{"title":"Testicular Cancer and the Importance of Early Diagnosis","authors":"Serife Zehra Altunkurek","doi":"10.5772/intechopen.89241","DOIUrl":"https://doi.org/10.5772/intechopen.89241","url":null,"abstract":"Prevalence of cancers is growing rapidly in all parts of the world. Testicular cancer (TC) is one of the greatest threats to health among 15to 34-year-old males. Since testicular cancer peaks in incidence among young men of reproductive age, it is an important type of cancer for men. Risk factors for testicular cancer include cryptorchidism (i.e., undescended testicles), family history, infertility, tobacco use, and white race. Therefore increasing awareness in this regard, a joint effort that encourages risk factors and preventive measures, must be shown. The treatments are very effective, which greatly increases the 5-year survival rate by approximately 98%. Prevention is the best option to tackle TC. Secondary preventive measures, the most important testicular self-examination (TSE), are well known and are encouraged to them. TSE helps prevent the diagnosis of late-stage TSE. Because the treatment of testicular cancer detected early is often associated with very positive results, routine screening and monthly self-examination in young men have been suggested. Although testicular cancer is rare, it is very effective to treat symptoms when they are diagnosed by TSE. As with breast cancer, early detection of TC is best done through self-examination.","PeriodicalId":446135,"journal":{"name":"Male Reproductive Health","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127693757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Henriques, S. Loureiro, M. Fardilha, M. T. Herdeiro
{"title":"The Role of Endocrine-Disrupting Chemicals in Male Fertility Decline","authors":"M. Henriques, S. Loureiro, M. Fardilha, M. T. Herdeiro","doi":"10.5772/intechopen.88330","DOIUrl":"https://doi.org/10.5772/intechopen.88330","url":null,"abstract":"Endocrine-disrupting chemicals (EDCs) are exogenous compounds with natural or anthropogenic origin omnipresent in the environment. These compounds disrupt endocrine function through interaction with hormone receptor or alteration of hormone synthesis. Humans are environmentally exposed to EDCs through the air, water, food and occupation. During the last decades, there has been a concern that exposure to EDCs may contribute to an impairment of human reproductive function. EDCs affect male fertility at multiple levels, from sperm production and quality to the morphology and histology of the male reproductive system. It has been proposed that exposure to EDCs may contribute to an impairment of sperm motility, concentration, volume and morphology and an increase in the sperm DNA damage. Moreover, EDCs exert reproductive toxicity inducing structural damage on the testis vasculature and blood-testis barrier and cytotoxicity on Sertoli and Leydig cells. This chapter will explore the effects of EDCs in male reproductive system and in the decline of male fertility.","PeriodicalId":446135,"journal":{"name":"Male Reproductive Health","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121607105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zampieri Nicola, B. Federica, P. Simone, Vestri Elettra, Camoglio Francesco Saverio
{"title":"Infertility Worldwide: The Lack of Global Pediatric Andrologists and Prevention","authors":"Zampieri Nicola, B. Federica, P. Simone, Vestri Elettra, Camoglio Francesco Saverio","doi":"10.5772/intechopen.88459","DOIUrl":"https://doi.org/10.5772/intechopen.88459","url":null,"abstract":"Andrology is the medical specialty dealing with men’s health and reproductive system, including the genital, hormonal, reproductive, sexual, as well as psychological aspects, from birth to adulthood. Regular andrological checkups are essential both to reveal possible problems and to receive thorough advice and information so as to ensure that sexual and reproductive functions are well preserved. Estimates report that about one in three males suffers from andrological diseases, their rates varying according to the age: 27–30% of pediatric male subjects have reproductive and/or sexual conditions. In adulthood, 40% of men are affected by andrological diseases, in particular infertility and sexual problems. We studied medical literature about infertility, its prevention, and its treatment; our outcomes were to evaluate the role of research to prevent infertility especially in pediatric and adolescent age. The analysis of the data shows that in absolute numbers, the conditions directly associated with infertility are less studied than the treatment with medically assisted procreation. This research is intended as a warning to the countries worldwide: all those involved in the pediatric treatment area should be stimulated to act toward this goal, and each country should bear the responsibility of promoting and financing andrological screening campaigns.","PeriodicalId":446135,"journal":{"name":"Male Reproductive Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128411598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Early Life Influences on Male Reproductive Health","authors":"J. Pontré, R. Hart","doi":"10.5772/intechopen.88382","DOIUrl":"https://doi.org/10.5772/intechopen.88382","url":null,"abstract":"Increasing concern exists regarding male reproductive health worldwide. This is due to the appearance of medical reports outlining apparent adverse trends, such as a worldwide decline in total fertility rate, and an increase in testicular disorders such as testicular cancer, cryptorchidism—in parallel with a probable decline in semen quality. This is of particular concern as there is evidence to suggest that a poor sperm count is potentially associated with overall lifelong morbidity and mortality, and is effectively a predictor of lifelong health risk. This chapter examines the evidence for this decline and its potential early life causes, from in-utero exposures to childhood development.","PeriodicalId":446135,"journal":{"name":"Male Reproductive Health","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126166500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amin Tamadon, Ulanbek Zhan-byrbekuly, Ilyas Kairgaliyev, A. Khoradmehr
{"title":"Mesenchymal Stem Cell Therapy of Male Infertility","authors":"Amin Tamadon, Ulanbek Zhan-byrbekuly, Ilyas Kairgaliyev, A. Khoradmehr","doi":"10.5772/intechopen.88343","DOIUrl":"https://doi.org/10.5772/intechopen.88343","url":null,"abstract":"Nowadays mesenchymal stem cell (MSC) therapy offers a broad spectrum of treatment of different conditions, including male infertility. Lots of studies sug-gest that injection of MSC promotes differentiation of germ cells and/or stimulates gonadal tissue development. Currently, there are plenty of MSC therapies of azoospermia which have been studied on animal models and demonstrated good results. Most of the studies were conducted using MSC derived from adipose tissue, the bone marrow, and umbilical cord. Despite the fact that this type of treatment in humans is not established as a first choice option, the use of these techniques gives us hope for a gradual introduction into our daily practice.","PeriodicalId":446135,"journal":{"name":"Male Reproductive Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130530836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Dąbrowska-Bender, Robert Słoniewski, U. Religioni, Anna Słoniewska, A. Staniszewska, Karolina Jabłkowska-Górecka, M. Milewska, A. Sobol, Anna Kupiecka
{"title":"Sexual and Psychoemotional Disorders in Male Patients Treated for Prostate Carcinoma","authors":"M. Dąbrowska-Bender, Robert Słoniewski, U. Religioni, Anna Słoniewska, A. Staniszewska, Karolina Jabłkowska-Górecka, M. Milewska, A. Sobol, Anna Kupiecka","doi":"10.5772/INTECHOPEN.87208","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.87208","url":null,"abstract":"The prostate carcinoma affect the quality of life of most male patients, includ-ing in particular their sexual and emotional life. The aim of study was to assess sexual and psychoemotional disorders in male patients diagnosed with prostate carcinoma and receiving cancer treatment. The study’s patients were recruited at the Oncological Hospital in Wieliszew, Poland, between September 2016 and December 2017. The study was performed in 166 male patients diagnosed with prostate cancer. Two standardized questionnaires were used in the study, EORTC QLQ-C30 and QLQ-PR25, for patients with prostate cancer, developed by the European Quality of Life Group. The type and stage of cancer treatments were a significant contributor to feeling tense, worried, depressed, and irritable among the study patients. The stage of treatment, however, caused a negative effect on these parameters. Pretreatment patients declared high or very high satisfaction with their sexual life, while posttreatment patients and those on cancer treatment indicated low sexual satisfaction. However, a feeling of embarrassment during intimate contact as well as erectile disorders correlated both with the type and stage of cancer treatment. Our results show that affected male patients should be offered continuous psychological care, especially those waiting for treatment and those on treatment.","PeriodicalId":446135,"journal":{"name":"Male Reproductive Health","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125159318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction","authors":"M. Ješeta, J. Nevoral","doi":"10.5772/INTECHOPEN.88142","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.88142","url":null,"abstract":"Endocrine disruptors (EDs) are chemical substances that affect physiological processes in the body via hormonal regulation. They are often detected in food, plastic water bottles, cosmetics, and many other daily need items. Thereafter, EDs are detected in many bodily fluids, pointing out the real exposure to even very low doses. Permanent and long-term utilization of EDs has harmful effects on male reproductive health mainly due to interference with sex hormone synthesis and mechanism of action. However, with decreasing dosage of EDs, the possibilities of unpredictable modes of action arise. In addition to various molecular actions of individual EDs, the interference of individual ones represents another dimension of the ED issue. This review provides an overview of the EDs and their possible impact on reproductive health in males, with focus on sperm quality with the mighty potential of epigenetic transmission to further generations. The “posttranslational” effect of EDs in really low doses in real exposure routes is stigmatized in this review, being strongly considered as creeping molecular action of individual EDs as well as amplifications of their copresence in the environment.","PeriodicalId":446135,"journal":{"name":"Male Reproductive Health","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124374198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Combinatorial Drug Therapy with Phytochemicals as Adjuvants in Prostate Cancer Management","authors":"Rajalakshmi Manikkam, Indu Sabapathy","doi":"10.5772/INTECHOPEN.86157","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86157","url":null,"abstract":"Prostate cancer is one of the leading cancers in men needs a long period for development from small lesion to become a clinical manifestation. The prostate specific antigen is a prominent tumor marker for prostate cancer. Androgens are involved in the development and progression of prostate cancer regulating the androgen receptor as androgen-dependent or androgen-independent types. The latter occurs in metastatic conditions of prostate cancer developed as hormone resistant prostate cancer (HRPC) that inappropriately activates transcription of other genes involved in molecular pathways inducing cellular proliferation and inhibiting apoptosis. Since prostate cancer is characterized by slow growth and long latency period and thus integration of phytochemicals/compounds in combination with other existing therapies have promising future to manage cancer, thus controlling the disease progression and mortality rate. Therefore, the medicinal plants therapeutic or prophylactic activities on prostate cancer exhibiting anti-androgenic effects, depleting PSA, down-regulating expression of androgen receptor, regulating cell cycle regulators have promising future to be applied as adjuvant drugs in prostate cancer treatment.","PeriodicalId":446135,"journal":{"name":"Male Reproductive Health","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121035531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mauro Luis Barbosa Júnior, Ericka Kristhine Valentin, Karolnine Kamargo Bragante
{"title":"The Pelvic Health Physical Therapy and the Prostatectomy","authors":"Mauro Luis Barbosa Júnior, Ericka Kristhine Valentin, Karolnine Kamargo Bragante","doi":"10.5772/INTECHOPEN.86979","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86979","url":null,"abstract":"Considering prostate adenocarcinoma, the cancer of higher incidence in men, having as treatment of choice the prostatectomy, and the high prevalence of urinary incontinence (UI) and erectile dysfunction (ED) after the surgery, the physiotherapy becomes an eligible treatment for such alterations. The rehabilitation of postprostatectomy effort urinary incontinence is considered a recommendation grade B. Erectile dysfunction has as its first line of treatment penile vacuum therapy. Pelvic health physical therapy has as its main tool the rehabilitation of the pelvic floor muscles (PFM), which can be assisted by biofeedback and electrotherapy. The training of these muscles accelerates the recovery process of post-prostatectomy stress urinary incontinence and has greater therapeutic relevance when the physiotherapeutic treatment is initiated in the pre-surgical period. Post-micturition dribble is also treated by training the pelvic floor muscles. Urinary urgency, associated or not with incontinence, can be treated with electrotherapy, which is considered second or third line of treatment. Erectile rehabilitation has two physical resources of treatment, physical therapy, one through the vacuum and the other of the shock wave. Both penile vacuum therapy and shock wave therapy are considered the first line of treatment in the approach to erectile dysfunction.","PeriodicalId":446135,"journal":{"name":"Male Reproductive Health","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133408385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sertoli Cell Phagocytosis: An Essential Event for Spermatogenesis","authors":"Fei Wang, Daishu Han","doi":"10.5772/INTECHOPEN.86808","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.86808","url":null,"abstract":"During spermatogenesis, most male germ cells undergo apoptosis, and the cytoplasmic portions of the elongating spermatids are shed as residual bodies (RB). Both apoptotic germ cells (AGC) and RB must be phagocytosed by Sertoli cells, which are essential to maintain testicular homeostasis for normal spermatogenesis. The phagocytosis of AGC and RB by Sertoli cells confers various meanings, including elimination of apoptotic components, removal of autoantigens, and the recycle of degenerated substrates as an energy source. Sertoli cell phagocytosis can be regulated by various mechanisms. The impairment of Sertoli cell phagocytosis may disrupt tissue homeostasis in the testis, thereby impairing to testicular function and spermatogenesis. This chapter discusses the mechanisms underlying phagocytic removal of AGC and RB by Sertoli cells and the consequences of this biological event for spermatogenesis and male fertility. Cross-talk between miR-471-5p and autophagy component proteins","PeriodicalId":446135,"journal":{"name":"Male Reproductive Health","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132526126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}