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Identifying patients at risk from nonalcoholic fatty liver-related hepatocellular carcinomas. 识别非酒精性脂肪肝相关肝细胞癌的高危患者。
IF 5
Hepatic Oncology Pub Date : 2016-04-01 Epub Date: 2016-03-23 DOI: 10.2217/hep-2016-0002
Mehmet Sayiner, Zobair M Younossi
{"title":"Identifying patients at risk from nonalcoholic fatty liver-related hepatocellular carcinomas.","authors":"Mehmet Sayiner, Zobair M Younossi","doi":"10.2217/hep-2016-0002","DOIUrl":"10.2217/hep-2016-0002","url":null,"abstract":"","PeriodicalId":44854,"journal":{"name":"Hepatic Oncology","volume":"3 2","pages":"101-103"},"PeriodicalIF":5.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095300/pdf/hep-03-101.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36471086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of miRNAs in cholangiocarcinoma. mirna在胆管癌中的作用。
IF 5
Hepatic Oncology Pub Date : 2016-04-01 Epub Date: 2016-03-29 DOI: 10.2217/hep-2015-0003
Jessica A Howell, Shahid A Khan
{"title":"The role of miRNAs in cholangiocarcinoma.","authors":"Jessica A Howell,&nbsp;Shahid A Khan","doi":"10.2217/hep-2015-0003","DOIUrl":"https://doi.org/10.2217/hep-2015-0003","url":null,"abstract":"<p><p>Cholangiocarcinoma (CCA) is a devastating malignancy with high mortality, in part due to the combination of late presentation, significant diagnostic challenges and limited effective treatment options. Late presentation and diagnosis contribute to the high mortality in CCA and there is an urgent unmet need for diagnostic and prognostic biomarkers to facilitate early diagnosis and treatment stratification to improve clinical outcomes. MiRs are small ncRNA molecules that regulate gene expression and modulate both tumor suppressive and oncogenic pathways. They have a well-defined role in carcinogenesis, including CCA. In this review, we outline the evidence for MiRs in the pathogenesis of CCA and their potential utility as diagnostic and prognostic biomarkers to guide clinical management.</p>","PeriodicalId":44854,"journal":{"name":"Hepatic Oncology","volume":"3 2","pages":"167-180"},"PeriodicalIF":5.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/hep-2015-0003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36469985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
The clinical role of 'liquid biopsy' in hepatocellular carcinoma. “液体活检”在肝细胞癌中的临床作用。
IF 5
Hepatic Oncology Pub Date : 2016-01-01 Epub Date: 2015-11-30 DOI: 10.2217/hep.15.38
Jessica A Howell, Rohini Sharma
{"title":"The clinical role of 'liquid biopsy' in hepatocellular carcinoma.","authors":"Jessica A Howell,&nbsp;Rohini Sharma","doi":"10.2217/hep.15.38","DOIUrl":"https://doi.org/10.2217/hep.15.38","url":null,"abstract":"<p><p>Circulating free tumor DNA (ctDNA) is DNA released from necrotic or apoptotic tumor cells into the bloodstream. Absolute levels of ctDNA, as well as genetic mutations and epigenetic changes detected in ctDNA are useful biomarkers of tumor biology, progression and response to therapy in many tumor types and recent evidence suggests they may be useful in hepatocellular carcinoma (HCC). ctDNA detected in blood, therefore, offers a minimally invasive, easily repeated 'liquid biopsy' of cancer, providing real-time dynamic analysis of tumor behavior and treatment response that could revolutionize both clinical and research practice in HCC. In this review, we provide a critical summary of the evidence for the utility of ctDNA as a diagnostic and prognostic biomarker in HCC.</p>","PeriodicalId":44854,"journal":{"name":"Hepatic Oncology","volume":"3 1","pages":"45-55"},"PeriodicalIF":5.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/hep.15.38","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36471082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Epidemiology and surgical management of intrahepatic cholangiocarcinoma. 肝内胆管癌的流行病学和外科治疗。
IF 5
Hepatic Oncology Pub Date : 2016-01-01 Epub Date: 2015-11-30 DOI: 10.2217/hep.15.34
Han Zhang, Feng Shen, Jun Han, Yi-Nan Shen, Guo-Qiang Xie, Meng-Chao Wu, Tian Yang
{"title":"Epidemiology and surgical management of intrahepatic cholangiocarcinoma.","authors":"Han Zhang,&nbsp;Feng Shen,&nbsp;Jun Han,&nbsp;Yi-Nan Shen,&nbsp;Guo-Qiang Xie,&nbsp;Meng-Chao Wu,&nbsp;Tian Yang","doi":"10.2217/hep.15.34","DOIUrl":"https://doi.org/10.2217/hep.15.34","url":null,"abstract":"<p><p>Intrahepatic cholangiocarcinoma (ICC) is a rare hepatobiliary malignancy arising from the epithelial cells of the intrahepatic bile ducts. The increased incidence of ICC worldwide may reflect both a true increase and the earlier detection of the disease. Despite the advances in modern surgical care, the curative chance for ICC remained suboptimal: tumor-free margins are hard to achieve due to tumor locations, and technical challenges and recurrence, either local or distant, may hamper the resectability in a large number of patients. Lymph node involvement and vascular invasions are considered negative predictive factors for survival of ICC patients. This review discusses the epidemiology, risk factors and surgical management of ICCs, and mainly focuses on outcomes and factors associated with surgical treatment.</p>","PeriodicalId":44854,"journal":{"name":"Hepatic Oncology","volume":"3 1","pages":"83-91"},"PeriodicalIF":5.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/hep.15.34","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36471085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Hepatocellular carcinoma: asphyxiate and then cook. 肝细胞癌:窒息后煮熟。
IF 5
Hepatic Oncology Pub Date : 2016-01-01 Epub Date: 2015-11-06 DOI: 10.2217/hep.15.31
Philippe Kolly, Jean-François Dufour
{"title":"Hepatocellular carcinoma: asphyxiate and then cook.","authors":"Philippe Kolly,&nbsp;Jean-François Dufour","doi":"10.2217/hep.15.31","DOIUrl":"https://doi.org/10.2217/hep.15.31","url":null,"abstract":"Hepatology, Department of Clinical Research, University of Bern, Bern, Switzerland University Clinic for Visceral Surgery & Medicine, Inselspital Bern, Bern, Switzerland *Author for correspondence: Tel.: +41 31 632 26 95; Fax: +41 31 632 97 65; jf.dufour@insel.ch","PeriodicalId":44854,"journal":{"name":"Hepatic Oncology","volume":"3 1","pages":"1-3"},"PeriodicalIF":5.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/hep.15.31","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36471143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 9th Annual Conference of the International Liver Cancer Association (ILCA) 2015. 2015年第九届国际肝癌协会(ILCA)年会。
IF 5
Hepatic Oncology Pub Date : 2016-01-01 Epub Date: 2015-11-30 DOI: 10.2217/hep.15.39
Jens U Marquardt, Peter R Galle
{"title":"The 9th Annual Conference of the International Liver Cancer Association (ILCA) 2015.","authors":"Jens U Marquardt,&nbsp;Peter R Galle","doi":"10.2217/hep.15.39","DOIUrl":"https://doi.org/10.2217/hep.15.39","url":null,"abstract":"<p><p>The 9th International Liver Cancer Association Annual Conference was held from 4th to 6th September 2015 in Paris, France, and attracted a record breaking 900 participants from 51 different countries and 386 submitted abstracts from scientists around the globe. The congress provided a comprehensive overview of current developments in primary liver cancers (i.e., hepatocellular carcinoma and cholangiocarcinoma) and covered a broad range of topics from basic science to clinical studies. Following the success of immunotherapies in recent years, a preconference workshop on immunopathogenesis and immunotherapy in hepatocellular carcinoma also took place. This report will provide a subjective summary of selected abstracts presented at the conference.</p>","PeriodicalId":44854,"journal":{"name":"Hepatic Oncology","volume":"3 1","pages":"9-12"},"PeriodicalIF":5.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/hep.15.39","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36471146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver cancer screening in high-risk populations. 高危人群的肝癌筛查
IF 5
Hepatic Oncology Pub Date : 2016-01-01 Epub Date: 2015-11-30 DOI: 10.2217/hep.15.35
Morris Sherman
{"title":"Liver cancer screening in high-risk populations.","authors":"Morris Sherman","doi":"10.2217/hep.15.35","DOIUrl":"https://doi.org/10.2217/hep.15.35","url":null,"abstract":"<p><p>Patients with liver disease have a risk of developing hepatocellular carcinoma (HCC), but the risk varies between different diseases and is also different according to several other variables, such as age, type of underlying liver disease and severity of disease. Several risk scores have been developed to more adequately quantitate HCC risk in individual patients. Each risk score is applicable to a specific population (chronic hepatitis B or C, patients on the transplant list, cirrhosis in general, and so on). Most publications on risk scores do not provide clear guidance as to what level of measured risk is sufficient to trigger surveillance.</p>","PeriodicalId":44854,"journal":{"name":"Hepatic Oncology","volume":"3 1","pages":"13-18"},"PeriodicalIF":5.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/hep.15.35","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36471147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Role of alcohol in the development and progression of hepatocellular carcinoma. 酒精在肝细胞癌发生发展中的作用。
IF 5
Hepatic Oncology Pub Date : 2016-01-01 Epub Date: 2015-11-30 DOI: 10.2217/hep.15.40
Iain H McKillop, Laura W Schrum, Kyle J Thompson
{"title":"Role of alcohol in the development and progression of hepatocellular carcinoma.","authors":"Iain H McKillop,&nbsp;Laura W Schrum,&nbsp;Kyle J Thompson","doi":"10.2217/hep.15.40","DOIUrl":"10.2217/hep.15.40","url":null,"abstract":"<p><p>Hepatocellular carcinoma (HCC) is a significant cause of cancer-related morbidity and mortality. Chronic, heavy ethanol consumption is a major risk for developing the worsening liver pathologies that culminate in hepatic cirrhosis, the leading risk factor for developing HCC. A significant body of work reports the biochemical and pathological consequences of ethanol consumption and metabolism during hepatocarcinogeneis. The systemic effects of ethanol means organ system interactions are equally important in understanding the initiation and progression of HCC within the alcoholic liver. This review aims to summarize the effects of ethanol-ethanol metabolism during the pathogenesis of alcoholic liver disease, the progression toward HCC and the importance of ethanol as a comorbid factor for HCC development.</p>","PeriodicalId":44854,"journal":{"name":"Hepatic Oncology","volume":"3 1","pages":"29-43"},"PeriodicalIF":5.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/hep.15.40","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36471081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives. 胆道癌的新辅助治疗:最新的和新的观点。
IF 5
Hepatic Oncology Pub Date : 2016-01-01 Epub Date: 2015-11-30 DOI: 10.2217/hep.15.43
Marco Imperatori, Loretta D'Onofrio, Eleonora Marrucci, Francesco Pantano, Alice Zoccoli, Giuseppe Tonini
{"title":"Neoadjuvant treatment of biliary tract cancer: state-of-the-art and new perspectives.","authors":"Marco Imperatori,&nbsp;Loretta D'Onofrio,&nbsp;Eleonora Marrucci,&nbsp;Francesco Pantano,&nbsp;Alice Zoccoli,&nbsp;Giuseppe Tonini","doi":"10.2217/hep.15.43","DOIUrl":"https://doi.org/10.2217/hep.15.43","url":null,"abstract":"<p><p>Gall bladder cancer (GBC), and intrahepatic and extrahepatic (perihilar or distal bile duct's) cholangiocarcinomas (CCA) are usually diagnosed in locally advanced or node-positive stage, with a short survival rate. Thus, it appears essential to explore novel strategies for improving disease downstage and radical surgery. Chemoradiotherapy followed by liver transplantation seems to be one of the most promising approaches for intrahepatic or perihilar disease while chemotherapy with novel radiotherapy techniques (such stereotactic body radiation) emerged as an attractive preoperative treatment in distal diseases. In this paper, we will review currently available knowledge about neoadjuvant treatment of biliary tract cancers (BTC) paying attention to challenges that make this type of management in clinical practice difficult.</p>","PeriodicalId":44854,"journal":{"name":"Hepatic Oncology","volume":"3 1","pages":"93-99"},"PeriodicalIF":5.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/hep.15.43","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36471084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Targeting glucose metabolism in cancer: new class of agents for loco-regional and systemic therapy of liver cancer and beyond? 靶向糖代谢治疗癌症:肝癌局部、局部和全身治疗的新药物?
IF 5
Hepatic Oncology Pub Date : 2016-01-01 DOI: 10.2217/HEP.15.36
L. Savic, J. Chapiro, G. Duwe, J. Geschwind
{"title":"Targeting glucose metabolism in cancer: new class of agents for loco-regional and systemic therapy of liver cancer and beyond?","authors":"L. Savic, J. Chapiro, G. Duwe, J. Geschwind","doi":"10.2217/HEP.15.36","DOIUrl":"https://doi.org/10.2217/HEP.15.36","url":null,"abstract":"Hepatocellular carcinoma (HCC) is one of the most prevalent cancers and the third leading cause of cancer-related deaths worldwide. In patients with unresectable disease, loco-regional catheter-based intra-arterial therapies (IAT) can achieve selective tumor control while minimizing systemic toxicity. As molecular features of tumor growth and microenvironment are better understood, new targets arise for selective anticancer therapy. Particularly, antiglycolytic drugs that exploit the hyperglycolytic cancer cell metabolism - also known as the 'Warburg effect' - have emerged as promising therapeutic options. Thus, future developments will combine the selective character of loco-regional drug delivery platforms with highly specific molecular targeted antiglycolytic agents. This review will exemplify literature on antiglycolytic approaches and particularly focus on intra-arterial delivery methods.","PeriodicalId":44854,"journal":{"name":"Hepatic Oncology","volume":"3 1 1","pages":"19-28"},"PeriodicalIF":5.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2217/HEP.15.36","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68215347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
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