International Journal of Hepatology最新文献_第10页

Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure 表达hgf的人脐带间充质干细胞对急性肝衰竭小鼠的治疗潜力

IF 1.8

International Journal of Hepatology Pub Date : 2016-02-28 DOI: 10.1155/2016/5452487

Yunxia Tang, Qiongshu Li, Fanwei Meng, Xingyu Huang, Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Jia Liu, Xiang Hu, Ji-fan Hu, Tao Li

{"title":"Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure","authors":"Yunxia Tang, Qiongshu Li, Fanwei Meng, Xingyu Huang, Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Jia Liu, Xiang Hu, Ji-fan Hu, Tao Li","doi":"10.1155/2016/5452487","DOIUrl":"https://doi.org/10.1155/2016/5452487","url":null,"abstract":"Human umbilical cord-derived mesenchymal stem cells (UCMSCs) are particularly attractive cells for cellular and gene therapy in acute liver failure (ALF). However, the efficacy of this cell therapy in animal studies needs to be significantly improved before it can be translated into clinics. In this study, we investigated the therapeutic potential of UCMSCs that overexpress hepatocyte growth factor (HGF) in an acetaminophen-induced acute liver failure mouse model. We found that the HGF-UCMSC cell therapy protected animals from acute liver failure by reducing liver damage and prolonging animal survival. The therapeutic effect of HGF-UCMSCs was associated with the increment in serum glutathione (GSH) and hepatic enzymes that maintain redox homeostasis, including γ-glutamylcysteine synthetase (γ-GCS), superoxide dismutase (SOD), and catalase (CAT). Immunohistochemical staining confirmed that HGF-UCMSCs were mobilized to the injured areas of the liver. Additionally, HGF-UCMSCs modulated apoptosis by upregulating the antiapoptotic Bcl2 and downregulating proapoptotic genes, including Bax and TNFα. Taken together, these data suggest that ectopic expression of HGF in UCMSCs protects animals from acetaminophen-induced acute liver failure through antiapoptosis and antioxidation mechanisms.","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"32 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2016-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79176754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Elbasvir/Grazoprevir: A Review of the Latest Agent in the Fight against Hepatitis C. Elbasvir/Grazoprevir:抗丙型肝炎最新药物综述

IF 1.8

International Journal of Hepatology Pub Date : 2016-01-01 Epub Date: 2016-06-15 DOI: 10.1155/2016/3852126

Allison M Bell, Jamie L Wagner, Katie E Barber, Kayla R Stover

引用次数: 33

The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis. 朝鲜蓟叶提取物对非酒精性脂肪性肝炎患者丙氨酸氨基转移酶和天冬氨酸氨基转移酶的影响

IF 1.8

International Journal of Hepatology Pub Date : 2016-01-01 Epub Date: 2016-05-11 DOI: 10.1155/2016/4030476

Vajiheh Rangboo, Mostafa Noroozi, Roza Zavoshy, Seyed Amirmansoor Rezadoost, Asghar Mohammadpoorasl

{"title":"The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis.","authors":"Vajiheh Rangboo, Mostafa Noroozi, Roza Zavoshy, Seyed Amirmansoor Rezadoost, Asghar Mohammadpoorasl","doi":"10.1155/2016/4030476","DOIUrl":"10.1155/2016/4030476","url":null,"abstract":"Background. Based on recent basic and clinical investigations, the extract of artichoke (Cynara scolymus) leaf has been revealed to be used for hepatoprotective and cholesterol reducing purposes. We aimed to assess the therapeutic effects of artichoke on biochemical and liver biomarkers in patients with nonalcoholic steatohepatitis (NASH). Methods. In a randomized double blind clinical trial, 60 consecutive patients suffering NASH were randomly assigned to receive Cynara scolymus extract (as 6 tablets per day consisting of 2700 mg extract of the herb) as the intervention group or placebo as the control group for two months. Results. Comparing changes in study markers following interventions showed improvement in liver enzymes. The levels of triglycerides and cholesterol were significantly reduced in the group treated with Cynara scolymus when compared to placebo group. To compare the role of Cynara scolymus use with placebo in changes in study parameters, multivariate linear regression models were employed indicating higher improvement in liver enzymes and also lipid profile particularly triglycerides and total cholesterol following administration of Cynara scolymus in comparison with placebo use. Conclusion. This study sheds light on the potential hepatoprotective activity and hypolipidemic effect of Cynara scolymus in management of NASH. This clinical trial is registered in the IRCT, Iranian Registry of Clinical Trials, by number IRCT2014070218321N1. ","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2016 ","pages":"4030476"},"PeriodicalIF":1.8,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34636611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostication of Learning Curve on Surgical Management of Vasculobiliary Injuries after Cholecystectomy. 胆囊切除术后血管损伤手术治疗学习曲线的预测。

IF 1.8

International Journal of Hepatology Pub Date : 2016-01-01 Epub Date: 2016-07-20 DOI: 10.1155/2016/2647130

Abu Bakar Hafeez Bhatti, Faisal Saud Dar, Haseeb Zia, Muhammad Salman Rafique, Nusrat Yar Khan, Mohammad Salih, Najmul Hassan Shah

{"title":"Prognostication of Learning Curve on Surgical Management of Vasculobiliary Injuries after Cholecystectomy.","authors":"Abu Bakar Hafeez Bhatti, Faisal Saud Dar, Haseeb Zia, Muhammad Salman Rafique, Nusrat Yar Khan, Mohammad Salih, Najmul Hassan Shah","doi":"10.1155/2016/2647130","DOIUrl":"https://doi.org/10.1155/2016/2647130","url":null,"abstract":"Background. Concomitant vascular injury might adversely impact outcomes after iatrogenic bile duct injury (IBDI). Whether a new HPB center should embark upon repair of complex biliary injuries with associated vascular injuries during learning curve is unknown. The objective of this study was to determine outcome of surgical management of IBDI with and without vascular injuries in a new HPB center during its learning curve. Methods. We retrospectively reviewed patients who underwent surgical management of IBDI at our center. A total of 39 patients were included. Patients without (Group 1) and with vascular injuries (Group 2) were compared. Outcome was defined as 90-day morbidity and mortality. Results. Median age was 39 (20-80) years. There were 10 (25.6%) vascular injuries. E2 injuries were associated significantly with high frequency of vascular injuries (66% versus 15.1%) (P = 0.01). Right hepatectomy was performed in three patients. Out of these, two had a right hepatic duct stricture and one patient had combined right arterial and portal venous injury. The number of patients who developed postoperative complications was not significantly different between the two groups (11.1% versus 23.4%) (P = 0.6). Conclusion. Learning curve is not a negative prognostic variable in the surgical management of iatrogenic vasculobiliary injuries after cholecystectomy. ","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2016 ","pages":"2647130"},"PeriodicalIF":1.8,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/2647130","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34307412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Different Nodules Identified during Liver Explant Gross Examination: Relevance and Need for Sectioning-Experience from India. 在肝移植大体检查中发现的不同结节:相关性和需要切片-来自印度的经验。

IF 1.8

International Journal of Hepatology Pub Date : 2016-01-01 Epub Date: 2016-06-22 DOI: 10.1155/2016/4390434

Nalini Bansal, Vivek Vij, Mukul Rastogi

{"title":"Different Nodules Identified during Liver Explant Gross Examination: Relevance and Need for Sectioning-Experience from India.","authors":"Nalini Bansal, Vivek Vij, Mukul Rastogi","doi":"10.1155/2016/4390434","DOIUrl":"https://doi.org/10.1155/2016/4390434","url":null,"abstract":"Objective. The goal of this study was to determine the etiopathological association of various hepatic nodules identified during gross examination of liver explants specimen and the grossing aspects of these abnormal nodules especially those smaller than 1 cm in diameter. Our aim was to analyze whether there is any association of macroregenerative and dysplastic nodule with hepatocellular carcinoma. Materials and Methods. Fifty consecutive liver explants specimens were analyzed for the presence of any abnormal nodule (abnormal nodule defined as any nodule different in color, texture, and appearance from adjacent liver tissue). Results. Of the total 40 abnormal nodules identified in 50 liver explant specimens, there were 12 (30%) HCC [including 5 small HCC (41% of total HCC) and 1 steatohepatitic HCC (8% of total HCC)], 11 (27%) MRNs, 8 (20%) dysplastic nodules, and 9 (22%) necrotic nodules. Most cases (72%) of MRN are seen in hepatitis C virus related cirrhosis with only 2 cases having associated HCC. Most cases of HCC were seen in cases of HBV associated cirrhosis (60%). The association of MRN was not found to be significantly associated with HCC with a p value of 1.0. Dysplastic nodules were found to be significantly associated with HCC with a p value of 0.02. Conclusion. In hepatic carcinogenesis, the role of MRN does not appear to be significant. However, the presence of dysplastic nodules is significantly associated with HCC. The study identified another variant of cirrhotic nodules herein called necrotic nodules that are mostly tan greenish in color and <0.5 cm in diameter. No dysplastic changes were identified in any of these nodules disqualifying the need of sectioning in such nodules. ","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2016 ","pages":"4390434"},"PeriodicalIF":1.8,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/4390434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34672717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Outcome following Resection of Biliary Cystadenoma: A Single Centre Experience and Literature Review 胆道囊腺瘤切除术后的预后:单中心经验及文献回顾

IF 1.8

International Journal of Hepatology Pub Date : 2015-12-29 DOI: 10.1155/2015/382315

M. Pitchaimuthu, G. Aidoo-Micah, C. Coldham, R. Sutcliffe, J. Roberts, P. Muiesan, J. Isaac, Darius F. Mirza, R. Marudanayagam

{"title":"Outcome following Resection of Biliary Cystadenoma: A Single Centre Experience and Literature Review","authors":"M. Pitchaimuthu, G. Aidoo-Micah, C. Coldham, R. Sutcliffe, J. Roberts, P. Muiesan, J. Isaac, Darius F. Mirza, R. Marudanayagam","doi":"10.1155/2015/382315","DOIUrl":"https://doi.org/10.1155/2015/382315","url":null,"abstract":"Background. Biliary cystadenomas (BCAs) are rare, benign, potentially malignant cystic lesions of the liver, accounting for less than 5% of cystic liver tumours. We report the outcome following resection of biliary cystadenoma from a single tertiary centre. Methods. Data of patients who had resection of BCA between January 1993 and July 2014 were obtained from liver surgical database. Patient demographics, clinicopathological characteristics, operative data, and postoperative outcome were analysed. Results. 29 patients had surgery for BCA. Male : female ratio was 1 : 28. Clinical presentation was abdominal pain (74%), jaundice (20%), abdominal mass (14%), and deranged liver function tests (3%). Cyst characteristics included septations (48%), wall thickening (31%), wall irregularity (38%), papillary projections (10%), and mural nodule (3%). Surgical procedures included atypical liver resection (52%), left hemihepatectomy (34%), right hemihepatectomy (10%), and left lateral segmentectomy (3%). Median length of stay was 7 (IQ 6.5–8.5) days. Two patients developed postoperative bile leak. No patients had malignancy on final histology. Median follow-up was 13 (IQ 6.5–15.7) years. One patient developed delayed biliary stricture and one died of cholangiocarcinoma 11 years later. Conclusion. Biliary cystadenomas can be resected safely with significantly low morbidity. Malignant transformation and recurrence are rare. Complete surgical resection provides a cure.","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"12 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2015-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87748703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Growing Up: Not an Easy Transition—Perspectives of Patients and Parents regarding Transfer from a Pediatric Liver Transplant Center to Adult Care 成长:一个不容易的过渡-关于从儿童肝移植中心转移到成人护理的患者和家长的观点

IF 1.8

International Journal of Hepatology Pub Date : 2015-11-22 DOI: 10.1155/2015/765957

S. Chandra, Shannon Luetkemeyer, R. Romero, N. Gupta

{"title":"Growing Up: Not an Easy Transition—Perspectives of Patients and Parents regarding Transfer from a Pediatric Liver Transplant Center to Adult Care","authors":"S. Chandra, Shannon Luetkemeyer, R. Romero, N. Gupta","doi":"10.1155/2015/765957","DOIUrl":"https://doi.org/10.1155/2015/765957","url":null,"abstract":"The transition from pediatric to adult care is a critical time when children with chronic illness sustain high morbidity and mortality. Transition services need to be focused on the adolescents' needs, which may differ from those perceived by healthcare providers. In this study, a survey of 31 patients with chronic liver disease and/or liver transplant who were “transferred” to adult services within the last 3 years was conducted. Patients were asked about their current health status and their perceptions of the overall transfer process. The mean age at transfer was 19.81 (18–21) years. Almost half the patients (47%) were not seen at the adult facility until 2–6 months after leaving the Children's hospital and 20% were not seen until 6–12 months. About 20% had their first contact with adult services through an emergency room visit. About 19% reported being out of medication during transition. Of the transplanted patients, 19% were being evaluated for a retransplant. The majority (82%) felt that an increased emphasis on promoting independence and “letting go” both by parents and by pediatric care providers was critical in their transition to independence and adult care services. This study provides thought-provoking insights, which are critical in designing the ideal transition program for children with chronic diseases.","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"1 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2015-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88294448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Acalculous Acute Cholecystitis in Previously Healthy Children: General Overview and Analysis of Pediatric Infectious Cases 既往健康儿童无结石性急性胆囊炎:儿科感染病例的总体概况和分析

IF 1.8

International Journal of Hepatology Pub Date : 2015-11-11 DOI: 10.1155/2015/459608

D. Poddighe, M. Tresoldi, A. Licari, G. Marseglia

引用次数: 37

Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response? 慢性丙型肝炎儿童血清脂联素、维生素D和甲胎蛋白:它们能预测治疗反应吗?

IF 1.8

International Journal of Hepatology Pub Date : 2015-11-10 DOI: 10.1155/2015/617623

M. Khedr, A. Sira, M. Saber, G. Raia

{"title":"Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response?","authors":"M. Khedr, A. Sira, M. Saber, G. Raia","doi":"10.1155/2015/617623","DOIUrl":"https://doi.org/10.1155/2015/617623","url":null,"abstract":"Background & Aims. The currently available treatment for chronic hepatitis C (CHC) in children is costly and with much toxicity. So, predicting the likelihood of response before starting therapy is important. Methods. Serum adiponectin, vitamin D, and alpha-fetoprotein (AFP) were measured before starting pegylated-interferon/ribavirin therapy for 50 children with CHC. Another 21 healthy children were recruited as controls. Results. Serum adiponectin, vitamin D, and AFP were higher in the CHC group than healthy controls (p < 0.0001, p = 0.071, and p = 0.87, resp.). In univariate analysis, serum adiponectin was significantly higher in responders than nonresponders (p < 0.0001) and at a cutoff value ≥8.04 ng/mL it can predict treatment response by 77.8% sensitivity and 92.9% specificity, while both AFP and viremia were significantly lower in responders than nonresponders, p < 0.0001 and p = 0.0003, respectively, and at cutoff values ≤3.265 ng/mL and ≤235,384 IU/mL, respectively, they can predict treatment response with a sensitivity of 83.3% for both and specificity of 85.7% and 78.6%, respectively. In multivariate analysis, adiponectin was found to be the only independent predictor of treatment response (p = 0.044). Conclusions. The pretreatment serum level of adiponectin can predict the likelihood of treatment response, thus avoiding toxicities for those unlikely to respond to therapy.","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"2012 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2015-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87713626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis 血清胱抑素C作为肝硬化患者早期肾功能损害指标的评价

IF 1.8

International Journal of Hepatology Pub Date : 2015-10-13 DOI: 10.1155/2015/309042

Mahmoud Omar, W. Abdel-Razek, Gamal Abo-Raia, M. Assem, G. El-Azab

{"title":"Evaluation of Serum Cystatin C as a Marker of Early Renal Impairment in Patients with Liver Cirrhosis","authors":"Mahmoud Omar, W. Abdel-Razek, Gamal Abo-Raia, M. Assem, G. El-Azab","doi":"10.1155/2015/309042","DOIUrl":"https://doi.org/10.1155/2015/309042","url":null,"abstract":"Background. Serum cystatin C (CysC) was proposed as an effective reflection of the glomerular filtration rate (GFR). However, its role in patients with liver cirrhosis has not been extensively verified especially in the detection of early RI. Patients and Methods. Seventy consecutive potential candidates for living donor liver transplantation with serum creatinine (Cr) <1.5 mg/dL were included. CysC, Cr, and estimated GFR [creatinine clearance (CCr), Cockcroft-Gault formula (C-G), MDRD equations with 4 and 6 variables, CKD-EPI-Cr, CKD-EPI-CysC, and CKD-EPI-Cr-CysC] were all correlated to isotopic GFR. Early RI was defined as GFR of 60–89 mL/min/1.73 m2. Results. Patients were 25.7% and 74.3% Child-Pugh classes B and C, respectively. GFR was ≥90, 60–89, and 30–59 mL/min/1.73 m2 in 31.4%, 64.3%, and 4.3% of the patients, respectively. All markers and equations, except C-G, were significantly correlated to GFR with CKD-EPI-Cr-CysC formula having the highest correlation (r = 0.474) and the largest area under the ROC curve (0.808) for discriminating early RI. At a cutoff value of 1.2 mg/L, CysC was 89.6% sensitive and 63.6% specific in detecting early RI. Conclusion. In patients with liver cirrhosis, CysC and CysC-based equations showed the highest significant correlation to GFR and were measures that best discriminated early RI.","PeriodicalId":46297,"journal":{"name":"International Journal of Hepatology","volume":"111 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2015-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73868288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28