Journal of Experimental Therapeutics and Oncology最新文献

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Odontogenic cyst with diverse histopathological features: report of an unusual case. 具有多种组织病理特征的牙源性囊肿:1例罕见病例报告。
Bhari S Manjunatha, Nagarajappa Das, Tanveer Ahmed
{"title":"Odontogenic cyst with diverse histopathological features: report of an unusual case.","authors":"Bhari S Manjunatha,&nbsp;Nagarajappa Das,&nbsp;Tanveer Ahmed","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>It is a well established fact that all inflammatory and developmental cysts of odontogenic origin have squamous epithelial linings. They may show various forms of metaplasia from a stratified squamous to more highly differentiated ciliated columnar or mucous cells. Dentigerous cyst represents is the most common developmental odontogenic cyst usually associated with an impacted tooth after complete formation of the crown. A dentigerous cyst encloses is seen attached to the neck of the tooth at the cementoenamel junction associated with an unerupted/ impacted tooth and grows by expansion of the dental follicles. We report a similar case of dentigerous cyst associated with an impacted tooth, histologically demonstrates the characteristics of a glandular odontogenic cyst with pseudo- stratified ciliated columnar epithelium lining with goblet cells and mucous cells.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":"12 4","pages":"295-302"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36715859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A mismatch of tumor grade and biologic behaviour in a rare case of Sclerosing Mucoepidermoid Carcinoma of Parotid - with review of literature. 罕见的腮腺硬化性黏液表皮样癌肿瘤分级与生物学行为的不匹配-并附文献复习。
Anju Devi, Anjali Narwal, Mala Kamboj, Sunita Singh
{"title":"A mismatch of tumor grade and biologic behaviour in a rare case of Sclerosing Mucoepidermoid Carcinoma of Parotid - with review of literature.","authors":"Anju Devi,&nbsp;Anjali Narwal,&nbsp;Mala Kamboj,&nbsp;Sunita Singh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Although mucoepidermoid carcinoma is the most common primary malignancy of the salivary glands, the sclerosing morphologic variant of this tumor is extremely rare and only 26 cases have been reported till date in the english literature. This report describes a case involving a 35-year-old female with an intermediate-grade sclerosing mucoepidermoid carcinoma of parotid gland and we review the litreture. Immunohitochemical markers, Her-2/neu and MIB-1 evaluated to help predict the clinical outcome and to determine whether an association exists between the histologic grade and immunohistochemical findings. A PAS stain revealed cytic spaces filled with basophilic material. We found MIB-1 labeling indices of >50% and strong positivity for Her-2/neu suggesting poor prognosis. Our case did not show any correlation between MIB-1 index and tumor grade as shown in other case reports. This unusual but distinctive variant of mucoepidermoid carcinoma can be difficult to recognize and is frequently misdiagnosed as a benign lesion.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":"12 4","pages":"307-315"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36715861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hemangioma-like telangiectatic granuloma: A diagnostic pitfall. 血管瘤样毛细血管扩张肉芽肿:一个诊断缺陷。
Zoya Chowdahry, Shalabh Mehrotra, Neeti Swarup, Falak Chowdhary, Aamir Chowdhary
{"title":"Hemangioma-like telangiectatic granuloma: A diagnostic pitfall.","authors":"Zoya Chowdahry,&nbsp;Shalabh Mehrotra,&nbsp;Neeti Swarup,&nbsp;Falak Chowdhary,&nbsp;Aamir Chowdhary","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>A telangiectatic granuloma is a localized reactive lesion associated with prolonged irritation to the soft tissues. It may be misdiagnosed as a vascular malformation, hemangiomas, angiosarcomas, etc; as clinical presentation of the lesions resembles each other. Here, we present a case of asymptomatic swelling in the maxilla of a 17-year old female patient. The case highlights the importance of clinicopathologic correlation for the correct diagnosis and management of the case.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":"12 4","pages":"291-294"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36715858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Writing oral pathology biopsy report: a guide for beginners. 口腔病理活检报告的书写:初学者指南。
Sandhya Tamgadge, Avinash Tamgadge, Bhagyashree Agre
{"title":"Writing oral pathology biopsy report: a guide for beginners.","authors":"Sandhya Tamgadge,&nbsp;Avinash Tamgadge,&nbsp;Bhagyashree Agre","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Descriptive pathology in surgical biopsy reports is mainly about writing histopathology reports. However, it is almost always performed under the pressure of time and accuracy. Accuracy is critical because the patient is still alive and the clinician is going to act on the diagnosis quickly. Most reports are evaluated and generated by a single pathologist. Therefore, possibility of making mistakes in writing a biopsy report is usually existing. A clear concise unambiguous writing style is extremely important to meet the needs of the report. In some reports there is insufficient information and in others excess verbiage is included with no medical value. The lack of a professional standard has resulted in some of the inconsistency in biopsy reports. Although much has been studied and written about biopsy reports but no such compiled studies along with descriptive pathology mentioned in oral and maxillofacial pathology literature. Therefore, extensive literature search had been made and various articles have been retrieved from various databases such as PubMed, Medline, google science direct etc. Duration of studies or articles have not been decided as there are very few such descriptive articles in reputed journals. Articles in the form of PDF, word and even website articles have been included. This review article presents extensive review of various parameters to be considered in writing histopathology report of oral lesions.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":"12 4","pages":"273-279"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36715855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unusual behavior of diffuse large B-cell lymphoma as cardiac invasion with rapid spontaneous regression after fine needle aspiration cytology. 弥漫性大b细胞淋巴瘤侵袭心脏的异常表现,细针穿刺细胞学检查后迅速自发消退。
Adel El-Badrawy, Reham Abd El-Wahab, Maha Elzaafarany, Ziad Emarah, Mona M Taalab, Noha Eisa, Mohammad K El-Badrawy, Mohamed Farouk Akl, Nirmeen Megahed, Sherif Arafa
{"title":"Unusual behavior of diffuse large B-cell lymphoma as cardiac invasion with rapid spontaneous regression after fine needle aspiration cytology.","authors":"Adel El-Badrawy,&nbsp;Reham Abd El-Wahab,&nbsp;Maha Elzaafarany,&nbsp;Ziad Emarah,&nbsp;Mona M Taalab,&nbsp;Noha Eisa,&nbsp;Mohammad K El-Badrawy,&nbsp;Mohamed Farouk Akl,&nbsp;Nirmeen Megahed,&nbsp;Sherif Arafa","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Spontaneous regression (SR) of lymphoma is a rare phenomenon. While the precise mechanism of SR remains unknown, apoptosis may be associated with its process. Here, we present a case of a 52-year-old woman was admitted to our hospital with cough and orthopnea for 2 weeks. Multi-detector computed tomography of whole body showed anterior and middle mediastinal soft tissue mass with multiple adjacent malignant lymphadenopathy. The mediastinal mass invaded right atrium and pericardium. Another left subphrenic retro-pancreatic mass was detected. This mass surrounded upper pole of left kidney. Fine needle aspiration cytology was done and revealed lymphocytic smear with advised tru-cut biopsy. CT guided tru-cut was taken after 8 days. During CT guided technique; marked regression of left subphrenic mass was detected. Post-contrast MDCT scan was done and revealed partial response of the masses after 8 days. The partial regressive course of this disease suggests the effectiveness of fine needle aspiration cytology in initiating spontaneous regression. Tru-cut biopsy revealed non-Hodgkin lymphoma (diffuse large B-cell type). We report a case of NHL with abnormal location and spontaneous regression.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":"12 4","pages":"287-290"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36715857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A radiolucent lesion presenting calcification histopathologically: a classical case of CEOT. 在组织病理学上表现为钙化的放射性病变:典型的CEOT病例。
Anjali Narwal, Anju Devi, Shruti Gupta, Ambika Gupta
{"title":"A radiolucent lesion presenting calcification histopathologically: a classical case of CEOT.","authors":"Anjali Narwal,&nbsp;Anju Devi,&nbsp;Shruti Gupta,&nbsp;Ambika Gupta","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm that accounts for approximately 1% of all odontogenic tumors. Histologically, it shows sheets of polyhedral epithelial cells with deep eosinophilic cytoplasm and prominent nuclei. Globules of amyloid like material among tumor cells which undergoes calcification are evident. We present a case of CEOT which presented classical histopathologic picture but clinico- radiological it presented variably. Its non association with impacted tooth, no calcifications in the incisional material and finally on excision giving its classical picture of prominent intercellular bridges, hyperchromatic polyhedral cells and amyloid with calcifications made it an interesting case to report.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":"12 4","pages":"317-322"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36715862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curing cancer by cancer function. 通过癌症功能来治疗癌症
Sunil Kumar Kashyap, Vikas Kumar Jain, Swati Jain, Ashutosh Pandey, Birendra Kumar Sharma, Amitabh Banerjee
{"title":"Curing cancer by cancer function.","authors":"Sunil Kumar Kashyap,&nbsp;Vikas Kumar Jain,&nbsp;Swati Jain,&nbsp;Ashutosh Pandey,&nbsp;Birendra Kumar Sharma,&nbsp;Amitabh Banerjee","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Cancer is the disease which exists when the cell is uncontrolled. This paper presents a controller for the same. The cancer cell is reviewed via algebraic structures.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":"12 4","pages":"333-334"},"PeriodicalIF":0.0,"publicationDate":"2018-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36765397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer Cell Controller. 癌细胞控制器。
Sunil Kumar Kashyap, Birendra Kumar Sharma, Amitabh Banerjee, Vikas Kumar Jain, Swati Jain, Ashutosh Pandey
{"title":"Cancer Cell Controller.","authors":"Sunil Kumar Kashyap,&nbsp;Birendra Kumar Sharma,&nbsp;Amitabh Banerjee,&nbsp;Vikas Kumar Jain,&nbsp;Swati Jain,&nbsp;Ashutosh Pandey","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Cancer is the disease which exists when the cell is uncontrolled. This paper presents a controller for the same. The cancer cell is reviewed via algebraic structures.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":"12 3","pages":"245-246"},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of novel prognostic markers PROX1 and FOXC2 in carcinogenesis of oral squamous cell carcinoma. 新型预后标志物PROX1和FOXC2在口腔鳞状细胞癌发生中的作用。
Neha S Agnihotri, Madhusudan Astekar
{"title":"The role of novel prognostic markers PROX1 and FOXC2 in carcinogenesis of oral squamous cell carcinoma.","authors":"Neha S Agnihotri,&nbsp;Madhusudan Astekar","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Oral squamous cell carcinoma is the most common malignant tumor of the head and neck regions and accounts for more than 90% of cancers in the oral cavity. The angiogenesis, lymphangiogenesis and epithelial mesenchymal transition are known to be pivotal for tumor progression and metastasis. In the last decade, much data has been generated concerning the molecular mechanisms of angiogenesis, lymphangiogenesis and its significance in pathological conditions. The main angiogenic and lymphangiogenic factors have been identified as vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor receptor 2 (VEGFR-2), forkhead box (FOX) C2 while vascular endothelial growth factor C/D (VEGF-C/D), vascular endothelial growth factor receptor 3 (VEGFR-3), Prospero homeobox 1 (PROX1), LYVE-1, podoplanin, Tie/Angioprotein (Ang) 2 and EphrinB2 respectively. PROX1 is a mammalian homologue of Drosophilia homeobox protein, prospero and important for the embryonic development of many mammalian tissues. It has been suggested that it plays various tissue dependent functional roles, which reflects both oncogenic potential and a tumor suppressive role. The exact role in OSCC remains controversial. FOXC2 is a transcription factor belongs to large family of protein, forkhead box. It has been shown to be involved in cancer angiogenesis, proliferation and metastasis through its induction of epithelial-to-mesenchymal transition while its significance in OSCC remains unknown. Based on these data, this article reviews the role of novel prognostic factors PROX1 and FOXC2 in carcinogenesis of OSCC so that they might be considered as an attractive therapeutic target for both tumor associated blood vessels, lymphatic vessels and tumor cells.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":"12 3","pages":"171-184"},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of hospital based prevalence of oral cancer among population of Kanpur, Uttar Pradesh. 北方邦坎普尔人口口腔癌医院患病率评估
Amrita Raj, Gayathri Ramesh, Sunita Pathak
{"title":"Assessment of hospital based prevalence of oral cancer among population of Kanpur, Uttar Pradesh.","authors":"Amrita Raj,&nbsp;Gayathri Ramesh,&nbsp;Sunita Pathak","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Oral cancer incidence depends on both qualitative and quantitative factors wherein the incidence of oral cancer in patients with smoking and tobacco chewing habit is 8.4 times higher than that of patients with no habit.</p><p><strong>Aim: </strong>To understand about the prevalence of oral cancer in population of Kanpur reported to the hospital and analyse the association with age, gender and tobacco habit.</p><p><strong>Material and method: </strong>All 320 cases of Squamous cell carcinoma diagnosed histopathologically, since January 2007 to December 2016, were retrieved from the archives and a retrospective study was conducted along with association with the variables such as age, gender, site, habit and histopathological type.</p><p><strong>Results: </strong>A total of 71 cases were reported in the age group of 30-39 (22.18%) and 60 cases (18.75%) were seen to be below 30yrs. Among individuals with habit, 135 (42.18%) were tobacco chewers and smoking was prevalent in about 48 (15%). The prevalence was more in males 37 (15.22%). Amongst both males (44.03%) and females (48.05%) gingivo-buccal sulcus was the most common site. The least common site was seen to be lip with only 10 (3.12%) patients. Well differentiated squamous cell carcinoma was common in both males and females with 155 (63.78%) and 47 (61.03%) respectively. Poorly differentiated squamous cell carcinoma was only reported in 4(1.64%) males.</p><p><strong>Conclusion: </strong>Early detection of these oral cancers will enable appropriate clinical management and monitoring. Moreover, improving the incidence, mortality, and survival rates of oral cancer requires a multi-tier structural approach that targets society, dentists, communities, and the individual.</p>","PeriodicalId":45335,"journal":{"name":"Journal of Experimental Therapeutics and Oncology","volume":"12 3","pages":"193-199"},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36122127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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