International Journal of Hepatology最新文献

{"title":"Infrahepatic Inferior Vena Cava Clamping Reduces Blood Loss during Liver Transection for Cholangiocarcinoma.","authors":"Natwutpong Leeratanakachorn,&nbsp;Vor Luvira,&nbsp;Theerawee Tipwaratorn,&nbsp;Suapa Theeragul,&nbsp;Apiwat Jarearnrat,&nbsp;Attapol Titapun,&nbsp;Tharatip Srisuk,&nbsp;Supot Kamsa-Ard,&nbsp;Ake Pugkhem,&nbsp;Narong Khuntikeo,&nbsp;Chawalit Pairojkul,&nbsp;Vajarabhongsa Bhudhisawasdi","doi":"10.1155/2021/1625717","DOIUrl":"https://doi.org/10.1155/2021/1625717","url":null,"abstract":"<p><strong>Background: </strong>Major hepatectomy is the mainstay of the treatment for cholangiocarcinoma. Infrahepatic inferior vena cava (IVC) clamping is an effective maneuver for reducing blood loss during liver transection. The impact of this procedure on major hepatectomy for cholangiocarcinoma is unknown. This study evaluated the effect of infrahepatic IVC clamping on blood loss during liver transection.</p><p><strong>Methods: </strong>Clinical and pathological data were collected retrospectively for 116 cholangiocarcinoma patients who underwent major hepatectomy between January 2015 and December 2016, to investigate the benefit of infrahepatic IVC clamping. Two of five surgeons adapted the policy performing infrahepatic IVC clamping during liver transection in all cases. Patients, therefore, were divided into those (<i>n</i> = 39; 33.6%) who received infrahepatic IVC clamping during liver transection (C1) and those (<i>n</i> = 77; 66.4%) who did not (C0).</p><p><strong>Results: </strong>The patients' backgrounds, operative parameters, and extent of hepatectomy did not differ significantly between the 2 groups, except for gender. A significantly lower blood loss (<i>p</i> = 0.028), blood transfusion (<i>p</i> = 0.011), and rate of vascular inflow occlusion requirement (<i>p</i> < 0.001) were observed in the C1 group. The respective blood losses in the C1 group and the C0 group were 498.9 (95% CI: 375.8-622.1) and 685.6 (95% CI: 571-800.2) millilitres.</p><p><strong>Conclusions: </strong>The current study found infrahepatic IVC clamping during liver transection for cholangiocarcinoma reduces blood loss, blood transfusion, and rate of vascular inflow occlusion requirement.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2021 ","pages":"1625717"},"PeriodicalIF":1.8,"publicationDate":"2021-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8413082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39386444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Hepatic Encephalopathy from a Commercial Medical Claims Database in the United States.","authors":"Aniruddha Potnis,&nbsp;Susan VanMeter,&nbsp;Jan Stange","doi":"10.1155/2021/8542179","DOIUrl":"https://doi.org/10.1155/2021/8542179","url":null,"abstract":"<p><strong>Introduction: </strong>Hepatic encephalopathy (HE), a complication of cirrhosis, is associated with increased healthcare resource utilization and mortality, and impaired quality of life. Information on the prevalence of HE in the US general population is limited.</p><p><strong>Methods: </strong>Prevalence of HE was estimated by sequential stepwise data analysis of the Symphony Health anonymized patient-level data (APLD) claims database. First, patients ≥ 18 years with International Classification of Diseases ninth/tenth edition, clinical modification (ICD-9/10-CM), and codes for cirrhosis from 2018 medical and hospital claims were used to estimate prevalence of cirrhosis within the data set and number of patients with cirrhosis in the US general population. Second, patients diagnosed with cirrhosis in the APLD data set from 2015-2016 with an HE ICD-9/10-CM code within 1 year of cirrhosis diagnosis were used to deduce the prevalence of HE within the data set and estimate the number of patients with HE in the US general population. Last, US DiagnosticSource data on serum ammonia level laboratory results measured within ±2 days of a confirmed HE event were merged with the APLD HE data set, then applied to the US general population.</p><p><strong>Results: </strong>Medical and hospital claims data were available for 272,256 patients with cirrhosis in 2018. An estimated 536,856 US adults had a diagnosis of cirrhosis (prevalence of 0.21%) in 2018. This proportion applied to the estimated number of patients with cirrhosis in the United States resulted in a prevalence estimate of 201,858 cirrhosis patients with HE in 2018. When factoring in serum ammonia data, prevalence was conservatively estimated as approximately 196,000 cirrhosis patients with HE and serum ammonia levels > 21 <i>μ</i>mol/L.</p><p><strong>Conclusions: </strong>In this longitudinal cohort-based study, it was estimated that ≈202,000 patients had HE in the United States in 2018, representing a considerable burden to society and payers.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2021 ","pages":"8542179"},"PeriodicalIF":1.8,"publicationDate":"2021-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39139896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Donor and Recipient Complement C3 Polymorphisms on Liver Transplant Outcome.","authors":"Maria Pires,&nbsp;James Underhill,&nbsp;Abdel Douiri,&nbsp;Alberto Quaglia,&nbsp;Wayel Jassem,&nbsp;William Bernal,&nbsp;Nigel Heaton,&nbsp;Phillip Morgan,&nbsp;Richard Thompson,&nbsp;J Michael Tredger","doi":"10.1155/2021/6636456","DOIUrl":"https://doi.org/10.1155/2021/6636456","url":null,"abstract":"<p><p>Despite early reports of an impact of complement C3 polymorphism on liver transplant patient and graft survival, subsequent evidence has been conflicting. Our aim was to clarify the contributions of donor and recipient C3 genotype, separately and together, on patient and graft outcomes and acute rejection incidence in liver transplant recipients. Eight donor/recipient groups were analyzed according to their genotype and presence or absence of C3 F allele (FFFS, FFSS, FSFF, FSFS, FSSS, SSFF, SSFS, and SSSS) and correlated with clinical outcomes of patient survival, graft survival, and rejection. The further impact of brain death vs. circulatory death during liver donation was also considered. Over a median 5.3 y follow-up of 506 patients with clinical information and matching donor and recipient tissue, five-year patient and graft survival (95% confidence interval) were 90(81-91)% and 77(73-85)%, respectively, and 72(69-94)% were rejection-free. Early disadvantages to patient survival were associated with donor C3 F variant, especially in brain-death donors. Recipient C3 genotype was an independent determinant of graft survival by Cox proportional hazards analysis (hazard ratio 0.26, <i>P</i> = 0.04), and the C3 F donor variant was again associated with worse liver graft survival, particularly in brain-death donors. C3 genotype did not independently determine rejection incidence, but a greater proportion of recipient C3 F carriers were rejection-free in the circulatory death, but not the brain-death cohort. Cox proportional hazards analysis revealed significant effects of acute rejection on patient survival (hazard ratio 0.24, <i>P</i> = 0.018), of retransplantation on rejection risk (hazard ratio 6.3, <i>P</i> = 0.009), and of donor type (circulatory-death vs. brain-death) on rejection incidence (hazard ratio 4.9, <i>P</i> = 0.005). We conclude that both donor and recipient complement C3 genotype may influence patient and graft outcomes after liver transplantation but that the type of liver donor is additionally influential, possibly via the inflammatory environment of the transplant.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2021 ","pages":"6636456"},"PeriodicalIF":1.8,"publicationDate":"2021-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39089181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients with Hepatitis C Infection and Normal Liver Function: A Neuropsychological and Neurophysiological Assessment of Cognitive Functions.","authors":"Jefferson Abrantes,&nbsp;Daniel Simplicio Torres,&nbsp;Carlos Eduardo Brandão-Mello","doi":"10.1155/2021/8823676","DOIUrl":"https://doi.org/10.1155/2021/8823676","url":null,"abstract":"<p><p>Several studies have proposed a link between chronic hepatitis C virus (HCV) infection and the development of cognitive disorders. However, the inclusion of confounding factors in their samples significantly limits the interpretation of the results. Therefore, here, we aimed to compare the neurophysiological and cognitive performance between patients with HCV infection and a control group after excluding other factors that may cause cognitive impairment. This cross-sectional, group-control, observational study was performed from September 12, 2014, to October 20, 2017. HCV-infected patients and healthy individuals between 18 and 77 years were considered eligible. The exclusion criteria included well-established causes of cognitive impairment, such as depression and cirrhosis. The participants were submitted to neuropsychological testing to evaluate global cognitive function (minimental), sustained attention, divided attention, selective attention, working memory, psychomotor speed, and executive function and to a neurophysiological evaluation using quantitative electroencephalograms and P300 cognitive evoked potentials. Among the 309 patients considered eligible for the study, we excluded 259 patients who had one or more characteristics from the preestablished exclusion criteria, 18 who did not undergo neuropsychological and neurophysiological testing, and five who exhibited depression. The final sample consisted of 27 patients each in the HCV and control groups. The groups did not differ in age, schooling, and sex. The patients in the HCV group exhibited poorer performances in the cognitive areas involving attention (<i>p</i> = 0.01), memory (<i>p</i> = 0.02), and psychomotor velocity (<i>p</i> = 0.04) apart from exhibiting prolonged latency in the P3b component (<i>p</i> = 0.03) and <i>Z</i> score (<i>p</i> = 0.02) of the P300 evoked cognitive potential. In this study performed with strict selection criteria, on conducting neuropsychological and neurophysiological evaluations, we detected the presence of cognitive impairment characterized by the involvement of attention, working memory, psychomotor processing speed, and memory in the HCV group.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2021 ","pages":"8823676"},"PeriodicalIF":1.8,"publicationDate":"2021-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8154309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39083621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of Selective Hepatic Inflow Vascular Occlusion with Anterior Approach in Liver Resection: Effectiveness in Managing Major Complications and Long-Term Survival.","authors":"Khai Viet Ninh, Nghia Quang Nguyen, Son Hong Trinh, Anh Gia Pham, Thi-Ngoc-Ha Doan","doi":"10.1155/2021/6648663","DOIUrl":"10.1155/2021/6648663","url":null,"abstract":"<p><strong>Background: </strong>Hepatectomy is always a challenge to surgeons and requires an appropriate approach for specific tumors to achieve effective complication management. Selective hepatic pedicle clamping is more considerable strategy when comparing with total hepatic pedicle clamping in the balance between reducing blood loss and transfusion with causing the hepatic parenchyma damages (two main complications affecting liver resection result).</p><p><strong>Objectives: </strong>In this study, we aim to describe the application of selective hepatic inflow vascular occlusion (SHIVO) and anatomical anterior approach in liver resection and evaluate the results, focusing on intraoperative and postoperative complications.</p><p><strong>Methods: </strong>We enrolled 72 patients who underwent liver resection with SHIVO at Viet Duc University Hospital in 4-year period (2011-2014) and then followed up all of them until June 2020 (in 52.6 ± 33 months; range, 2-105 months) or up to the time of death. All the patients were diagnosed with primary or secondary liver cancer, and their future remnant liver volume measured on 64-slice CT scan (dm³) to body weight (kg) > 0.8% (for right hepatectomy). Perioperative parameters were collected and analyzed.</p><p><strong>Results: </strong>The average operation time was 196.2 ± 62.2 minutes, and blood loss was 261.4 ± 202.9 ml; total blood transfusion proportion during and after surgery was 16.7%. Complications accounted for 44.5% of patients in which pleural effusion was the most common one (41.7%). There were no liver failure and biliary fistula after surgery. No deaths were recorded during 30 days postoperatively. Average hospital stay was 11.4 ± 3.7 days. Blood transfusions during the operation and major liver resection were the factors significantly affecting the percentage of complications after liver surgery in our study. In the last follow-up evaluation, 44 patients were dead and 28 patients were alive, in which 7 with recurrence and 21 without recurrence. The overall survival rate was 38.9%.</p><p><strong>Conclusion: </strong>SHIVO in anatomical liver resection is a safe and feasible approach to help resect precisely targeted tumors and manage several complications in liver resection.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2021 ","pages":"6648663"},"PeriodicalIF":1.8,"publicationDate":"2021-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39008401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Roles of Impaired Autophagy in Fatty Liver Disease and Hepatocellular Carcinoma.","authors":"Suryakant Niture, Minghui Lin, Leslimar Rios-Colon, Qi Qi, John T Moore, Deepak Kumar","doi":"10.1155/2021/6675762","DOIUrl":"10.1155/2021/6675762","url":null,"abstract":"<p><p>Autophagy is a conserved catabolic process that eliminates dysfunctional cytosolic biomolecules through vacuole-mediated sequestration and lysosomal degradation. Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). Autophagy prevents NAFLD and AFLD progression through enhanced lipid catabolism and decreasing hepatic steatosis, which is characterized by the accumulation of triglycerides and increased inflammation. However, as both diseases progress, autophagy can become impaired leading to exacerbation of both pathological conditions and progression into HCC. Due to the significance of impaired autophagy in these diseases, there is increased interest in studying pathways and targets involved in maintaining efficient autophagic functions as potential therapeutic targets. In this review, we summarize how impaired autophagy affects liver function and contributes to NAFLD, AFLD, and HCC progression. We will also explore how recent discoveries could provide novel therapeutic opportunities to effectively treat these diseases.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2021 ","pages":"6675762"},"PeriodicalIF":1.8,"publicationDate":"2021-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38902760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Serum 25-Hydroxy Vitamin D (25-OHD) and Hepatic Encephalopathy in HCV-Related Liver Cirrhosis.","authors":"Mohamed Abd Ellatif Afifi,&nbsp;Ahmed Mohamed Hussein,&nbsp;Mahmoud Rizk","doi":"10.1155/2021/6669527","DOIUrl":"https://doi.org/10.1155/2021/6669527","url":null,"abstract":"<p><strong>Background: </strong>Patients with liver cirrhosis experience a large variety of metabolic disorders associated with more hepatic decompensation. Hepatic encephalopathy (HE) is a significant complication in liver cirrhosis patients, presenting a wide spectrum of neuropsychological symptoms. A deficiency of 25-hydroxy vitamin D (25-OHD) in the general population is associated with a loss of cognitive function, dementia, and Alzheimer's disease. <i>Aim of the Study</i>. Our study aims to check the relationship between low serum 25-OHD and HE in patients with HCV-related liver cirrhosis and assess its link with patient mortality. <i>Patients and Methods</i>. This study was observationally carried out on 100 patients with HCV-related liver cirrhosis. The patients were divided into 2 groups: Group A-included 50 HCV-related cirrhotic patients with HE, and Group B-included 50 HCV-related cirrhotic patients without HE. Assessment of disease severity using the end-stage liver disease (MELD) model and Child Turcotte Pugh (CTP) scores were done, and 25-OHD levels were measured. Comparison of vitamin D levels in different etiologies and different CTP categories was made using one-way ANOVA. Pearson's correlation between the level of vitamin D and other biomarkers was applied.</p><p><strong>Results: </strong>There was a statistically significant Vitamin D level difference between the two groups. A lower level of vitamin D was observed in the HE group where the severe deficiency was 16%, while it was 6% in the other group and the moderate deficiency was 24% in HE group as compared to 10% in the other group. The insufficient vitamin D level represented 46% of the non-HE group while none of the HE group falls in this category. Vitamin D level was statistically higher in Grade 1 HE than in Grade 2 which is higher than in Grades 3 to 4. Vitamin D level was also significantly higher in those who improved from HE as compared to those who died.</p><p><strong>Conclusion: </strong>The lower levels of 25-OHD were associated with the higher incidence of HE in cirrhotic HCV patients. The worsening vitamin D deficiency was associated with increased severity of the liver disease, so vitamin D may be considered a prognostic factor for the severity of liver cirrhosis and high mortality rate in HE patients.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2021 ","pages":"6669527"},"PeriodicalIF":1.8,"publicationDate":"2021-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7896845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25408455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant Effects of Eugenol on Oxidative Stress Induced by Hydrogen Peroxide in Islets of Langerhans Isolated from Male Mouse.","authors":"Ali Akbar Oroojan,&nbsp;Narges Chenani,&nbsp;Marzieh An'aam","doi":"10.1155/2020/5890378","DOIUrl":"https://doi.org/10.1155/2020/5890378","url":null,"abstract":"<p><strong>Background: </strong>The antioxidant system in islets of Langerhans is weak, which can lead to diabetes. Meanwhile, the main component of cloves that produce antioxidant effects is eugenol. Accordingly, the present study was conducted to investigate the antioxidant effect of eugenol on oxidative stress induced by hydrogen peroxide (H₂O₂) in islets of Langerhans isolated from the male mice.</p><p><strong>Materials and methods: </strong>In this experimental study, adult Naval Medical Research Institute (NMRI) mice (20-25 g) were prepared. The collagenase digestion method was used for dissecting the islets of Langerhans. H₂O₂ 50 <i>μ</i>M was administered for 30 min to induce oxidative stress, with 50, 100, and 200 <i>μ</i>M of eugenol employed for 2 hours before the administration of H₂O₂. The experimental groups were divided into five groups: (control, H₂O₂, and H₂O₂+eugenol 50, 100, and 200 <i>μ</i>M). Finally, the islet's lipid peroxidation and antioxidants levels were measured by the ELISA assay method.</p><p><strong>Results: </strong>Malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), and catalase (CAT) increased in all groups when compared to the control (<i>P</i> < 0.05). MDA diminished in H₂O₂+eugenol 50, 100, and 200 <i>μ</i>M (<i>P</i> < 0.01) groups versus the H₂O₂. TAC was elevated when eugenol 50, 100, and 200 <i>μ</i>M was administered in oxidative stress-induced islets (<i>P</i> < 0.001). Also, CAT increased in the H₂O₂+eugenol 50 (<i>P</i> < 0.05) group in comparison with the H₂O₂ group.</p><p><strong>Conclusions: </strong>In conclusion, H₂O₂ induced oxidative stress and lipid peroxidation in the islets, and administration of eugenol recovered these alterations by raising the level of TAC and CAT, while reducing MDA as a lipid peroxidation biomarker.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2020 ","pages":"5890378"},"PeriodicalIF":1.8,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38827877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Factors of Radiofrequency Ablation plus Systemic Chemotherapy for Unresectable Colorectal Cancer with Liver Metastasis.","authors":"Ky Thai Doan,&nbsp;Long Nguyễn Việt,&nbsp;Thinh Nguyen Tien,&nbsp;Binh Nguyen Canh,&nbsp;Hoai Ngo Thi,&nbsp;Ngoc Nguyen Thanh,&nbsp;Bieu Bui Quang,&nbsp;Quang Le Van,&nbsp;Hyun Woong Lee,&nbsp;Bang Mai Hong","doi":"10.1155/2020/8836922","DOIUrl":"https://doi.org/10.1155/2020/8836922","url":null,"abstract":"<p><strong>Introduction: </strong>Survival outcomes in patients with unresectable colorectal cancer (CRC) liver metastasis treated by radiofrequency ablation (RFA) combined with systemic chemotherapy and correlation with potential prognostic factors were investigated. <i>Material and Methods</i>. A retrospective cohort study was conducted on 61 CRC patients with unresectable liver metastasis who underwent liver tumor-directed percutaneous RFA combined with conventional systemic chemotherapy between October 2013 and September 2018. Survival analyses were conducted using the Kaplan-Meier method, and the log-rank test was used to characterize differences in the median survival time and the 1-year, 3-year, and 5-year overall survival rates of subgroups to identify prognostic factors.</p><p><strong>Results: </strong>Median overall survival and progression-free survival of all patients were 32 and 14 months, respectively. The cumulative survival rates at 1-, 3-, and 5-years were 93.2%; 44.5%, and 38.2%, respectively. Univariate analysis revealed that pre-RFA serum CEA levels, Eastern Cooperative Oncology Group (ECOG) status, number of liver lesions, the size of the largest lesion, and the total lesion size were prognostic factors. However, multivariate analysis demonstrated that only the number of liver lesions and the size of the largest lesion were independent prognostic factors for survival.</p><p><strong>Conclusion: </strong>RFA plus systemic chemotherapy provides an encouraging survival outcome for patients with unresectable CRC liver metastasis. Multivariate analysis demonstrated that the number and size of liver metastatic lesions are independent prognostic factors for survival.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2020 ","pages":"8836922"},"PeriodicalIF":1.8,"publicationDate":"2020-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/8836922","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38767681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The High Prevalence of Negative Hepatitis B Surface Antibody (Anti-HBs) among Pregnant Women in Bandung, Indonesia: A Community-Based Study.","authors":"Dolvy Girawan,&nbsp;Raden T D Judistiani,&nbsp;Nelly A Risan,&nbsp;Muhammad B Bestari,&nbsp;Eka S Nugraha,&nbsp;Yudith S Ermaya,&nbsp;Dwi Prasetyo","doi":"10.1155/2020/3414869","DOIUrl":"https://doi.org/10.1155/2020/3414869","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis B virus (HBV) infection is a disease that creates a high global burden by affecting approximately 3.5% of the total world population. The main transmission of this disease is from mother to child (MTCT). HBV vaccination program was already initiated in Indonesia in 1987. However, after three decades, the HBV infection prevalence stays stagnant. This study aimed to explore the seroprevalence of HBV markers and the attributable risk factors of pregnant women at risk of transmitting HBV to their offspring.</p><p><strong>Method: </strong>A cross-sectional study was conducted on pregnant women from primary midwifery and obstetric clinics across Bandung, Indonesia, to assess the HBsAg, anti-HBc, and anti-HBs serological markers. Questionnaire-based interviews were used to obtain the sociodemographic determinants. Logistic regression was applied to assess the association of each determinant factor to positive HBsAg or negative anti-HBs as a dependent variable, which was then reported as odds ratios (OR).</p><p><strong>Results: </strong>A total of 196 subjects were recruited with 12/196 (6.1%) of them were positive HBsAg. After exclusions of those with positive HBsAg and anti-HBc, 24/175 (13.7%) women were isolated as positive anti-HBs, leaving 151/175 (86.3%) women with negative anti-HBs who were susceptible to HBV infection. Low body mass index (BMI) less than 18.5 kg/m² was a risk factor for positive HBsAg with OR = 5.850 (95% CI 1.466-23.34), <i>p</i> = 0.012. Nevertheless, no significant determinant factor was associated with negative anti-HBs.</p><p><strong>Conclusion: </strong>Most pregnant women in Bandung, Indonesia, are susceptible to HBV infection, as marked by the negative anti-HBs status.</p>","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2020 ","pages":"3414869"},"PeriodicalIF":1.8,"publicationDate":"2020-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3414869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38554084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}