Journal of Clinical Neonatology最新文献_第3页

Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting 静脉注射西地那非治疗资源有限的新生儿持续性肺动脉高压

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Journal of Clinical Neonatology Pub Date : 2023-07-01 DOI: 10.4103/jcn.jcn_33_23

Mirta Noemi Mesquita Ramirez, M. Acevedo, Olivia Cardozo Sarubbi, Dina Carrera, Pedro Villalba Cabral

{"title":"Intravenous sildenafil for the treatment of persistent pulmonary hypertension of the newborn in a resource-limited setting","authors":"Mirta Noemi Mesquita Ramirez, M. Acevedo, Olivia Cardozo Sarubbi, Dina Carrera, Pedro Villalba Cabral","doi":"10.4103/jcn.jcn_33_23","DOIUrl":"https://doi.org/10.4103/jcn.jcn_33_23","url":null,"abstract":"Introduction: Treatment of severe persistent pulmonary hypertension of the newborn (PPHN) is based on the administration of selective pulmonary vasodilators. Inhaled nitric oxide is the only vasodilator therapy approved by the Food and Drug Administration. Non-selective vasodilator such as sildenafil has been the treatment available administered orally in most developing countries to manage newborn with PPHN. The aim of the study was to describe the effects and tolerability of intravenous (IV) sildenafil, as a loading dose of 0.4 mg/kg, followed by a continuous infusion of 1.6 mg/kg for 72 h on the oxygenation index (OI) in neonates with PPHN. Materials and Methods: This was an exploratory observational prospective study. Newborns ≥35 weeks of gestational age, post-natal age ≤72 h, with PPHN and an OI ≥20 were included in the study. Sildenafil was administered intravenously as a loading dose of 0.4 mg/kg, followed by a continuous infusion of 1.6 mg/kg for 72 h. During the sildenafil infusion, monitoring of vital signs and respiratory parameters was performed. The data were analysed with the SPSS v21. Results: Twenty-five infants were included. A significant improvement (P = 0.01) of OI (at admission, median: 25 and interquartile range [IQR] = 8) was observed at the end of the loading dose (3 h) (18 IQR = 4) and at 72 h (7 IQR = 4). No serious adverse effects were observed. Before hospital discharge, seven patients died. Conclusions: IV sildenafil administered, in newborns with PPHN with an IO ≥20, improved oxygenation in most of the patients without serious side effects.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"12 1","pages":"99 - 104"},"PeriodicalIF":0.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42799656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hand drying practices following handwashing in neonatal intensive care units: Time for a closer evaluation of this neglected component of “hand hygiene?” 新生儿重症监护室洗手后的手干燥做法:是时候对这一被忽视的“手卫生”组成部分进行更密切的评估了?

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Journal of Clinical Neonatology Pub Date : 2023-07-01 DOI: 10.4103/jcn.jcn_41_22

Sanjana Hansoge, T. Babu

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Incidental finding of non-occlusive aortic thrombi in two extremely pre-mature infants 两例极早产儿非闭塞性主动脉血栓的偶然发现

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Journal of Clinical Neonatology Pub Date : 2023-07-01 DOI: 10.4103/jcn.jcn_20_23

E. Rivero, S. Manzar

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Determination of the strength of SNAPPE II score (Score for Neonatal Acute Physiology with Perinatal Extension-II) to predict neonatal mortality in a neonatal intensive care unit of tertiary care hospital: A prospective observational study 确定SNAPPE II评分(围生期新生儿急性生理评分-II)预测三级医院新生儿重症监护病房新生儿死亡率的强度:一项前瞻性观察研究

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Journal of Clinical Neonatology Pub Date : 2023-07-01 DOI: 10.4103/jcn.jcn_36_23

Swapnali Bansode, H. Bhandekar, M. Tiwari, Pradeep Pazare

{"title":"Determination of the strength of SNAPPE II score (Score for Neonatal Acute Physiology with Perinatal Extension-II) to predict neonatal mortality in a neonatal intensive care unit of tertiary care hospital: A prospective observational study","authors":"Swapnali Bansode, H. Bhandekar, M. Tiwari, Pradeep Pazare","doi":"10.4103/jcn.jcn_36_23","DOIUrl":"https://doi.org/10.4103/jcn.jcn_36_23","url":null,"abstract":"Aim: The Score for Neonatal Acute Physiology with Perinatal Extension-II (SNAPPE-II) is a novel risk prediction system for neonatal mortality. This observational study aims to determine its ability to predict mortality risk in neonates admitted to the neonatal intensive care unit (NICU). Methodology: This prospective observational research was conducted for 12 months, from October 2021 to September 2022. Seventy-eight newborns, who fulfilled the inclusion criteria, were enrolled in our study. The outcomes of neonates were compared with the degree of SNAPPE II score calculated for respective neonates after admission. A receiver operating characteristic (ROC) curve was generated to determine the optimum SNAPPE-II cutoff score for mortality. Results: During the period of research, 292 newborns got admitted to our NICU. Among these, 78 neonates met the requirements for inclusion. Thirty-two infants (39.71%) of the 78 neonates died, while 47 were discharged. Newborns who died had substantially higher SNAPPE-II scores than those who lived (median [interquartile range] 37 [5–67] vs. 13 [0–48], P = 0.001). The area under the ROC curve (area under the curve): 0.837 (95% confidence interval, 0.73–0.91); SNAPPE II score demonstrated the ability to predict mortality. The cutoff score with the highest sensitivity and specificity for predicting death was 29. Compared to newborns with a SNAPPE II score of 29 or less, those over 29 had a considerably increased chance of mortality. The odds ratio estimate was 15.27, which indicates that neonates with high scores have around 15 times the risk of dying, as do those with low scores. Conclusion: This study suggests that the SNAPPE II score is a valuable tool for predicting mortality in neonates admitted to the NICU.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"12 1","pages":"91 - 95"},"PeriodicalIF":0.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48987332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic resonance imaging for diagnosis and prognosticating neurological outcome in cases of neonatal seizure 磁共振成像诊断和预测新生儿癫痫的神经预后

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Journal of Clinical Neonatology Pub Date : 2023-07-01 DOI: 10.4103/jcn.jcn_43_23

Krishna Dathan, V. Lakshmi

{"title":"Magnetic resonance imaging for diagnosis and prognosticating neurological outcome in cases of neonatal seizure","authors":"Krishna Dathan, V. Lakshmi","doi":"10.4103/jcn.jcn_43_23","DOIUrl":"https://doi.org/10.4103/jcn.jcn_43_23","url":null,"abstract":"Background: Neonatal seizures are one of the leading causes of neonatal mortality and morbidity. In cases of neonatal seizures, the cause of the seizures determines the long-term outcome. There are a number of adverse outcomes associated with this condition, including hearing loss,recurrence of seizures, impaired mental and motor development, and cerebral palsy. The use of magnetic resonance imaging (MRI) of the brain for the diagnosis of neonatal seizures has become one of the most common diagnostic methods since it does not require radiation and is possible to perform during the newborn's physiological sleep. Aim of this study was to examine etiological associations, the long-term neurological consequences, and the use of magnetic resonance imaging as a tool for predicting neurodevelopmental outcomes in newborn infants with seizures. Methods: In this retrospective cohort study, a tertiary care hospital was used as the setting. The study included neonates with seizures who underwent MRI scans of their brains during their hospitalization. A structured clinical follow-up period of 18 to 24 months was used to assess the neurodevelopment of the child. Results: A total of 92 percent of 48 infants who underwent MRIs had an underlying cause. A diagnosis of hypoxic-ischemic encephalopathy was the most common (27%), followed by a diagnosis of meningitis (23.2%).Of the 43 infants who were followed up, 21 were found to have neurodevelopmental impairment (NDI), while ten were found to have moderate to severe neurodevelopmental impairment, with these outcomes being more common in infants without HIE. MRI findings were abnormal in 32 of 48 infants scanned. The absence of major cerebral lesions is highly correlated with a normal neurological outcome. Conclusion: MRI helped identify the etiology of seizures in 92 percent of cases. At 18-24 months, the risk of neurodevelopmental delay is low if the MRI brain shows no lesions. The findings of this study demonstrate the utility of MRI in neonates for diagnosing and predicting neurological outcomes.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"12 1","pages":"115 - 119"},"PeriodicalIF":0.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42689791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pros and cons of incorporating ChatGPT AI chatbots in neonatal care: An imaginary discussion with medical professionals and parents 将ChatGPT AI聊天机器人纳入新生儿护理的利弊:与医疗专业人员和父母的假想讨论

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Journal of Clinical Neonatology Pub Date : 2023-07-01 DOI: 10.4103/jcn.jcn_19_23

A. Almudeer, Noor Ali, A. Jamal, M. Temsah

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Isolated macrostomia with bilateral facial cleft in a preterm neonate 孤立性大口畸形伴双侧面裂一例早产儿

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Journal of Clinical Neonatology Pub Date : 2023-07-01 DOI: 10.4103/jcn.jcn_30_23

Prashanth Raghavendra, Sruthi S. Nair, A. Haribalakrishna, Revati Tekwani

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Oromandibular limb hypogenesis syndrome in a neonate 新生儿口下颌肢体发育不良综合征

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Journal of Clinical Neonatology Pub Date : 2023-07-01 DOI: 10.4103/jcn.jcn_28_23

Prashanth Raghavendra, Medha Goyal, A. Haribalakrishna

引用次数: 0

Apgar score at various gestational ages 不同胎龄的Apgar评分

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Journal of Clinical Neonatology Pub Date : 2023-07-01 DOI: 10.4103/jcn.jcn_21_23

M. Zakerihamidi, Sheila Kianifar, A. Moradi, H. Boskabadi

{"title":"Apgar score at various gestational ages","authors":"M. Zakerihamidi, Sheila Kianifar, A. Moradi, H. Boskabadi","doi":"10.4103/jcn.jcn_21_23","DOIUrl":"https://doi.org/10.4103/jcn.jcn_21_23","url":null,"abstract":"Introduction: The Apgar score is an accepted method for reporting the condition of a newborn. The present study was performed to evaluate the Apgar score at different gestational ages. Methodology: This cross-sectional study was performed on 1161 newborns with a gestational age of 25–40 weeks born in the maternity ward of Ghaem Hospital in Mashhad during 2014–2021 with available sampling. The data collection was performed with the researcher-made checklist, including neonatal characteristics. The neonatal Apgar scores of the 1st and 5th min and the cord pH after birth were registered in gestational ages categorized to 25–28.6, 29–32.6, 33–36.6, and 37–40 weeks. Results: The mean 1st and 5th min Apgar scores after birth were as below: At the gestational age of <29 weeks, 6 and 7.3, at 29–33 weeks, 6.60 and 8.2, at 33–37 weeks, 7.5 and 8.7, and at more than 37 weeks, 8.2 and 9.6. There was a moderate correlation between gestational age at birth and 1st and 5th min Apgar score. Conclusion: Apgar score components improve in higher gestational ages; therefore, a lower Apgar score is acceptable at lower gestational ages. The results of the present study show the real Apgar score for different gestational ages. This can be a criterion for evaluating the Apgar score of the baby at any gestational age.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"12 1","pages":"105 - 108"},"PeriodicalIF":0.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45753638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of nursing position on cardiac output and cerebral circulation in healthy term neonates using bedside ultrasound: A cross-sectional study 护理体位对健康足月新生儿床旁超声心输出量和脑循环的影响：横断面研究

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Journal of Clinical Neonatology Pub Date : 2023-07-01 DOI: 10.4103/jcn.jcn_34_23

V. Iyer, D. V. Venkatesh Murthy

{"title":"The impact of nursing position on cardiac output and cerebral circulation in healthy term neonates using bedside ultrasound: A cross-sectional study","authors":"V. Iyer, D. V. Venkatesh Murthy","doi":"10.4103/jcn.jcn_34_23","DOIUrl":"https://doi.org/10.4103/jcn.jcn_34_23","url":null,"abstract":"Objective: The objective of this study was to evaluate cardiac and cerebral circulation in stable term neonates. Study Design: This was a prospective observational study to evaluate the relationship between cardiac output (CO) and cerebral circulation in different positions. The study was carried out at a tertiary neonatal intensive care unit from May to November 2018. Methodology: Nineteen healthy term neonates were included in the study. The CO was measured in the supine, right, and left lateral positions using Doppler echocardiography, and simultaneously, the resistive index (RI) of the middle cerebral artery was measured. The CO and cerebral blood flow in each nursing position were measured. Results: The mean CO measured in the supine, right, and left lateral positions was found to be 350,356, and 334 mL/kg/min, and the corresponding RI was 0.84, 0.83, and 0.81, respectively. The CO was increased in the right lateral position compared to the supine and left lateral position; whereas the RI was increased in the supine position compared to the right and the left lateral position although not statistically significant. Conclusions: There was no statistically significant relationship between cerebral blood flow and CO in different body positions.","PeriodicalId":45332,"journal":{"name":"Journal of Clinical Neonatology","volume":"12 1","pages":"96 - 98"},"PeriodicalIF":0.2,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46838140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0