Argentine Journal of Cardiology最新文献_第6页

Mechanisms of Dysfunction and Prognostic Markers in Bicuspid Aortic Valve 二尖瓣主动脉瓣功能障碍机制及预后指标

Argentine Journal of Cardiology Pub Date : 2018-12-21 DOI: 10.7775/rac.87.2.14512

M. C. Carrero, G. D. Babio, G. M. Juarez, I. Constantin, F. Verón, M. Mezzadra, G. V. Janavel, P. Stutzbach

{"title":"Mechanisms of Dysfunction and Prognostic Markers in Bicuspid Aortic Valve","authors":"M. C. Carrero, G. D. Babio, G. M. Juarez, I. Constantin, F. Verón, M. Mezzadra, G. V. Janavel, P. Stutzbach","doi":"10.7775/rac.87.2.14512","DOIUrl":"https://doi.org/10.7775/rac.87.2.14512","url":null,"abstract":"Background: The most common complication of the bicuspid aortic valve (BAV) is aortic valve dysfunction, but it is difficult to predictwhich patients will develop aortic stenosis (AS) or significant aortic regurgitation (AoR) (moderate/severe).Objectives: The aim of this work was to analyze the progression and the variables associated with the development of AS and significantAoR in adults with BAV.Methods: Consecutive patients with BAV were studied between 2009 and 2017. The progression of their aortic valve dysfunctionwas analyzed and in the group without baseline dysfunction, significant predictors of AoR and AS were identified through univariateand multivariate analysis.Results: Two hundred and forty-three patients (mean age 43±14.9 years, 73.2% men) were included in the study. The majority(n=194, 79.8%) with type I and raphe BAV (n=179, 73.6%). In the baseline echocardiogram, 111 patients presented mild (45.6%);49, moderate (20.1%); and 10, severe (4.1%) AoR. Baseline AS was less frequent: 20 subjects had moderate (8.2%) and 12, severe(4.9%) AS.Two patients died and 20 valve surgeries (8.2%) were performed in 4.7±1.7 follow-up years. Patients with significant baselinevalve dysfunction presented a higher rate of progression requiring valve surgery (p<0.0001). There were 39 new cases (17.2%) ofsignificant AoR or AS at follow-up. Aortic valve prolapse (p<0.001) and male sex (p<0.04) were associated with the development ofsignificant AoR (p<0.001). Baseline calcification score was associated with significant AS (p<0.02).Conclusions: A high proportion of patients with BAV and significant baseline aortic valve dysfunction required short-term surgery.Clinical and morphological characteristics associated with the development of significant aortic valve dysfunction were identified.","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127971220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of Interleukin-6 G-174C and G-572C and Interleukin-1 C-511T and C+3953T Polymorphisms with Ischemic Heart Disease in Quito, Ecuador 厄瓜多尔基多地区白介素-6 G-174C和G-572C、白介素-1 C- 511t和C+3953T多态性与缺血性心脏病的关系

Argentine Journal of Cardiology Pub Date : 2018-12-21 DOI: 10.7775/RAC.87.2.14330

R. Cifuentes, Luis Alejandro Cárdenas Arguello, Edwin Roberto Guzman Clavijo, Rommel Oswaldo Espinoza de los Moneteros Duche, Fabian Santiago Cruz Murillo, Fátima Leticia Caiza Llumiquinga

{"title":"Relationship of Interleukin-6 G-174C and G-572C and Interleukin-1 C-511T and C+3953T Polymorphisms with Ischemic Heart Disease in Quito, Ecuador","authors":"R. Cifuentes, Luis Alejandro Cárdenas Arguello, Edwin Roberto Guzman Clavijo, Rommel Oswaldo Espinoza de los Moneteros Duche, Fabian Santiago Cruz Murillo, Fátima Leticia Caiza Llumiquinga","doi":"10.7775/RAC.87.2.14330","DOIUrl":"https://doi.org/10.7775/RAC.87.2.14330","url":null,"abstract":"Introduccion: En los ultimos anos se ha evidenciado que los procesos inflamatorios estan directamente relacionados con la formacionde la placa ateroesclerotica, causante de la cardiopatia isquemica (CI). Por esta razon, toda molecula relacionada con aquellos procesoses de vital importancia. Las interleucinas (IL) son citoquinas proinflamatorias y sus polimorfismos aparentemente incrementanel proceso inflamatorio. Los mas asociados con la cardiopatia isquemica son algunos polimorfismos de las interleucinas 1 (IL-1)y 6 (IL-6).Objetivos: Establecer la relacion de los polimorfismos G-174C y G-572C de la interleucina-6 y C-511T y C+3953T de la interleucina-1 con la cardiopatia isquemica.Material y metodos: Se desarrollo un estudio de tipo analitico retrospectivo, de 76 casos y 76 controles, de pacientes atendidos enel servicio de hemodinamica del Hospital Carlos Andrade Marin (HCAM), de Quito. La genotipificacion se hizo mediante la reaccionen cadena de la polimerasa con enzimas de restriccion (PCR-RFLP).Resultados: De los cuatro polimorfismos estudiados, unicamente el IL-6174 GG tuvo una asociacion estadisticamente significativacon la cardiopatia isquemica. La regresion logistica usada para determinar los predictores mas importantes de cardiopatia isquemicamostro que el genotipo IL-6 174 GG (OR 4,065, p=<0,001) se asocio con un incremento del riesgo de presentar cardiopatia isquemicade forma independiente.Conclusiones: El genotipo GG del polimorfismo IL-6 G-174C confiere un riesgo 4 veces superior de desarrollar cardiopatia isquemica,mientras que los tres polimorfismos restantes no confieren riesgos.","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122811948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical treatment of chagasic cardiomyopathy 恰加斯型心肌病的外科治疗

Argentine Journal of Cardiology Pub Date : 2018-12-21 DOI: 10.7775/rac.87.2.14070

E. Bravo, Germán J. Chaud, F. Moll, E. Aguilar, Víctor Yunes, C. Manfredi

引用次数: 0

Index of Authors 2018 2018年作者索引

Argentine Journal of Cardiology Pub Date : 2018-12-20 DOI: 10.7775/RAC.86.6.14543

Revista Argentina de Cardiología Arbitrajes

引用次数: 0

Heart Failure. Different Aspects of the Same Problem 心力衰竭。同一问题的不同方面

Argentine Journal of Cardiology Pub Date : 2018-12-19 DOI: 10.7775/AJC.87.1.14528

E. Roig

引用次数: 0

Mitral Valve Prolapse 二尖瓣脱垂

Argentine Journal of Cardiology Pub Date : 2018-12-01 DOI: 10.7775/RAC.85.5.12256

Rubén Álvarez, J. M. Lewkowicz

引用次数: 0

Prospective Registry of Antithrombotic Therapy in Acute Coronary Syndromes (EPICOR) 急性冠脉综合征(EPICOR)抗栓治疗的前瞻性登记

Argentine Journal of Cardiology Pub Date : 2018-10-31 DOI: 10.7775/ajc.87.1.14242

M. Trivi, Alejandro Lakowski, C. Zeballos, E. Duronto, L. Marquez, C. Rapallo, J. Fuselli, G. Zapata

{"title":"Prospective Registry of Antithrombotic Therapy in Acute Coronary Syndromes (EPICOR)","authors":"M. Trivi, Alejandro Lakowski, C. Zeballos, E. Duronto, L. Marquez, C. Rapallo, J. Fuselli, G. Zapata","doi":"10.7775/ajc.87.1.14242","DOIUrl":"https://doi.org/10.7775/ajc.87.1.14242","url":null,"abstract":"Presentamos los resultados a dos anos de seguimiento de la cohorte argentina del estudio EPICOR, un registro internacional, multicentrico, observacional, prospectivo, disenado para determinar los patrones de utilizacion de la terapia antitrombotica en pacientes con sindrome coronario agudo en el contexto de la practica clinica habitual. Se enrolaron 438 pacientes consecutivos con infarto de miocardio con supradesnivel del segmento ST (STEMI, 41%) o SCA sin supradesnivel del segmento ST (NSTE-ACS, 59%), externados vivos de centros hospitalarios publicos, privados y de comunidad. La media de edad fue 62 anos, 76% eran varones, 71% hipertensos, 64% fumadores, 19% diabeticos y 40% tenian antecedentes de patologia cardiovascular previa. La mortalidad global fue de 4,8% al ano, y 7,3% a los 2 anos. El uso de doble antiagregacion plaquetaria fue de 80% al ano y 53% a los 2 anos (p>0.0001), sin diferencias entre aquellos con o sin supradesnivel del ST. La incidencia de eventos isquemicos y hemorragicos mayores a los 2 anos fue de 15,3% y 1,8% respectivamente. Conclusion: se observo un elevado porcentaje de persistencia de la doble antiagregacion plaquetaria a los 2 anos, mas alla del ano recomendado por las guias, con baja incidencia de hemorragias mayores, lo que sugiere una seleccion clinica de riesgo-beneficio.","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121725218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Tratamiento con hormonas tiroideas para revertir insuficiencia cardíaca grave causada por miocardiopatía dilatada 甲状腺激素治疗可逆转扩张性心肌病引起的严重心力衰竭

Argentine Journal of Cardiology Pub Date : 2018-10-04 DOI: 10.7775/ajc.86.3.12890

Dimitri Novitzky

引用次数: 0

Impact of Allostatic Load on Cognitive Level, Memory and Left Ventricular Mass 适应负荷对认知水平、记忆和左心室质量的影响

Argentine Journal of Cardiology Pub Date : 2018-09-26 DOI: 10.7775/AJC.87.1.13508

S. C. D. Robert

{"title":"Impact of Allostatic Load on Cognitive Level, Memory and Left Ventricular Mass","authors":"S. C. D. Robert","doi":"10.7775/AJC.87.1.13508","DOIUrl":"https://doi.org/10.7775/AJC.87.1.13508","url":null,"abstract":"Introduccion: La carga alostatica (CA) se ha propuesto como un marco general para comprender los efectos acumulativos delestres a lo largo de la vida de las personas. A pesar de su creciente interes no se han realizado, en la Argentina, investigacionesque relacionen su impacto en el corazon y en el cerebro.Objetivos: Evaluar la asociacion de CA, definida en forma operativa por un rango de mediciones de los sistemas simpatico,parasimpatico, el eje hipotalamo hipofisario adrenal, y de los sistemas inflamatorio, con el nivel cognitivo (NC), la memoriay la masa del ventriculo izquierdo en adultos de mediana edad.Resultados: Fueron estudiados 86 pacientes con un promedio de edad de 53,5 anos IC (intervalo de confianza) 95% de 51,3 a55,7. La CA se asocio en forma inversa y significativa con el NC: coeficiente -1,1 Error estandar (EE) 0,5 p = 0,04 independientementede la edad, el sexo y el nivel educacional R cuadrado ajustado 0,40 p < 0,001. De los 7 sistemas estudiados soloel cardiovascular y el inflamatorio mantuvieron una asociacion inversa y significativa. Tambien la CA se asocio en formainversa con la memoria. En cuanto a su impacto en el corazon, la CA se asocio en forma positiva con la masa del ventriculoizquierdo (VI), coeficiente 10,86 p < 0,001. R cuadrado ajustado 0,23 p < 0,001.Conclusiones: La CA nos permite contar con una herramienta objetiva para medir el estres cronico. Los resultados obtenidosindican que el incremento de la CA produce un dano en el cerebro (deficit cognitivo y en la memoria tempranos) y en el corazon(incremento de la masa del VI).","PeriodicalId":447734,"journal":{"name":"Argentine Journal of Cardiology","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114868342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Opening Speech of the 2017 SAC Academic Ceremony 2017年SAC学术典礼开幕词

Argentine Journal of Cardiology Pub Date : 2018-07-03 DOI: 10.7775/RAC.85.6.12521

M. González

引用次数: 0