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Journal of Experimental Therapeutics and Oncology最新文献

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Superselective intraarterial cerebral infusion of cetuximab with blood brain barrier disruption combined with Stupp Protocol for newly diagnosed glioblastoma. 超选择性脑动脉灌注西妥昔单抗合并血脑屏障破坏联合Stupp方案治疗新诊断的胶质母细胞瘤。
Journal of Experimental Therapeutics and Oncology Pub Date : 2018-05-01
Kay O Kulason, Julia R Schneider, Shamik Chakraborty, Christopher G Filippi, Bidyut Pramanik, Tamika Wong, Sherese Fralin, Karissa Tan, Ashley Ray, Rachel A Alter, Rafael Ortiz, Alexis Demopoulos, David J Langer, John A Boockvar
{"title":"Superselective intraarterial cerebral infusion of cetuximab with blood brain barrier disruption combined with Stupp Protocol for newly diagnosed glioblastoma.","authors":"Kay O Kulason,&nbsp;Julia R Schneider,&nbsp;Shamik Chakraborty,&nbsp;Christopher G Filippi,&nbsp;Bidyut Pramanik,&nbsp;Tamika Wong,&nbsp;Sherese Fralin,&nbsp;Karissa Tan,&nbsp;Ashley Ray,&nbsp;Rachel A Alter,&nbsp;Rafael Ortiz,&nbsp;Alexis Demopoulos,&nbsp;David J Langer,&nbsp;John A Boockvar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>We describe the first case of a novel treatment for a newly diagnosed glioblastoma (GBM) using superselective intraarterial cerebral infusion (SIACI) of cetuximab after osmotic disruption of the blood-brain barrier (BBB) with mannitol. A 51year-old female underwent craniotomy for removal of a right frontal GBM. Pathology confirmed EGFR amplification, and she underwent three treatments of SIACI of cetuximab to the tumor site. The first treatment was given within a week of starting standard of care chemoradiation (Stupp protocol), which is a combination of radiation treatment (2 Gy per/ day x 30 days, total of 60 Gy) and oral temozolomide (75 mg/m<sup>2</sup>). The second and third SIACI of cetuximab were administered 3 and 6 months later, while the patient continued on maintenance temozolomide. Post-radiation changes on MRI were stable, and there were no signs of recurrence at 4 and 6 months post-resection. Herein, we detail the technical aspects of this novel treatment paradigm and suggest that SIACI of cetuximab after BBB disruption using mannitol, combined with the standard of care chemoradiation therapy, may be an effective treatment method for newly diagnosed EGFR amplified glioblastoma.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Necrotising sialometaplasia: a diagnostic perplexity? An innocent entity to malignant masquerade. 坏死性唾液化生:一个诊断难题?一个无辜的实体以恶意的伪装。
Journal of Experimental Therapeutics and Oncology Pub Date : 2018-05-01
Neeti Swarup, Meghanand T Nayak, Zoya Chowdhary, S Chandarani
{"title":"Necrotising sialometaplasia: a diagnostic perplexity? An innocent entity to malignant masquerade.","authors":"Neeti Swarup,&nbsp;Meghanand T Nayak,&nbsp;Zoya Chowdhary,&nbsp;S Chandarani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Necrotising Sialometaplasia is a benign self limiting reactive condition of major and minor salivary glands, which can arouse suspicion for malignancy, clinically and histopathologically. Here, we report a case of 38-year-old female with a painful ulcer on the palate. The case enlightens the importance of clinicopathologic correlation and diligent follow up in diagnosis and management of the case.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of low level radiation on concentrations of some trace elements in radiation workers. 低水平辐射对辐射工作人员体内某些微量元素浓度的影响。
Journal of Experimental Therapeutics and Oncology Pub Date : 2018-05-01
Nima Rostampour, Tinoosh Almasi, Masoumeh Rostampour, Hamid Reza Sadeghi, Ehsan Khodamoradi, Reyhaneh Razi, Zahra Derakhsh
{"title":"Impact of low level radiation on concentrations of some trace elements in radiation workers.","authors":"Nima Rostampour,&nbsp;Tinoosh Almasi,&nbsp;Masoumeh Rostampour,&nbsp;Hamid Reza Sadeghi,&nbsp;Ehsan Khodamoradi,&nbsp;Reyhaneh Razi,&nbsp;Zahra Derakhsh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Small variations in trace element levels may cause important physiological changes in the human body. This study aims to evaluate five important trace elements in radiation workers.</p><p><strong>Method: </strong>In this study, 44 radiation workers and an equal number of non-radiation workers were selected as the case and control group, respectively. The concentrations of iron, magnesium, zinc, copper, and selenium in the serum of the participants were measured using an Atomic Absorption Spectrometry (AAS).</p><p><strong>Results: </strong>The mean concentrations of iron, magnesium, zinc, copper, and selenium for the case group were 107.3 µg/dl, 2.3 mg/dl, 80.9 µg/dl, 112.6 µg/dl and 216.7 ng/ml, respectively. The results for the control group were 121.9 µg/dl, 2.3 mg/dl, 82.3 µg/dl, 112.8 µg/dl and 225.2 ng/ml, respectively.</p><p><strong>Conclusions: </strong>The mean concentration of iron in the case group was significantly lower than the control group (p-value = 0.012), while the concentrations of other elements in both of the groups were not significantly different. In the case group, except magnesium (p-value = 0.021), no significant relationship was found between age and the elemental concentrations. According to Spearman's test, there was a meaningful statistical correlation between the sex and concentration of iron, Mg, Zn, and Se. Also, the correlation between the concentration of magnesium and the weights of radiation workers was significant (p-value =0.044).</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticancer activity of chlorhexidine and cranberry extract: an in-vitro study. 氯己定和蔓越莓提取物的抗癌活性:体外研究。
Journal of Experimental Therapeutics and Oncology Pub Date : 2018-05-01
Mahesh R Khairnar, Umesh Wadgave, Harish Jadhav, Rahul Naik
{"title":"Anticancer activity of chlorhexidine and cranberry extract: an in-vitro study.","authors":"Mahesh R Khairnar,&nbsp;Umesh Wadgave,&nbsp;Harish Jadhav,&nbsp;Rahul Naik","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Oral cancer is considered to be a global pandemic. The study was conducted to assess the anti-cancer activities of Chlorhexidine (CHX) and Cranberry against oral cancer cell lines.</p><p><strong>Material and methods: </strong>Anticancer activity of CHX and Cranberry extract (CE) was assessed against AW13516 (poorly to moderately differentiated squamous cell carcinoma of tongue) and KB (Nasopharyngeal carcinoma) using Sulforhodamine B (SRB) assay at the Advanced Centre for Treatment Research and Education in Cancer (ACTREC) Mumbai, India. Three dose related parameters GI50, TGI and LC50 were calculated for each drug.</p><p><strong>Results: </strong>CE (80µg/ml) showed no anti-cancer property against AW13516 cell line; however it showed 70.6% growth inhibition against KB cell line. CHX demonstrated 80.15% & 95.7% of growth inhibition against AW13516 & KB cell line respectively. Both the drugs were less potential than positive control drug Adriamycin, as reflected by their GI50, TGI and LC50 values.</p><p><strong>Conclusion: </strong>CHX exhibited better anti-cancer properties than CE for both the oral cancer cell lines.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibitory effects of mushroom extracts on progression of carcinogenesis in mice. 香菇提取物对小鼠癌变进程的抑制作用。
Journal of Experimental Therapeutics and Oncology Pub Date : 2018-05-01
Caroline Wasonga, Charles Omwandho
{"title":"Inhibitory effects of mushroom extracts on progression of carcinogenesis in mice.","authors":"Caroline Wasonga,&nbsp;Charles Omwandho","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Hepatocellular carcinoma is a common primary malignancy of hepatocytes that has caused many fatalities globally. To manage the increasing cases of hepatocellular carcinoma, natural products like mushrooms have been tested for their anti-oxidant, anti-tumour and therapeutic properties. This study aimed to investigate the effect of Agaricus bisporus on progression of chemically induced carcinogenesis in mice. Carcinogenesis was induced in experimental and positive group of mice. Development and progression of carcinogenesis was monitored by quantifying levels of Lactate dehydrogenase, total sialic acid and by histological analysis. The results of the study showed that, unlike lactate dehydrogenase, the levels of sialic acid consistently decreased throughout the experimental period in mice that were fed on mushroom extracts compared to the positive control. Histological analysis also showed protection of the hepatocytes from carcinogenesis progression. Overall, the results from tumour markers and histological analysis, showed that addition of Agaricus bisporus extracts to diet slowed down progression of carcinogenesis and these extracts therefore may be useful as supplementary diet to conventional cancer therapies.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic non-healing ulcer of the oral cavity: tuberculosis or carcinoma? 口腔慢性不愈合溃疡:结核还是癌?
Journal of Experimental Therapeutics and Oncology Pub Date : 2018-05-01
Neeti Swarup, Meghanand T Nayak, Nitali Arun, S Chandarani, Zoya Chowdhary
{"title":"Chronic non-healing ulcer of the oral cavity: tuberculosis or carcinoma?","authors":"Neeti Swarup,&nbsp;Meghanand T Nayak,&nbsp;Nitali Arun,&nbsp;S Chandarani,&nbsp;Zoya Chowdhary","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Tuberculosis is a chronic granulomatous lesion, which primarily has an affinity for the lungs. It can involve other sites like lymph nodes, kidney, oral cavity. Infection of the oral cavity by M. tuberculosis can be as a Primary infection or as a Secondary infection. Primary presentation of oral tuberculosis is in the form of the chronic non healing ulcer. A Primary infection or an Asymptomatic Secondary infection can impose a great diagnostic dilemma, as it may mimic neoplasia. Here we present a case of a 32-year-old asymptomatic female with secondary infection.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive molar pregnancy in rudimentary uterine horn. 初生子宫角侵袭性磨牙妊娠。
Journal of Experimental Therapeutics and Oncology Pub Date : 2018-05-01
Zeynep Aslı Oskovi Kaplan, Ali Levent Şirvan, Hasan Onur Topçu
{"title":"Invasive molar pregnancy in rudimentary uterine horn.","authors":"Zeynep Aslı Oskovi Kaplan,&nbsp;Ali Levent Şirvan,&nbsp;Hasan Onur Topçu","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Incidence of molar pregnancy is 1-3/1000 pregnancies. Invasive mole is a local invasive form of gestational trophoblastic neoplasias which is mostly seen in reproductive age and usually follows a molar pregnancy and rarely has an initial presentation. Ectopic pregnancy in rudimentary uterine horn is extremely rare and is seen in 1/100,000 - 140,000 pregnancies. Invasive mole has seldom been reported in ectopic localizations but not in a patient with Müllerian duct anomaly. Here we represent a case of invasive mole in a reproductive age patient with unicornuate uterus and rudimentary communicating uterine horn. Invasive mole presented initially, mimicking ectopic pregnancy. The patient underwent diagnostic laparoscopy and resection of rudimentary uterine horn was performed. The pathology result was reported as an invasive mole. Serum b-hCG levels normalized on post-operative first month and no additional chemotherapy was needed.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cavitary myiasis and its management. 空洞蝇蛆病及其治疗。
Journal of Experimental Therapeutics and Oncology Pub Date : 2018-05-01
Shreya Gour, Gayathri Ramesh, Vijayendra Kumar, G K Thapliyal, Ramesh Nagarajappa
{"title":"Cavitary myiasis and its management.","authors":"Shreya Gour,&nbsp;Gayathri Ramesh,&nbsp;Vijayendra Kumar,&nbsp;G K Thapliyal,&nbsp;Ramesh Nagarajappa","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Myiasis is a parasitic disease of humans and vertebrates, caused by fly larvae feeding on the host's necrotic or living tissue. Myiasis is classified into cutaneous and cavitary myiasis. Cavitary myiasis is rare and occurs more frequently in tropical and subtropical regions of Africa and America associated with low economic status and poor hygiene. This article reviews current literature, provides general descriptions, and discusses life cycles of each species. It also gives diagnosis, treatment techniques and descriptions of each type of illness that result from interaction / infestation.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of life of cancer patients. 癌症患者的生活质量。
Journal of Experimental Therapeutics and Oncology Pub Date : 2018-05-01
Solanki Jitender, Rajive Mahajan, Vikram Rathore, Rahul Choudhary
{"title":"Quality of life of cancer patients.","authors":"Solanki Jitender,&nbsp;Rajive Mahajan,&nbsp;Vikram Rathore,&nbsp;Rahul Choudhary","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Cancer is a one of the major public health problem both in developed and developing countries around the globe. Quality-of-life (QOL) of a cancer patient before and after the treatment is an important issue especially for the cancer survivors, their families, and the care providers. In cancer prospective, Quality-of-life can been defined as a sense of well-being, it is a multidimensional perspective that includes dimensions such as physical, psychological, social, and spiritual, changes in one QOL dimension can influence perceptions in other dimensions also. Cancer patients should demand information related to adverse effects of chemotherapy and actions to be taken to reduce them, also there should be provision of providing sufficient information prior to beginning of the treatment procedure irrespective to type of treatment, so that patient is aware of all the treatment modalities and their side effects and self-care strategies so as to reduce treatment-related concerns.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer medicine: a direction. 癌症医学:一个方向。
Journal of Experimental Therapeutics and Oncology Pub Date : 2018-05-01
Sunil Kumar Kashyap, Birendra Kumar Sharma, Amitabh Banerjee, Anil Kumar Tiwari, Vikas Kumar Jain, Swati Jain, Ashutosh Pandey
{"title":"Cancer medicine: a direction.","authors":"Sunil Kumar Kashyap,&nbsp;Birendra Kumar Sharma,&nbsp;Amitabh Banerjee,&nbsp;Anil Kumar Tiwari,&nbsp;Vikas Kumar Jain,&nbsp;Swati Jain,&nbsp;Ashutosh Pandey","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The medicine of cancer is directed in this paper. The pie theory is applied for the proposed medicine. The improbability and un-constancy are the major theories, which are used to design this anti-cancer medicine.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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