X-rays (CXR) examinations are requested for clinically unstable inpatients who cannot be transported to the radiology department. These examinations often have limitations, such as reduced source-to-image distance (SID) in anterior-posterior (AP) position due to limited space in ward environments. This study aimed to investigate the effect of entrance skin dose (ESD) and the diagnostic image quality of reduced SID from the standard 180cm to 150cm and 100cm on semi-erect AP CXRs.</div></div><div><h3>Method</h3><div>A human tissue equivalent Alderson Rando phantom was positioned in a hospital bed at an AP semi-erect 45-degree angle. Three exposures were taken for each SID; the dose was recorded with an Ion Chamber attached to the anterior chest wall to record the ESD and the dose area product (DAP). The mean dose from the three SID positions was compared using a t-test. Image quality was assessed using Image Quality Score (IQS) and RadLex criteria for diagnostic quality using Analysis of Variance (ANOVA).</div></div><div><h3>Results</h3><div>A linear response of decreasing the SID resulted in a 40.1 % increase in ESD (53.7 μGy; <em>p</em> = &lt; 0.001) from 180 cm to 150 cm SID and a 121.5 % increase (329.9 μGy; <em>p</em> = &lt; 0.001) from 180 cm to 100 cm SID. There was also a decrease in image quality from 180 cm to 100 cm SID (IQS <em>p</em> = 0.03), with 100 cm scoring poor against lower lung field visual reproduction and limited diagnostic quality on RadLex.</div></div><div><h3>Conclusion</h3><div>The findings demonstrate that in controlled X-ray settings, the ESD is increased when the SID is reduced from 180cm to 150cm SID (40.1 %) and to 100cm SID (121.5 %), which furthermore decreases image quality (<em>p</em> = 0.03) and the diagnostic value of the image. It is recommended that radiographers maintain the standard 180 cm SID during adult inpatient semi-erect AP CXR examinations to maintain as low as reasonably practicable (ALARP) diagnostic X-ray examinations.</div></div>","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":"56 4","pages":"Article 101986"},"PeriodicalIF":1.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global trends in radiography research: A bibliometric study of three key journals 放射学研究的全球趋势:三个关键期刊的文献计量学研究
IF 1.3
Journal of Medical Imaging and Radiation Sciences Pub Date : 2025-05-13 DOI: 10.1016/j.jmir.2025.101960
Siddig Ibrahim Abdelwahab , Manal Mohamed Elhassan Taha , Abdullah Farasani , Saleh M. Abdullah , Jobran M. Moshi , Abrar Fahad Alshahrani , Nizar A. Khamjan , Zenat A. Khired , Ahmad Assiri , Ali Mohammed Alqassmi , Amal Mayudh Alhusayni , Ibrahim Abdel Aziz Ibrahim , Saeed Alshahrani , Waseem Hassan
{"title":"Global trends in radiography research: A bibliometric study of three key journals","authors":"Siddig Ibrahim Abdelwahab ,&nbsp;Manal Mohamed Elhassan Taha ,&nbsp;Abdullah Farasani ,&nbsp;Saleh M. Abdullah ,&nbsp;Jobran M. Moshi ,&nbsp;Abrar Fahad Alshahrani ,&nbsp;Nizar A. Khamjan ,&nbsp;Zenat A. Khired ,&nbsp;Ahmad Assiri ,&nbsp;Ali Mohammed Alqassmi ,&nbsp;Amal Mayudh Alhusayni ,&nbsp;Ibrahim Abdel Aziz Ibrahim ,&nbsp;Saeed Alshahrani ,&nbsp;Waseem Hassan","doi":"10.1016/j.jmir.2025.101960","DOIUrl":"10.1016/j.jmir.2025.101960","url":null,"abstract":"<div><div>Previous bibliometric studies of radiography journals have been limited in scope, covering selective time periods such as 1997–2011, 2013–2022, or 2004–2011, and analyzing relatively small datasets ranging from 706 to 1,830 articles with a few limitations. The present study examined 3,875 papers published in <em>Radiography, Journal of Medical Imaging and Radiation Sciences</em>, and <em>Journal of Medical Radiation Sciences</em> since their inclusion in the Scopus database.</div><div>Quantitative bibliometric indicators, including publication counts, citation performance, and mean citations per article/year, were computed using the Bibliometrix package in R Studio. Co-authorship and institutional collaboration networks were visualized using VOSviewer. Keyword co-occurrence analysis was also conducted to identify dominant research areas and trace their evolution over time.</div><div>Findings revealed a substantial rise in research output, increasing from 15 publications in 1995 to 456 in 2024. Citation impact peaked in 2017, with a gradual decline in subsequent years. The most prolific authors included Hogg P., Bolderston A., and Reed W., while the University of Salford, University of Toronto, and University of Sydney emerged as the leading institutions across the three journals. The United Kingdom, Canada, and Australia were dominant contributors, with a notable rise in participation from African and Asian countries. Funding was primarily supported by national health agencies, cancer-focused organizations, and academic institutions.</div><div>Keyword analysis revealed nine major thematic clusters, including diagnostic imaging technologies, oncology, clinical practice, education, patient-centered care, and public health. Importantly, eight highly cited papers (≥100 citations) were identified, many of which contributed significantly to the professionalization of radiography, expanded the role of radiographers in diagnostic reporting, and integrated emerging technologies such as AI and digital imaging—marking key milestones in the field’s development.</div><div>In summary, this study presents the large-scale, journal-inclusive bibliometric profile of radiography research. It offers new insights into global contributions, and collaboration patterns, thus serving as a valuable foundation for shaping future research strategies.</div></div>","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":"56 5","pages":"Article 101960"},"PeriodicalIF":1.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Geometric and dosimetric impact of inter-professional contour variability in the upper abdomen for MR-linac 上腹部不同专业间轮廓变化对MR-linac的几何和剂量学影响
IF 1.3
Journal of Medical Imaging and Radiation Sciences Pub Date : 2025-05-13 DOI: 10.1016/j.jmir.2025.101980
A. Shessel , M. Velec , Z.A. Liu , A. Moreira , J. Dang , A. Hosni , J. Lukovic , R.M. Appleyard , T. Rosewall
{"title":"Geometric and dosimetric impact of inter-professional contour variability in the upper abdomen for MR-linac","authors":"A. Shessel ,&nbsp;M. Velec ,&nbsp;Z.A. Liu ,&nbsp;A. Moreira ,&nbsp;J. Dang ,&nbsp;A. Hosni ,&nbsp;J. Lukovic ,&nbsp;R.M. Appleyard ,&nbsp;T. Rosewall","doi":"10.1016/j.jmir.2025.101980","DOIUrl":"10.1016/j.jmir.2025.101980","url":null,"abstract":"<div><h3>Background and purpose</h3><div>To quantify the geometric accuracy and dosimetric impact of delineation variability for Radiation Therapists (RTs) compared to Radiation Oncologists (ROs) when contouring the organs at risk (OARs) within the upper abdomen on MR imaging.</div></div><div><h3>Materials and methods</h3><div>Eight RT and five RO volunteers contoured six abdominal OARs on MR images for three primary liver cancer cases. The clinical plan was then recalculated, and the study contours were used to generate dose-volume histograms for the OARs. Dice Similarity Coefficient (DSC), Distance to Agreement (DTA) and doses at threshold OAR volumes were used to quantify differences in RT vs. RO contours.</div></div><div><h3>Results</h3><div>RO STAPLE to RT STAPLE comparisons resulted in DSC ≥0.7 for each patient and each organ. The median DTA surface differences between the RO STAPLE and RT STAPLE were &lt;0.4 cm for all OARs except duodenum and small bowel. The mean dose values for the 8 RT and 5 RO were less than 5 % different in 10/24 OAR volumes. RT contours resulted in mean differences &gt;5 % hotter than RO contours in 7 OAR volumes, and &gt;5 % colder in 7 OAR volumes. Colder OAR volumes were found for duodenum, large and small bowel. Only the stomach 5cc mean dose exceeded the threshold dose constraint for both RO and RT contours. Dose differences between RO STAPLE and individual RT contours were not significantly correlated with either DSC or DSC (<em>ρ</em> &lt; 0.404). There were large inter-patient differences in the dosimetric impact of delineation variability.</div></div><div><h3>Conclusions</h3><div>Inter-observer delineation variability of OAR in the upper abdomen can be large for both ROs and RTs. The dosimetric impact of those volumetric differences is moderated by proximity of the OAR to the target and the orientation of the plan dosimetry.</div></div>","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":"56 5","pages":"Article 101980"},"PeriodicalIF":1.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Which has more influence on dose distribution for whole neck radiation therapy, daily neck volume change, or residual setup errors? 哪一个对全颈部放射治疗的剂量分布影响更大,每日颈部体积变化,还是残余设置误差?
IF 1.3
Journal of Medical Imaging and Radiation Sciences Pub Date : 2025-05-11 DOI: 10.1016/j.jmir.2025.101968
Yuki Aoyama, Tetsuya Tomida, Shogo Tsunemine, Susumu Nagata
{"title":"Which has more influence on dose distribution for whole neck radiation therapy, daily neck volume change, or residual setup errors?","authors":"Yuki Aoyama,&nbsp;Tetsuya Tomida,&nbsp;Shogo Tsunemine,&nbsp;Susumu Nagata","doi":"10.1016/j.jmir.2025.101968","DOIUrl":"10.1016/j.jmir.2025.101968","url":null,"abstract":"<div><h3>Introduction</h3><div>The demand for treatment replanning has been reported in radiation therapy for the head-and-neck region because of changes in the patient’s volume or tumor shape. As the dose calculation for PreciseART<sup>Ⓡ</sup> is automatically determined based on megavoltage computed tomography images, monitoring the impacts of daily volume changes on the dose distribution could help performing the treatment replanning with Re-CT images at most optimal time. However, performing treatment replanning at the optimal timing is difficult unless the factors influencing volume changes or setup errors are determined. Therefore, this study aimed to infer the major influencing factors.</div></div><div><h3>Methods</h3><div>Thirty patients who underwent intensity-modulated radiation therapy in the head-and-neck region at Shizuoka Cancer Center were enrolled in this study. The differences in the dose distributions per volume change and setup error were evaluated to obtain correlation coefficients. Volume changes were defined as a change in structure volume for the neck region, and setup errors were defined as uncorrectable differences in the vertebral body positions when images are collated in pitch, yaw (i.e., residual setup error), and at shoulder positions.</div></div><div><h3>Results</h3><div>The highest correlation value coefficient indicates the volume change with −0.71 for D95%_CTV, followed by −0.68 for Dmean_CTV, and −0.63 for Dmean_PTV. The correlation between the radiation dose and setup errors was lower than between volume change and radiation dose.</div></div><div><h3>Conclusion</h3><div>Based on our findings, neck volume change has a greater impact on dose distribution compared to residual setup errors.</div></div>","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":"56 5","pages":"Article 101968"},"PeriodicalIF":1.3,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Professional growth, partnership, and the power of advocacy 专业成长,伙伴关系,以及倡导的力量
IF 1.3
Journal of Medical Imaging and Radiation Sciences Pub Date : 2025-05-10 DOI: 10.1016/j.jmir.2025.101976
Maria Dimopoulos , Samantha Skubish
{"title":"Professional growth, partnership, and the power of advocacy","authors":"Maria Dimopoulos ,&nbsp;Samantha Skubish","doi":"10.1016/j.jmir.2025.101976","DOIUrl":"10.1016/j.jmir.2025.101976","url":null,"abstract":"","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":"56 5","pages":"Article 101976"},"PeriodicalIF":1.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of debriefing in supporting, retaining, and educating radiography students: An exploratory narrative review 汇报在支持、保留和教育放射学学生中的作用:一项探索性的叙述回顾
IF 1.3
Journal of Medical Imaging and Radiation Sciences Pub Date : 2025-05-09 DOI: 10.1016/j.jmir.2025.101971
Mark Ngo , Emily Skelton , Benard Ohene-Botwe , Stamatia Papathanasiou , Cletus Amedu , Liam Mannion , Shafq Ahmed , Caroline Vince , David Stuart , Claire Richards , Leah Untisz-Sly , Judy Brook , Emma Hyde , Chris O’Sullivan , Christina Malamateniou
{"title":"The role of debriefing in supporting, retaining, and educating radiography students: An exploratory narrative review","authors":"Mark Ngo ,&nbsp;Emily Skelton ,&nbsp;Benard Ohene-Botwe ,&nbsp;Stamatia Papathanasiou ,&nbsp;Cletus Amedu ,&nbsp;Liam Mannion ,&nbsp;Shafq Ahmed ,&nbsp;Caroline Vince ,&nbsp;David Stuart ,&nbsp;Claire Richards ,&nbsp;Leah Untisz-Sly ,&nbsp;Judy Brook ,&nbsp;Emma Hyde ,&nbsp;Chris O’Sullivan ,&nbsp;Christina Malamateniou","doi":"10.1016/j.jmir.2025.101971","DOIUrl":"10.1016/j.jmir.2025.101971","url":null,"abstract":"<div><h3>Introduction</h3><div>Clinical placements are essential for the development of practical and professional skills for radiography students. However, they can also be a substantial source of stress. The shift from theoretical learning within the safety of the classroom environment to the unforeseen realities of clinical practice can be challenging. This narrative review aims to explore the role of debriefing in the context of simulation-based education (SBE) and clinical debriefing (CD), highlighting their relevance in supporting, retaining, and educating radiography students by improving their experiences during clinical placements.</div></div><div><h3>Method</h3><div>The literature search utilised databases including PubMed, Scopus, Cochrane Library, CINAHL, and MEDLINE. Key search terms included radiography, student, debriefing, resilience, retention, support, and emotional well-being. Due to limited radiography-specific research, the search was expanded to include broader healthcare literature, prioritising papers from the past decade.</div></div><div><h3>Results</h3><div>Debriefing following SBE allows students to process emotions, reactions, and mentally prepare for similar situations in clinical placements. Incorporating SBE debriefing into radiography programmes may help familiarise students with the structure and purpose of debriefs. The benefits of CD in radiography are not as well studied or established. Broader research from other health professions highlights the potential of CD to promote resilience and support the emotional and psychological well-being of individuals. Routine CD can provide a supportive, safe space for reflections and to express emotions. Prompted CD, performed after challenging events, should be conducted in a psychologically safe environment by well-trained facilitators. Where multiple students are involved, group debriefing may be more effective than individual sessions. Facilitators should create a safe space for emotional expression, avoid pressuring students to disclose detailed accounts of the traumatic experience, and provide follow-up support where necessary.</div></div><div><h3>Conclusion</h3><div>Establishing debriefing frameworks to the unique challenges faced by radiography professionals could better equip students to navigate the emotional demands of clinical placements. Future research could explore radiography students' and educators' perspectives on clinical debriefing, and evaluate the feasibility and effectiveness of specific debriefing models to support students before, during, and after practice placements. This knowledge can inform the development of formal guidelines to better educate and retain radiography students.</div></div>","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":"56 5","pages":"Article 101971"},"PeriodicalIF":1.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Phase I-II Dose Escalation Study of Stereotactic Body Radiation Therapy for Breast Cancer 立体定向放射治疗乳腺癌的I-II期剂量递增研究
IF 1.3
Journal of Medical Imaging and Radiation Sciences Pub Date : 2025-05-01 DOI: 10.1016/j.jmir.2025.101931
Danny Vesprini , Daniel Palhares , Merrylee McGuffin , Sandi Bosnic , Dylan Breitkreutz , Hanbo Chen , Ezra Hahn , Irene Karam , Claire McCann , Hany Soliman , Eileen Rakovitch , Justin Lee
{"title":"A Phase I-II Dose Escalation Study of Stereotactic Body Radiation Therapy for Breast Cancer","authors":"Danny Vesprini ,&nbsp;Daniel Palhares ,&nbsp;Merrylee McGuffin ,&nbsp;Sandi Bosnic ,&nbsp;Dylan Breitkreutz ,&nbsp;Hanbo Chen ,&nbsp;Ezra Hahn ,&nbsp;Irene Karam ,&nbsp;Claire McCann ,&nbsp;Hany Soliman ,&nbsp;Eileen Rakovitch ,&nbsp;Justin Lee","doi":"10.1016/j.jmir.2025.101931","DOIUrl":"10.1016/j.jmir.2025.101931","url":null,"abstract":"<div><h3>Purpose/Aim</h3><div>Assess the maximum tolerated dose and acute toxicities of stereotactic ablative body radiotherapy (SABR) for intact breast cancer to help inform a clinically acceptable dose for future randomized trials.</div></div><div><h3>Methods/Process</h3><div>This prospective Phase I-II dose escalation trial enrolled breast cancer patients who declined or were not candidates for surgery (medically inoperable, unresectable, metastatic) and were deemed appropriate for breast SABR as a primary treatment modality. Eligible patients had cT1-T4 unifocal tumours, were N0-N2, and had M0 or M1 disease. Radiation was delivered twice weekly using VMAT. There were 4 dose levels (DL; 36, 40, 44 and 48Gy in 4 fractions). Acute toxicity was recorded and monitored for up to 12 weeks post treatment. According to the stopping rule, if more than 2 patients experienced grade 3 or higher toxicity within 12 weeks post treatment (excluding grade 3 skin toxicity) at a specified DL, all remaining patients would have been treated at the last tolerated dose, otherwise accrual would proceed to the next DL. Acute toxicities including desquamation, erythema, edema and pain as per CTCAE version 4.03 were assessed weekly during treatment and then 2-3 weeks, 6 weeks and 12 weeks post treatment.</div></div><div><h3>Results or Benefits/Challenges</h3><div>Twenty-four patients were accrued with 6 treated in each DL. The majority of patients had cT1/2 tumours (n = 23), 1 had a cT3 tumour, 4 had nodal involvement (N1 = 4) and 3 patients had M1 disease. The acute toxicity stopping rule was not met at any DL. No patient experienced grade 3 toxicity in any domain and no patients experienced grade 2 desquamation. Five patients experienced grade 1 (dry) desquamation within 12 weeks of treatment (36 Gy, n = 1; 40 Gy, n = 1; 48 Gy, n = 3). One patient (36Gy DL) experienced grade 2 erythema. There were no patients with grade 2 toxicity in any of the other domains.</div></div><div><h3>Conclusions/Impact</h3><div>This dose escalation study using SABR as primary therapy for intact breast cancers showed very low acute toxicity despite delivering ablative doses (up to BED = 105Gy10). Based on the toxicity reported here and assuming that dose-escalation provides better local control, this study suggests that the highest DL used, 48Gy in 4 fractions, is a suitable option for future clinical trials exploring primary radiotherapy for breast cancer. Long term outcomes, including QoL questionnaires and VAS pain scale will be reported once the data is mature, which will be essential to confirm these preliminary safety results.</div></div>","PeriodicalId":46420,"journal":{"name":"Journal of Medical Imaging and Radiation Sciences","volume":"56 1","pages":"Article 101931"},"PeriodicalIF":1.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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