Allergy & Rhinology最新文献

{"title":"Effect of topical beclomethasone on inflammatory markers in adults with eosinophilic esophagitis: A pilot study.","authors":"Neeti Bhardwaj,&nbsp;Faoud Ishmael,&nbsp;Erik Lehman,&nbsp;Deborah Bethards,&nbsp;Francesca Ruggiero,&nbsp;Gisoo Ghaffari","doi":"10.2500/ar.2017.8.0202","DOIUrl":"https://doi.org/10.2500/ar.2017.8.0202","url":null,"abstract":"<p><strong>Background: </strong>Topical corticosteroids have proven efficacy in the treatment of eosinophilic esophagitis (EoE) and are considered the cornerstone of therapy.</p><p><strong>Objective: </strong>To evaluate the effect of topical beclomethasone dipropionate (BDP) therapy on clinical outcomes, esophageal eosinophilia, and other markers of inflammation in patients with EoE.</p><p><strong>Methods: </strong>Nine subjects with a biopsy-proven diagnosis of EoE were enrolled. In a cross-over design, the subjects were randomly assigned to a sequence of BDP and placebo. Treatment periods were 8 weeks, with a 4-week washout period. The subjects had endoscopic biopsies and blood tests at baseline and after each treatment period. They were instructed to maintain a diary of symptoms. Immuno-histochemical studies were performed for interleukins IL-4, IL-5, IL-13, granulocyte-macrophage colony-stimulating factor (GM-CSF), and transforming growth factor (TGF) beta. Reverse transcription polymerase chain reaction was performed for IL-3, IL-4, IL-5, IL-10, IL-13, IL-17F, IL-25, IL-33, chemokine ligands (CCL)2, CCL5, CCL11, GM-CSF, and TGF-beta levels. The mast cell tryptase (MCT) level was measured in esophageal tissues.</p><p><strong>Results: </strong>BDP led to a significantly larger decrease in esophageal eosinophilia compared with placebo, but there was no significant change in peripheral eosinophilia and high-sensitivity C-reactive protein between the two groups. The study was not powered enough for us to report a significant improvement in clinical symptoms. There was a significant decrease in tissue IL-13 and MCT levels from baseline to the end of treatment between the treatment and placebo groups. Mean fold decreases in cytokine expression between the baseline and treatment groups were observed for IL-17F, IL-25, CCL2, and CCL5.</p><p><strong>Conclusion: </strong>Treatment with topical BDP was associated with significant decrease in esophageal eosinophilia, MCT and IL-13. BDP is a potential alternative to fluticasone propionate and budesonide for treatment of EoE. Larger studies are needed to validate these findings.</p>","PeriodicalId":45192,"journal":{"name":"Allergy & Rhinology","volume":"8 2","pages":"85-94"},"PeriodicalIF":2.2,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/ar.2017.8.0202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35063388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential diagnosis and proper treatment of acute rhinosinusitis: Guidance based on historical data analysis.","authors":"Gregor Cevc","doi":"10.2500/ar.2017.8.0206","DOIUrl":"https://doi.org/10.2500/ar.2017.8.0206","url":null,"abstract":"<p><strong>Background: </strong>The time course of rhinovirus positive and negative rhinosinusitis has not been quantified yet, which aggravates proper selection and justification of the optimum treatment for this illness. Such quantitative information would facilitate an early and proper identification of the disease and its differentiation from acute bacterial rhinosinusitis, and could diminish harmful overuse of antibiotics, arguably driven by patients' want for attention and the treating physicians' inability to offer an adequate verbal comfort in its stead.</p><p><strong>Objective: </strong>Extraction of the quantitative information needed to identify rhinovirus positive or negative rhinosinusitis and to allow selection of the most appropriate treatment from the published time dependence of individual clinical symptoms of the disease.</p><p><strong>Methods: </strong>Scrutiny (and modeling) of temporal evolution of all noteworthy symptoms of rhinosinusitis with a simple mathematical expression that relies on two adjustable parameters per symptom (and potentially a general time offset as an extra adjustable parameter).</p><p><strong>Results: </strong>Adverse effects of rhinosinusitis can be grouped according to the sequence of their exponential appearance and ∼2.6 times slower exponential disappearance, rhinovirus negative rhinosinusitis generally improving ∼25% faster and being ∼40% less severe. The major early local symptoms (throat soreness and scratchiness, headache) vanish with a half-life of ∼1.8 days, whereas further local symptoms take ∼1.6 times longer to disappear. At least 50-60% improvement of two prominent early symptoms, sore throat and sneezing (but not of nasal discharge, cough, and hoarseness) by day 5 of the disease implies a nonbacterial origin of rhinitis and should exclude use of antibiotics.</p><p><strong>Conclusion: </strong>Temporal evolution of all rhinosinusitis symptoms is qualitatively similar, which makes the early symptom decay a good proxy for, and predictor of, the disease perspective. Knowing a symptom intensity at just three to four time points suffices for reconstructing its entire time course and total intensity or gravity. This permits an easy and early identification of rhinosinusitis, and its plausible differentiation from acute bacterial rhinosinusitis, disease treatment optimization, and corresponding clinical trials simplification and/or shortening.</p>","PeriodicalId":45192,"journal":{"name":"Allergy & Rhinology","volume":"8 2","pages":"45-52"},"PeriodicalIF":2.2,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/ar.2017.8.0206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35062445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential expression of microRNAs and their possible roles in patients with chronic idiopathic urticaria and active hives.","authors":"Ching-Kow E Lin,&nbsp;John S Kaptein,&nbsp;Javed Sheikh","doi":"10.2500/ar.2017.8.0199","DOIUrl":"https://doi.org/10.2500/ar.2017.8.0199","url":null,"abstract":"<p><strong>Background: </strong>Chronic idiopathic urticaria (CIU) is a complicated skin disease with unknown pathophysiology. MicroRNAs (miRNA) have been shown to be active in cellular regulation. The goal of this pilot study was to examine whether miRNAs may be involved in the regulation of CIU or as biomarkers for CIU.</p><p><strong>Methods: </strong>Four groups of three patients each were selected: patients with either active hives or no hives and with positive or negative chronic urticaria (CU) index results. MiRNAs were isolated from patient plasma and analyzed by using miRNA microarray technology to determine the amount of each of the 2567 known human miRNAs.</p><p><strong>Results: </strong>A total of 16 miRNAs were found to be differentially expressed in patients with active hives. Among them, five (2355-3p, 4264, 2355-5p, 29c-5p, and 361-3p) were significantly increased in samples with positive CU index results, which could be useful biomarkers for patients with chronic autoimmune urticaria. The miRNA data bases were used to find the targets of these selected miRNA sequences. These potential targets were then compared against a list of 154 urticaria-related genes. Twenty-five genes were found to match. These included eight that were significantly downregulated and eight that were significantly upregulated; however, seven of the eight downregulated genes (FBXL20, OPHN1, YPEL2, STARD9, EZH1, KLHL24, ING4) and five of the eight upregulated genes (BYSL, PNO1, ADAMTS9, STEAP4, SRGN) have no reported roles in signaling. For the 13 genes with reported roles in signaling, the following pathways were found: transforming growth factor beta signaling pathway (NRC31, KITLG, THBS1, CCL2), glucocorticoid receptor signaling pathway (NR3C1, SELE, CCL2), p53 signaling pathway (CCNG2, THBS1, CCL2), p21-activated kinase pathway (PAK1IP1, KITLG, CCL2), phosphoinositide-3 kinase protein kinase B signaling pathway (KITLG, CHRM, THBS1), and neuroactive ligand-receptor interaction (NRC31, HRH1, CHRM), which could play important roles in CIU.</p><p><strong>Conclusion: </strong>A better understanding of those genes with undefined function and simultaneous quantitation of both miRNAs and messenger RNAs are needed to fully understand CIU disease.</p>","PeriodicalId":45192,"journal":{"name":"Allergy & Rhinology","volume":"8 2","pages":"67-80"},"PeriodicalIF":2.2,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/ar.2017.8.0199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35062449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of intraoperative flexible endoscopy in frontal sinus surgery.","authors":"Eric T Carniol,&nbsp;Alejandro Vázquez,&nbsp;Tapan D Patel,&nbsp;James K Liu,&nbsp;Jean Anderson Eloy","doi":"10.2500/ar.2017.8.0205","DOIUrl":"https://doi.org/10.2500/ar.2017.8.0205","url":null,"abstract":"<p><strong>Background: </strong>Surgical management of the frontal sinus can be challenging. Extensive frontal sinus pneumatization may form a far lateral or supraorbital recess that can be difficult to reach by conventional endoscopic surgical techniques, requiring extended approaches such as the Draf III (or endoscopic modified Lothrop) procedure. Rigid endoscopes may not allow visualization of these lateral limits to ensure full evacuation of the disease process.</p><p><strong>Methods: </strong>Here we describe the utility of intraoperative flexible endoscopy in two patients with far lateral frontal sinus disease.</p><p><strong>Results: </strong>In both cases, flexible endoscopy allowed confirmation of complete evacuation of pathologic material, thereby obviating more extensive surgical dissection.</p><p><strong>Conclusion: </strong>In cases where visualization of the far lateral frontal sinus is inadequate with rigid endoscopes, flexible endoscopy can be used to determine the need for more extensive dissection.</p>","PeriodicalId":45192,"journal":{"name":"Allergy & Rhinology","volume":"8 2","pages":"81-84"},"PeriodicalIF":2.2,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/ar.2017.8.0205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35063387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 Kounis syndrome in a patient with idiopathic anaphylaxis.","authors":"Monica Sandhu,&nbsp;Jason Casselman,&nbsp;Brian Peppers,&nbsp;Haig Tcheurekdjian,&nbsp;Robert W Hostoffer","doi":"10.2500/ar.2017.8.0198","DOIUrl":"https://doi.org/10.2500/ar.2017.8.0198","url":null,"abstract":"<p><p>Anaphylactic insults that cause cardiovascular signs and symptoms have been defined as Kounis syndrome, which has been associated with specific triggered anaphylactic reactions. Kounis syndrome has not been described in patients with no evidence of coronary artery disease (type I Kounis) in a scenario of idiopathic anaphylaxis. We reported a case of a 65-year-old white woman with no evidence of coronary artery disease who experienced two myocardial infarctions on separate occasions attributable to idiopathic anaphylaxis.</p>","PeriodicalId":45192,"journal":{"name":"Allergy & Rhinology","volume":"8 2","pages":"103-104"},"PeriodicalIF":2.2,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/ar.2017.8.0198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35063391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myxofibrosarcoma of the maxillary sinus.","authors":"Anni Wong,&nbsp;Richard Chan Woo Park,&nbsp;Neena M Mirani,&nbsp;Jean Anderson Eloy","doi":"10.2500/ar.2017.8.0200","DOIUrl":"https://doi.org/10.2500/ar.2017.8.0200","url":null,"abstract":"<p><strong>Background: </strong>Myxofibrosarcoma (MFS) is a common sarcoma in the extremities of older individuals but is extremely uncommon in the head and neck region. Diagnosis may be challenging but is critical to the management of the patient. We discuss the radiographic and histopathologic characteristics of this destructive tumor. The distinguishing features of MFS and its differential diagnosis are reviewed to familiarize the managing otolaryngologist with this rare entity.</p><p><strong>Methods: </strong>A 61-year-old woman presents with a 6-week history of severe left facial pain and left eye pain. Imaging demonstrates significant right and left-sided maxillary sinus opacification with destruction of the left maxillary sinus as well as the left medial and inferior orbital walls.</p><p><strong>Results: </strong>Histopathologic examination revealed spindle and stellate tumor cells of variable cellularity in myxoid stroma with cellular pleomorphism consistent with MFS of intermediate-to high grade. The patient underwent resection of the left-sided lesion with orbital exenteration and repair of the defect with microvascular free flap followed by postoperative radiotherapy.</p><p><strong>Conclusion: </strong>MFS must be differentiated from other lesions with myxoid qualities. Histopathologic examination is required for definitive diagnosis. Management includes complete tumor excision with adequate tumor margins. Adjuvant postoperative radiotherapy should be considered for larger tumors with positive resection margins or lesions of intermediate-to-high grade.</p>","PeriodicalId":45192,"journal":{"name":"Allergy & Rhinology","volume":"8 2","pages":"95-99"},"PeriodicalIF":2.2,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/ar.2017.8.0200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35063389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Landmarks for rapid localization of the sphenopalatine foramen: A radiographic morphometric analysis.","authors":"Anne K Maxwell,&nbsp;Henry P Barham,&nbsp;Anne E Getz,&nbsp;Todd T Kingdom,&nbsp;Vijay R Ramakrishnan","doi":"10.2500/ar.2017.8.0196","DOIUrl":"https://doi.org/10.2500/ar.2017.8.0196","url":null,"abstract":"<p><strong>Background: </strong>Transnasal endoscopic sphenopalatine artery ligation is becoming the procedure of choice for surgical management of intractable posterior epistaxis. Landmarks for localization of the sphenopalatine foramen can assist in rapid surgical exposure of the sphenopalatine artery.</p><p><strong>Objective: </strong>This study examined distances from easily identified endoscopic surgical landmarks to the sphenopalatine foramen.</p><p><strong>Methods: </strong>By using computed tomography of the sinus to study radiologic anatomy in 50 adults, distances were measured between five simple endoscopic landmarks and the sphenopalatine foramen. The two-tailed t-test was used for statistical analysis.</p><p><strong>Results: </strong>Right- and left-sided measurements were similar. The mean (standard deviation [SD]) anteroposterior distances to the sphenopalatine foramen were the following: from the maxillary line (36.7 ± 5.5 mm), anterior head of the middle turbinate (33.8 ± 6.7 mm), basal lamella (11.8 ± 1.9 mm), and choanal arch (-9.2 ± 1.4 mm). The mean (SD) distance in the vertical dimension from the nasal floor was 26.6 ± 2.6 mm. Female patients had statistically shorter distances to the sphenopalatine foramen from the maxillary line, anterior head of the middle turbinate, choanal arch, and nasal floor.</p><p><strong>Conclusion: </strong>Reliable endoscopic landmarks exist in relation to consistent anatomic structures and can be used to help quickly estimate the location of the sphenopalatine foramen at the onset of the procedure.</p>","PeriodicalId":45192,"journal":{"name":"Allergy & Rhinology","volume":"8 2","pages":"63-66"},"PeriodicalIF":2.2,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/ar.2017.8.0196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35062448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete response of skull base inverted papilloma to chemotherapy: Case report.","authors":"Edward C Kuan,&nbsp;John W Frederick,&nbsp;Miguel F Palma Diaz,&nbsp;Dean W Lim,&nbsp;Jeffrey D Suh","doi":"10.2500/ar.2017.8.0201","DOIUrl":"https://doi.org/10.2500/ar.2017.8.0201","url":null,"abstract":"<p><strong>Background: </strong>Inverted papilloma (IP) is the most common benign sinonasal neoplasm. Endoscopic techniques, improved understanding of pathophysiology, and novel surgical approaches have allowed rhinologists to treat IPs more effectively, with surgery being the mainstay of therapy. Frontal sinus IP poses a challenge for surgical therapy due to complex anatomy and potentially difficult surgical access.</p><p><strong>Objectives: </strong>We reported a unique case of a massive frontal sinus IP that presented with intracranial and orbital extension, with near resolution after chemotherapy.</p><p><strong>Methods: </strong>A retrospective case review of a patient with a frontal sinus IP treated at a tertiary academic medical center.</p><p><strong>Results: </strong>A 75-year-old male patient presented with nasal obstruction, purulent nasal discharge, and a growing left supraorbital mass. Endoscopy demonstrated a mass that filled both frontal and ethmoid sinuses, with orbital invasion. There also was substantial erosion of the posterior table, which measured 1.73 × 1.40 cm. A biopsy specimen demonstrated IP with carcinoma in situ. The patient was deemed unresectable on initial evaluation and, subsequently, underwent chemotherapy (carboplatin and paclitaxel). The tumor had a dramatic response to chemotherapy, and the patient elected for definitive surgery to remove any residual disease. During surgery, only a small focus of IP was found along the superior wall of the frontal sinus. No tumor was found elsewhere, including at the site of skull base erosion. The final pathology was IP without carcinoma in situ or dysplasia.</p><p><strong>Conclusion: </strong>This was the first reported case of chemotherapeutic \"debulking\" of IP, which facilitated surgical resection, despite substantial intracranial and orbital involvement. Although nearly all IPs can be treated surgically, rare cases, such as unresectable tumors, may benefit from systemic chemotherapy.</p>","PeriodicalId":45192,"journal":{"name":"Allergy & Rhinology","volume":"8 2","pages":"105-108"},"PeriodicalIF":2.2,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/ar.2017.8.0201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35063392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing environmental allergies: Comparison of skin-prick, intradermal, and serum specific immunoglobulin E testing.","authors":"Denisa Ferastraoaru,&nbsp;Maria Shtessel,&nbsp;Elizabeth Lobell,&nbsp;Golda Hudes,&nbsp;David Rosenstreich,&nbsp;Gabriele de Vos","doi":"10.2500/ar.2017.8.0194","DOIUrl":"https://doi.org/10.2500/ar.2017.8.0194","url":null,"abstract":"<p><strong>Background: </strong>Allergists commonly perform intradermal skin testing (IDST) after negative skin-prick testing (SPT) to comprehensively diagnose environmental allergic sensitization. However, with the availability of modern methods to detect serum-specific immunoglobulin E (ssIgE), it is unclear if ssIgE testing could substitute for IDST.</p><p><strong>Objective: </strong>To determine the efficacy of ssIgE testing and IDST when added to SPT in diagnosing environmental allergic sensitizations.</p><p><strong>Methods: </strong>SPT, IDST, and ssIgE testing to nine common environmental allergens were analyzed in 75 patients with oculonasal symptoms who presented to our allergy clinics in the Bronx, New York, between January 2014 and May 2015.</p><p><strong>Results: </strong>A total of 651 SPT and 499 ssIgE tests were independently performed and revealed 162 (25%) and 127 (25%) sensitizations, respectively. When SPT results were negative, IDST results revealed 108 of 452 additional sensitizations (24%). In contrast, when SPT results were negative, ssIgE test results only revealed 9% additional sensitizations. When both SPT and IDST results were negative, ssIgE testing only detected 3% of additional sensitizations, and ssIgE levels were typically low in these cases (median, 1.25 kU/L; range, 0.357-4.47 kU/L). When both SPT and ssIgE test results were negative, IDST results detected 15% additional sensitizations.</p><p><strong>Conclusion: </strong>IDST detected more additional environmental sensitizations compared with ssIgE testing. IDST, therefore, may be useful when the SPT and/or ssIgE testing results were negative, but the exposure history indicated relevant allergic sensitization. Serology added only a little more information if both SPT and IDST results were negative but may be useful in combination with SPT if IDST cannot be performed.</p>","PeriodicalId":45192,"journal":{"name":"Allergy & Rhinology","volume":"8 2","pages":"53-62"},"PeriodicalIF":2.2,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/ar.2017.8.0194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35062447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral silent sinus syndrome: A rare case and review of literature.","authors":"Michal Trope,&nbsp;Joseph S Schwartz,&nbsp;Bobby A Tajudeen,&nbsp;David W Kennedy","doi":"10.2500/ar.2017.8.0197","DOIUrl":"https://doi.org/10.2500/ar.2017.8.0197","url":null,"abstract":"<p><strong>Objective: </strong>In this report, we presented a rare case of bilateral silent sinus syndrome (SSS) in an otherwise healthy 57-year-old man treated with functional endoscopic sinus surgery (FESS). A systematic review of the literature regarding bilateral SSS was performed.</p><p><strong>Case report: </strong>A 57-year-old man with well-controlled allergic rhinitis in the absence of previous surgery or trauma presented with bilateral SSS, which was successfully managed with bilateral FESS.</p><p><strong>Methods: </strong>A medical literature data base search of the terms \"silent sinus syndrome\" \"maxillary atelectasis,\" \"imploding antrum syndrome,\" and \"bilateral silent sinus syndrome\" was performed. The results were then narrowed to include only relevant articles.</p><p><strong>Results: </strong>Relevant articles included three case reports and two articles that describe or mention bilateral SSS. Of the three case reports found, two patients presented with bilateral SSS, whereas the third patient presented metachronously, with the contralateral SSS manifesting 4 months after presentation of the initial ipsilateral SSS.</p><p><strong>Conclusion: </strong>The present literature regarding bilateral SSS is likely incomplete, and further investigation is required to provide greater insight into the prevalence of this disease. In this report, bilateral FESS was successful in resolving symptoms and preventing disease progression.</p>","PeriodicalId":45192,"journal":{"name":"Allergy & Rhinology","volume":"8 2","pages":"100-102"},"PeriodicalIF":2.2,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2500/ar.2017.8.0197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35063390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}