NUCLEAR MEDICINE REVIEW最新文献_第4页

Neurolymphomatosis diagnosed on [18F]FDG PET/CT. [18F]FDG PET/CT诊断神经淋巴瘤

IF 0.6

NUCLEAR MEDICINE REVIEW Pub Date : 2023-01-01 DOI: 10.5603/NMR.2023.0012

Yassir Benameur, Omar Ait Sahel, Salah Nabih Oueriagli, Abderrahim Doudouh

引用次数: 0

Ossifying fibroma presented as an incidental [18F]FDG PET/CT uptake within the hard palate. 骨化纤维瘤表现为硬腭内偶然的FDG PET/CT摄取[18F]。

IF 0.9

NUCLEAR MEDICINE REVIEW Pub Date : 2023-01-01 DOI: 10.5603/NMR.2023.0014

Minchanat Satja, Napisa Bunnag, Sira Vachatimanont

引用次数: 0

Prostate-specific membrane antigen expression in intracranial lesions - a review of the primary, metastatic, and nonneoplastic lesions. 前列腺特异性膜抗原在颅内病变中的表达——原发、转移和非肿瘤性病变的综述。

IF 0.9

NUCLEAR MEDICINE REVIEW Pub Date : 2023-01-01 DOI: 10.5603/nmr.97019

Kacper Pełka, Aleksandra Bodys-Pełka, Jolanta Kunikowska

引用次数: 0

Confirmation of PSMA expression measured on [68Ga]Ga-PSMA PET/CT by immunohistochemistry in prostate adenocarcinoma. [68Ga]Ga-PSMA PET/CT免疫组化检测前列腺癌组织中PSMA表达的证实

IF 0.9

NUCLEAR MEDICINE REVIEW Pub Date : 2023-01-01 DOI: 10.5603/NMR.2023.0008

Tarik Sengoz, Nilay Sen Turk, Yusuf Ozlulerden, Sinan Celen, Aziz Gultekin, Olga Yaylali, Dogangun Yuksel

{"title":"Confirmation of PSMA expression measured on [68Ga]Ga-PSMA PET/CT by immunohistochemistry in prostate adenocarcinoma.","authors":"Tarik Sengoz, Nilay Sen Turk, Yusuf Ozlulerden, Sinan Celen, Aziz Gultekin, Olga Yaylali, Dogangun Yuksel","doi":"10.5603/NMR.2023.0008","DOIUrl":"https://doi.org/10.5603/NMR.2023.0008","url":null,"abstract":"Background: Our aim is to determine the accuracy of [68Ga]Ga-PSMA PET/CT in showing PSMA expression in primary prostate cancer and to investigate the relationship between SUVmax and immunohistochemical PSMA expression, Gleason score, and PSA value.Material and methods: We retrospectively analyzed 66 male patients who were diagnosed with primary prostate adenocarcinoma, underwent pre-treatment [68Ga]Ga-PSMA PET/CT examination for staging, and performed radical prostatectomy between March 2018-August 2020. Immunohistochemical staining was applied to the radical prostatectomy specimens of all patients to detect PSMA expression. The results were evaluated as an immunoreactive score (IRS) and a modified IRS was obtained. Gleason score groups and prostate-specific antigen (PSA) serum values of the patients were obtained from the patient files.Results: The high SUVmax of primary prostate tumors was significantly correlated with a high modified IRS score (score 2; 3), high PSA value, high Gleason score, and metastasis. In correlation analysis, a positive correlation was found between SUVmax and PSA value and modified IRS score (r = 0.69, p = 0.001; r = 0.39, p = 0.001). In addition, there was a statistically significant weak correlation between PSA serum concentration and modified IRS scores (r = 0.267; p = 0.03). In regression analysis, the percentage of positive cells had a statistically significant and increasing effect on SUVmax (p = 0.031; std beta = 0.268; 95% CI = 0.231-4.596).Conclusions: In prostate adenocarcinoma, SUVmax of the primary tumor in [68Ga]Ga-PSMA PET/CT correlates with immunohistochemical PSMA expression. In addition, high SUVmax is associated with markers of poor prognoses, such as high PSMA expression, PSA value, and Gleason score.","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"26 0","pages":"68-73"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9697826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vertebral photopenia on [67Ga]Ga-citrate and [18F]FDG PET/CT imaging in a patient with non-Hodgkin lymphoma. [67Ga]枸橼酸镓和[18F]FDG PET/CT成像显示非霍奇金淋巴瘤患者椎体光减少。

IF 0.9

NUCLEAR MEDICINE REVIEW Pub Date : 2023-01-01 DOI: 10.5603/NMR.a2022.0042

Georgios Meristoudis, Ioannis Ilias, Vasilios Giannakopoulos

引用次数: 0

An approach to develop personalized radiopharmaceuticals by modifying 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG). 通过修饰2-[18F]氟-2-脱氧-D-葡萄糖（2-[18F]FDG）开发个性化放射性药物的方法。

IF 0.9

NUCLEAR MEDICINE REVIEW Pub Date : 2023-01-01 DOI: 10.5603/nmr.93869

Gergana Simeonova, Boyan Todorov

{"title":"An approach to develop personalized radiopharmaceuticals by modifying 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG).","authors":"Gergana Simeonova, Boyan Todorov","doi":"10.5603/nmr.93869","DOIUrl":"https://doi.org/10.5603/nmr.93869","url":null,"abstract":"Background: A challenge for modern medicine is the development of clinical protocols for precise diagnosis and therapy. This study aimed to propose a simple method for modification of 2-[18F]FDG used routinely in hospitals in a way, appropriate for patients' personalized radiopharmaceuticals approach.Material and methods: For the purposes of the presented study chemo selective method for indirect radiofluorination was applauded to custom synthesized aminooxy- and hydrazine-functionalized tetrazines for 18F-glycolation via oxime or hydrazone formation. 2-[18F]FDG produced with medical baby cyclotron in Nuclear Medicine Clinic at the University Hospital St. Marina-Varna, was used. Thin layer chromatography (TLC) and radio TLC were used to follow the progress of synthesis and to determine radio chemical yield (RCY).Results: The 2-[18F]FDG was modified with two bifunctional tetrazines aminooxy-acetic acid-6-(2-aminooxy-acetoxy)-[1,2,4,5] tetrazin-3-yl ester (Tz1) and {3-[4-(6-phenyl-[1,2,4,5]tetrazin-3-yl)-phenoxy]-propyl}-hydrazine (Tz2) via oxime and hydrazone formation. The radiolabeling was carried out as one-pot reaction with following parameters: temperature 70-75°C; catalyst p- diaminobenzene (Cat.); pH = 4.2; time 30 minutes; RCY = 70-99%. The radiolabeled tetrazines are appropriate for further bioorthogonal (pretargeting) strategy by click reactions with trans-cyclooctene conjugated bioactive molecules. The methodology is applicable to standard clinical conditions.","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"26 0","pages":"109-115"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41165366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

123I-ioflupane SPECT in the assessment of Parkinson’s disease in a patient with retinitis pigmentosa 123I-ioflupane SPECT评估一例视网膜色素变性患者的帕金森病

IF 0.9

NUCLEAR MEDICINE REVIEW Pub Date : 2022-10-27 DOI: 10.5603/nmr.a2022.0040

Francesco Dondi, M. Gregorelli, D. Albano, F. Bertagna, R. Giubbini

引用次数: 0

Editorial Note. 编辑说明。

IF 0.6

NUCLEAR MEDICINE REVIEW Pub Date : 2022-01-01 DOI: 10.5603/NMR.2022.0001

Grzegorz Kamiński

引用次数: 0

99mTc-Vitamin C SPECT/CT imaging in SARS-CoV-2 associated pneumonia. 99mtc -维生素C在SARS-CoV-2相关性肺炎中的SPECT/CT成像

IF 0.9

NUCLEAR MEDICINE REVIEW Pub Date : 2022-01-01 DOI: 10.5603/NMR.a2022.0026

Haluk B Sayman, Kubra N Toplutas, James Tunick, Omer Aras

引用次数: 0

Degree of agreement between dacryoscintigraphy and dacryocystography examinations results in primary acquired nasolacrimal duct obstruction. 原发性获得性鼻泪管阻塞的泪道造影与泪道造影检查结果的一致程度。

IF 0.9

NUCLEAR MEDICINE REVIEW Pub Date : 2022-01-01 DOI: 10.5603/NMR.a2022.0004

Elyas Aditya, Yunia Irawati, Benny Zulkarnaien, Joedo Prihartono

{"title":"Degree of agreement between dacryoscintigraphy and dacryocystography examinations results in primary acquired nasolacrimal duct obstruction.","authors":"Elyas Aditya, Yunia Irawati, Benny Zulkarnaien, Joedo Prihartono","doi":"10.5603/NMR.a2022.0004","DOIUrl":"https://doi.org/10.5603/NMR.a2022.0004","url":null,"abstract":"Background: This diagnostic study aimed to assess degree of agreement between dacryoscintigraphy and dacryocystography as supporting examinations in patients with primary acquired nasolacrimal duct obstruction (PANDO). Patients with PANDO who complained of epiphora and visited our outpatient clinic were subsequently sent for dacryoscintigraphy and dacryocystography examinations. Side effects and convenience of both examinations were assessed by observation and questionnaire.Material and methods: Through irrigation and probing, there were 47 out of 62 eyes were found with PANDO. As much as 87.1% subjects were female, with mostly (74.2%) aged > 40 years old. With dacryoscintigraphy, time needed to reach sac was 0 minutes, 5 minutes (duct), and 12.5 minutes (nasal cavity).Results: Degree of agreement between both examinations was 83.8% to determine obstruction and 70.9% to locate obstruction. There were 22 subjects complained about pain in dacryocystography examination while none with dacryoscintigraphy (p < 0.005). Sixteen subjects feel dacryoscintigraphy examination was more convenient, eleven subjects feel dacryocystohraphy was more convenient, while 4 subjects feel the two examinations were similar.Conclusions: Even though dacryocystography examination was considered more painful than dacryoscintigraphy, both examinations had high convenience level for patients. Dacryoscintigraphy and dacryocystography also had a good agreement in detecting and locating obstruction in PANDO.","PeriodicalId":44718,"journal":{"name":"NUCLEAR MEDICINE REVIEW","volume":"25 1","pages":"12-17"},"PeriodicalIF":0.9,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10535483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0