Rare Tumors最新文献_第10页

Vaginal oligometastatic disease of colorectal primary: Report of a novel therapeutic approach. 原发结肠直肠阴道少转移性疾病:一种新的治疗方法的报告。

IF 0.9

Rare Tumors Pub Date : 2021-09-23 eCollection Date: 2021-01-01 DOI: 10.1177/20363613211044566

Sobiya Ansari, Yixiang Liao, Summer Dewdney, Dian Wang, Parul Barry

{"title":"Vaginal oligometastatic disease of colorectal primary: Report of a novel therapeutic approach.","authors":"Sobiya Ansari, Yixiang Liao, Summer Dewdney, Dian Wang, Parul Barry","doi":"10.1177/20363613211044566","DOIUrl":"https://doi.org/10.1177/20363613211044566","url":null,"abstract":"Vaginal oligometastatic disease of colorectal primary is a rare malignancy with few reported cases in the literature and no standardized treatment paradigm. We report on the definitive management of an unusual case of an elderly woman with the aforementioned disease. A 78-year-old African-American woman presented with vaginal spotting and was found to have a vaginal lesion. Final pathology was consistent with moderately differentiated adenocarcinoma of colorectal primary. Extensive work up, which included endoscopies, pathologic analyzes, and imaging workup, did not reveal a primary gastrointestinal malignancy. The patient underwent partial vaginectomy and final pathology once again confirmed moderately differentiated adenocarcinoma of colorectal primary (CDX 2 and CEA positive, ER/PR, and CK 7 negative) with negative margins. She went on to receive adjuvant concurrent chemoradiation with 5-FU based chemotherapy. She received 45 Gy in 25 fractions to the whole pelvis followed by an HDR brachytherapy boost to 12 Gy in two fractions. Unfortunately, 10 months after completing radiation, she was found to have adenocarcinoma arising from a hepatic flexure colon polyp on colonoscopy. She required definitive surgical resection and was staged as mpT3N0M1. She received 12 cycles of 5-FU and at 2-year follow-up was found to be disease free with no evidence of locoregional recurrence or distant metastatic disease. Continued long-term follow up is warranted.","PeriodicalId":46078,"journal":{"name":"Rare Tumors","volume":" ","pages":"20363613211044566"},"PeriodicalIF":0.9,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/6f/10.1177_20363613211044566.PMC8474297.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39494352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The first case report of primary thyroid teratocarcinosarcoma: An analog to sinonasal teratocarcinosarcoma. 原发性甲状腺畸胎癌肉瘤一例报告:类似鼻窦畸胎癌肉瘤。

IF 0.9

Rare Tumors Pub Date : 2021-08-29 eCollection Date: 2021-01-01 DOI: 10.1177/20363613211043662

Akwasi Ofori Abayie, Kofi Mensah Nyarko, Markus Bährle, Alfred Brütting

{"title":"The first case report of primary thyroid teratocarcinosarcoma: An analog to sinonasal teratocarcinosarcoma.","authors":"Akwasi Ofori Abayie, Kofi Mensah Nyarko, Markus Bährle, Alfred Brütting","doi":"10.1177/20363613211043662","DOIUrl":"https://doi.org/10.1177/20363613211043662","url":null,"abstract":"Teratocarcinosarcoma is a rare and aggressive tumor usually affecting the sinonasal tract. It arises primarily from the nasal cavity, paranasal sinuses with some reported cases arising from the nasopharynx and oral cavity and commonly referred to as Sinonasal Teratocarcinosarcoma (SNTC). We present the first case of teratocarcinosarcoma as a primary thyroid cancer in a 17-year-old male patient who presented with a rapidly growing anterior neck mass with no symptoms. Physical examination revealed circa 4 cm × 5 cm slightly right sided, non-tender, firm anterior neck swelling. A thyroid ultrasound revealed an enlarged thyroid gland with multiple thyroid nodes. Magnetic Resonance Imaging (MRI) of the head and neck showed no sinonasal tract tumor. Thyroidectomy and surgical resection of the tumor was performed. Histological examination revealed teratocarcinosarcoma of the thyroid gland, an analog to SNTC with no primary sinonasal tissue involvement. This implies that, teratocarcinosarcoma can occur in primary tissues other than sinonasal origin contrary to conventional knowledge.","PeriodicalId":46078,"journal":{"name":"Rare Tumors","volume":" ","pages":"20363613211043662"},"PeriodicalIF":0.9,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/1b/10.1177_20363613211043662.PMC8408892.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39386457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Aggressive osteoblastoma with a secondary aneurysmal bone cyst treated with denosumab. 地诺单抗治疗侵袭性成骨细胞瘤伴继发性动脉瘤性骨囊肿。

IF 0.9

Rare Tumors Pub Date : 2021-08-29 eCollection Date: 2021-01-01 DOI: 10.1177/20363613211034710

Karlton Wong, Jomjit Chantharasamee, Scott Nelson, Mark A Eckardt, Kambiz Motamedi, Francis J Hornicek, Arun S Singh

{"title":"Aggressive osteoblastoma with a secondary aneurysmal bone cyst treated with denosumab.","authors":"Karlton Wong, Jomjit Chantharasamee, Scott Nelson, Mark A Eckardt, Kambiz Motamedi, Francis J Hornicek, Arun S Singh","doi":"10.1177/20363613211034710","DOIUrl":"https://doi.org/10.1177/20363613211034710","url":null,"abstract":"Osteoblastomas and aneurysmal bone cysts (ABC) are rare benign bone tumors that make up about 1%-2% of primary bone malignancies, typically occurring in young patients with a median age of 20 years, most commonly effecting the axial skeleton. ABCs may develop independently as primary lesions, or secondary to other bony lesions including osteoblastomas, chondroblastomas, and giant cell tumors. Treatment of unresectable or extensive osteoblastomas can be challenging. In 2013, the Food and Drug Administration (FDA) approved denosumab for the treatment of giant cell tumors of the bone due to its efficacy in these morbid bony lesions. Various case reports have shown that osteoblastomas can respond to denosumab. Furthermore, numerous ABC case reports have described the efficacy of denosumab in these situations. We herein describe a unique case of a young patient with an aggressive osteoblastoma and secondary ABCs who was successfully treated with denosumab.","PeriodicalId":46078,"journal":{"name":"Rare Tumors","volume":" ","pages":"20363613211034710"},"PeriodicalIF":0.9,"publicationDate":"2021-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2c/5f/10.1177_20363613211034710.PMC8408893.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39388559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Choriocarcinoma metastatic to the skin: A rare occurrence associated with dismal outcome. 绒毛膜癌转移到皮肤:一种罕见的发生与令人沮丧的结果。

IF 0.9

Rare Tumors Pub Date : 2021-08-20 eCollection Date: 2021-01-01 DOI: 10.1177/20363613211039724

Mousa ElKhaldi, Rakan Radi, Maysa Al-Hussaini

引用次数: 0

Olaratumab's failure in soft tissue sarcoma. 奥拉拉单抗在软组织肉瘤中的失败。

IF 0.9

Rare Tumors Pub Date : 2021-07-18 eCollection Date: 2021-01-01 DOI: 10.1177/20363613211034115

Maroun Bou Zerdan, Aram H Bidikian, Ibrahim Alameh, Clara El Nakib, Hazem I Assi

{"title":"Olaratumab's failure in soft tissue sarcoma.","authors":"Maroun Bou Zerdan, Aram H Bidikian, Ibrahim Alameh, Clara El Nakib, Hazem I Assi","doi":"10.1177/20363613211034115","DOIUrl":"https://doi.org/10.1177/20363613211034115","url":null,"abstract":"Soft tissue sarcomas remain one of the rarest malignancies with numerous subtypes that go undiagnosed. The PDGFRα antagonist Olaratumab (Lartruvo) was withdrawn from the market due to disappointing findings in the phase III studies. We share our experience with this medication in a tertiary care center in the Middle East and North Africa region. Monitor the effect of Olaratumab on sarcomas when it was used prior to its withdrawal, and compare our findings with the literature. We performed a retrospective analysis of adult patients with advanced-/metastatic soft tissue sarcomas treated with at least two cycles of Olaratumab at a tertiary care center in Lebanon during the period from January 1, 2017 to December 31, 2018. Fifteen patients were included in the study. The mean age was 49 with a range of 26-75 years. The median duration of the use of Olaratumab was 21.3 months with a range of 7.3-37 months. The average number of number of cycles received per patient was four. Five patients were deceased. Median PFS was 7.87 months (95% CI 5.28-10.45), and mean OS was 12.26 months (95% CI 8.47-16.05) Median OS was 9.8 months (95% CI 6.07-13.53). Olaratumab has been withdrawn from the market, and it is currently being investigated as part of the phase II ANNOUNCE 2 trial. Our experience from a tertiary care center shows results similar to those reported in the literature. The immunogenicity and heterogeneity of soft tissue sarcomas pose a challenge to the treatment of soft tissue sarcomas, but they also allow a wide array of possible management solutions.","PeriodicalId":46078,"journal":{"name":"Rare Tumors","volume":" ","pages":"20363613211034115"},"PeriodicalIF":0.9,"publicationDate":"2021-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/20363613211034115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39276934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of chordoma presenting as a Pancoast tumor. 一例罕见的脊索瘤表现为Pancoast肿瘤。

IF 0.9

Rare Tumors Pub Date : 2021-07-02 eCollection Date: 2021-01-01 DOI: 10.1177/20363613211029493

Philip T Sobash, Krishna Vedala, Daniel Alfano, Heather Pinckard-Dover, Jason L Muesse, Raman Desikan

引用次数: 0

Extragonadal germ cell tumor, a report of two cases presenting in the gastrointestinal tract. 生殖道外生殖细胞瘤2例报告。

IF 0.9

Rare Tumors Pub Date : 2021-06-30 eCollection Date: 2021-01-01 DOI: 10.1177/20363613211029487

Mousa Elkhaldi, Ahamd Moayad Naser, Yazan AlHalaseh, Maysa Al-Hussaini

引用次数: 2

Undifferentiated pleomorphic sarcoma in oropharyngeal mucosa of patients with multiple basal cell carcinomas. 多发性基底细胞癌患者口咽黏膜中的未分化多形性肉瘤。

IF 0.9

Rare Tumors Pub Date : 2021-06-30 eCollection Date: 2021-01-01 DOI: 10.1177/20363613211026483

Andrea Dekanić, Marko Velepič, Margita Belušić Gobić, Ita Hadžisejdić, Nives Jonjić

引用次数: 0

Breast erythema and nodular skin metastasis as the first manifestation of breast implant-associated anaplastic large cell lymphoma. 乳房红斑和结节性皮肤转移是乳房植入物相关间变性大细胞淋巴瘤的首要表现。

IF 0.9

Rare Tumors Pub Date : 2021-06-30 eCollection Date: 2021-01-01 DOI: 10.1177/20363613211028498

Noellie Ducastel, Ioana-Mariana Cimpean, Ivan Theate, Olivier Vanhooteghem

引用次数: 2

Intraosseous ancient Schwannoma: A rare case in the mandible and a literature review. 骨内古老神经鞘瘤:下颌骨一例罕见病例并文献复习。

IF 0.9

Rare Tumors Pub Date : 2021-06-27 eCollection Date: 2021-01-01 DOI: 10.1177/20363613211026480

Neda Kardouni Khoozestani, Maziar Motiee-Langroudi, Ali Salehi, Paniz Ranji

引用次数: 6