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The Role of MRI-TRUS Fusion Biopsy in the Diagnosis of Clinical Significant Prostate Cancer (CsPca) MRI-TRUS融合活检在临床显著性前列腺癌(CsPca)诊断中的作用
Male Reproductive Health Pub Date : 2019-04-03 DOI: 10.5772/INTECHOPEN.85243
Benelli Andrea, V. Chiara, Guzzo Sonia, Varca Virginia, Gregori Andrea
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引用次数: 0
Polymorphism of Xenobiotic Detoxification Genes and Male Infertility 外源解毒基因多态性与男性不育
Male Reproductive Health Pub Date : 2018-11-05 DOI: 10.5772/INTECHOPEN.79233
Nguyen Thi Dai Trang, V. T. Huyen
{"title":"Polymorphism of Xenobiotic Detoxification Genes and Male Infertility","authors":"Nguyen Thi Dai Trang, V. T. Huyen","doi":"10.5772/INTECHOPEN.79233","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.79233","url":null,"abstract":"Infertility is a multifactorial disease caused by both genetic and environmental factors. It is observed in 10–15% of couples, among which male infertility contrib-utes for half the cases. Thus, identifying underlying causes of male infertility and for proper methods for treating and/or preventing sperm damage is of paramount importance. It is found that one of the factors that has been recently implicated in male infertility is oxidative stress, mediated by reactive oxygen species (ROS) that are produced during the metabolic process, as well as during the exposure to environmental chemical agents and their interaction with tissue-specific enzymes. Several studies have identified genetic variations at different loci, connected with male infertility, that may shed light on some idiopathic cases of seminal fluid abnormalities. In this chapter, we make an effort to decipher the contribution of polymorphisms in xenobiotic detoxification genes in the male infertility development.","PeriodicalId":446135,"journal":{"name":"Male Reproductive Health","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133299473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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