Journal of Applied Laboratory Medicine最新文献_第2页

Revisiting Chromosomal Translocations: Insights From Healthy Individuals and Lymphoma.

IF 1.8

Journal of Applied Laboratory Medicine Pub Date : 2025-03-27 DOI: 10.1093/jalm/jfaf031

Sulaf Farhat Maghrabi, Zeina N Al-Mahayri, Fawza Monem

引用次数: 0

Use of Reference Change Values When Only 2 Analytical Results Are Known.

IF 1.8

Journal of Applied Laboratory Medicine Pub Date : 2025-03-27 DOI: 10.1093/jalm/jfaf033

Arne Åsberg, Gustav Mikkelsen

引用次数: 0

Volumetric Absorptive Microsampling Combined with Mass Spectrometry to Support Pharmacokinetically-Guided Precision Dosing of Mycophenolate Mofetil in Pediatric Lupus Nephritis Patients.

IF 1.8

Journal of Applied Laboratory Medicine Pub Date : 2025-03-26 DOI: 10.1093/jalm/jfaf022

Junfang Zhao, Xueheng Zhao, Tomoyuki Mizuno, Kei Irie, Prasad Devarajan, Hermine I Brunner, Kenneth D R Setchell

{"title":"Volumetric Absorptive Microsampling Combined with Mass Spectrometry to Support Pharmacokinetically-Guided Precision Dosing of Mycophenolate Mofetil in Pediatric Lupus Nephritis Patients.","authors":"Junfang Zhao, Xueheng Zhao, Tomoyuki Mizuno, Kei Irie, Prasad Devarajan, Hermine I Brunner, Kenneth D R Setchell","doi":"10.1093/jalm/jfaf022","DOIUrl":"https://doi.org/10.1093/jalm/jfaf022","url":null,"abstract":"Background: The immunosuppressant mycophenolate mofetil (MMF) is used off-label in patients with systemic lupus erythematosus (SLE) although the optimum dosing regimen is not well established. This study evaluated the use of volumetric absorptive microsampling (VAMS) for capillary whole blood collected by finger-prick, combined with tandem mass spectrometry and limited timepoint sampling to determine concentrations of mycophenolic acid (MPA) and its glucuronide conjugate, MPA-7-O-glucuronide (MPAG) in SLE patients. This approach permitted pharmacokinetically guided optimized dosing of MPA.Methods: Blood was collected by finger-prick and venipuncture from patients (n = 10) at trough, 30, and 120 min postdosing with MMF. MPA/MPAG concentrations were assayed from dried VAMS devices by stable-isotope dilution LC-MS-MS and compared to MPA/MPAG concentrations measured in plasma by high performance liquid chromatography after adjusting for hematocrit.Results: There was no significant difference between MPA concentrations from VAMS-collected dried capillary blood hematocrit-adjusted and those for plasma. The area under the concentration-time curve (AUC) estimated from plasma equivalent concentrations converted from capillary VAMS results correlated well with the AUC estimated from plasma concentrations (R2 = 0.97).Conclusions: The plasma pharmacokinetics of MMF metabolites can be reliably estimated from concentrations in capillary blood using VAMS devices and only 3 timed collections. Sampling whole blood by finger-prick, a less invasive approach for patients, coupled with the specificity of LC-MS/MS can be accurately used as an alternative to plasma sampling to establish the optimal dosing regimen of MMF for patients with SLE based on dried blood samples.","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143711439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on Can Hemoglobin A1c Be Greater Than 100%? A Case of Homozygous Hemoglobin J-Iran.

IF 1.8

Journal of Applied Laboratory Medicine Pub Date : 2025-03-25 DOI: 10.1093/jalm/jfaf020

Sharon M Geaghan

引用次数: 0

The 2024 PhD Board-Certified Clinical Chemist Compensation Survey. 2024 年博士学位委员会认证临床化学家薪酬调查。

IF 1.8

Journal of Applied Laboratory Medicine Pub Date : 2025-03-24 DOI: 10.1093/jalm/jfaf017

Jaime H Noguez, Anna E Merrill, Adam J McShane, Yachana Kataria

{"title":"The 2024 PhD Board-Certified Clinical Chemist Compensation Survey.","authors":"Jaime H Noguez, Anna E Merrill, Adam J McShane, Yachana Kataria","doi":"10.1093/jalm/jfaf017","DOIUrl":"https://doi.org/10.1093/jalm/jfaf017","url":null,"abstract":"Background: Board-certified clinical chemists with doctor of philosophy (PhD) degrees are essential to laboratory medicine and healthcare, yet comprehensive data on their total compensation is limited. The Association for Diagnostics & Laboratory Medicine (ADLM, formerly AACC) Society for Young Clinical Laboratorians Core Committee conducted its fifth compensation survey in April 2024, providing updated data on salary, benefits, and job satisfaction among board-certified clinical chemists.Methods: The 2024 compensation survey was distributed to all doctoral-level ADLM members based in the United States and Canada (n = 1576). Confidential, self-reported data were collected from respondents on various demographic and professional characteristics, including academic degree, board certification, years of experience, employment sector, total compensation (defined as base salary plus bonus), geographic location, race/ethnicity, and sex. The study included a total of 291 respondents for analysis.Results: Ninety-two percent (n = 267) of the respondents resided in the United States and 90% held a PhD degree. More than half of the respondents were employed in academic, hospital, or healthcare system settings. Among those with board certification, 86% were certified by the American Board of Clinical Chemistry (ABCC). The median total compensation for ABCC board-certified PhD clinical chemists working in the United States (n = 158) was $220 000 to $229 000.Conclusions: The 2024 survey highlights a continued upward trend in compensation for board-certified PhD clinical chemists, reflecting their expertise and contributions to healthcare. This report serves as a critical resource for professionals to advocate for equitable and competitive compensation as well as benefits that support career advancement and development.","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Sodium Fluctuation in Altered Consciousness: A Puzzle or a Key to Diagnosis?

IF 1.8

Journal of Applied Laboratory Medicine Pub Date : 2025-03-21 DOI: 10.1093/jalm/jfae165

Suet Ying Woon, Subashini C Thambiah, Hanisah Abdul Hamid, Intan Nureslyna Samsudin, Yin Ye Lai

引用次数: 0

Commentary on Acute Sodium Fluctuation in Altered Consciousness: A Puzzle or a Key to Diagnosis?

IF 1.8

Journal of Applied Laboratory Medicine Pub Date : 2025-03-21 DOI: 10.1093/jalm/jfaf016

Sharon M Geaghan

引用次数: 0

An Unexpected Cause of Rhabdomyolysis.

IF 1.8

Journal of Applied Laboratory Medicine Pub Date : 2025-03-20 DOI: 10.1093/jalm/jfae168

Manon Robert, Justine Blin, Alizée Violin, Kalyane Bach-Ngohou, Damien Masson

引用次数: 0

Commentary on An Unexpected Cause of Rhabdomyolysis.

IF 1.8

Journal of Applied Laboratory Medicine Pub Date : 2025-03-20 DOI: 10.1093/jalm/jfaf019

Jessica M Colón-Franco

引用次数: 0

Evaluation of a Fluorescence Immunoassay for Detection of Clostridioides difficile Glutamate Dehydrogenase and Toxin Antigens.

IF 1.8

Journal of Applied Laboratory Medicine Pub Date : 2025-03-19 DOI: 10.1093/jalm/jfaf010

Elizabeth M Garrett, Meng Pu, April M Bobenchik

{"title":"Evaluation of a Fluorescence Immunoassay for Detection of Clostridioides difficile Glutamate Dehydrogenase and Toxin Antigens.","authors":"Elizabeth M Garrett, Meng Pu, April M Bobenchik","doi":"10.1093/jalm/jfaf010","DOIUrl":"https://doi.org/10.1093/jalm/jfaf010","url":null,"abstract":"Background: Clostridioides difficile infection (CDI) is a leading cause of nosocomial infections in the United States, causing longer hospital stays, significant morbidity, and increased healthcare costs. Accurate CDI diagnosis is essential for timely treatment and infection control. Laboratory diagnosis of CDI commonly involves the detection of glutamate dehydrogenase (GDH) and/or toxins A and B by immunoassays or the toxin genes by nucleic acid amplification. This study assesses the performance of a new commercial test, the Sofia® 2 C. difficile Fluorescent Immunoassay (Sofia 2; FIA; QuidelOrtho), for detecting C. difficile GDH and toxins.Methods: Sofia 2 was compared to enzyme immunoassays (EIAs) C. diff Quik Chek Complete (Techlab Inc.) and Immunocard (Meridian Bioscience) using remnant stool samples from 262 patients with suspected CDI.Results: Sofia 2 demonstrated high agreement with the EIA methods for GDH (positive percentage agreement (PPA): 100%, negative percentage agreement (NPA): 94%, overall percentage of agreement (OPA): 95%) and toxins (PPA: 100%, NPA: 99%, OPA: 99%) detection. Compared to standard-of-care (SOC) testing including toxin gene PCR with the following toxin antigen test, Sofia 2 demonstrates strong PPA (100%), NPA (98%), positive predictive value (71%), and negative predictive value (100%).Conclusions: Sofia 2 C. difficile FIA generates rapid results that are comparable to other commercial immunoassays with a simple workflow, supporting its use for CDI diagnosis in clinical practice.","PeriodicalId":46361,"journal":{"name":"Journal of Applied Laboratory Medicine","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0