E. Galliera, L. Massaccesi, G. Banfi, E. De Vecchi, V. Ragone, M. C. Corsi Romanelli
{"title":"Effect of Oxidative Stress on Bone Remodeling in Periprosthetic Osteolysis","authors":"E. Galliera, L. Massaccesi, G. Banfi, E. De Vecchi, V. Ragone, M. C. Corsi Romanelli","doi":"10.1007/s12018-021-09278-7","DOIUrl":"https://doi.org/10.1007/s12018-021-09278-7","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"19 1","pages":"14 - 23"},"PeriodicalIF":1.8,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47936337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Russell T Turner, Lara H Sattgast, Vanessa A Jimenez, Kathleen A Grant, Urszula T Iwaniec
{"title":"Making Sense of the Highly Variable Effects of Alcohol on Bone.","authors":"Russell T Turner, Lara H Sattgast, Vanessa A Jimenez, Kathleen A Grant, Urszula T Iwaniec","doi":"10.1007/s12018-021-09277-8","DOIUrl":"10.1007/s12018-021-09277-8","url":null,"abstract":"<p><p>Alcohol consumption is often reported to influence bone health in a dose-dependent manner where moderate alcohol intake is deemed beneficial and heavy drinking detrimental. However, this relationship may not be valid for individual alcohol consumers, as small quantities of alcohol can have detrimental skeletal effects and not all studies report clinically relevant bone loss with long-duration alcohol abuse. These discrepant findings suggest that factors beyond quantity of alcohol consumed contribute to the observed skeletal response. We propose that the interplay between intrinsic (e.g., age, sex, skeletal site) and extrinsic (e.g., age of onset of drinking, duration of drinking, comorbidities) factors influence the precise impact of alcohol consumption on bone health. In this review, we summarize literature reporting the effects of alcohol on the human skeleton. Based on the finding that alcohol alters the circulating levels of dozens of peptides shown to influence bone metabolism, we arrive at the conclusion that no single unifying mechanism adequately explains the diversity of reports or successfully predicts individuals most likely to be impacted favorably or unfavorably by alcohol consumption. We propose that a more holistic approach - in which drinking pattern and intrinsic factors are accounted for - is required to better understand and respond to the end organ effects of alcohol on the skeleton.</p>","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"19 1","pages":"1-13"},"PeriodicalIF":2.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47801150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Abed, F. Alassaf, M. Qazzaz, M. Alfahad, Mahmood H. M. Jasim
{"title":"Insights into the Perspective Correlation Between Vitamin D and Regulation of Hormones: Thyroid and Parathyroid Hormones","authors":"M. Abed, F. Alassaf, M. Qazzaz, M. Alfahad, Mahmood H. M. Jasim","doi":"10.1007/s12018-021-09279-6","DOIUrl":"https://doi.org/10.1007/s12018-021-09279-6","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"1 1","pages":"1-7"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-021-09279-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43661465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Cici, A. Corrado, C. Rotondo, R. Colia, F. Cantatore
{"title":"Adipokines and Chronic Rheumatic Diseases: from Inflammation to Bone Involvement","authors":"D. Cici, A. Corrado, C. Rotondo, R. Colia, F. Cantatore","doi":"10.1007/s12018-021-09275-w","DOIUrl":"https://doi.org/10.1007/s12018-021-09275-w","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"1 1","pages":"1-14"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-021-09275-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45016869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Towards a Standard Approach to Assess Tibial Bone Loss Following Total Knee Arthroplasty","authors":"T. Anijs, I. Kouwert, N. Verdonschot, D. Janssen","doi":"10.1007/s12018-021-09276-9","DOIUrl":"https://doi.org/10.1007/s12018-021-09276-9","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"1 1","pages":"1-15"},"PeriodicalIF":1.8,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-021-09276-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44444463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Supamit Ukarapong, Tossaporn Seeherunvong, G. Berkovitz
{"title":"Current and Emerging Therapies for Pediatric Bone Diseases","authors":"Supamit Ukarapong, Tossaporn Seeherunvong, G. Berkovitz","doi":"10.1007/s12018-020-09272-5","DOIUrl":"https://doi.org/10.1007/s12018-020-09272-5","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"18 1","pages":"31 - 42"},"PeriodicalIF":1.8,"publicationDate":"2020-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-020-09272-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42323099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Nicolin, F. Costantinides, Erica Vettori, F. Berton, G. Marchesi, R. Rizzo, R. Di Lenarda
{"title":"Can Periodontal Disease Be Considered Linked to Obesity and Lipoinflammation? Mechanisms Involved in the Pathogenesis Occurrence","authors":"V. Nicolin, F. Costantinides, Erica Vettori, F. Berton, G. Marchesi, R. Rizzo, R. Di Lenarda","doi":"10.1007/s12018-020-09273-4","DOIUrl":"https://doi.org/10.1007/s12018-020-09273-4","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"18 1","pages":"43-49"},"PeriodicalIF":1.8,"publicationDate":"2020-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-020-09273-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47605210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Periodontitis and Rheumatoid Arthritis: the Common Thread","authors":"Namrata S. Jajoo, Anup U. Shelke, R. Bajaj","doi":"10.1007/s12018-020-09271-6","DOIUrl":"https://doi.org/10.1007/s12018-020-09271-6","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"1 1","pages":"1-13"},"PeriodicalIF":1.8,"publicationDate":"2020-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-020-09271-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46663957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hadis Ashrafizadeh, Mohadeseh Ashrafizadeh, A. A. Oroojan
{"title":"Type 2 Diabetes Mellitus and Osteoarthritis: the Role of Glucose Transporters","authors":"Hadis Ashrafizadeh, Mohadeseh Ashrafizadeh, A. A. Oroojan","doi":"10.1007/s12018-020-09270-7","DOIUrl":"https://doi.org/10.1007/s12018-020-09270-7","url":null,"abstract":"","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"1 1","pages":"1-17"},"PeriodicalIF":1.8,"publicationDate":"2020-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12018-020-09270-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46545994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bone Metabolism in SARS-CoV-2 Disease: Possible Osteoimmunology and Gender Implications.","authors":"Gianmaria Salvio, Claudio Gianfelice, Francesca Firmani, Stefano Lunetti, Giancarlo Balercia, Gilberta Giacchetti","doi":"10.1007/s12018-020-09274-3","DOIUrl":"10.1007/s12018-020-09274-3","url":null,"abstract":"<p><p>Even though inflammatory conditions are known to exert adverse effects on bone metabolism, there are no published data regarding SARS-CoV-2 infection and subsequent fracture risk. We present a brief review of the molecular mechanisms linking inflammatory diseases to increased fracture risk/osteoporosis and of the therapeutic strategies that can prevent bone resorption in patients with inflammatory disease, focusing on the RANK-RANKL system. We also make some considerations on gender differences in infection response and on their implications for survival and for the consequences of COVID-19. Several inflammatory cytokines, especially IL-1, IL-6, and TNF-α, stimulate osteoclast activity, favoring bone resorption through the RANK-RANKL system. Data from the previous SARS-CoV outbreak suggest that the present disease also has the potential to act directly on bone resorption units, although confirmation is clearly needed. Even though the available data are limited, the RANK-RANKL system may provide the best therapeutic target to prevent bone resorption after COVID-19 disease. Vitamin D supplementation in case of deficiency could definitely be beneficial for bone metabolism, as well as for the immune system. Supplementation of vitamin D in case of deficiency could be further advantageous. In COVID-19 patients, it would be useful to measure the bone metabolism markers and vitamin D. Targeting the RANK-RANKL system should be a priority, and denosumab could represent a safe and effective choice. In the near future, every effort should be made to investigate the fracture risk after SARS-CoV-2 infection.</p>","PeriodicalId":45316,"journal":{"name":"Clinical Reviews in Bone and Mineral Metabolism","volume":"18 4","pages":"51-57"},"PeriodicalIF":0.8,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38360919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}