Medical-Surgical Journal-Revista Medico-Chirurgicala最新文献

{"title":"Pulmonary rehabilitation between a past in shadows and a bright future","authors":"P. Postolache","doi":"10.22551/msj.2022.03.01","DOIUrl":"https://doi.org/10.22551/msj.2022.03.01","url":null,"abstract":"","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73415408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senescent fibroblasts beta-galactosidase induced by extracellular vesicles obtained from MSC-iPSC under the action of various modulators","authors":"I. Cazan","doi":"10.22551/msj.2022.03.11","DOIUrl":"https://doi.org/10.22551/msj.2022.03.11","url":null,"abstract":"(Abstract): The absolute majority of published experimental data involve mesenchymal stem cells, although the possibilities offered by the use of pluripotent stem cells reprogrammed from mesenchymal stem cells are practically infinite. Aim : The goal of our study was represented by tracking the effects of stimulation and inhibition of multiple functional, intracellular pathways of senescent dermal fibroblasts in culture, in the presence of microvesicles released from pluripotent stem cells reprogrammed from mesenchymal stem cells. Material and methods : We used flow cytometry to measure the production of the be-ta-galactosidase level by dermal fibroblasts in culture after 30 passages and ultraviolet treatment. Results : Reduction of β-galactosidase concentrations in senescent dermal fibroblasts was evident upon administration of exosomes (approximately 20% on average) and exosomes co-administered with: LY-294002 (a highly selective PI3K kinase inhibitor, 41% on average); nutlin-3 (which stabilizes the non-genomic actions of p53, respectively the MDM2/p53 pathway, 63% on average); rapamycin (which stimulates autophagy and the mTOR pathway and related ones, 62% on average); and metformin (a pharmacologically active substance, considered a reprogrammer of energy metabolism, 73% on average). Conclusions : Exosomes derived from pluripotent stem cells induced from mesenchymal stem cells, administered in the culture medium of senescent dermal fibroblasts, can modify the degree and evolution of the senescence of these last cells by potentiating, activating, or stimulating some intracellular pathways of biological signal transduction, but especially through epigenetic reprogramming of energy metabolism.","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90172362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidities in patients with post-operative meningitis in neurosurgery","authors":"V. Dorobăţ","doi":"10.22551/msj.2022.03.02","DOIUrl":"https://doi.org/10.22551/msj.2022.03.02","url":null,"abstract":"NEUROSURGERY (Abstract): Meningitis is a serious condition that affects the central nervous sys-tem and can be caused by bacterial, viral, or fungal infection . Postoperative meningitis is a post procedural complication and disorder of the nervous system. Material and methods : We performed a retrospective study between 2016 and 2019 including 627 patients who underwent neurosurgical interventions. Of these, 32 presented postoperative meningitis being admitted between 2016 and 2019 to the “Sf. Parascheva” Clinical Hospital of Infectious Diseases, Iasi, in order to assess the impact of comorbidities among these patients. Results : From 24 patients with comorbidities, we evaluated a percentage of 45.83% patients with ischemic heart disease. We identified a number of 15 patients (62.5%) with arterial hypertension, which demonstrates the high prevalence of vascular diseases among these cases. Also, we found 4 cases with metabolic disorders which means 16.66% from all the patients with associated pathology. On the other hand, we analyzed the prevalence of other important associated comorbidities which can increase the mortality and morbidity associated risk. Conclusions : The impact of multiple comorbidities on the management and evolution of infectious diseases, especially in postoperative meningitis, is complex and needs collaboration with colleagues from all the specialties involved.","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77191412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology profile of West Nile virus meningitis infections in North-East of Romania","authors":"Georgiana Enache-Leonte","doi":"10.22551/msj.2022.03.13","DOIUrl":"https://doi.org/10.22551/msj.2022.03.13","url":null,"abstract":"PROFILE NILE ROMANIA (Abstract): Meningitis is a disease with global presence that represents a worldwide issue, with the West Nile Virus as an etiological factor. The severity of viral meningitis depends on different factors such as age, immune system and etiological agents. Aim: The aim of the study was to study the frequency of West Nile Virus meningitis and to bring a contribution to the existing knowledge of the WNV distribution on adult individuals in Romania. Results : They showed a complete etiological and symptomatic picture for WNV meningitis with the main cause being the climatic changes experienced for the sudden appearance of an increased number of WNV infections. Conclusions : This retrospective study may constitute a foundation for a plan to prevent a possible epidemic of meningitis caused by the West Nile virus.","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82100479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and study of rectal ibuprofen mucoadhesive hydrogels","authors":"E. Rédai","doi":"10.22551/msj.2022.03.18","DOIUrl":"https://doi.org/10.22551/msj.2022.03.18","url":null,"abstract":"HYDROGELS Abstract): The rectal route represents an alternative to oral administration in pediat-rics. Ibuprofen is a non- steroidal anti-inflammatory agent, used in all age groups to reduce pain, fever, and inflammation. Aim: to develop and characterize ibuprofen-containing mucoadhesive rectal gels. Material and methods: Carbopol 940, sodium alginate, and low viscosity hydroxypropyl methylcellulose HPMC were used as gel-forming agents and propyl-ene-glycol and glycerin as permeation enhancers. 5% of ibuprofen was incorporated in all formulations. Three gels have been prepared containing 1% Carbopol, 0.5% Carbopol and 5% HPMC, and 5% sodium alginate. The influence of formulation variables on the pharma-co-technical parameters (adhesivity, pH, and diffusion) was studied. The amount of API released through the membrane using a Franz cell in the acceptor media was measured. Mathematical models were applied to model the release of the active substance. Results: The pH of gels ranged between 4.2-5.0. Viscosity varied between 165 and 212 mPas. The detachment force was from 0.02 to 0.12 N. All three gels were formulated suitable for children and adults. Conclusions: The obtained experimental results showed a superior release of ibuprofen from the 5% sodium alginate gel.","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87939019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of aerobic exercise on memory, depression, and anxiety like symptoms in an animal model of autism","authors":"A. Ciobica","doi":"10.22551/msj.2022.03.12","DOIUrl":"https://doi.org/10.22551/msj.2022.03.12","url":null,"abstract":"","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75705240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude and variation of the manganese, iron and ammonia in drinking water from Timis county, Romania","authors":"C. Petrescu","doi":"10.22551/msj.2022.03.14","DOIUrl":"https://doi.org/10.22551/msj.2022.03.14","url":null,"abstract":"MAGNITUDE AND VARIATION OF THE MANGANESE, IRON AND AMMONIA IN DRINKING WATER FROM TIMIS COUNTY, ROMANIA (Abstract): The aim of the performed study was to investigate the magnitude and variation of the manganese, iron and ammonia, as identified key issues, considering presence/absence of chlorination, area, property and time when the samples were collected. Material and methods: The observational case-study was conducted for 2 years (2016-2017) on a sample of 1,086 water sources in Timis County. A statistically significant difference (p<0.001) resulted between chlorinated and non-chlorinated sources for manganese and for iron mean-concentrations, Timisoara and Timis County (rural) public wells for manganese and for iron mean concentrations, and public and companies` wells in Timisoara for manganese. Results: Statistically significant differences of ammonia mean concentrations were also found between Timis County and Timisoara for public wells (p<0.001) and for companies (p=0.002), in non-chlorinated water. Calculated medians of manganese concentrations in well water were high in Timisoara (200 µg/L) and in Timis County (95 µg/L) and exceeded MAC (50 µg/L). The highest concentration of manganese (500 µg/L) was recorded in Timisoara, in 2016. Median of iron (93 µg/L) concentrations in public wells in Timis-County (rural) was much higher than median (50 µg/L) in public wells in Timisoara. Both median values didn`t exceed MAC (200 µg/L). Still, the highest mean concentration of iron (3,780 µg/L) was found in a public well from Timisoara, in 2016. Median of ammonia concentrations in public wells (non-chlorinated water) in Lugoj (0.6 mg/L) also surpassed MAC (0.5 mg/L). Conclusions: excessive concentrations of manganese, iron and ammonia were found in drinking water in Timis County, with significant variation in space, time and depending on property and chlorination.","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79403009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum health-related quality of life and associated perinatal factors among women in North-East Romania","authors":"D. Grab","doi":"10.22551/msj.2022.03.07","DOIUrl":"https://doi.org/10.22551/msj.2022.03.07","url":null,"abstract":"ROMANIA (Abstract): The aim of this cross-sectional study was conducted to assess the health-related quality of life and its af-fecting factors among women from North-East Romania at six weeks postpartum. Material and methods: The study was conducted in a tertiary care hospital, at the “Cuza-Vodă” University Hospital of Obstetrics and Gynecology in Iași (Romania), from May to December 2021. The validated short-form (SF-36) questionnaire was used to assess health-related quality of life (HRQoL) of 321 women at six weeks postpartum. Results: The mean Physical Component Summary and Mental Component Summary scores, two summary measures that aggregate the eight most important domains of health status, were both reported higher than 50% (59.05 ± 19.48, 55.08 ± 25.17, respectively). Highest median scores were reported in body pain (69.25 ± 28.87) and physical functioning domains (65.42 ± 14.78). Lowest median scores were reported in vitality (44.57± 20.20) and general health perceptions (48.73 ± 25.99). Factors associated with higher overall HRQoL were maternal age under 30 and multiparity. Number of days of peripartum hospitalization was inversely proportional to all scales of the SF-36 questionnaire. Conclusions: In this study, we highlight the need for additional studies on ways to predict the onset of labor, in order to shorten the period of peripartum hospitalization of pregnant women in North-East Romania, and implicitly to improve their quality of life . rRNA analysis which detects not only live and active microbes but also dead and dormant microbes. 51 adult patients (age>20) were included in this study with mean age of 45, between 2012 and 2017 and followed up through 2020; patients who had taken antibiotics within 3 months before biopsies and with primary sclerosis cholangitis were not enrolled in this study; no patients enrolled developed colorectal cancer during the follow-up period. Colon mucosal bi-opsy were obtained at enrollment and 16S rRNA sequencing was performed. 24 patients were in remission of which 7 developed relapses during follow-up and 27 in active UC which were classified into response group (n=6), refractory group (n=13) and non-response group (n=8) according to their treatment response in 6 months. Results : no difference in the gut microbiota composition between rectum and colon; the proportion of Bacteroides de-creased as the severity of mucosal inflammation increased; unexpectedly Bacteroides was significantly lower in the non-relapse group than in the relapse group; secondly, the proportion of Enterobacteriaceae increased as the mucosal inflammation increased; in the active period a high proportion of Enterobacteriaceae was resistance to any treatments; the proportion of Clostridiales was higher in the non-relapse group whereas Prevotella was higher in the response group. In conclusion, gut microbiota composition can predict treatments strategies and clinical course of UC in terms of the relapse rate during the remissi","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73836949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brâncuși-Gerota “Écorché” – 120th anniversary since its completion","authors":"S. Grădinaru","doi":"10.22551/msj.2022.03.19","DOIUrl":"https://doi.org/10.22551/msj.2022.03.19","url":null,"abstract":"(Abstract): The Écorché or “Ecorșeul”, is the first of the many works of art done by Constantin Brâncuși, the world-renowned Romanian artist. It was achieved in collaboration with the famous anatomist Prof. Dr. Dimitrie Gerota and represents a national premiere in being the first anatomical work conceived in such detail in 20 th century Romania. The debutant artist assimilated knowledge about the human anatomy from the dissection of human bodies, this being a process which harmoniously binds art with the study of anatomy. Inspired by An-tinous’s statue, Brâncuși used, in his work, its stature and flamboyant pose. Awe-inspiring are the copies of Brâncusi’s Écorché, which, worked in plaster and attentively supervised by Brâncuși. They were donated later to Medical Schools and Art Schools around Romania for academic study. The Écorché, which was realized with intense efforts, brings national and international renown to the young sculptor, at the very start of his carrier, which became, with the passing of time, a work linked closely to his name, despite the modernist and ab-stract current which embodied his","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89429497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations on cases of diffuse axonal injury autopsied in the Institute of Forensic Medicine Iasi, Romania","authors":"I. Hunea","doi":"10.22551/msj.2022.03.04","DOIUrl":"https://doi.org/10.22551/msj.2022.03.04","url":null,"abstract":"CONSIDERATIONS ON CASES OF DIFFUSE AXONAL INJURY AUTOPSIED IN THE (Abstract) : Traumatic brain injury (TBI), mainly caused by road traffic accidents and falls, is one of the main causes of mortality. Survivors often present with debilitating motor, sensory and cognitive symptoms, leading to a reduced quality of life and a profound economic burden on society. Material and methods : The study was conducted by analyzing forensic cases autopsied at the Institute of Forensic Medicine Iasi, between 2015-2020, diagnosed antemortem with traumatic brain injury and diffuse axonal injury (DAI). The analysis includes a retrospective study of the forensic necropsy cases conducted between 2015-2020. Data were loaded and processed using statistical functions in SPSS 18.0 at the 95% significance level. Results: The analysis of forensic cases autopsied at the Institute of Forensic Medicine Iasi between 2015-2020 showed a number of 7818 autopsied cases, of which 3545 were violent deaths. Of these, 567 had as cause of death craniocerebral trauma; of these only 70 cases were accompanied by the imaging diagnosis of DAI, which corresponds to 12% of all cases of craniocerebral trauma. Conclusions : The imaging diagnosis of DAI was refuted by pathological examination in 24 of the cases, out of a total of 70 patients with a radiological diagnosis of DAI, corresponding to 34.28% of cases. The survival rate of rural patients was significantly higher (14.27 vs. 7.33 days; p=0.03). Patients with DAI have a high mortality, supported by a 50% decrease after the first week in the chance of survival.","PeriodicalId":45975,"journal":{"name":"Medical-Surgical Journal-Revista Medico-Chirurgicala","volume":null,"pages":null},"PeriodicalIF":0.1,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87790908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}