NOTES AND QUERIES最新文献

Toxicity analysis of busulfan pharmacokinetic therapeutic dose monitoring. 丁砜药代动力学治疗剂量监测的毒性分析。

IF 0.1 3区文学

NOTES AND QUERIES Pub Date : 2026-03-01 Epub Date: 2022-06-07 DOI: 10.1177/10781552221104422

Kelly J Gaffney, Theresa A Urban, Mariana Lucena, Faiz Anwer, Robert M Dean, Aaron T Gerds, Betty K Hamilton, Deepa Jagadeesh, Matt E Kalaycio, Jack Khouri, Brad Pohlman, Ronald Sobecks, Allison Winter, Lisa Rybicki, Navneet S Majhail, Brian T Hill

{"title":"Toxicity analysis of busulfan pharmacokinetic therapeutic dose monitoring.","authors":"Kelly J Gaffney, Theresa A Urban, Mariana Lucena, Faiz Anwer, Robert M Dean, Aaron T Gerds, Betty K Hamilton, Deepa Jagadeesh, Matt E Kalaycio, Jack Khouri, Brad Pohlman, Ronald Sobecks, Allison Winter, Lisa Rybicki, Navneet S Majhail, Brian T Hill","doi":"10.1177/10781552221104422","DOIUrl":"10.1177/10781552221104422","url":null,"abstract":"Busulfan-based conditioning regimens are associated with serious toxicities and literature reports increased risk of toxicities when daily area under the curve concentrations exceed 6000 µM-minute. We implemented real time pharmacokinetic-guided therapeutic drug monitoring of busulfan for myeloablative conditioning regimens. The objective was to compare toxicity of intravenous busulfan before and after therapeutic drug monitoring implementation. The primary endpoint was incidence of hepatotoxicity. Medical records were retrospectively reviewed with weight-based dose Busulfan/Cyclophosphamide (BuCy) conditioning from August 2017 through March 2018 (N = 14) and therapeutic drug monitoring from April 2018 through December 2018 (N = 22). Recipients of busulfan therapeutic drug monitoring were younger than those receiving weight-based dose (median: 45 vs. 58 years, p = 0.008). No other baseline differences were observed. There was no difference in hepatotoxicity between therapeutic drug monitoring and weight-based dose (median 1 vs. 0 days, p = 0.40). In the therapeutic drug monitoring group, 45% of patients had increases and 41% had decreases in busulfan dose after Bu1. Repeat pharmacokinetic after Bu2 were required in 32% of patients. A pharmacokinetic dose monitoring program for myeloablative conditioning intravenous busulfan regimens may be considered a safe practice in stem cell transplant recipients. The majority of patients receiving pharmacokinetic-guided therapeutic drug monitoring required dose changes and therapeutic drug monitoring patients had no significant difference in toxicity compared to those receiving weight-based dose.","PeriodicalId":45476,"journal":{"name":"NOTES AND QUERIES","volume":"1 1","pages":"184-188"},"PeriodicalIF":0.1,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83031369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How do digital range of motion measurement devices 'measure-up' to traditional goniometry in assessing shoulder range of motion? A systematic review and meta-analysis. 在评估肩关节活动范围方面，数字活动范围测量设备如何 "衡量 "传统动态关节角度计？系统回顾和荟萃分析。

IF 0.1 3区文学

NOTES AND QUERIES Pub Date : 2024-07-01 Epub Date: 2023-08-31 DOI: 10.1177/17585732231195554

J Shepherd, S Hansjee, P Divall, P Raval, H P Singh

{"title":"How do digital range of motion measurement devices 'measure-up' to traditional goniometry in assessing shoulder range of motion? A systematic review and meta-analysis.","authors":"J Shepherd, S Hansjee, P Divall, P Raval, H P Singh","doi":"10.1177/17585732231195554","DOIUrl":"10.1177/17585732231195554","url":null,"abstract":"Background: Shoulder range of motion (ROM) is traditionally measured using universal goniometry. However, novel devices to measure shoulder ROM digitally are becoming increasingly available. We aimed to synthesise the current evidence to answer: 1) what technologies are currently in use? 2) Are they reliable? 3) How do they compare to goniometry?Methods: Systematic review of the literature was conducted according to PRISMA guidelines. MEDLINE, Embase, CINAHL, Emcare and Cochrane databases were searched to identify studies comparing a digital device measuring shoulder ROM to goniometry in participants > = 18years. Quality of studies was assessed using COSMIN risk of bias tool. End points included device validity compared to goniometry and intra-rater reliability.Results: 15 articles were included, representing 372 participants and 608 shoulders, and reporting data for five device categories; infrared/RGB-D, 3D-motion-analysis, combined 3D/infra-red, 2D-video-analysis and virtual-reality. Nine studies reported mean bias and 95% limits of agreement (LOA) compared to goniometry. Pooled mean bias was -0.25 degrees (-1.25, 0.75 95% LOA, random effects model) overall. This did not differ by device type (p = 0.83), sensor or non-sensor-based devices (p = 0.62) or plane of movement (p = 0.91).Conclusions: These devices compare well to goniometry and represent a possible means of increasing efficiency and facilitating telemedicine.","PeriodicalId":45476,"journal":{"name":"NOTES AND QUERIES","volume":"1 1","pages":"363-381"},"PeriodicalIF":0.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11418675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83155353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low and high body mass index and lower numbers of screws in the articular segment are risk factors for non-union of distal humeral fractures in the elderly: A multi-center retrospective study (TRON study). 低体重指数和高体重指数以及关节段螺钉数量较少是老年人肱骨远端骨折不愈合的风险因素：一项多中心回顾性研究（TRON 研究）。

IF 0.1 3区文学

NOTES AND QUERIES Pub Date : 2024-07-01 Epub Date: 2022-10-17 DOI: 10.1177/17585732221131923

Kenya Iwase, Yasuhiko Takegami, Katsuhiro Tokutake, Yasutaka Oshika, Hiroki Yokoyama, Kohei Tanaka, Tadahiro Sakai, Shiro Imagama

{"title":"Low and high body mass index and lower numbers of screws in the articular segment are risk factors for non-union of distal humeral fractures in the elderly: A multi-center retrospective study (TRON study).","authors":"Kenya Iwase, Yasuhiko Takegami, Katsuhiro Tokutake, Yasutaka Oshika, Hiroki Yokoyama, Kohei Tanaka, Tadahiro Sakai, Shiro Imagama","doi":"10.1177/17585732221131923","DOIUrl":"10.1177/17585732221131923","url":null,"abstract":"Background: Distal humerus fracture in the elderly is a challenging fracture for orthopedic surgeons. Non-union is one of the serious complications of distal humerus fracture after surgery. This retrospective multicenter study aimed to estimate the incidence of distal humeral non-union after open reduction and internal fixation, determine factors related to non-union, and compare the postoperative results of cases with non-union to cases with the union.Methods: Among 423 patients diagnosed with distal humeral fracture and who were treated by surgical therapy in 2010-2020 from our database called TRON. Only 190 subjects met the inclusion criteria. We performed a logistic regression analysis with the presence of non-union as the response variable to examine risk factors. We compare the Mayo Elbow Performance Scores of cases with non-union to cases with the union.Results: Non-union occurred after surgery in 15 patients (7.9%). The logistic regression analysis showed that body mass index<20 kg/m2 and ≥25 kg/m2, and ≤3 screws in the articular segment were significant explanatory factors for non-union (odds ratio 10.4 and 47.8, respectively). The Mayo Elbow Performance Scores were significantly worse in patients with non-union.Discussion: Low and high body mass index and three or fewer screws in the articular segment might be risk factors for non-union of distal humerus fracture in the elderly. Non-union is associated with poor clinical outcomes.","PeriodicalId":45476,"journal":{"name":"NOTES AND QUERIES","volume":"1 1","pages":"312-320"},"PeriodicalIF":0.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82918297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "A Review of 13470 Head and Neck Injuries From Trampoline Jumping". 蹦床跳跃造成的 13470 例头颈部损伤回顾 "的更正。

IF 0.1 3区文学

NOTES AND QUERIES Pub Date : 2024-06-01 Epub Date: 2023-05-17 DOI: 10.1177/19433875231173469

引用次数: 0

Exploring the Relationship Between Anticipated Stigma and Community Shared Concerns about HIV on Defaulting from HIV Care in Rural South Africa. 探索南非农村地区预期的污名化和社区对艾滋病毒的共同关注与不接受艾滋病毒护理之间的关系。

IF 0.1 3区文学

NOTES AND QUERIES Pub Date : 2024-05-01 Epub Date: 2023-08-31 DOI: 10.1037/sah0000475

Erica N Browne, Marie C D Stoner, Chodziwadziwa Kabudula, Mi-Suk Kang Dufour, Torsten B Neilands, Hannah H Leslie, Rebecca L West, Dean Peacock, F Xavier Gómez-Olivé, Kathleen Kahn, Audrey Pettifor, Sheri A Lippman

{"title":"Exploring the Relationship Between Anticipated Stigma and Community Shared Concerns about HIV on Defaulting from HIV Care in Rural South Africa.","authors":"Erica N Browne, Marie C D Stoner, Chodziwadziwa Kabudula, Mi-Suk Kang Dufour, Torsten B Neilands, Hannah H Leslie, Rebecca L West, Dean Peacock, F Xavier Gómez-Olivé, Kathleen Kahn, Audrey Pettifor, Sheri A Lippman","doi":"10.1037/sah0000475","DOIUrl":"10.1037/sah0000475","url":null,"abstract":"Although stigma has been associated with people living with HIV defaulting from care, there is a gap in understanding the specific impact of individual stigma and community-level concern about HIV on defaulting.Methods: This is a secondary analysis of a unique dataset that links health facility-based medical records to a population-representative community survey conducted in 2018 in rural Mpumalanga province, South Africa. We used the parametric g-formula to estimate associations among individual anticipated stigma, low perceived community and local leader concern about HIV, and defaulting from care in the prior year. In addition, we estimated the population-level effects of intervening to reduce stigma and increase concern on defaulting.Results: Among 319 participants on treatment, 42 (13.2%) defaulted from care during the prior year. Anticipated stigma (risk ratio [RR] 1.22, 95% confidence interval [CI]: 0.72, 2.74), low perceived concern about HIV/AIDS from community leadership (RR 1.12, 95% CI 0.76, 3.38), and low shared concerns about HIV/AIDS in the community (RR 1.37; 95% CI 0.79, 3.07) were not significantly associated with default. Hypothetical population intervention effects to remove individual anticipated stigma and low community concerns yielded small reductions in default (~1% reduction).Conclusions: In this sample, we found limited impact of reducing anticipated stigma and increasing shared concern about HIV on retention in care. Future studies should consider the limitations of this study by examining the influence of other sources of stigma in more detail and assessing how perceptions of stigma and concern impact the full HIV testing and care cascade.","PeriodicalId":45476,"journal":{"name":"NOTES AND QUERIES","volume":"1 1","pages":"173-180"},"PeriodicalIF":0.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11230650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82945959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"文学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Institutions to Inclusion: How Children with Disabilities Gained Educational Rights in the U.S. 从机构到融合：美国残疾儿童如何获得教育权

IF 1.7 3区文学

NOTES AND QUERIES Pub Date : 2024-02-01 Epub Date: 2022-06-05 DOI: 10.1177/10598405221105054

Michelle L Nighswander, Patricia A Blair

引用次数: 0

Chaucer, House of Fame, 1039 乔叟：《名望之家》，1039 页

IF 0.1 3区文学

NOTES AND QUERIES Pub Date : 2024-01-09 DOI: 10.1093/notesj/gjad123

A. S. G. Edwards

引用次数: 0

Chaucer’s Truth and Phillipps MS 11409: A Retraction 乔叟的真理与菲利浦斯 MS 11409：回溯