Journal of Clinical and Translational Endocrinology最新文献

{"title":"Decreased insulin dose-adjusted hemoglobin A1c in adults with cystic fibrosis-related diabetes treated with elexacaftor-tezacaftor-ivacaftor","authors":"Espérie Burnet ,&nbsp;Deborah Grunewald ,&nbsp;Etienne Larger ,&nbsp;Florence Camus-Bablon ,&nbsp;Catherine Eisenhauer ,&nbsp;François Mifsud ,&nbsp;Clémence Martin ,&nbsp;Isabelle Honoré ,&nbsp;Reem Kanaan ,&nbsp;Nicolas Carlier ,&nbsp;Johanna Fesenbeckh ,&nbsp;Helen Mosnier-Pudar ,&nbsp;Pierre-Régis Burgel","doi":"10.1016/j.jcte.2025.100407","DOIUrl":"10.1016/j.jcte.2025.100407","url":null,"abstract":"<div><h3>Background</h3><div>Elexacaftor-tezacaftor-ivacaftor (ETI) became available for adults with cystic fibrosis (CF) in 2019, but its impact on CF-related diabetes (CFRD) remains unclear.</div></div><div><h3>Methods</h3><div>A single-center retrospective cohort study was conducted among adults with CFRD to examine the change in insulin dose-adjusted Hemoglobin A1c (IDAA1c). Linear mixed effects model (LMEM) analysis was used to investigate the change in IDAA1c between baseline and 24 months of follow up, comparing an ETI-treated group to an unexposed group. Baseline values were those documented at treatment initiation for the ETI-treated group and in March 2020 (±3 months) for the unexposed group.</div></div><div><h3>Results</h3><div>A total of 49 adults were included, 39 were treated with ETI and 10 were not. Median [Interquartile range] time since CFRD diagnosis at baseline was 13 [7–18] and 14 [10–18] years, respectively (p = 0.610). In the ETI-treated group, mean weight increased by a 4.44 kg (95 % Confidence Interval, 95 %CI: 3.08 to 5.79, p &lt; 0.001), insulin total daily dose decreased by 5 units (95 %CI: −9 to 0, p = 0.033), and hemoglobin A1c (%) decreased by 0.65 points (95 %CI: −0.96 to −0.34, p &lt; 0.001). No change was observed in the unexposed group. LMEM analysis found a numerically significant association between ETI and decreased IDAA1c, estimated at −1.14 points (95 %CI: −2.35 to 0.06, p = 0.067) after adjusting for age, sex, time since CFRD diagnosis and the introduction of Metformin.</div></div><div><h3>Conclusion</h3><div>A numerically significant association between ETI and IDAA1c decrease was observed in adults with established CFRD after 24 months of treatment, suggesting ETI contributed to improved glycemic control.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"41 ","pages":"Article 100407"},"PeriodicalIF":4.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell division cycle 20 promotes tumor progression and predicts poor clinical outcome in childhood and adult adrenocortical carcinoma","authors":"Jiahong Chen ,&nbsp;Peisheng Huang ,&nbsp;Yongcheng Shi ,&nbsp;Shanshan Mo ,&nbsp;Cheng-Ya Hsu ,&nbsp;Shumin Fang ,&nbsp;Chuanfan Zhong ,&nbsp;Le Zhang ,&nbsp;Lanting Zuo ,&nbsp;Jianming Lu ,&nbsp;Weide Zhong ,&nbsp;Zhuoya Huang ,&nbsp;Zhong Dong","doi":"10.1016/j.jcte.2025.100406","DOIUrl":"10.1016/j.jcte.2025.100406","url":null,"abstract":"<div><h3>Background</h3><div>Adrenocortical carcinoma (ACC) is an uncommon and highly aggressive tumor with a grim prognosis. Numerous investigations have elucidated a close association between the dysregulated expression of multiple genes within tumors and the initiation as well as progression of neoplasms. These dysregulated genes not only exert pivotal roles in tumorigenesis but also harbor significant potential as prognostic biomarkers.</div></div><div><h3>Methods</h3><div>This study utilized transcriptomic data from public databases of ACC and normal tissue samples to screen for differentially expressed genes (DEGs). Subsequently, univariate Cox regression and receiver operating characteristic (ROC) curve were employed to identify potential prognostic biomarkers for ACC. Immunohistochemistry and in vitro cell experiments were conducted to validate the expression and potential functions of Cell division cycle 20 (CDC20) in ACC cells. Additionally, we analyzed the relationship between CDC20 and CD8+ T cells, immunotherapy response, somatic mutations, and copy number variations.</div></div><div><h3>Results</h3><div>CDC20 has emerged as an independent adverse prognostic factor in ACC, with significantly elevated expression levels. In vitro cell experiments have demonstrated that downregulation of CDC20 expression suppresses proliferation and migration of ACC cells. Notably, our study has identified CDC20 expression as most closely associated with TP53 mutation. Additionally, CDC20 expression levels exhibit a negative correlation with infiltration of CD8+ T cells. Patients with low CDC20 expression may show improved response to anti-PD-1 immunotherapy.</div></div><div><h3>Conclusion</h3><div>CDC20 serves as a reliable and robust biomarker in ACC, playing a crucial role in predicting survival outcomes and assessing immunotherapy response in adult and childhood ACC patients.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"41 ","pages":"Article 100406"},"PeriodicalIF":4.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated glucose levels in melanoma patients − a real-world analysis","authors":"Joan Walter ,&nbsp;Bojan Bojanic ,&nbsp;Manuel Dittli ,&nbsp;Nadia Fehr ,&nbsp;Thomas Sartoretti ,&nbsp;Moritz Schwyzer ,&nbsp;Katharina Binz ,&nbsp;Antonio G. Gennari ,&nbsp;Matthias Ernst ,&nbsp;Martin W. Huellner ,&nbsp;Michael Messerli","doi":"10.1016/j.jcte.2025.100405","DOIUrl":"10.1016/j.jcte.2025.100405","url":null,"abstract":"<div><h3>Aim</h3><div>To assess the glycemic status of consecutive melanoma patients undergoing standardized capillary fasting blood glucose (cFBG) assessment prior to fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) examination.</div></div><div><h3>Methods</h3><div>This retrospective study included 336 consecutive melanoma patients at the University Hospital Zurich, Switzerland. Fasting cFBG levels were measured prior to FDG PET/CT and classified according to American Diabetes Association guidelines. Multivariable linear regression analysis was performed to identify independent predictors of cFBG levels. Sensitivity analyses were performed on patients examined before 11 AM and fasting for 8 h as well as patients without known diabetes.</div></div><div><h3>Results</h3><div>The cohort included 336 melanoma patients with a median age of 67 years (IQR 57–76), 36 % female (122/336), and 12 % (40/336) with known diabetes mellitus. The median cFBG was 103 mg/dL (IQR 94–112; 5.7 mmol/L, IQR 5.2–6.2). Overall, 58 % (194/336) of patients had non-normal cFBG levels (≥100 mg/dL; ≥5.6 mmol/L), consistent with findings from a sensitivity analysis of patients presenting before 11 AM, where 58 % (115/198) exhibited non-normal levels. Excluding patients with known diabetes, 56 % (165/296) of patients had non-normal cFBG levels, with 7 % (20/210) having levels ≥126 mg/dL (≥7.0 mmol/L), indicative of possible undiagnosed diabetes mellitus. Multivariable linear regression analysis identified male gender, active disease, and subcutaneous fat as independent predictors of cFBG levels, whereas traditional risk factors such as BMI, visceral fat, hypertension or lack of exercise were not independent predictors.</div></div><div><h3>Conclusion</h3><div>More than half of melanoma patients have elevated cFBG levels, even in those without known diabetes, highlighting the need for improved glycemic screening and management.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"41 ","pages":"Article 100405"},"PeriodicalIF":4.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 inhibitor therapy in overweight and obese patients with cystic fibrosis-related diabetes: Case series","authors":"Ammar Ahmed ,&nbsp;Roshini Asirvatham ,&nbsp;Jagdeesh Ullal ,&nbsp;Amir Moheet","doi":"10.1016/j.jcte.2025.100403","DOIUrl":"10.1016/j.jcte.2025.100403","url":null,"abstract":"<div><div>Cystic fibrosis-related diabetes (CFRD) is the most prevalent extrapulmonary comorbidity in CF. While insulin remains the standard treatment, increasing rates of overweight and obesity due to CFTR modulators highlight the need for new therapies. SGLT2 inhibitors, effective in type 2 diabetes, have not been studied in CFRD. This case series presents eight CFRD patients treated with SGLT2 inhibitors alongside insulin for one year. Half had BMI reductions (1.33–2.89 kg/m2); others had increases. Glycemic control improved in six, worsened in two due to insulin nonadherence. Insulin adjustments showed no pattern. One patient discontinued due to genital infections; overall tolerance was high.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"41 ","pages":"Article 100403"},"PeriodicalIF":4.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting accelerated fetal growth in pregnancy: beyond maternal hyperglycemia – The role of prothymosin-α, inflammatory cytokines, and angiogenic factors","authors":"Maria Mirabelli ,&nbsp;Marta Greco ,&nbsp;Stefano Iuliano ,&nbsp;Francesco Dragone ,&nbsp;Eusebio Chiefari ,&nbsp;Daniela Foti ,&nbsp;Antonio Brunetti","doi":"10.1016/j.jcte.2025.100404","DOIUrl":"10.1016/j.jcte.2025.100404","url":null,"abstract":"<div><div><em>Aim</em>: This study investigates prothymosin-α (ProT-α), an immunomodulatory protein, as a potential biomarker for insulin resistance in gestational diabetes (GDM), and as a predictor of fetal growth by 20 weeks of gestation (wg). <em>Methods</em>: Forty-six women with singleton pregnancies were classified into GDM (n = 8) and normal glucose tolerance (NGT; n = 38) groups based on 75 g OGTT results. Maternal glucose, insulin, cytokines, and ProT-α levels were measured, and fetal growth was assessed by ultrasound at 20 wg, focusing on abdominal circumference (AC) and estimated fetal weight (EFW) percentiles. <em>Results</em>: Women with GDM were older, had a higher BMI, glucose, and insulin levels, with fetuses showing higher AC and EFW percentiles. IL-8, TNFα, and IL-1α were lower in the GDM group, while ProT-α was also lower but not significantly. ProT-α inversely correlated with EFW percentiles, independent of GDM. Regression analysis identified 2-hour post-load glucose, VEGF, and EGF as positive predictors of fetal growth acceleration, while IL-10 and ProT-α were negative predictors. <em>Conclusions</em>: Fetal growth is influenced by maternal glucose, inflammation, and angiogenesis. ProT-α may serve as an independent biomarker for predicting fetal growth in early pregnancy, suggesting further investigation into its role in GDM, obesity, and insulin resistance.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"41 ","pages":"Article 100404"},"PeriodicalIF":4.2,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “False negative rate and concordance of ThyGeNEXT®+ThyraMIR® testing with post-thyroidectomy histopathology” [J. Clin. Translat. Endocrinol. 40 (2025) 100396]","authors":"Sobrina S. Mohammed ,&nbsp;Daniel Mettman ,&nbsp;Mariana Garcia-Touza ,&nbsp;Betty Drees ,&nbsp;Maricel Ridella","doi":"10.1016/j.jcte.2025.100397","DOIUrl":"10.1016/j.jcte.2025.100397","url":null,"abstract":"","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"40 ","pages":"Article 100397"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Prediction of BRAF and TERT status in PTCs by machine learning-based ultrasound radiomics methods: A multicenter study” [J. Clin. Translat. Endocrinol. 40 (2025) 100390]","authors":"Hui Shi ,&nbsp;Ke Ding ,&nbsp;Xue Ting Yang ,&nbsp;Ting Fan Wu ,&nbsp;Jia Yi Zheng ,&nbsp;Li Fan Wang ,&nbsp;Bo Yang Zhou ,&nbsp;Li Ping Sun ,&nbsp;Yi Feng Zhang ,&nbsp;Chong Ke Zhao ,&nbsp;Hui Xiong Xu","doi":"10.1016/j.jcte.2025.100394","DOIUrl":"10.1016/j.jcte.2025.100394","url":null,"abstract":"","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"40 ","pages":"Article 100394"},"PeriodicalIF":4.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucocorticoids: The culprit behind metabolic disorders in primary Aldosteronism? A narrative review","authors":"Piotr Kmieć ,&nbsp;Renata Świątkowska-Stodulska","doi":"10.1016/j.jcte.2025.100401","DOIUrl":"10.1016/j.jcte.2025.100401","url":null,"abstract":"<div><div>In recent years, a new approach toward aldosterone secretion autonomy has emerged as a consequence of studies demonstrating its continuum from subclinical, mild to overt and severe forms. These clinical insights were accompanied by immense progress in deciphering the tissue and cellular pathology underlying primary aldosteronism (PA).</div><div>Thus far, research has not sufficiently elucidated the relationships between overt PA and metabolic disorders. Similarly, the role of glucocorticoid cosecretion in this patient group remains unclear. Milder than overt PA forms have been scarcely investigated.</div><div>This review critically analyzes these issues on the basis of a literature search of the PubMed database.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"41 ","pages":"Article 100401"},"PeriodicalIF":4.2,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in psychosocial outcomes according to BMI among adults living with type 1 diabetes: A cross-sectional BETTER analysis","authors":"Anne Bonhoure ,&nbsp;Marie-Laure Lalanne-Mistrih ,&nbsp;Meryem Talbo ,&nbsp;Valérie Boudreau ,&nbsp;Virginie Messier ,&nbsp;Aude Bandini ,&nbsp;Laurence Secours ,&nbsp;Sonia Fontaine ,&nbsp;Anne-Sophie Brazeau ,&nbsp;Rémi Rabasa-Lhoret","doi":"10.1016/j.jcte.2025.100400","DOIUrl":"10.1016/j.jcte.2025.100400","url":null,"abstract":"<div><h3>Aims</h3><div>The prevalence of overweight and obesity in people with type 1 diabetes has increased significantly, presenting additional psychosocial challenges that vary by gender. This study investigates the relationship between BMI and psychosocial outcomes in adult men and women with type 1 diabetes.</div></div><div><h3>Methods</h3><div>This cross-sectional analysis used data from people with type 1 diabetes in the BETTER registry, stratified by gender and categorized into BMI groups (&lt;25, 25–29.9, ≥ 30 kg/m²). Psychosocial outcomes included depression, diabetes distress, and stigmatization related to diabetes. One-way ANOVA assessed differences between BMI groups by gender. Multivariable logistic regression then analyzed gender differences within each BMI group, adjusting for age and HbA1c.</div></div><div><h3>Results</h3><div>Among 1028 participants (66 % women, mean BMI 26.4 ± 5.1 kg/m², mean age 45.4 ± 15.0 years), 460 adults (45 %) had a BMI &lt; 25, 356 (35 %) between 25–29.9, and 212 (21 %) ≥ 30 kg/m². Women in the ≥ 30 kg/m² group, compared to the &lt; 25 kg/m² group, had more symptoms of depression, more drug prescriptions for depression/anxiety, and higher diabetes distress (p &lt; 0.001 for all). In men, psychosocial outcomes did not differ significantly across BMI groups. Multivariable regression showed women were more likely than men to report prescriptions for depression/anxiety and high diabetes distress, particularly in the higher BMI groups.</div></div><div><h3>Conclusions</h3><div>In adults living with type 1 diabetes, higher BMI is associated with adverse psychosocial outcomes, particularly in women. Gender-specific interventions addressing mental health, stigma, and weight management could be beneficial to improve overall well-being.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"41 ","pages":"Article 100400"},"PeriodicalIF":4.2,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study","authors":"Betina Biagetti ,&nbsp;Esteban Cordero Asanza ,&nbsp;Carlos Pérez-López ,&nbsp;Víctor Rodríguez Berrocal ,&nbsp;Almudena Vicente ,&nbsp;Cristina Lamas ,&nbsp;Fernando Guerrero-Pérez ,&nbsp;Andreu Simó-Servat ,&nbsp;Guillermo Serra ,&nbsp;Ana Irigaray Echarri ,&nbsp;M. Dolores Ollero ,&nbsp;Inmaculada González Molero ,&nbsp;Rocío Villar-Taibo ,&nbsp;María Dolores Moure Rodríguez ,&nbsp;Pablo García-Feijoo ,&nbsp;María Noelia Sánchez Ramirez ,&nbsp;Alba Gutiérrez Hurtado ,&nbsp;Vanessa Capristan-Díaz ,&nbsp;Rosa Camara ,&nbsp;Marta Gallach ,&nbsp;Marta Araujo-Castro","doi":"10.1016/j.jcte.2025.100399","DOIUrl":"10.1016/j.jcte.2025.100399","url":null,"abstract":"<div><h3>Background</h3><div>Pituitary apoplexy (PA) is a rare but potentially life-threatening condition. While conservative management is an option in selected cases, predictors of conversion to surgery after initial conservative management remain unclear.</div></div><div><h3>Objective</h3><div>To identify predictors of transitioning to surgery in PA who were initially managed conservatively, and to assess the timing and impact of surgical conversion.</div></div><div><h3>Methods</h3><div>This multicenter observational study included 134 patients with PA initially managed conservatively. Patients were categorized into successful conservative management (no surgery or surgery scheduled after 30 days) and conversion to surgery (surgery within 8–30 days). Logistic and Cox regression analyses were performed to identify predictors of conversion to surgery and time to transition, respectively.</div></div><div><h3>Results</h3><div>Among the 134 patients enrolled, the median age was 61.4 years (interquartile range: 16.0) years and 93 (69.4 %) men], 69 (51.5 %) ultimately required surgery, with most transitions occurring within the first two weeks. In logistic regression analysis, larger tumor size (OR: 1.09, 95 % CI: 1.02–1.16) and higher BMI (OR: 1.11, 95 % CI: 1.01–1.22) were independently associated with conversion to surgery. However, Cox regression did not identify any variables predicting time to transition. Additionally, patients who converted to surgery had a significantly longer hospital stay (21.0 vs. 7.5 days, p &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>Half of the patients initially managed conservatively required convertion to surgery. Tumor size and BMI were associated with an increased likelihood of surgery, but no factors predicted when surgery would occur, suggesting that the decision to conversion to surgery may be influenced by multiple clinical factors rather than a single determinant.</div></div>","PeriodicalId":46328,"journal":{"name":"Journal of Clinical and Translational Endocrinology","volume":"40 ","pages":"Article 100399"},"PeriodicalIF":4.2,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}