脉冲振荡测量系统在慢性阻塞性肺疾病诊断中的应用

IF 0.2 Q4 RESPIRATORY SYSTEM
Nehal Elzahapy, R. Sharshar, A. Mohamed, W. El-Shimy
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引用次数: 0

摘要

背景慢性阻塞性肺疾病(COPD)的诊断和评估主要基于肺功能检查,肺功能检查在COPD中具有非常重要的意义。脉冲振荡法是一种评估呼吸系统机械结构的不费力的方法。目的评价脉冲振荡测量系统(impulse oscillation system, IOS)作为COPD的诊断工具,阐明IOS参数与COPD严重程度的敏感性和相关性。患者和方法本研究包括30名健康志愿者,第一组(对照组):15名吸烟者,15名不吸烟者,60名COPD患者,第二组:30名轻中度COPD患者,第三组:30名重度COPD患者。所有参与者依次进行IOS评估以检测阻抗,之后进行肺活量测定,并在第一剂量吸入治疗(沙丁胺醇)后15-45分钟重复这两项。IOS在检测轻中度COPD小气道影响方面比肺活量测定更敏感。导致慢性阻塞性肺病,显著增加IOS-resistant参数(R5, R5-20),电抗参数(AX),和减少电抗(X5)参数观察两组慢性阻塞性肺病(第二和第三组)与对照组相比i IOS参数与肺量测定的参数显著相关,特别是大气道参数(R5与用力呼气量在第一第二postbronchodilator组II和III), small-airway参数(R5-20 X5,结论IOS可用于检测轻中度COPD患者的小气道影响,可作为重度COPD患者肺活量测定的替代方法,分级更准确。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impulse oscillometry system as a new diagnostic tool in patients with chronic obstructive pulmonary disease
Background Both diagnosis and assessment of chronic obstructive pulmonary disease (COPD) are based mainly on pulmonary-function tests that are of very important significance in COPD. Impulse oscillometry is a noneffort-dependent method to assess the mechanical structure of the respiratory system. Objectives The study aims to evaluate impulse oscillometry system (IOS) as a diagnosis tool of COPD, in a trial to clarify the sensitivity and correlations of IOS parameters with COPD severity. Patients and methods The study included 30 healthy volunteers, group I (control group): 15 smokers, 15 nonsmokers, and 60 patients with COPD, group II: 30 patients with mild-to-moderate COPD, and group III: 30 patients with severe COPD. All participants were sequentially assessed by IOS to detect impedance, after this, spirometry was done, and both were repeated 15–45 min after the first dose of inhalation therapy (salbutamol). IOS is more sensitive in detecting small-airway affection in mild-to-moderate COPD than spirometry. Results In COPD, a significant increase in IOS-resistant parameters (R5, R5–20), reactance parameter (AX), and a decrease in reactance (X5) parameter was observed in two groups of COPD (groups II and III) if compared with control group I. IOS parameters significantly correlated with spirometric parameters, particularly large-airway parameters (R5 correlated with forced expiratory volume in the first second postbronchodilator in group II and group III), small-airway parameters (R5–20, X5, and AX correlated with maximal mid-expiratory flow postbronchodilator in group III). Conclusions IOS is very useful in detecting small-airway affection in mild and moderate COPD and could be done as an alternative to spirometric tests in severe COPD patients with more accurate grading.
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来源期刊
自引率
0.00%
发文量
46
审稿时长
22 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.
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