Egyptian Journal of Chest Diseases and Tuberculosis最新文献

{"title":"Effect of hypofractionated radiotherapy on lung functions in breast cancer patients","authors":"Enass Rezk, Aya Abdeldayem, A. Farag, H. Abdelhamid","doi":"10.4103/ecdt.ecdt_20_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_20_22","url":null,"abstract":"Background Adjuvant hypofractionated radiotherapy (RT) used in the management of breast cancer cases, although reduce time and cost, may have serious effects due to the increased dose of radiation. Radiation-induced lung injury is an important side effect of thoracic radiation. Aim In our study, patients assessed by spirometry to detect acute changes in lung functions resulted from radiation exposure during the treatment of breast cancer. Patients and methods In this prospective study, 31 patients with breast cancer, who received adjuvant RT in Ain Shams University Hospitals, were assessed by spirometry before and 8 weeks after the end of RT. Radiation pneumonitis (RP) was graded using the Common Terminology Criteria for Adverse Events, version 5. Pulmonary function was evaluated by spirometry before and 8 weeks after finishing RT to detect changes in forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC ratio, forced expiratory flow at 25–75% of FVC (FEF25%–75%), and FEF50% of . Results Five (16.1%) patients developed symptomatic RP. Significant reduction was noticed in FVC and FEV1, while FEV1/FVC ratio, FEF25%–75%, and FEF50% were not significantly affected. It was also observed that FEV1 was sensitive in anticipating RP. Conclusion Spirometry parameters, FEV1 and FVC, significantly decreased after 8 weeks of RT ending, without significant decrease in other parameters, favoring restrictive lung injury pattern. Since most cancer breast patients who developed RP were asymptomatic, spirometry was found to be beneficial in identifying patients with risk of radiation-induced lung injury (RP).","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"151 1","pages":"75 - 79"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77766563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endobronchial inflammatory polyps: A rare clinical entity","authors":"Sharad Joshi, Nitesh Tayal, Rajesh Gupta, Ankit Bhatia","doi":"10.4103/ecdt.ecdt_60_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_60_22","url":null,"abstract":"Endobronchial inflammatory polyps are one of the rarest benign bronchial tumors. Tumors of benign etiology are even rare. Inflammatory bronchial polyps are frequently solitary although rarely can be multifocal. We are presenting a rare case of multiple endobronchial inflammatory polyps presenting as pneumonia.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"36 1","pages":"134 - 137"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80951157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV-related pulmonary manifestations among egyptian patients","authors":"Zeinab M. Zaki, Magdy Khalil, K. Wagih, H. Ezzelregal","doi":"10.4103/ecdt.ecdt_45_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_45_22","url":null,"abstract":"Context After description of the new first case of AIDS in 1981, the HIV pandemic expanded very rapidly to become a great global public health problem with wide health, economic, social, and developmental consequences that have not been seen with any other disease. Globally, there have been gains across the HIV testing and treatment cascade. The greatest contributor to the illness and deaths in persons infected with HIV is pulmonary disease. Aims The aim was to study the pattern of respiratory manifestations in HIV-infected patients among a sample of Egyptians. Settings and design A prospective, observational study. Patients and methods This study recruited 121 HIV patients with respiratory system involvement admitted to Abbassia Fever Hospital or Abbassia Chest Hospitals between December 2017 and March 2020. Clinical assessment included demographic data, history of chest symptoms, and comorbidities and local and general examination. Chest imaging was requested/reviewed, and procedures were performed as required. Laboratory assessment included CD4 count, and microbiological examinations of sputum and pleural fluid if found. Statistical analysis used SPSS program (Statistical Package for the Social Sciences) software, version 18.0. Results Of the participants 62 % have been receiving or previously received antiretroviral treatment. Cough was the most frequent symptom in 91.7%. Pleural collection was the most frequent radiological finding on chest radiology in 23% of patients. Tuberculosis was commonly a concomitant infection in 29.7% of patients. CD4 count ranged from 16 to 450 cells/mm3. The diagnosis of PJP and multidrug resistance tuberculosis was highly significantly associated with low CD4 count (P<0.01). Conclusion HIV infection is associated with a wide range of respiratory manifestations with infectious complications representing the majority of them. Low CD4 count, receiving antiretroviral treatment, and the source of HIV infection (sexual or intravenous drug abuse) are documented as risk factors for respiratory involvement in HIV patients.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"48 1","pages":"120 - 129"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75256692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of CD24 as a potential biomarker for malignant pleural mesothelioma","authors":"Mohamed Shaaban Mousa, Ahmed Mamdooh Ghoname, Dalia Abd El-Kareem Ateya, Hamed A H Abdallah, Salwa Hassan Ahmed","doi":"10.4103/ecdt.ecdt_11_23","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_11_23","url":null,"abstract":"Abstract Objectives Pleural mesothelioma is a rapidly progressing pleural neoplasm caused by asbestos exposure of a long latency around 30-40 years. Patients with mesothelioma are usually diagnosed at a late stage with poor outcomes in terms of morbidity and mortality with 6–12 months’ median survival. Despite the prohibited use of asbestos, malignant pleural mesothelioma is still increasingly being occurred in young age and female patients. Different un-standardized biomarkers have been used to diagnose MPM as mesothelin and febulin with controversial results, so we used CD 24 as a biomarker to diagnose and differentiate between different subtypes of malignant pleural mesothelioma. Materials and methods Our cohort study included total of fifty-nine patients with exudative pleural effusion. All patients underwent full history taking, clinical examination, blood tests (CBC, coagulation profile, liver and kidney functions), tapping of pleural effusion and to send pleural fluid investigations for LDH, albumin, total protein and albumin, then confirmed exudative pleural effusion patients were subjected to thoracic ultrasonography and medical thoracoscopy for the majority of cases or ultrasound guided biopsy in selected cases to obtain pleural biopsies for histopathology and then the examination of pleural biopsies for CD24 expression. Results Our study demonstrated the possibility of using CD24 as a biomarker in the immunostaining of pleural biopsies to differentiate between malignant pleural mesothelioma and pleural malignancy other than mesothelioma (18 mesothelioma cases versus 2 nonmesothelioma malignant cases) with high statistical significance P value < 0.001 and also it can discriminate between subtypes of mesothelioma as it showed marked significance in epithelioid subtype (12 epithelioid versus 1 sarcomatoid versus 5 biphasic subtypes) with more uptake by score +2 in epithelioid mesothelioma. Conclusions CD24 can be supposed to be a routine biomarker for immunohistochemistry of pleural tissue samples in diagnosis of mesothelioma and it can be used to differentiate between subtypes of malignant mesothelioma subtypes.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of thrombocytopenia in coronavirus disease patients in comparison with patients with normal platelet count","authors":"Gehan M Elassal, Mahmoud M Mahmoud, Dina E Aly","doi":"10.4103/ecdt.ecdt_121_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_121_22","url":null,"abstract":"Abstract Background Known as severe acute respiratory syndrome coronavirus 2, the severe acute respiratory syndrome coronavirus is a new coronavirus illness [coronavirus disease-2019 (COVID-19)], it spreads quickly over the world. Patients with COVID-19 frequently have changes in platelet count. The platelet count is a highly useful clinical tool for tracking patients with aggressive viral infections who have rapidly changing health conditions since it is a sensitive indicator of sickness severity. Aim To study thrombocytopenia as a prognostic factor in COVID-19 patients and its relation with the length of hospital stay and prognosis. Patients and methods A total of 60 COVID-19 patients were involved in the prospective study during the period from June 2020 to December 2020 who were admitted to the isolation hospital, Ain Shams University Hospitals. Then for each patient, complete blood count at admission was done, repeated on day 7, day 14, and day 21. Patients were followed regarding the length of hospital stay and mortality. Results Out of 60 patients, 10 (16.6%) patients were thrombocytopenic. The length of hospital stay was significantly higher in a thrombocytopenic group. There was a high statistically significant difference between the normal platelets count group and the thrombocytopenic groups regarding outcome ( P <0.001). In thrombocytopenic patients, five (50%) showed deterioration, four (40%) patients died and one patient in this group showed complete recovery. Conclusion Thrombocytopenia is associated with increased length of hospital stay and poor prognosis in patients with COVID-19.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"2022 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical and functional profile of ICU patients and correlation between functional scales (Physical function in ICU test – scored PFIT)","authors":"Mohamed A Tageldin, Riham H Raafat, Zeynab Noah","doi":"10.4103/ecdt.ecdt_129_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_129_22","url":null,"abstract":"Abstract Background Each component of the original physical function ICU test (PFIT) had little clinical utility. Given the growing body of research on ICU strength and mobility, objective functional evaluations with great clinical usefulness are needed. Scoring the original PFIT improves clinical utility and research to compare ICU patient function and intervention responsiveness. Aim To evaluate the muscle strength and functional condition of ICU patients and link these procedures to the length of stay at Ain Shams University Hospital and outcome. Patients and methods The research included 40 patients who were admitted to the respiratory ICU either mechanically ventilated or not. Results There was high significant decrease in TLC; there was high significant increase in Hb, albumin, K, and Mg according to two assessment points. Most patients had a score of 3 of shoulder strength and knee strength but score 2 regarding Sit to stand assistance. There was high significant increase in PFIT-s in the second assessment. There was substantial enhancement in the second assessment compared with first assessment regarding different score results. Conclusion Based on the finding we conclude that, prolonged immobility during hospitalization results in loss of muscle strength and functional capacity. There was positive correlation between muscular strength and functional status, considering PFIT scales. The longer length of stay in ICU, the greater the loss of functional capacity in critical patients.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135667898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive ventilation in patients with acute severe asthma: ‘Be Sure, Be vigilant’","authors":"Gopal Chawla, A. Esquinas","doi":"10.4103/ecdt.ecdt_32_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_32_22","url":null,"abstract":"","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"90 1","pages":"130 - 131"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80295665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma prevalence among medical students of jazan university, saudi arabia: A cross-sectional study","authors":"Abdulrahman Hakami, Abuobaida Yassin, Meshal Bajoned, Reem Maashi, Amna Zila, Nuha Dilyh, Samar Dilyh, Fatima Ezzi, Maha Madkhali","doi":"10.4103/ecdt.ecdt_50_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_50_22","url":null,"abstract":"Background Both adults and children experience bronchial asthma, which is the most common chronic respiratory condition. The prevalence of asthma varies widely by geography and age, with its prevalence ranging from 0.2 to 21.0% in adults. However, there are no data on the prevalence of asthma among adults in the Jazan Region, which is located in the southern part of Saudi Arabia. Objective To assess the prevalence of asthma among medical students in Jazan University, Jazan Region of Saudi Arabia. Methods In this cross-sectional study, the prevalence of asthma was determined using a modified and translated International Study of Asthma and Allergies in Childhood questionnaire. Adult students of health-related colleges at Jazan University constituted the target population in the region. Results There were 1210 responders, which included 654 (54.0%) males and 556 (46.0%) females. In total, 761 (62.9%) students (35.3% men) resided in rural areas, whereas 449 (37.1%) students resided in urban areas. Additionally, 20.2% of students experienced life-long wheezing. During the previous 12 months, 218 (18%) and 191 (15.8%) students experienced exercise-induced wheezing and nonexercise-induced wheezing, respectively. Furthermore, 188 (15.5%) students had a medical history of asthma, and the prevalence of asthma did not differ significantly between males and females (P=0.412). A physician confirmed that 13.7% of the participants had asthma. Conclusion Our results demonstrated a high frequency of asthma among the medical students of Jazan University in the Jazan Region. Asthma diagnosis was predicted using an identifiable questionnaire and without using physiological measures and laboratory factors.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"17 1","pages":"25 - 32"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75003047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of coronavirus disease 2019 cases at the isolation department of el-dakhla general hospital","authors":"Mohamed Tageldein, Mahmoud Mohamed, M. Ibrahim","doi":"10.4103/ecdt.ecdt_36_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_36_22","url":null,"abstract":"Background Coronavirus disease 2019 (COVID-19) infection is currently the greatest atypical pneumonia outbreak, causing widespread anxiety and fear. Objectives To study cases with clinical manifestations that have been identified as COVID-19 according to the Egyptian Ministry of Health’s criteria, their management protocol, and outcome data at the isolation department of El-Dakhla General Hospital. Patients and methods This work was performed upon 106 patients with clinical symptoms of COVID-19 at the isolation department of El-Dakhla General Hospital. Results Mortality was associated with older age. No patients within the died group had been vaccinated. Vaccination was significantly associated with decreased severity of chest affection, admission to the ICU, and duration of admission. Mortality was associated with severity of chest affection. All died patients were admitted to the ICU. This study also revealed that abnormal vital and laboratory data were significantly associated with mortality. On using binary regression analysis of factors to be significantly associated with mortality, lower duration of admission and not being admitted to ICU decreased the risk of mortality among the studied patients, yet was statistically nonsignificant (P>0.05), whereas higher C-reactive protein on admission increased the risk by 1.186 folds. Conclusion Age, vaccination state, severity of chest affection, ICU admission and duration, use of some medications, vital data, and laboratory data are important factors to assess the prognosis and severity of COVID infection.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"48 1","pages":"33 - 39"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76198598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impulse oscillometry system as a new diagnostic tool in patients with chronic obstructive pulmonary disease","authors":"Nehal Elzahapy, R. Sharshar, A. Mohamed, W. El-Shimy","doi":"10.4103/ecdt.ecdt_10_22","DOIUrl":"https://doi.org/10.4103/ecdt.ecdt_10_22","url":null,"abstract":"Background Both diagnosis and assessment of chronic obstructive pulmonary disease (COPD) are based mainly on pulmonary-function tests that are of very important significance in COPD. Impulse oscillometry is a noneffort-dependent method to assess the mechanical structure of the respiratory system. Objectives The study aims to evaluate impulse oscillometry system (IOS) as a diagnosis tool of COPD, in a trial to clarify the sensitivity and correlations of IOS parameters with COPD severity. Patients and methods The study included 30 healthy volunteers, group I (control group): 15 smokers, 15 nonsmokers, and 60 patients with COPD, group II: 30 patients with mild-to-moderate COPD, and group III: 30 patients with severe COPD. All participants were sequentially assessed by IOS to detect impedance, after this, spirometry was done, and both were repeated 15–45 min after the first dose of inhalation therapy (salbutamol). IOS is more sensitive in detecting small-airway affection in mild-to-moderate COPD than spirometry. Results In COPD, a significant increase in IOS-resistant parameters (R5, R5–20), reactance parameter (AX), and a decrease in reactance (X5) parameter was observed in two groups of COPD (groups II and III) if compared with control group I. IOS parameters significantly correlated with spirometric parameters, particularly large-airway parameters (R5 correlated with forced expiratory volume in the first second postbronchodilator in group II and group III), small-airway parameters (R5–20, X5, and AX correlated with maximal mid-expiratory flow postbronchodilator in group III). Conclusions IOS is very useful in detecting small-airway affection in mild and moderate COPD and could be done as an alternative to spirometric tests in severe COPD patients with more accurate grading.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":"72 1","pages":"70 - 74"},"PeriodicalIF":0.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80496063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}