Rare Tumors最新文献_第3页

Extra-gastrointestinal stromal tumour of the lesser omentum presenting as a massive intra-abdominal swelling: A case report and literature review. 表现为腹内巨大肿物的小网膜胃肠道外间质瘤：病例报告和文献综述。

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Rare Tumors Pub Date : 2024-03-27 eCollection Date: 2024-01-01 DOI: 10.1177/20363613241242572

John Adi Ashindoitiang, Victor Ikechukwu Canice Nwagbara, Theophilus Ipeh Ugbem, Nkami Joseph Enya, Ikechimka Ogbugbanduchi Aniebo, Joseph Christopher Ekong, Sidney Esotu Obinna, Maurice Efana Asuquo

{"title":"Extra-gastrointestinal stromal tumour of the lesser omentum presenting as a massive intra-abdominal swelling: A case report and literature review.","authors":"John Adi Ashindoitiang, Victor Ikechukwu Canice Nwagbara, Theophilus Ipeh Ugbem, Nkami Joseph Enya, Ikechimka Ogbugbanduchi Aniebo, Joseph Christopher Ekong, Sidney Esotu Obinna, Maurice Efana Asuquo","doi":"10.1177/20363613241242572","DOIUrl":"10.1177/20363613241242572","url":null,"abstract":"Extra gastrointestinal stromal tumour(EGIST) is rare and is regarded as gastrointestinal stromal tumour(GIST) that originates outside of the gastrointestinal tract. They originate from other intraabdominal tissues such as the omentum, mesentery and peritoneum. The cell of origin is the interstitial cell of Cajal(ICC), a pacemaker cell that controls gastrointestinal peristalsis and the tumor is characterized by the expression of KIT(CD117) a transmembrane tyrosine kinase receptor. Here, a 49-year-old female who presented with a 6 month history of abdominal pain, progressive abdominal swelling and the presence of an upper abdominal mass. She had surgical resection and adjuvant imatinib for the intraabdominal mass diagnosed on histology and immunohistochemistry as EGIST of the lesser omentum. Serial CT 14 months after surgery revealed no evidence of recurrence or metastasis. Clinicians should consider EGIST in the differential diagnosis of abdominal masses.","PeriodicalId":46078,"journal":{"name":"Rare Tumors","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-grade mucoepidermoid carcinoma mimicking benign cystic lesions in the salivary gland: A diagnostic dilemma. 模仿唾液腺良性囊性病变的低级别粘液表皮样癌：诊断难题。

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Rare Tumors Pub Date : 2024-03-23 eCollection Date: 2024-01-01 DOI: 10.1177/20363613241242397

Wangpan Shi, Timothy Law, Kevin Thomas Brumund, Jennifer Chang, Charmi Patel, Grace Lin, Jingjing Hu

{"title":"Low-grade mucoepidermoid carcinoma mimicking benign cystic lesions in the salivary gland: A diagnostic dilemma.","authors":"Wangpan Shi, Timothy Law, Kevin Thomas Brumund, Jennifer Chang, Charmi Patel, Grace Lin, Jingjing Hu","doi":"10.1177/20363613241242397","DOIUrl":"10.1177/20363613241242397","url":null,"abstract":"Mucoepidermoid carcinoma (MEC) is a common malignancy arising in the parotid gland. The diagnosis of MEC is typically based on its morphological features alone, characteristically containing mucocytes, intermediate cells and epidermoid cells. However, when cystic degeneration is diffuse, it is challenging to distinguish MEC from other benign cystic tumors. This is a case report of a 58-year-old Caucasian man who presented with a parotid mass. H&E sections of the mass reveal multiloculated cysts lined by bland-looking epithelium with only rare papillary architectures. The papillary proliferation contains mucocytes, and epidermoid cells highlighted by the p63 immunohistochemistry study. The diagnosis was confirmed by FISH result of positive MAML2 (11q21) rearrangement. Patient underwent parotidectomy and is disease-free 6 months post-surgery. MEC with cystic degeneration is a common diagnostic pitfall which can mimic many benign lesions in the salivary gland. We present a rare case with MEC with extensive cystic change, its molecular and pathologic findings and review the diagnostic features of MEC, its benign mimickers and useful tools for distinguishing these entities.","PeriodicalId":46078,"journal":{"name":"Rare Tumors","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10960343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140207873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retroperitoneal mixed neuroendocrine non-neuroendocrine neoplasm: A case report and review of literature. 腹膜后混合性神经内分泌非神经内分泌肿瘤：病例报告和文献综述。

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Rare Tumors Pub Date : 2024-03-21 eCollection Date: 2024-01-01 DOI: 10.1177/20363613241242383

John Adi Ashindoitiang, Victor Ikechukwu Canice Nwagbara, Theophilus Ugbem Ipeh, Ben Chukwu, Henry Olaleye Obanife, Alfred Ottoh Eyong, Maurice Efana Asuquo

引用次数: 0

Primary lung low-grade fibromyxoid sarcoma: A rare case with A diagnostic dilemma. 原发性肺低分化纤维肉瘤：罕见病例与诊断难题。

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Rare Tumors Pub Date : 2024-02-29 eCollection Date: 2024-01-01 DOI: 10.1177/20363613241234201

Aida Ayadi, Yoldez Houcine, Chirine Moussa, Houda Rouis, Tarek Abid, Begueret Hugues, François Le Loarer

引用次数: 0

Real-world evidence for ultra rare cancers. 超罕见癌症的现实证据。

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Rare Tumors Pub Date : 2024-02-15 eCollection Date: 2024-01-01 DOI: 10.1177/20363613241234207

Leonidas Mavroeidis, Andrea Napolitano, Paul Huang, Robin L Jones

引用次数: 0

Dermatofibrosarcoma protuberans: Case series in a tropical setting and review of literature. 原发性皮纤维肉瘤：热带地区的系列病例和文献综述。

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Rare Tumors Pub Date : 2024-02-15 eCollection Date: 2024-01-01 DOI: 10.1177/20363613241234243

John Adi Ashindoitiang, Victor Ikechukwu Canice Nwagbara, Ugbem Theophilus Ipeh, George Peter Owusu, Maurice Efana Asuquo

{"title":"Dermatofibrosarcoma protuberans: Case series in a tropical setting and review of literature.","authors":"John Adi Ashindoitiang, Victor Ikechukwu Canice Nwagbara, Ugbem Theophilus Ipeh, George Peter Owusu, Maurice Efana Asuquo","doi":"10.1177/20363613241234243","DOIUrl":"10.1177/20363613241234243","url":null,"abstract":"Dermatofibrosarcoma protuberans (DFSP) is an infrequent cutaneous tumour that may involve subcutaneous fat and in some cases fascia, muscles and bone. The infrequent occurrence lessens its clinical awareness in addition to its clinical semblance to many common cutaneous lesions. It is characterized by proclivity for local recurrence. We evaluated the clinical presentation and treatment outcomes of six consecutive cases of DFSP with histologic diagnosis in the University of Calabar Teaching Hospital, Calabar seen between January 2013 and December 2022. This was compared with total cutaneous malignances in the same period. The six consecutive patients comprised of two males and four females (M = F: 1:2) whose ages ranged from 21 to 57 years (mean of 36.5 years) and accounted for 7% of cutaneous malignancies. The site distribution was trunk (back) involved in 3 (50%) of the patients, limbs 3 (50%); upper 1 (17%) and lower limb 2 (33%). Clinical presentation was in the form of firm cutaneous mass with some ulcerated lesions that bled and some fungated. 50 percent of the patients presented with recurrent lesions and in all there was no regional lymphadenopathy or evidence of metastasis. There was a patient with Neurofibromatosis- 1 who had a huge fungated limb lesion offered amputation, four had wide local excision and one incision biopsy. Follow up was poor and the period ranged from 2 to 14 months (mean 7 months). Dermatofibrosarcoma protuberans is an uncommon tumour with clinical semblance to other cutaneous lesions. Early presentation, preoperative histologic diagnosis will enhance the goal of ensuring adequate excision. Adjuvant therapy with Imatinib with or without adjuvant radiotherapy are recommended in the treatment plan in view of the frequency of late presentation with advanced recurrent lesions and poor follow up.","PeriodicalId":46078,"journal":{"name":"Rare Tumors","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10874159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139900683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An extremely rare case of recurrent pleomorphic myxoidliposarcoma with response to eribulin chemotherapy - A case report. 对艾瑞布林化疗有反应的复发性多形性肌样唇肉瘤--一例极为罕见的病例报告。

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Rare Tumors Pub Date : 2023-12-08 eCollection Date: 2023-01-01 DOI: 10.1177/20363613231212380

Raghavendra Rao, Sameer Rastogi, Divya Kashyap, Shamim A Shamim, Adarsh Barwad

{"title":"An extremely rare case of recurrent pleomorphic myxoidliposarcoma with response to eribulin chemotherapy - A case report.","authors":"Raghavendra Rao, Sameer Rastogi, Divya Kashyap, Shamim A Shamim, Adarsh Barwad","doi":"10.1177/20363613231212380","DOIUrl":"https://doi.org/10.1177/20363613231212380","url":null,"abstract":"Pleomorphic myxoid liposarcoma (PML) is a newly recognized entity with aggressive clinical behavior and a tendency to recur. It has histological features of both myxoid and pleomorphic liposarcoma and lacks the molecular and structural chromosomal abnormalities associated with myxoid and pleomorphic liposarcoma. The data about their response to chemotherapy is quite sparse. We report a case of incidentally detected pleomorphic myxoid liposarcoma of the mediastinum in a 32-year-old gentleman. After resection and adjuvant chemotherapy with doxorubicin and ifosfamide, there was no evidence of residual disease at the end of treatment. During a routine follow-up 5 months later, he was found to have a recurrence of the disease with histological confirmation. He received a trabectedin given its activity in myxoid liposarcoma. However, he had toxicities and progression leading to its discontinuation. Subsequently, eribulin was started as the next line of therapy. After 4 cycles of chemotherapy, response assessment was suggestive of partial response, which is still maintained after 7 cycles of eribulin. This is the first report of this entity responding to a newer chemotherapy regimen.","PeriodicalId":46078,"journal":{"name":"Rare Tumors","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10710107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138811991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter re: Uveal melanoma metastasis to the liver: Unveiling effective strategies with HEPZATO KIT. 葡萄膜黑色素瘤转移到肝脏:用HEPZATO KIT揭示有效的策略。

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Rare Tumors Pub Date : 2023-11-20 eCollection Date: 2023-01-01 DOI: 10.1177/20363613231218172

Ushna Zameer, Wajiha Shaikh, Anood Choudhary

引用次数: 0

Talquetamab: A promising immunotherapy for multiple myeloma. Talquetamab:一种有前途的多发性骨髓瘤免疫疗法。

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Rare Tumors Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI: 10.1177/20363613231211051

Amna Tariq, Abdul Wahid, Fatima Asif, Mahnoor Khan

引用次数: 0

Follicular adenoma with bizarre nuclei and wild-type P53 expression: A case report and literature review. 具有奇异细胞核和野生型P53表达的滤泡腺瘤：一例报告和文献复习。

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Rare Tumors Pub Date : 2023-10-28 eCollection Date: 2023-01-01 DOI: 10.1177/20363613231212383

Daniel Nguyen, Nyein Nyein Htun, Beverly Wang

{"title":"Follicular adenoma with bizarre nuclei and wild-type P53 expression: A case report and literature review.","authors":"Daniel Nguyen, Nyein Nyein Htun, Beverly Wang","doi":"10.1177/20363613231212383","DOIUrl":"https://doi.org/10.1177/20363613231212383","url":null,"abstract":"Introduction: Thyroid cancer is the most common endocrine tumor in humans. Follicular adenoma/carcinoma is the second most common subtype. Multiple histological patterns have been identified. Follicular adenoma with bizarre nuclei is one of the patterns associated with p53 mutation and has an unclear clinical prognosis.Case report: A 74-year-old female presented with incidental findings of elevated TSH levels and normal thyroid markers. Ultrasound was performed and revealed multiple bilateral thyroid nodules measuring up to 1.9 cm. Fine needle aspiration was performed, and cytology showed one Bethesda category 5 nodule. Total thyroidectomy with neck dissection was performed, and the pathology showed follicular adenoma with bizarre nuclei. Based on the results of immunohistochemistry, the neoplastic cells exhibited staining for wild-type p53 and low levels of the proliferation index Ki-67.Conclusions: We report a rare case of thyroid follicular adenoma with bizarre nuclei. In contrast to previous reports of this tumor, our patient showed a p53 wild-type pattern using immunohistochemistry. More studies are needed to better understand the etiology and clinical prognosis of this tumor.","PeriodicalId":46078,"journal":{"name":"Rare Tumors","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2023-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0